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Lee, Woohyeong,Shin, Changhoon,Park, Soo Eun,Joo, Jung Min American Chemical Society 2019 Journal of organic chemistry Vol.84 No.20
<P>Thiazole-containing π-conjugated moieties are important structural units in the development of new electronic and photochromic materials. We have developed a Pd-catalyzed <I>syn</I>-hydroarylation reaction of diaryl alkynes with thiazoles that provides access to thiazole-containing triarylethylenes. Pd(II) complexes derived from Pd(0) species and carboxylic acids facilitated C-H functionalization of the unsubstituted thiazole with high C5 selectivity. The catalytic system was also compatible with other azoles, such as oxazoles and a pyrazole, allowing the stereoselective syntheses of various trisubstituted olefins.</P> [FIG OMISSION]</BR>
C−H Alkenylation of Pyrroles by Electronically Matching Ligand Control
Kim, Hyun Tae,Lee, Woohyeong,Kim, Eunmin,Joo, Jung Min Wiley (John WileySons) 2018 Chemistry, an Asian journal Vol.13 No.17
<P>Directing group and substrate control strategies have frequently been employed for the regioselective C-H alkenylation of acid- and oxidant-sensitive pyrrole heterocycles. We developed an undirected, aerobic strategy for the C-H alkenylation of N-alkylpyrroles by ligand control. For C2-alkenylation of electron-rich N-alkylpyrroles, an electrophilic palladium catalyst derived from Pd(OAc)(2) and 4,5-diazafluoren-9-one (DAF) was used. Alternatively, a combination of Pd(OAc)(2) and a mono-protected amino acid ligand, Ac-Val-OH, was useful for C5-alkenylation of N-alkylpyrroles possessing electron-withdrawing groups at the C2 position. This approach based on the electronic effects of heterocycles and catalysts can rapidly provide a wide range of alkenyl pyrroles from readily available N-alkylpyrroles and alkenes.</P>
Vo Thuy-Trang T.,Kong Gyeyeong,Kim Chaeyeong,Juang Uijin,Gwon Suhwan,Jung Woohyeong,Nguyen Huonggiang,Kim Seon-Hwan,Park Jongsun 한국독성학회 2023 Toxicological Research Vol.39 No.3
Scavenger Receptor Class F Member 2 (SCARF2), also known as the Type F Scavenger Receptor Family gene, encodes for Scavenger Receptor Expressed by Endothelial Cells 2 (SREC-II). This protein is a crucial component of the scavenger receptor family and is vital in protecting mammals from infectious diseases. Although research on SCARF2 is limited, mutations in this protein have been shown to cause skeletal abnormalities in both SCARF2-deficient mice and individuals with Van den Ende-Gupta syndrome (VDEGS), which is also associated with SCARF2 mutations. In contrast, other scavenger receptors have demonstrated versatile responses and have been found to aid in pathogen elimination, lipid transportation, intracellular cargo transportation, and work in tandem with various coreceptors. This review will concentrate on recent progress in comprehending SCARF2 and the functions played by members of the Scavenger Receptor Family in pre-diagnostic diseases.