제조방법에 따른 강하주의 품질 특성

정순택,유영주 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.2

This studies were performed to develop a Korean traditional folk liquor namely Gangha-ju has been prepared at Bosung district in Korea, and manufacturing conditions and anti-oxidation activity and antimicrobial activity of Gangha-ju were investigated. Ethyl-alcohol 20% and 30% Gangha-ju were brewed with glutinous rice wine, distilled liquor and 6 herbs of ginger, cinnamon, etc. Chemical and physical properties of 30% Gangha-ju were acidity 0.22, pH 4.31, amino acidity 3.26, transmittance 59 and conductivity 911 ㎲/m, and 20% Gangha-ju were 0.43, 4.20, 6.26, 62 and 924㎲/m. Volatile flavor compounds of ethyl alcohol, acetic acid, butanol, n-amyl alcohol, iso-pentyl alcohol, ethyl acetate, butyl acetate, acetaldehyde and furfural were detected, and main aroma compounds of Gangha-ju were isopentyl alcohol and ethyl acetate. Anti-oxidation activity by DPPH method was evaluated 31.32%, and nitrite scavenging effect was 31.7%. Anti-microbial activity against several microorganisms was pronounced strong activity over a wide range of test organisms, and Leuconostoc mesenteroids and Salmonella Ttyphimurium, Staphylococcus epidermidis were found to be more sensitive to Gangha-ju than Eschericha coli and Aspergillus flavus.

Mechanical Characterization of Nano-Structured Materials Using Nanoindentation

( Ju Young Kim ),( Sung Hoon Kim ),( Jung Suk Lee ),( Kyung Woo Lee ),( Dong Il Kwon ) 대한금속재료학회 ( 구 대한금속학회 ) 2006 METALS AND MATERIALS International Vol.12 No.3

The principal strengths of the nanoindentation technique, which is used extensively to measure the mechanical properties of nano/micro materials, are easy sample preparation and simple experimental method. Hardness and Young`s modulus are essential properties measured by nanoindentation; hardness corresponds to resistance to plastic deformation whereas Young`s modulus is related to elastic deformation. Two key difficulties arise in association with nanoindentation on small volumes: measurement accuracy and material response. Here we discuss the indentation size effect (ISE) considering tip bluntness and variation in hardness of nano-multilayers with a bilayer period, representative research on measurement improvement, and material response at nanoscales.

최근 9년간 신경정신과에 입원한 환자에 대한 임상적 고찰(1972∼1980년)

이정호,안일남,오석환,정영조,최영민,원장섭,김영훈,하혜경,이승탁,이영주 인제대학교 1983 仁濟醫學 Vol.4 No.2

정신질환 환자들에 대한 정확한 생태를 파악함은 정신 건강과 치료 대책을 세우는데 중요하다. 이에 본 저자들은 1972년부터 1980떤 사이에 인제의대 부속 서울백병원 신경정신과에 입원하여 치료 받았던 환자들에 대한 제반 요인들을 분석 검토하였다. Clinical charactristics of neuropsychiatric inpatients were evaluated and discussed with special referrence to their diagnostic distribution. All discharged cases from neuropsychatric ward of Seoul Paik Hospital during nine years from 1972 to 1980 were 2863. Among them 813 cases were discarded from this study because their clinical charts were vague in description of failed to find out. The materials of this study were extracted from 2050 discharged cases. Total number of cases of inpatients were gradually increasing by each year from 1972 to 1980. Psychoneurosis was diagnosed in 45.2%, schizophrenia in 26.9%, organic brain syndrome in 8.9%, major affective disorder in 5.5%, personality disorder in 4.8%, other psychiatric disorder in 1.5%, psychophysiologic disorder in 1.0%, mental retardation in 0.5%, paranoid state in 0.5%, and other psychosis in 0.3%. The gruop of patients, ranging in age from 21 to 40 was the highest (75.2%) in this study. Male patients were 43.9% and female patients were 56.1%. Schizophrenia leas diagnosed in 32.9%, depressive neurosis in II.3%, anxiety neurosis in 9.3%, and personality disorder in 8.1% in male patients. Hysterical neurosis was diagnosed in 25.5%, depressive neurosis in 22.2%, schizophrenia in 22.2%, and anxiety neurosis in 7.0% in female patients. The authors evaluated the route of admission of patients. Sixty-eight point three percent of total studied cases were admitted through outpatient department, 20.9% of cases were admitted through emergeney room, and 8.2% of cases were transfered from other department or hospital. Among patients who were admitted to psychiatric wards through emergency room and transferred from other department or hospital, psychoneurosis was the hightest diagnostic group in rate. Most of patients who were transferred from other department or hospital were from Internal Medical Department. There were no relationship between seasonality of admission and diagnostic group in this study. readmission rate of total studied patients in neuropsychiatric department of Seoul Paik Hospital was 30%. The readmission rate of personality disorder, mental retardation, schizophrenia, and major affective disorder were relatively high. The cases who were discharged against medical advice were 441. Among them misunderstanding about psychiatric treatment was predominent. Twenty seven percent of patients had physical illness at or during admission. The patients who were diagnosd as psychophysiological disorder had physical illness in 42.8%, 35.4% in personality disorder, 33.9% in major affective disorder, and 24.3% in schizophrenia. About nine percent of total studied cases had the history of attempted suicide. Major affective disorder, Personality disorder, Deressive neurosis, and Other Psychosis showed high incidence of history of attempted suicide prior to admission.

Inducing apoptpsis by the inhibition of c-myb in oral squamous carcinoma cell line, KB cell

Lee,Jung-Chang 대한구강생물학회 2007 International Journal of Oral Biology Vol.32 No.4

Oral squamous cell carcinoma (OSCC) is the most commonmalignancy and is a major cause of worldwide cancer mortality.The proto-oncogene c-myb plays an important role in regulationof cell growth and differentiation, and it is expressed at highlevels in hematopoietic cells and many other types of cancers.However, the function of c-myb is not well known in OSCC.The present study aimed to reveal the function of c-myb and totest the alternation of cell growth and signaling by c-myb inOSCC. In this study, c-myb and dominant-negatibe myb(DN-myb) were expressed in an adenovirus-mediated gene deliverysystem to KB cells. The over-expressed c-myb broughtincreased cellular proliferation compared with control cells.However, DN-myb infected KB cells showed significantreduction of cell growth and enhanced induction of apoptosis toactivate PARP and caspase 9. c-myb induced increase of IGF-I,-II and IGF-IR expressions while DN-myb down-regulatedthese expression. Activation of ERK and Akt/PKB pathwaywas shown only in c-myb transduced cells. These findingssuggest that the role of c-myb in cell growth of oral cancer cellsis partially mediated through the modulation of IGFs, ERK andAkt/PKB. From this results, DN-myb is strongly recommendedas a curable gene for the treatment of c-myb dependentmalignancies such as OSCC.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

노인의 Helicobacter pylori 재균율

박주상,홍원선,이영수,이은주,명승재,정훈용,양석균,김진호,민영일 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

급성 골수성 백혈병 환자에서 발생한 침습성 아스페르길루스중에 대한 수술적치료 1 예

배영환;어원식;어상민;김승만 김태영;박수영;서영경;정은주;안효정 인제대학교 2011 仁濟醫學 Vol.32 No.-

Invasive pulmonary aspergillosis is known to have a poor prognosis and major cause of morbidity and motality in patients with hematologic disease. Without adequate therapy, invasive pulmonary aspergillosis will almost always progress to fatal pneumonia. Early administration of antifungal agents in patient with invasive pulmonary aspergillosis is most important. And surgical resection of aspergillous-infected tissue may be useful in patients with lesions that are contiguous with great vessel and lesions causing hemoptysis. We reported a rare case of surgical resection as curative treatment for invasive pulmonary aspergillosis patient in 58-year-old man who had the history of acute myeloid leukemia.

장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

회맹장 판막에 발생한 아니사키스증 1례

이재익,박정하,김준영,조영완,진한영,강명주,정은욱,박석주,양성연 인제대학교 2006 仁濟醫學 Vol.27 No.-

Anisakiasis refers to parasitic infestation by nematode larvae that belongs to the subfamily Anisakinae, and this condition is seen in people who eat inadequately prepared or raw salt-water fish. While gastric anisakiasis is commonly diagnosed by endoscopic technique, intestinal anisakiasis is rare because it is less common and the clinical and radiologic features are poorly understood. The authors report a case of human anisakiasis involving the ileocecal valve in 62-year-old man who had the history of eating raw cuttlefish.