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( Hun Jun Park ),( Tai Ho Rho ),( Chan Seok Park ),( Sung Won Jang ),( Woo Seung Shin ),( Yong Seog Oh ),( Man Young Lee ),( Eun Ju Cho ),( Ki Bae Seung ),( Jae Hyung Kim ),( Kyu Bo Choi ) 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.3
Background: The brachial-ankle pulse wave velocity (baPWV) is a useful parameter to assess arterial stiffness. However, it is difficult to evaluate arterial stiffness in hypertensive patients because the baPWV is affected by the blood pressure itself. This study was designed to estimate the relationship between the change of the blood pressure parameters and the baPWV (ΔbaPWV) when hypertensive patients were subjected to an acute reduction of blood pressure. Methods: Thirty patients with essential hypertension and whose blood pressure was higher than 140/90 mmHg were enrolled. In all the patients, the blood pressure and baPWV were measured using an automatic waveform analyzer with the patients at a resting state. When the reduction of blood pressure was more than 10 mmHg after sublingual administration of nifedipine 10 mg, then the blood pressure and baPWV were measured again in the same manner and then they were compared with the baseline values. Spearman`s correlation and multiple linear regression tests were performed to estimate the relationship between the change of the blood pressure parameters (ΔSBP, ΔDBP, ΔMAP and ΔPP) and the ΔbaPWV. Results: The baPWV was significantly decreased shortly after the administration of nifedipine (1903.6±305.2 cm/sec vs. 1716±252.0 cm/sec, respectively, p<0.01). The ΔbaPWV was correlated with the ΔSBP (r=0.550, p<0.01), ΔDBP (r=0.386, p<0.05), ΔMAP (r=0.441, p<0.05), and ΔPP (r=0.442. p<0.05). On the multiple regression analysis, the ΔSBP was the only significant variable for predicting the ΔbaPWV, and the linear equation was ΔbaPWV=8.7×SBP-48. Conclusions: The baPWV is affected by the systolic blood pressure level to a large degree and careful attention must be paid to the blood pressure level when evaluating arterial stiffness with using the baPWV.
Methyl Aminolevulinate국소 광역동요법으로 치료한 기저세포암 2예
이주희 ( Ju Hee Lee ),노용관 ( Yong Kwan Rho ),이혜인 ( Hye In Lee ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),송계용 ( Kye Yong Song ),허창훈 ( Chang Hun Huh ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.6
Topical photodynamic therapy (PDT) via topical 5-aminolevulinic acid (ALA) is potentially useful for the treatment of basal cell carcinoma. However, as a photosensitizer used in PDT, methyl aminolevulinate (MAL) can replace ALA, because MAL has more advantages than ALA. We treated two patients with basal cell carcinoma using MAL-PDT. Topical MAL-PDT may be a safe and effective treatment modality for basal cell carcinoma. (Korean J Dermatol 2008;46(6):796∼799)
Methyl Aminolevulinate를 이용하여국소 광역동요법으로 치료한 광선 구순염
허창훈 ( Chang Hun Huh ),이혜인 ( Hye In Lee ),노용관 ( Yong Kwan Rho ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),송계용 ( Kye Yong Song ),이주희 ( Ju Hee Lee ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.6
Actinic cheilitis is a pathologic condition affecting mainly the lower lip caused by long term exposure of the lips to UV radiation in sunlight. Analogous to actinic keratosis of the skin, actinic cheilitis is considered as a precancerous lesion and may develop into squamous cell carcinoma. Photodynamic therapy (PDT) is a treatment modality involving the use of a photosensitizing agent, oxygen, and light of a specific wavelength to produce controlled cell death. Photodynamic therapy (PDT) using the new highly selective photosensitizer methyl aminolevulinate (MAL) (Metvix(R), Galderma, U.K.) is a promising new treatment modality for premalignant and malignant skin lesions. We report a case of actinic cheilitis treated with PDT using MAL, with satisfactory outcome in both clinical and pathological aspects. (Korean J Dermatol 2008;46(6):835∼838)
눈꺼풀테회전술과 눈꺼풀성형을 이용한 반흔성 눈꺼풀속말림의 치료
김선아,노주헌.Sun A Kim. M.D.. Ju Hun Rho. M.D. 대한안과학회 2005 대한안과학회지 Vol.46 No.2
Purpose: To report the efficacy of tarsal marginal rotation with blepharoplasty in the management of cicatricial entropion of the upper eyelid. Methods: In 9 consecutive patients, 14 eyelids with moderate cicatricial entropion of the upper eyelid were enrolled in this study. All 14 eyelids underwent tarsal margin rotation with blepharoplasty. In cases where one eyelid was involved, the fellow eyelid underwent upperlid blepharoplasty at the same time. The mean follow-up period was 17.7 months (range, 11 to 53 months). Results: In all 14 upper eyelids, the eyelashes rotated away from the surface of the eye postoperatively. There was not recurrence in 13 eyelids and the effect of correction was maintained for the follow-up period. However, in one eyelid the cicatricial entropion recurred after months. Tarsal margin rotation was repeated and there was no recurrence for 6 months. Conclusions: Tarsal margin rotation with blepharoplasty appears to be effective in managing cicatricial entropion of the upper eyelid in both functional and cosmetic aspects.