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증례 : D-Penicillamine에 의한 약물유발 폐렴 및 담즙 정체성 황달 1예
류희정 ( Hee Juang Ryu ),안창혁 ( Chang Hyeok An ),김선숙 ( Sun Suk Kim ),백한주 ( Han Joo Baek ),박정웅 ( Jung Woong Park ),정성환 ( Sung Hwan Jeong ),정동해 ( Dong Hae Chung ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
D-penicillamine의 부작용은 드물지만 호흡기계, 간담도계, 혈액학적 장애 등 다양하게 보고되고 있다. 하지만 폐 침윤과 담즙 정체성 황달이 동시에 발생된 예는 세계적으로 그 보고가 매우 드물다. 저자들은 부분형 반상 경피증으로 D-penicillamine을 복용한지 10일만에 발열과 기침, 전신 발진으로 내원한 44세의 여자 환자에서 고해상 전산화 단층 촬영에서 양측 폐의 미만성 반점형 간유리음영과 간세침조직검사에서 간문맥 염증과 간세포 손상이 동반된 쓸개즙 정체를 관찰하였다. 환자는 D-penicillamine에 의한 약물유발 폐렴 및 담즙 정체성 황달로 진단되었고, 스테로이드 치료 없이 D-penicillamine의 투여 중단 만으로 증상 및 폐 병변과 간기능이 호전되었다. D-penicillamine 복용시 임상적으로 폐나 간의 부작용이 의심될 때 빠른 진단과 더불어 D-penicillamine의 투여 중단이 매우 중요할 것으로 사료된다. It has been reported that D-penicillamine has pulmonary, renal, hepatobilliary and hematologic side effects. However, it is extremely rare that pulmonary infiltration occurs with cholestatic jaundice at the same time. A 44-year-old woman with morphea developed fever and cough following a short exposure to D-penicillamine (10 days). Her sclera was slightly icteric and the liver function test was abnormal. Bilateral diffuse ground glass appearance of lung was observed on HRCT. Liver biopsy revealed cholestasis with portal inflammation and hepatocytes injury. The patient regained a satisfactory recovery after cessation of D-penicillamine without steroid therapy. Simultaneous occurrence of drug-induced pneumonitis and cholestatic jaundice following even a short exposure to D-penicillamine should be recognized. (Korean J Med 69:S964-S969, 2005)
An Adaptive Utterance Verification Framework Using Minimum Verification Error Training
Sung-Hwan Shin,Ho-Young Jung,Biing-Hwang Juang 한국전자통신연구원 2011 ETRI Journal Vol.33 No.3
This paper introduces an adaptive and integrated utterance verification (UV) framework using minimum verification error (MVE) training as a new set of solutions suitable for real applications. UV is traditionally considered an add-on procedure to automatic speech recognition (ASR) and thus treated separately from the ASR system model design. This traditional two-stage approach often fails to cope with a wide range of variations, such as a new speaker or a new environment which is not matched with the original speaker population or the original acoustic environment that the ASR system is trained on. In this paper, we propose an integrated solution to enhance the overall UV system performance in such real applications. The integration is accomplished by adapting and merging the target model for UV with the acoustic model for ASR based on the common MVE principle at each iteration in the recognition stage. The proposed iterative procedure for UV model adaptation also involves revision of the data segmentation and the decoded hypotheses. Under this new framework, remarkable enhancement in not only recognition performance, but also verification performance has been obtained.
A Study on the Application of Safeguards to Small Modular Reactor
Jinha Choi,Hyun-Jo Kim,Byung-Doo Lee,Sung-Ho Lee,Juang Jung 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
In addition to Korea, various countries such as the United States, the United Kingdom, France, and China are designing small module-type reactors. In particular, a small modular reactor is the power of 300 MWe or less, in which the main equipment constituting the nuclear reactor is integrated into a single container. Depending on the purpose, small modular reactors are being developed to help daily life such as power, heating supply, and seawater desalination, or for power supply such as icebreakers, nuclear submarines, and spacecraft propellants. Small modular reactors are classified according to form. It can be classified into light-water reactors/ pressurized light-water reactors based on technology proven in commercial reactors, and non-lightwater reactors based on fuel and coolant type such as Sodium-cooled Fast Reactor, High temperature gas-cooled reactor, Very high temperature reactor and Moltenn salt reactor. SMRs, which are designed for various purposes, have the biggest difference from commercial nuclear reactors. The size of SMRs is as small as 1/5 of that of the commercial reactors. Several modules may be installed to generate the same power as commercial reactors. Because of the individually operation for each module, load follow is possible. Also, The reactor can be cooled by natural convection because the size is small enough. It is manufactured as a module, the construction period can be reduced. Depending on the characteristics of these SMRs, application for safeguards is considered. There are many things to consider in terms of safeguards. Therefore, it is IAEA inspection or other approaches for SMRs installed and remotely operated in isolated areas, data integrity for remote monitoring equipment to prevent the diversion of nuclear materials, verification method and material accountancy and control for new fuel types and reactors. Since SMR is more compact and technical intensive, safeguards should be considered at the design stage so that safeguards can be efficiently and effectively implemented, which is called the Safeguards by design (SBD) in the IAEA. In this paper, according to the characteristics of SMR, we will analyze the advantages/disadvantages from the point of view of safeguards and explain what should be considered.
Vo Thuy-Trang T.,Kong Gyeyeong,Kim Chaeyeong,Juang Uijin,Gwon Suhwan,Jung Woohyeong,Nguyen Huonggiang,Kim Seon-Hwan,Park Jongsun 한국독성학회 2023 Toxicological Research Vol.39 No.3
Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.