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      • The Empirically Comparative Analysis of Benchmarking Studies in China and Abroad

        Jun-yi Ren 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

        To make statistical classifying of the numerous publications on benchmarking studies in China and abroad, to reveal the conditions and trends of benchmarking study both in china and abroad to make empirically comparative analysis between them at the four aspects like number of publications, the research time dimension, mainstream of research, development conditions and development trend, and then to summarize some provlems that exist in Chinese benchmarking research areas.

      • An Empirical Study on the Market Decision-Making ㅡ Mechanism of Chinese Peasant Consumers

        Jun-yi Ren 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

        Consumers from all walks of life may show different purchasing orientations. Decision-making mechanism is utilized to analyze consumption psychology of Chinese peasant consumers, their purchase behaviours and product cognition etc. This orientation has the role of psychological compulsion that consumer may not be aware when they make the purchase decision, while the role of psychological compulsion essentially dominates their decisions. To analyze psychological orientation and decision-making mechanism utilizing factor analysis, cluster analysis, and consumption psychology. Meanwhile, when income reaches some degree, income doesn’t have obvious effect on the decision-making mechanism of peasants’ purchase on durable goods, the category of consumer style depends on the “individual” factor of peasants’ consumption psychology.

      • KCI등재

        An improved regularized particle fi lter for remaining useful life prediction in nuclear plant electric gate valves

        Ren-yi Xu,Hang Wang,Min-jun Peng,Yong-kuo Liu 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6

        Accurate remaining useful life (RUL) prediction for critical components of nuclear power equipment is animportant way to realize aging management of nuclear power equipment. The electric gate valve is oneof the most safety-critical and widely distributed mechanical equipment in nuclear power installations. However, the electric gate valve's extended service in nuclear installations causes aging and degradationinduced by crack propagation and leakages. Hence, it is necessary to develop a robust RUL predictionmethod to evaluate its operating state. Although the particle filter(PF) algorithm and its variants can dealwith this nonlinear problem effectively, they suffer from severe particle degeneracy and depletion, whichleads to its sub-optimal performance. In this study, we combined the whale algorithm with regularizedparticle filtering(RPF) to rationalize the particle distribution before resampling, so as to solve theproblem of particle degradation, and for valve RUL prediction. The valve's crack propagation is studiedusing the RPF approach, which takes the Paris Law as a condition function. The crack growth is observedand updated using the root-mean-square (RMS) signal collected from the acoustic emission sensor. Atthe same time, the proposed method is compared with other optimization algorithms, such as particleswarm optimization algorithm, and verified by the realistic valve aging experimental data. The conclusion shows that the proposed method can effectively predict and analyze the typical valve degradationpatterns

      • KCI등재

        Exploring the Key Genes and Pathways of Osteoarthritis in Knee Cartilage in a Rat Model Using Gene Expression Profiling

        Yi-Ming Ren,Xin Zhao,Tao Yang,Yuan-Hui Duan,Yun-Bo Sun,Wen-Jun Zhao,Meng-Qiang Tian 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6

        Purpose: To compare differentially expressed genes (DEGs) mediating osteoarthritis (OA) in knee cartilage and in normal kneecartilage in a rat model of OA and to identify their impact on molecular pathways associated with OA. Materials and Methods: A gene expression profile was downloaded from the Gene Expression Omnibus database. Analysis ofDEGs was carried out using GEO2R. Enrichment analyses were performed on the Gene Ontology (GO) and Kyoto Encyclopedia ofGenes and Genomes pathway using the Search Tool for the Retrieval of Interacting Genes database (http://www.string-db.org/). Subsequently, the regulatory interaction network of OA-associated genes was visualized using Cytoscape software (version 3.4.0;www.cytoscape.org). Results: In the gene expression profile GSE103416, a total of 99 DEGs were identified. Among them, 76 DEGs (76.77%) were overexpressed,and the remaining 23 DEGs (23.23%) were underexpressed. GO and pathway enrichment analyses of target geneswere performed. Using gene-gene interaction network analysis, relevant core genes, including MET, UBB, GNAI3, and GNA13,were shown to hold a potential relationship with the development of OA in cartilage. Using quantitative real-time PCR, the Gna13/cGMP-PKG signaling pathway was identified as a potential research target for therapy and for further understanding the developmentof OA. Conclusion: The results of the present study provide a comprehensive understanding of the roles of DEGs in knee cartilage in relationto the development of OA.

      • Spin-orbit coupling effects on the stability of two competing structures in Pb/Si(111) and Pb/Ge(111)

        Ren, Xiao-Yan,Kim, Hyun-Jung,Yi, Seho,Jia, Yu,Cho, Jun-Hyung American Physical Society 2016 Physical Review B Vol.94 No.7

        <P>Using first-principles density-functional theory (DFT) calculations with/without including the spin-orbit coupling (SOC), we systematically investigate the (4/3)-monolayer structure of Pb on the Si(111) or Ge(111) surface within the two competing structural models termed the H-3 and T-4 structures. We find that the SOC influences the relative stability of the two structures in both the Pb/Si(111) and the Pb/Ge(111) systems, i.e., our DFT calculation without including the SOC predicts that the T-4 structure is energetically favored over the H-3 structure by Delta E = 25 meV for Pb/Si(111) and 22 meV for Pb/Ge(111), but the inclusion of SOC reverses their relative stability as Delta E = -12 and -7 meV, respectively. Our analysis shows that the SOC-induced switching of the ground state is attributed to a more asymmetric surface charge distribution in the H-3 structure compared to the T-4 structure, which is associated with the hybridization of the Pb p(x), p(y), and p(z) orbitals. This asymmetry of surface charge distribution gives rise to a relatively larger Rashba spin splitting of surface states as well as a relatively larger pseudogap opening in the H-3 structure. By the nudged elastic-band calculation, we obtain a sizable energy barrier from the H-3 to the T-4 structure as similar to 0.59 and similar to 0.27 eV for Pb/Si(111) and Pb/Ge(111), respectively. Based on the predicted thermodynamics and kinetics of Pb/Si(111) and Pb/Ge(111), we suggest not only the coexistence of the two energetically competing structures at low temperatures, but also the order-disorder transition at high temperatures.</P>

      • A Rapid and Efficient Pre-deployment Key Scheme for Secure Data Transmissions in Sensor Networks Using Lagrange Interpolation Polynomial

        Hua-Yi Lin,De-Jun Pan,Xin-Xiang Zhao,Zhi-Ren Qiu 보안공학연구지원센터 2008 International Journal of Security and Its Applicat Vol.2 No.3

        This study proposes a pre-deployment key management scheme that requires a few memory capacities and CPU computations to address secure data transmissions in Wireless Sensor Networks (WSNs). The proposed scheme exploits threshold key management mechanisms by Lagrange Interpolation polynomial generating a key set for sensor nodes, and uses symmetric and irreversible cryptography schemes to encrypt transmitted data by the generated keys with Message Authentication Code (MAC). The sensor nodes merely have to aggregate and encrypt received data without complicated cryptography operations. The proposed approach can achieve rapid and efficient secure data transmissions with low communications, and is proper to be implemented on large-scale sensor networks.

      • KCI등재

        Establishment of a novel myocarditis mouse model based on cyclosporine A

        Zhao Tian Hao,Jiang Yi Xuan,Chen Kai Qin,Qiu Dan,Xu Yan Zhe,Ye Chun,Ren Ting,Zhang Bo,Dai Bin,Hu Jue,Lu Jun,Zhou Fang Liang,Xiao Rong,Lu Fang Guo,Wei Ke 한국유전학회 2022 Genes & Genomics Vol.44 No.12

        Background: Myocarditis is a myocardial injury that can easily cause adolescent death. Traditional research models of animal invasion with viral components, lipopolysaccharide (LPS) or porcine myocardial myosin, among others, have the shortcomings of potential biological safety hazards and high animal mortality. Objective: To explore the construction of a novel myocarditis model with cyclosporine A and the potential genes and pathways associated with it. Methods: BALB/c mice were used in this study, and cyclosporin A and LPS were injected into the peritoneal cavity of mice. The successful establishment of the model was assessed by detecting serum myocardial injury markers and inflammatory factors levels, HE, IHC staining, and RT-qPCR methods. Key genes were obtained using the GSE35182 dataset from the GEO database and validated with the RT-qPCR method. Results: We found that a large number of inflammatory cells infiltrated the myocardium of mice in each group of Cyclosporin A constructed model, while the expression of inflammatory factor indicators was increased, and this model has the characteristics of high degree of local inflammation in myocardial tissue, low mortality, and safe and non-toxic treatment. Using GSE35182 data, we selected 18 Hub genes and validated Hub genes in myocardial tissue with RT-qPCR and found that multiple signaling pathways such as Toll-likereceptor signaling pathway(TLRs), Rap1 signal pathway(Rap1), and Chemokine signaling pathway may be involved in the development of myocarditis. Conclusion: Cyclosporin A can construct a new myocarditis model, and TLRs, Chemokines and Rap1 signaling pathways may be the core pathways of myocarditis.

      • Anti-inflammatory and Anticancer Activities of Ethanol Extract of Pendulous Monkshood Root in vitro

        Huang, Xian-Ju,Ren, Wei,Li, Jun,Chen, Lv-Yi,Mei, Zhi-Nan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

        Aim: Pendulous monkshood root is traditionally used for the treatment of several inflammatory pathologies such as rheumatisms, wounds, pain and tumors in China. In this study, the anti-inflammatory and anticancer activities and the mechanism of crude ethanol extract of pendulous monkshood root (EPMR) were evaluated and investigated in vitro. Materials and Methods: The cytotoxic effects of EPMR on different tumor cell lines were determined by the MTT method. Cell apoptosis and cell nucleus morphology were assessed by Hoechst 33258 staining. Moreover, nitric oxide (NO) levels and intracellular oxidative stress in peritoneal macrophages were determined to further elucidate mechanisms of action. Results: The data showed that EPMR could produce significant dose-dependent toxicity on three kinds of tumor cells. Furthermore, EPMR displayed obvious anti-inflammatory effects on LPS-induced mouse peritoneal macrophages at the dosage of 4 - 200 ${\mu}g/mL$. The results demonstrated the therapeutic potential of Pendulous Monkshood Root on cancer and inflammatory diseases. Conclusion: Our results indicate that EPMR has anti-inflammatory and anticancer properties, suggesting that pendulous monkshood root may be a useful anti-tumor and anti-inflammatory reagent in the clinic.

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