난소 과자극증후군과 동반된 뇌바닥동맥 혈전증

박준철,임수연,배진곤,김종인,이정호,Park, Joon-Cheol,Lim, Su-Yeon,Bae, Jin-Gon,Kim, Jong-In,Rhee, Jeong-Ho 대한생식의학회 2008 Clinical and Experimental Reproductive Medicine Vol.35 No.1

보조생식술 시행 후 혈전색전증의 발생은 매우 드물기는 하나 치명적인 합병증이다. 과배란 유도시 중증 난소 과자극 증후군은 $0.1{\sim}0.5%$에서 발생하며, 중증 난소 과자극증후군 환자의 128명 중 한 명에서 혈전색전증이 발생하는 것으로 알려져 있다. 발병기전으로는 과배란 유도에 따른 고에스트로젠 혈증에 의한 혈액응고인자의 변화, 혈관 투과성의 증가에 따른 혈액농축 및 순환혈액의 감소 등을 원인으로 추정하고 있으나 그 정확한 기전은 알려진 바가 없다. 또한 thrombophilia나, 혈전색전증의 과거력 및 가족력이 있는 경우 발병율이 증가한다. 혈전증의 발생 부위는 정맥이 67%이나, 33%는 동맥에 발병하며 주로 뇌동맥에 발생된다고 보고되었다. 본 예는 3년간의 이차성 불임을 주소로 내원하여 시험관 아기시술을 시행하였으며 hCG 투여 8일 후 난소 과자극증후군이 중등도로 발생하였다. hCG 투여 후 11일째 갑작스런 의식 소실 및 우측 상지의 운동장애가 발생하여 시행한 MRI상 뇌바닥동맥 (basilar a.) 혈전증으로 진단되었으며, 혈관내 혈전 용해술 및 풍선 확장술 시행후 재관류에 성공하였다. 시술 2일 후 의식 및 운동장애는 완전히 회복되었으며 시술 7일 후 말더듬증 역시 회복되어 후유장애 없이 건강한 상태이다. Thrombophilic study상 Protein S결핍 소견을 보였고, 또한 vWF-associated Ag.이 증가된 양상을 보였다. 지금까지 국내에서 난소 과자극증후군 이후에 발생한 뇌경색은 5예가 보고되었으며, 이중 4예에서 protein S deficiency 소견을 보였으므로 선별 검사로 유용할 것으로 사료된다. 저자 등은 3년간의 이차성 불임을 주소로 내원한 33세 환자에서 시험관 아기시술시 hCG 투여 11일째에 발생한 뇌바닥동맥 혈전증을 간단한 문헌 고찰과 함께 보고하는 바이다. Thromboembolic disease associated with assisted reproductive techniques is considered to be extremely rare but most serious complication. The reasons for this are thought to hypercoagulable state characteristic of OHSS due to high serum levels of estrogen, hemoconcentration and reduced circulating blood volume, but is still unclear. The risk is increased those with rare hypercoagulable conditions such as antiphospholipid antibody syndrome, protein C deficiency, protein S deficiency, antithrombin III deficiency, and those with a personal or family history of thromboembolic disease. The majority of thrombosis reported were venous site but arterial thrombosis mostly intracerebral was reported 5 cases in Korea so far. We present a case of basilar a. thrombosis at 11 days after hCG injection. The patient developed the right hemiparesis, and recovered after intraarterial thrombolysis and transluminal angioplasty. Protein S activity was decreased and vWF antigen was increased. Decreased protein S activity was also found in previous reported 4 cases, so we suggest screening test for protein S in OHSS patients.

조기 난소기능 부전증 환자에서 자가면역 질환과의 상관관계

박준철,김종인,이정호,Park, Joon-Cheol,Kim, Jong-In,Rhee, Jeong-Ho 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.3

Objective: To assess the association with autoimmune endocrine diseases and detection rate of autoimmune antibodies and its clinical significance in patients with premature ovarian failure. Methods: Twenty eight patients with primary or secondary amenorrhea manifesting hormonal and clinical features of premature ovarian failure (primary POF: 7, secondary POF: 21) were investigated. We tested them TFT, 75 g OGTT, ACTH and S-cortisol for thyroiditis, IDDM, Addison's disease, and antithyoglobulin antibody, antimicrosomal antibody, antinuclear antibody, rheumatic factor, anti-smooth muscle antibody, anti-acetylcholine receptor antibody for non-organ specific autoimmune disorders. Results: Only one patient was diagnosed as IDDM and no patients had abnormal TFT or adrenal function test. More than one kind of autoantibody was detected in 11 patients of all (39.2%): 5 patients (71.4%) of primary POF group and 6 patients (21.4%) of secondary POF group. Eleven patients (39.3%) had antithyroglobulin antibody, 4 (14.3%) had antimicrosomal antibody, 2 (7.1%) had antinuclear antibody, 2 (7.1%) had rheumatic factor, 1 (3.6%) had anti-smooth muscle antibody, 1 (3.6%) had anti-acetylcholine receptor antibody. Conclusions: Premature ovarian failure may occur as a component of an autoimmune polyglandular syndrome, so patients should be measured with free thyroxine, thyroid-stimulating hormone, fasting glucose and electrolytes. Measurement of thyroid autoantibodies in POF patients may be important in identifying patients at risk of developing overt hypothyoidism, but other autoantibodies may not be suitable for screening test.

불임 검사시 자궁난관 조영술의 진단 정확도

박준철,김종인,이정호,Park, Joon Cheol,Kim, Jong In,Rhee, Jeong Ho 대한생식의학회 2005 Clinical and Experimental Reproductive Medicine Vol.32 No.3

Objective: This study was performed to evaluate the accuracy of hysterosalpingography (HSG) for evaluating female infertility patients by comparison with hysteroscopic and laparoscopic examination. Methods and Material: Total 219 infertile patients were retrospectively analyzed between January 1, 2002 and December 31, 2003. Ninety seven patients (44.3%) were primary infertility, 122 patients (55.7%) were secondary infertility. We performed hysteroscopic and laparoscopic examination on next cycle when HSG revealed any abnormal finding, and 3~6 cycles later if HSG was normal. Results: The accuracy of HSG was 65.2% compared with hysteroscopic examination (sensitivity 88.4%, specificity 46.4%, false positive rate 53.6%, false negative rate 11.6%). The most common abnormal finding of hysteroscopy was uterine synechia (67.4%) followed by endometrial polyp, uterine anomaly (e.g. uterine septum), endometrial hyperplasia. Compared with laparoscopic examination, the accuracy of HSG was 76.9% (sensitivity 98.9%, specificity 70.6%, +LR 3.36, -LR 0.02). The positive predictive value of normal patent tube was excellent (99.6%) but that of proximal tubal blockage was only 46.7%. The unilateral tubal obstruction of HSG was poor accuracy (+LR 3.85 -LR 0.68) and 70% of those was patent by laparoscopic examination. Laparoscopic examination also revealed that 53% of patients had peritubal adhesion and 37% of patients has additional pelvic findings, especially endometriosis. Among the patients had normal HSG, 53.5% patients with normal ultrasonography was diagnosed endometriosis (25.6% of them had endometriosis stage I-II). Conclusion: Normal HSG shows a high negative predictive value. Nevertheless, the incidence of associated pelvic disease in the normal HSG group is high enough to warrant diagnostic laparoscopy if nonsurgical treatment is unsuccessful. Because HSG has poor accuracy in predicting distal tubal blockage and peritubal adhesion, and poor positive predictive value of proximal tubal blockage, laparoscopic examination could be considered in abnormal HSG group.

신이론 신기술: 돼지사료에 공액리놀레산(CLA)의 첨가급여 효과

박준철,Park, Jun-Cheol 한국사료협회 2011 飼料 Vol.50 No.-

P2P 오버레이 네트워크에서의 능동적 공격에 대한 방어

박준철,Park Jun-Cheol 한국통신학회 2006 韓國通信學會論文誌 Vol.31 No.4c

피어-투-피어(P2P) 네트워크는 개방적, 평면적, 자율적 특성으로 인하여 참여 피어들의 악의적인 공격에 근원적으로 취약하다. 본 논문에서는 부트스트래핑(bootstrapping) 단계 및 온라인 단계에서의 악의적 피어들의 공격을 효율적으로 방어하는 문제를 다룬다. 본 논문은 부트스트래핑 단계에서 네트워크의 신뢰성 있는 노드를 이용하여 새로 가입하는 피어에게 ID 관련 정보를 안전하게 부여하는 멤버쉽 처리 프로토콜을 제시한다. 이 신뢰성 있는 노드들은 새로운 피어들이 네트워크에 참여할 때만 사용되곤 그 이외의 P2P 동작에는 관여하지 않는다. 온라인 단계에서의 공격에 대하여 본 논문에서는 P2P 오버레이를 통해 전송되는 메시지의 구조를 제안하여, 메시지 변경, 재생 공격 및 잘못된 정보를 가지는 메시지 공격들의 검출이 용이해지도록 한다 제안한 기법들은 함께 적용되어 악의적 피어들의 속임수를 억제함으로써 피어들로 하여금 네트워크의 프로토콜을 준수하게 만든다. 제안 기법들은 기본적 P2P 오버레이 모델을 가정하여 비구조적 및 구조적의 다수 P2P 네트워크들에 적용될 수 있다. A peer-to-peer(P2P) network is inherently vulnerable to malicious attacks from participating peers because of its open, flat, and autonomous nature. This paper addresses the problem of effectively defending from active attacks of malicious peers at bootstrapping phase and at online phase, respectively. We propose a secure membership handling protocol to protect the assignment of ID related things to a newly joining peer with the aid of a trusted entity in the network. The trusted entities are only consulted when new peers are joining and are otherwise uninvolved in the actions of the P2P networks. For the attacks in online phase, we present a novel message structure applied to each message transmitted on the P2P overlay. It facilitates the detection of message alteration, replay attack and a message with wrong information. Taken together, the proposed techniques deter malicious peers from cheating and encourage good peers to obey the protocol of the network. The techniques assume a basic P2P overlay network model, which is generic enough to encompass a large class of well-known P2P networks, either unstructured or not.

난관수종액이 생쥐 배아발달에 미치는 영향

박준철,김정아,김동자,배진곤,김종인,이정호,Park, Joon-Cheol,Kim, Jeong-A,Kim, Dong-Ja,Bae, Jin-Gon,Kim, Jong-In,Rhee, Jeong-Ho 대한생식의학회 2010 Clinical and Experimental Reproductive Medicine Vol.37 No.2

목 적: 난관수종액내의 사이토카인 농도를 측정하고, 사이토카인 농도가 다른 난관수종액을 이용하여 생쥐 배아 발생에 미치는 영향을 비교하고자 하였다. 연구방법: 난관수종액은 자궁난관 조영술에서 난관수종이 진단되어 복강경을 통한 난관 절제술을 시행하는 경우 난관 절제술 전에 난관으로부터 채취한 다음 3,000 rpm에서 10분간 원심분리시킨 후 상층액만을 $-20^{\circ}C$에서 보관하였다. 난관수종액의 사이토카인의 조성 및 농도를 확인하기 위하여 interleukin (IL)-$1{\alpha}$, IL-$1{\beta}$, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-$\alpha$, interferon (IFN)-$\gamma$, vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), monocyte chemotactic protein (MCP)-1 등을 ELISA 방법으로 측정하였다. 기본 배양액에 난관수종액을 5%, 10%, 30%의 비율로 첨가하여 각 군별로 배반포로의 발달을 관찰하였다. 결 과: 난관수종액내에서 IL-$1{\alpha}$, IL-$1{\beta}$, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-$\alpha$, IFN-$\gamma$, VEGF, EGF, MCP-1가 검출되었으며, 그 농도에 있어서는 큰 차이를 보였다. 정상 혈청 농도에 비하여 난관수종액-1은 IL-6, IL-10이 증가되어 있었고, 난관 수종액-2는 IFN-$\gamma$, MCP-1 및 VEGF가 증가되어 있었다. 각 난관수종액의 Th1/Th2 비는 HSF-1의 경우 IFN-$\gamma$:IL-10이 3.69로 정상인 데 비하여 HSF-2의 경우 IFN-$\gamma$:IL-10이 61.14로 크게 증가되어 있었다. 난관수종액을 포함하지 않는 배양액에서는 배반포기 발달률은 76.7%이었고, 난관수종액-1군은 74%로 대조군과 차이를 보이지 않았지만, 난관수종액-2군의 경우 27.7%로서 대조군 및 난관수종액-1군과도 유의한 차이를 보였다. 난관수종액-1의 경우 난관수종액 농도에 따른 차이는 없었으며, 난관수종액-2군의 경우 농도에 증가함에 따라 배반포로의 발달이 감소하기는 하였지만 통계적으로 유의하지는 않았다. 결 론: 난관수종액마다 사이토카인의 조성이 다르며 이에 따라 생쥐 배아발달에 미치는 영향이 다를 수 있다. 염증성 사이토카인이 증가된 난관수종액이 배아발달에 악영향을 미칠 것으로 추정된다. 특정 사이토카인에 의한 작용을 규명하기는 위해서는 향후 지속적인 연구가 필요할 것으로 생각된다. Objective: The aim of this study was to measure the concentrations of cytokines contained in the hydrosalpingeal fluid and to evaluate the effect on the mouse embryo development with the different cytokine concentration. Methods: The hydrosalpingeal fluids (HSF) were collected during the surgery for hydrosalpinx which was confirmed by hysterosalphingogram. The cytokines in HSF including interleukin (IL)-$1{\alpha}$, IL-$1{\beta}$, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-$\alpha$, Interferon-$\gamma$ (IFN-$\gamma$), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), monocyte chemotactic protein-1 (MCP-1) were measured by ELISA method. HSF were added up to culture media with 5%, 10%, and 30% concentrations. The blastulation rates were compared. Results: IL-$\alpha$, IL-$1{\beta}$, IL-2, IL-4, IL-6, IL-8, IL-10, TNF-$\alpha$, IFN-$\bamma$, VEGF, EGF, and MCP-1 were detected, but the concentrations were different from each sample. IL-6 and IL-10 were increased in HSF-1 group, and IFN-$\gamma$, MCP-1, VEGF were increased in HSF-2 compared with normal serum range. The Th1/Th2 ratio of HSF-2 (IFN-$\gamma$:IL10) was highly elevated to 61.64, compared with that of HSF-1 (3.69). The blastulation rate was significantly decreased in HSF-2 group (27.7%) compared those of the HSF-1 group (74%) and control group (76.7%). It showed the trend that the blastulation rate was decreased depending on the concentration HSF of culture media in HSF-2 group, but it was not statistically significant. Conclusion: The composition and concentration of cytokines in each HSF were different, and increased proinflammatory cytokines in HSF might be associated with poor embryonic development. Further study will be needed about the effect of each cytokines in HSF.

PANI/PAN 나노웹의 제조와 전기전도성

박준철,안병욱,강태진,Park, Jun-Chul,Ahn, Byung-Wook,Kang, Tae-Jin 한국섬유공학회 2006 한국섬유공학회지 Vol.43 No.4

Polyaniline(PANI)/pelyacrylronitrile(PAN) nanoweb was obtained by electrospinning and in situ polymerization. The electrospinning dope was prepared through dissolving purified PAN in dimethylsulfoxide. To obtain PAN nanoweb of the proper morphology for PANI in situ polymerization, the dopes were electrospun with varying voltage, tip-to-collector distance(TCD) and dope concentration. Then, PANI, one of the conductive polymers, was polymerized on the surface of PAN nanoweb by in situ polymerization. The relationship between the electrical conductivity of PANI/PAN nanoweb and several polymerization variables was investigated. Aniline concentration, diffusion time, polymerization time, and molar ratio of aniline to oxidant (ammonium persulfate) were handled. The electrical conductivity was measured by 4-point probe method.

도로교통소음의 전파특성 및 영향

박준철,김윤신,강대준,Park, Joon-Cheol,Kim, Yoon-Shin,Kang, Dae-Joon 한국환경보건학회 2008 한국환경보건학회지 Vol.34 No.4

This study was performed to investigate propagation characteristics and effects of road traffic noise generated from vehicles. Noise levels of expressway and general road were measured at four points in a straight line based on distance from the road, and analyzed. The average noise level of expressway was 78.9 dBA at 5 m, 76.4 dBA at 10 m, 72.0 dBA at 20 m, 69.0 dBA at 30 m. That of general road was lower about $3.1{\sim}3.5\;dBA$ than that of expressway. There was no significant difference in distance attenuation between expressway noise and general road noise. The farer the distance from source is, the more the attenuation is. The influence range of noise is assessed by noise environmental standards or road noise limits. Noise levels of the time zone were measured at a boundary line of apartment to grasp noise variation by time. The time zone of lowest noises was $3{\sim}4$ a.m. and that of highest noise was $8{\sim}10$ a.m. Data recorded on tapes were analyzed to understand the characteristics of frequency because these characteristics are important factors to plan the noise reduction measures, namely path measures.

F급 가스터빈의 압력비 증가 시 운전데이터를 이용한 열효율 변동 예측

박준철,허기무,윤성훈,문윤재,유호선,이재헌,Park, Joon-Chul,Heo, Ki-Moo,Yoon, Sung-Hoon,Moon, Yoon-Jae,Yoo, Ho-sun,Lee, Jae Heon 한국플랜트학회 2014 플랜트 저널 Vol.10 No.3

국내 S복합발전본부의 150 MW급 가스터빈 축류압축기(18단)에서 저압단(1~9단)을 교체하여 압축기의 압력비를 기존 13.5에서 증가시킬 때 가스터빈 열효율을 예측하였다. 압력비 13.5일 때의 운전자료로 구한 압축기 단열효율과 터빈 단열효율을 적용하여 압력비 14.2에서 터빈일이 최대가 되는 압력비인 18.2까지 압력비를 1씩 증가하면서 열효율을 예측하였다. 압력비 증가 시 이론 열효율은 각 압력비에 대하여 각각 36.95%에서 38.6%까지 예측되었다. 압축기 저압단 교체 후 압력비가 16.2으로 증가되었을 때 실시한 성능시험 결과 열효율은 35.11%였다. 압력비 16.2일 때의 이론 열효율 37.87%와 비교하여 7.86% 범위에서 일치하였다. 압축기 교체 전 압력비 13.5일 때의 운전자료로 구한 압축기 단열효율과 터빈 단열효율을 이용하여 압력비 증가 시의 열효율을 성능시험 열효율의 7.86%내에서 예측할 수 있다. The gas turbine thermal efficiency has been predicted when the compressor pressure ratio increases from the previously set 13.5. Thermal efficiency has been predicted from 14.2 up to 18.2 at which the turbine work reaches its maximum value on the assumption that isentropic efficiency of the compressor and the turbine are constant using the operating data at the pressure ratio of 13.5. 35.11% of thermal efficiency has been acquired by the performance test when the pressure ratio increased to 16.2 since replacing the compressor low pressure stages. It's been approved that predicting thermal efficiency using the operating data at the pressure ratio of 13.5 is useful within 7.86% of tolerance as the figure measured by the performance test.

PRF, MUF 집성재의 휨 강도와 접착 성능 평가

박준철,김건호,홍순일,Park Jun-Chul,Kim Keon-Ho,Hong Soon-Il 한국가구학회 2004 한국가구학회지 Vol.15 No.2

As glulam is a woody material, it is necessary to be more careful in a gluing process. It takes 6-7 hours at $40-60^{\circ}C$ to harden PRF resin used in making structural glulam, and about 24 hours at room temperature. In the present process which can not use a press continuously, reducing the hardening time is necessary to increase production. The experiment was done to compare the adhesive properties of PRF resin and MUF resin through bending test, block shear strength test and water soaking test. In comparing the bending strength of prediction MOE is 1.2 times higher that actual MOE. PRF and MUF do not show significant difference in MOE and MOR, and in block shear strength test, such as shear strength and wood failure rate. However, in water soaking and boiling water soaking tests PRF and MUF show the significant difference in delamination rate.