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정종철,최홍란,오희균,박준아,류선열,이종호,김영운,정숭룡 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3
Malignant fibrous histiocytoma rarely occurs in the jaws. Although the histogenesis of this tumor remains controversal, it is best regarded as a primitive and pleomorphic nature reflected by collagen production and occasional phagocytosis. It is common for metastatic foci to appear in lung and regional lymph node. There are variable treatments such as radiotherapy, surgical excision or combination, therapy of surgical excision, chemotherapy and radiotherapy. With the review of literatures, the authors report the clinical study of two cases of malignant fibrous histiocytoma of the jaw.
골반내에 발생한 Proximal-type 유상피성 육종 1예
길준철,이상수,전병화,김성훈,손우석,목정은,박양순,강길현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4
유상피성 육종은 매우 드문 악성 연조직 육종으로, 전형적인 경우들은 주로 젊은 남성의 수부, 전완부와 같은 신체의 원위부에 피하 혹은 심재성 피부 종괴로 발생하며, 조직학적 소견상 적은 비정형성을 나타내는 유상피성 세포와 방추형 세포의 증식에 의한 다발성 결절 형태의 배열을 보인다. 최근에 전형적인 유상피성 육종과 조직학적 유사성을 가지나 더 공격적인 형태인 proximal-type 유상피성 육종이 보고되었으며, proximal-type은 전형적인 유상피성 육종에 비하여 현저한 유상피성 세포의 발현과 매우 심한 비정형성을 나타내며, 세포가 매우 크고, 소포성 핵과 뚜렷한 핵소체를 보이며, 자주 rhabdoid 세포의 양상을 띈다. 임상적으로는 전형적인 형태에 비하여 호발 연령이 조금 늦고, 주로 체간부에, 특히 골반, 회음부, 생식기 등과 같은 심부에 발생하고, 더욱 공격적인 양상을 나타낸다. 저자들은 13세 소녀에서 원발부위를 알 수 없는, 골반내에 발생한 proximal-type 유상피성 육종 1예를 경험하여, 문헌 고찰과 함께 보고하는 바이다. Epithelioid sarcoma is a rare malignant soft-tissue sarcoma with an unknown histiogenesis, typically presenting as a subcutaneous or deep dermal mass lesion in the distal portions of the extremities of young adults. Recently, a more aggressive, so-called 'proximal-type' epithelioid sarcoma has been reported. In contrast to conventional epithelioid sarcoma, the proximal type is characterized by a predominantly large cell epithelioid cytomorphology, marked cytologic atypia, and frequent occurrence of rhabdoid features in most patients. Proximal-type epithelioid sarcoma has a predilection for appearing in the genitalia, especially the vulva, penis, pelvis and buttocks. Also this lesion appears to be somewhat more aggressive or at least metastasizes earlier than the conventional epithelioid sarcoma. We report a 13-year-old girl who presented with a buge mass filling the pelvic cavity which was painful, hard and fixed on palpation, and was radiologically diagnosed as a malignant germ cell tumors on the CT scan. The mass was surgically excised and pathologically proved to be an proximal-type epithelioid sarcoma of unknown origin.
Park, Sae-Gwang,Jung, Young-Joo,Lee, Young-Yi,Yang, Cheul-Min,Kim, Ik-Jung,Chung, Jun-Ho,Kim, Ik-Sang,Lee, Youn-Jae,Park, Sung-Jae,Lee, Jeong-Nyeo,Seo, Su-Kil,Park, Yong-Hong,Choi, In-Hak MARY ANN LIEBERT INC PUBL 2006 VIRAL IMMUNOLOGY Vol.19 No.1
<P>CDR3 of the heavy-chain variable region of immunoglobulin is a region in which somatic mutation occurs heavily after secondary antibody response, resulting in an affinity maturation of antibodies in vivo. The aim of this study was to improve the affinity of a human single-chain variable fragment (scFv) specific for pre-S1 of hepatitis B virus (HBV) by introducing random mutagenesis in CDR3 variable region of heavy chain (V(H)) of the parental scFv clone 1E4. By using a BIAcore for panning and screening, we have selected three clones (A9, B2, and B9) with lower highest affinity (K(D)) than 1E4. Affinities of selected clones ranged from 1.7 x 10(7) mol/L to 6.3 x 10(8) mol/L, which were increased by factors of 1.4 to 4.0, respectively, compared to the parental clone. Binding inhibition assay using flow cytometry and polymerase chain reaction revealed that B2 (6.4 x 10(8) mol/L) had a higher neutralizing activity against pre-S1 or HBV virion binding to liver cell line. This anti-pre-S1 scFv can be considered as a potential therapeutic tool for a passive immunotherapy for HBV infection.</P>
국내양식 민물장어 4 종(Anguilla japonica, A. rostrata, A. bicolor pacifica 및 A. marmorata)의 주요 영양성분의 평가
안준철 ( Jun Cheul Ahn ),정원석 ( Won Seog Chong ),나진호 ( Jin Ho Na ),윤형복 ( Hyoeng Bok Yun ),신경재 ( Kyung Jae Shin ),이경우 ( Kyeong Woo Lee ),박준택 ( Jun Taek Park ) 한국수산과학회 2015 한국수산과학회지 Vol.48 No.1
The basic and main nutritive ingredients of two temperature (Anguilla japonica and A. rostrata) and two tropical ( A. bicolor pacifica and A. marmorata) fresh water eel species that are farmed domestically were evaluated. With exception of A. rostrata, eels cultured at the same farm were used for analysis. The contents of crude protein were in the order A. marmorata (17.7%)> A. rostrata (17.5%)> A. bicolor pacifica (17.4%)> A. japonica (15.8%) and the contents of crude lipids were A. japonica (21.5%)> A. rostrata (15.4%)> A. bicolor pacifica (10.5%)> A. marmorata (8.9%). These values differed significantly even among the three species of eel farmed under identical culture conditions. In comparison, all four species of eel showed similar pattern in overall amino acid composition, although slight differences in the compositions of some amino acids were observed. The fatty acid compositions of muscle tissues were notably different among four species of eel, especially between the tropical and temperature eels. In a taste-test of the meat of the four eel species, which considered taste, flavor and texture, the overall preference was in the order A. japonica, A. marmorata, A. bicolor pacifica and A. rostrata.
Multi-agent에 근거한 공급망관리에서의 협상알고리즘
박준철 ( Jun Cheul Park ),엄완섭 ( Wan Sup Um ) 한국경영공학회 2015 한국경영공학회지 Vol.20 No.1
In supply chain management, improving the efficiency of the overall supply chain is of key interest. Because of market globalization and the advancement of e-commerce the importance of supply chain network is increasing. A supply chain can produce products for multiple markets. Also, an individual company is likely to have only limited visibility of the supply chain structure, which makes it difficult to make future demand estimations, because the pattern of demand propagation through the supply chain depends on the capabilities and strategies of companies along the path from the markets to the company. There will be the conflict among the pursuit of the profit of all members of the SCM. In order to maximize the total profit of the SCM, negotiation among all members is necessary. In this research, we consider only purchasing agent and supplier agent. We consider multi-agent based automated negotiation system to find the best negotiation strategy that makes all members of the SCM satisfied in a simple SCM. And we propose the trade-off algorithm to provide the total maximum profits and the minimum difference in profits of both attendances in negotiations. Multi-agent based automated negotiation system could be transformed into linear programming with negotiation information. The ideas behind the suggested model are trade-off algorithm with an agent and we consider multiple factors that are color, price, mileage, and delivery date. We``ve compared multi-agent based automated negotiation system with negotiation system with trade-off mechanism. We have used utility function as a performance measure in order to compare offer set that purchasing agent receipted.
인터넷 정보시스템업체 종사원이 지각하는 고용불안정이 조직신뢰와 조직몰입에 미치는 영향
박준철(Jun-Cheul Park) 한국인터넷전자상거래학회 2009 인터넷전자상거래연구 Vol.9 No.1
The purpose of this paper was to investigate the perceived job insecurity of internet information system employees impact on organizational trust and organizational commitment. 310 samples participated in the study. Results showed that job insecurity had significant influence on organizational trust and organizational commitment, and job insecurity was found to have significant indirect impact on the organizational commitment. In depth discussion on contributions and limitations of this study was provided through conclusion and discussion section.
박준철(Park, Jun-Cheul) 한국산업경영학회 2007 한국산업경영학회 발표논문집 Vol.2007 No.4
This paper understands the conceptual nature of blog participation behaviors and explores major antecedent personal values(internal value, external value) that may influence the participation behaviors. Blog users' personal values are proposed to affect blog users' level of participation. Based on data from blog users, confirmatory factor analysis indicated that there exists three distinct dimensions(physical, emotional, and mental/information input) underlying the participation behaviors. The empirical result showed that blog users' personal values(internal value, external value) have significant effect on their participation behaviors. However, the indirect effect of internal value on participation behaviors does not seem to be clear. It was statistically significant when the blog user paricipation was considered as an overall construct, while it was not when the participation behavior was analyzed in terms of input dimensions. 본 연구는 선행연구를 바탕으로 블로그 이용자의 블로그 참여행위를 입력 내용에 따라 3가지(물리적, 감정적, 정신.정보 입력)로 분류하였다. 그리고 이들 블로그 참여행위에 영향을 미치는 선행변수로 개인가치(내부지향 개인가치, 외부지향 개인 가치)를 고려하였다. 블로그 이용자를 대상으로 실시한 확인요인분석 결과 블로그 참여행위에는 3가지 입력 종류가 존재하고 있음을 확인할 수 있었다. 즉 내부지향 개인가치, 외부지향 개인가치에 따라 블로그 참여행위가 중대한 영향을 받게 됨을 알 수 있었다. 하지만 개인가치 태도를 통한 간접효과는 블로그 참여의 개념적 구조에 따라 다른 결과를 보여 주었다. 즉 외부지향 개인가치는 총체적 개념과 독립된 개념으로 구분하여 분석하였을 때 간접효과는 통계적으로 유의하였다. 하지만 내부지향 개인가치는 총체적 개념과 독립된 개념 모두 유의하지 않는 것으로 나타났다.