고도정수처리 공정에서의 천연유기물질 특성변화 및 소독부산물 전구물질의 제거특성 평가

노재순,손희종,박은주,황영도,최동훈,배석문,신판세 慶星大學校 環境問題硏究所 2002 環境硏報 Vol.12 No.1

In this research the movement and apparent molecular weight distribution of hydrophilic/hydrophobic organic matters in advanced water treatment process were investigated using the raw water of Maeri area, located in downstream of Nakdong river, and the variation of the disinfection by-product formation potential was also investigated. In the raw water used in experiments, the content of BDOC (biodegradable dissolved organic carbon) in dissolved organic carbon (DOC) was about 39%, and this value is far above a normal, Pre-ozone treatment showed an increase of 40% in the BDOC content, and this means that biodegradability was remarkably increased by ozone treatment BDOC concentration in BAC treated water was 0.09 mg/L, which means 84% of BDOC removal rate compared with that in post-ozone treated water. The variation of chlorine disinfection by-product formation potential in each process unit of water treatment process was analyzed. TOXFP concentration in raw water was 449 ㎍/L, and the contents of THMFP and HAAFP among TOXFP were 24% and 23%, respectively. The removabilities of these materials BAC process had an order of TOXFP > HAAFP > THMFP. BAC process was less effective for THMFP than others. The distribution of hydrophilic organic matters were evaluated in each treatment process. Hydrophilic and hydrophobic matters in the raw water had a ratio of 50 : 50, and the ozone treatment decreased the content of hydrophobic matters. The BAC treatment made the ratio 85:15. These mean that the removal of hydrophilic matters is more difficult than that of hydrophobic materials in water treatment process. In addition the portions of humic and fulvic acid in hydrophobic matters were analyzed. Fulvic acid a large portion among hydrophobic matters in the raw water, and the portion was 78%. Ozone treatment was more effective on the removal of fulvic acid than humic acid. After BAC treatment, the concentration of residual fulvic acid was high than humic acid. Chlorine disinfection by-product formation for hydrophilic and hydrophobic mattrts was compared in each process unit. in the raw water TOXFP and THMFP formation for hydrophobic matter was higher, and HAAFP was highly formated for hydrophobic matter. After post-ozone or BAC treatment, chlorine disinfection by-product formation has high potential for hydrophobic matters. Comparing humic and fulvic acids, chlorine disinfection by-product formation potential was higher for humic acid than for fulvic acid in all processes. In the comparison of the reactivity with chlorine disinfection by-product per unit DOC, THMFP and DOXFP showed higher reactivity with hydrophobic matter than with hydrophilic matter in all processes, and HAAFP was highly reacitive with hydrophilic matter. Apparent molecular weight distributions of organic matters were investigated in each process step.The content of low molecular weight organic matters less than 1000 Da in DOC was high in all processes except raw water, but molecular weight organic matters more than 1000 da was higher than molecular weight organic matters less than 1000 Da in the formation potential of chlorine disinfection by-product.

쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고

김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.

유아의 창의성 수준에 따른 언어표현력의 차이

노영희(Noh, Young-Hee),장연주(Chang, Youn-Ju) 한국열린유아교육학회 2011 열린유아교육연구 Vol.16 No.6

본 연구는 유아의 창의성과 언어 능력은 관계성이 있다는 선행 연구에 기초하여 창의성 수준에 따라 문장표현력과 어휘표현력을 하위 요인으로 언어표현력의 관계를 알아보고자 하였다. 이를 위해 만 5세 유아 90명을 대상으로 창의성검사를 실시하고 fox story stem을 제시한 이야기 자료를 수집하여 분석하였다. 연구결과 첫째, 문장 수 평균은 창의성이 높은 집단이 더 높았으며, 집단 간 유의미한 차이는 나타나지 않았다. 둘째, 평균발화길이의 평균은 창의성이 높은 집단이 더 높았으며, 통계적으로도 유의미한 차이가 있었다. 셋째, 창의성이 높은 집단의 9품사(명사, 대명사, 수사, 동사, 조사, 형용사, 관형사, 감탄사, 부사) 사용 평균이 더 높았으며, 특히 명사, 수사, 조사는 통계적으로 유의한 차이가 있었다, 마지막으로, 창의성이 높은 집단의 독창적인 어휘 사용 평균이 더 높았으며 특히 형용사와 조사는 통계적으로 유의한 차이가 있었다. 이러한 연구 결과는 유아 언어 창의성 연구에 유용한 기초자료를 제공하며, 유아의 창의성 발달과 관련된 제 변인에 대한 시사점을 제시하고 있다. The purpose of the study was to investigate the relationship between 5 year-old’s creativity and language expression. The research questions were there are differences in 5 year-old’s language expression according to the creativity levels. The subjects of the study were 90 five year-olds, 44 boys, 46 girls. They attended a child care center and a kindergarten in an urban city, and were in middle income class of Korea. The subjects were grouped into two levels (45 in high level group, 45 in low level group) according to their creativity scores. ‘Teacher’s Creativity Rating Scale for Young Children’ developed by Noh Young Hee, Kim Kyung Chul and Kim Ho (2006) was used for scoring children’s creativity. To measure young children’s language expression, the researcher told each child a sentence of a fox story and asked them to develop the story. Each child’s story was recorded and transcribed. The data was analyzed using t-test, SPSS program. The results of the study are as follows. First, There are no differences in number of utterances according to the creativity levels. Second, there are some significant differences in MLU(Mean Length of Utterances) according to the creativity levels. MLU of high creativity level group was longer than the low creativity level group. Third, there are significant differences in nouns, postpositions and numerals according to the creativity levels. Fourth, there are significant differences in rare adjectives and rare postpositions according to the creativity levels.

Hydrogen production by steam reforming of methane over nickel based structured catalysts supported on calcium aluminate modified SiC

Noh, Young Su,Lee, Kwan-Young,Moon, Dong Ju Pergamon Press 2019 International journal of hydrogen energy Vol.44 No.38

<P><B>Abstract</B></P> <P>Steam reforming of methane (SRM) is an immensely important process for the production of hydrogen and syngas (H<SUB>2</SUB>, CO). Ni-based alumina supported catalysts are conventionally used in the SRM process, but the coke formation and sintering are still challenging problems to develop an economical process. It was reported that the Lewis basicity of the support obviously plays a crucial role to prevent the coke formation, and basic supports such as calcium aluminate (CA<SUB>x</SUB>) has shown superior resistance for carbon deposition, but in case of CA<SUB>x</SUB> the major drawback is low thermal conductivity.</P> <P>In this work, in order to improve the catalytic performance of SRM, the Nickel based structured catalysts supported on the modified calcium aluminate (CA<SUB>x</SUB>) with silicon carbide (SiC) were prepared. All synthesized catalysts were characterized by various techniques including N<SUB>2</SUB>-physisorption, XRD, H<SUB>2</SUB>-TPR, XPS, CO<SUB>2</SUB>-TPR, TGA, TPH, and thermal conductivity analysis. It was found that the CA<SUB>x</SUB> play an important role obtaining higher hydrogen yield and improved resistance to the carbon deposition. Even though, the methane conversion and H<SUB>2</SUB> yield efficiency for Ni supported on SiC modified CA<SUB>x</SUB>/Al<SUB>2</SUB>O<SUB>3</SUB> (NASC) catalyst was slightly lower than NAS and NAC catalysts, which caused by the weak interaction of active metal, but the NASC catalyst showed superior resistance to the coke formation compared to other catalysts. It was concluded that NASC catalysts is a promising candidates for the production of hydrogen by the steam reforming of methane.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Granule type Ni/Al<SUB>2</SUB>O<SUB>3</SUB> catalysts modified with SiC and Ca aluminate were prepared. </LI> <LI> Using SiC and Ca aluminate with Al<SUB>2</SUB>O<SUB>3</SUB> had improved the coke resistance of catalyst. </LI> <LI> SiC & Ca aluminate addition to support affected metal dispersion and surface area. </LI> <LI> The support modification enhanced the thermal conductivity and surface basicity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Optimal Timing for the Administration of Capecitabine with Preoperative Chemoradiation for Locally Advanced Rectal Cancer

Young Ju Noh,Won Sik Choi,Jong Hoon Kim,Jin Cheon Kim,Chang Sik Yu,Hee Cheol Kim,Tae Won Kim,Heung Moon Chang,Min Hee Ryu,Seung Do Ahn,Sang-wook Lee,Seong Soo Shin,Jung Eun Lee,Eun Kyung Choi 대한암학회 2006 Cancer Research and Treatment Vol.38 No.1

Purpose: Capecitabine is an oral fluoropyrimidine carbamate and it is known as an effective radiosensitizer. Capecitabine and its metabolite reach their peak concentration in the plasma at 1~2 hours after a single oral administration of capecitabine and the levels fall rapidly thereafter. To verify the radiosensitizing effect of capecitabine that is based on such pharmacokinetic characteristics, we performed a retrospective analysis on the optimal timing of capecitabine administration with performing preoperative chemoradiation for locally advanced rectal cancer.Materials and Methods: Among 171 patients who were treated with preoperative radiotherapy and concurrent capecitabine administration for rectal cancer, 56 patients were administered capecitabine at 1~2 hours before radiotherapy (group A), and at other time in the other 115 patients (group B). Total mesorectal excision was done at 4 to 6 weeks after the completion of chemoradiation.The radiosensitizing effect of capecitabine was evaluatedon the basis of the pathological response.Results: Complete pathological regression of the primary tumor was observed in 12 patients (21.4%) for group A and in 11 patients (9.6%) for group B (p=0.031). Residual disease less than 0.5 cm (a good response) was observed in 19 patients (33.9%) for group A and in 23 patients (20.0%) for group B (p=0.038). On multivariate analysis, the capecitabine ingestion time showed marginal significance. Conclusion: When performing preoperative chemoradiation for locally advanced rectal cancer, the radiosensitizing effect of capecitabine was enhanced when it was administered 1 hour before radiotherapy. (Cancer Res Treat. 2006;38:30-34)

Dietary patterns are associated with physical growth among school girls aged 9-11 years

Noh, Hwa-Young,Song, Yoon-Ju,Lee, Jung-Eun,Joung, Hyo-Jee,Park, Min-Kyung,Li, Shan Ji,Paik, Hee-Young The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.

The purpose of this study was to identify dietary patterns among Korean elementary school girls based on the change in body mass index (BMI), body fat, bone mineral density (BMD), and bone mineral content (BMC) during 22 months and to explore the characteristics of dietary patterns identified. Girls aged 9-11 years were recruited and 3-day dietary data were collected four times. Subjects with a diet record of 8 or more days and anthropometric data measured at baseline and 22 months later were included (n = 198). Reduced rank regression was utilized to derive dietary patterns using a change in BMI, body fat, and calcaneus BMD and BMC as response variables. Two dietary patterns were identified: the "Egg and Rice" dietary pattern and "Fruit, Nuts, Milk Beverage, Egg, Grain" (FNMBEG) dietary pattern. Subjects who had high score on the FNMBEG pattern consumed various food groups, including fruits, nuts and seeds, and dairy products, whereas subjects in the "Egg and Rice' dietary pattern group did not. Both dietary patterns showed a positive association with change in BMI and body fat. However, subjects who had a higher score on the "Egg and Rice" dietary pattern had less of a BMC increase, whereas subjects who had a higher score on the FMBEG dietary pattern had more increased BMC over 22 months after adjusting for age, body and bone mass, and Tanner stage at baseline. Our results provide evidence that a well-balanced diet contributes to lean body mass growth among young girls.

Current Updates on the Genome Analysis of Leptotrombidium pallidum, a Major Vector Mite for Scrub Typhus

Ju Hyeon Kim,Jong Yul Roh,Deok Ho Kwon,Young Ho Kim,Kyungjae A. Yoon,Seungil Yoo,Yoonhee Shin,Seung-Jae Noh,E-hyun Shin,Mi-Yeoun Park,Young Ran Ju,Si Hyeock Lee 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10

Leptotrombidium pallidum is the major vector mite for Orientia tsutsugamushi, the causative agent of scrub typhus, in Asian countries, including Korea. The genome size of L. pallidum was previously estimated to be 191 ± 7 Mb (Kim et al., 2014). Genomic DNA (gDNA) was extracted from a single female from a 9-generation inbred L. pallidum colony and used for whole genome amplification (WGA). The resulting amplified gDNA was used for the construction of paired-end and mate-pair libraries and sequenced using Illumina platforms (HiSeq2000 and MiSeq). An unamplified gDNA sample extracted from 20 female mites was also used for sequencing in parallel. More than 45Gb sequence reads from both paired-end and mate-pair libraries of the WGA gDNA were trimmed and then de novo assembled using the CLC Asembly Cell v.4.0 for contig assembly and SSPACE for scaffolding. The assembly generated approximately 6,545 scaffolds with N50 value of 92,945 and total size of ~193Mb, which was in a good agreement with our previous estimation. Repeat analysis showed that about 30% of genome (~58Mb) was masked as repeats, most of which were unclassified novel elements. For gene predictions, generated were the PASA models based on genomic alignments of RNA-seq reads from 4 different chigger mite samples (i.e. male, female, larva, and protonymph) and the GeneWise models based on genomic alignments of protein sequences from 4 closely related species with chigger mite. Independently, ab initio gene predictions were performed with AUGUSTUS and FgeneSH with custom trained matrices optimized for L. pallidum and GENEID with pre-trained matrix for Acyrthopsiphon pisum. By combining all together, 15,842 genes were predicted finally. Manual curation is in progress for various groups of genes, including chemosensory receptor genes, immune-related genes, acaricide target genes, etc.

Genomic organization, sequence characterization and expression analysis of Tenebrio molitor apolipophorin-III in response to an intracellular pathogen, Listeria monocytogenes

Ju Young Noh,Bharat Bhusan Patnaik,Hamisi Tindwa,Gi Won Seo,Dong Hyun Kim,Hongray Howrelia Patnaik,Yong Hun Jo,Yong Seok Lee,Bok Ruel Lee,Nam Jung Kim,In Seok Bang,Yeon Soo Han 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10

Apolipophorin III (apoLp-III) is a well-known hemolymph protein having a functional role in lipid transport and immune response of insects. We cloned full-length cDNA encoding putative apoLp-III from larvae of the coleopteran beetle, Tenebrio molitor (TmapoLp-III), by identification of clones corresponding to the partial sequence of TmapoLp-III, subsequently followed with full length sequencing by a clone-by-clone primer walking method. The complete cDNA consists of 890 nucleotides, including an ORF encoding 196 amino acid residues. Excluding a putative signal peptide of the first 20 amino acid residues, the 176-residue mature apoLp-III has a calculated molecular mass of 19,146 Da. Genomic sequence analysis with respect to its cDNA showed that TmapoLp-III was organized into four exons interrupted by three introns. Several immune-related transcription factor binding sites were discovered in the putative 5’-flanking region. BLAST and phylogenetic analysis reveals that TmapoLp-III has high sequence identity (88%) with Tribolium castaneum apoLp-III but shares little sequence homologies (<26%) with other apoLp-IIIs. Homology modeling of Tm apoLp-III shows a bundle of five amphipathic helices, including a short helix 3’. The ‘helix-short helix-helix’ motif was predicted to be implicated in lipid binding interactions, through reversible conformational changes and accommodating the hydrophobic residues to the exterior for stability. Highest level of TmapoLp-III mRNA was detected at late pupal stages, albeit it is expressed in the larval and adult stages at lower levels. The tissue specific expression of the transcripts showed significantly higher numbers in larval fat body and adult integument. In addition, TmapoLp-III mRNA was found to be highly up-regulated in late stages of L. monocytogenes or E. coli challenge. These results indicate that TmapoLp-III may play an important role in innate immune responses against bacterial pathogens in T. molitor.

Histomorphometric Evaluation Of Osteogenesis With Brushite Implant Surfaces In Dogs

( Young Ju Park ),( Min Su Jeon ),( Bo Gyun Kim ),( Jun Ho Song ),( Byong Moo Yeon ),( Young Woo Lee ),( Kyung Lok Noh ),( Da Young Kim ),( Ean O Pang ),( Jun Hyun Kim ),( Tae In Gang ),( Jeong Hun Na 대한악안면성형재건외과학회 2008 Maxillofacial Plastic Reconstructive Surgery Vol.30 No.2S

Anti-wrinkle Compounds Isolated from the Seeds of Arctium lappa L.

Ju-Young Hwang(황주영),Tae-Soon Park(박태순),Dong-Hee Kim(김동희),Eun-Young Hwang(황은영),Jung-Noh Lee(이정노),Ji young Lee(이지영),Ghang-Tai Lee(이강태),Kunkook Lee(이건국),Jun-Ho Son(손준호) 한국생명과학회 2012 생명과학회지 Vol.22 No.8

본 연구에서는 우방자를 70% 에탄올로 추출하여 얻어진 추출물을 n-hexane, methylene chloride, ethyl acetate로 순차용매 분획하였다. 각 분획물에 대해 activity-guided isolation을 수행하여 활성물질의 분리 정제를 실시하였다. 활성을 나타내는 물질은 silica gel chromatography (230 mesh), sephadex LH 20, recrystallization method를 이용하여 분리하였다. 각 화합물의 화학구조는 NMR 스펙트럼 데이터 해석하였고 arctiin, arctigenin, diarctigenin, matairesinol 으로 동정하였다. 이들을 human dermal fibroblast HS68 세포에 처리하여 얻어진 상등액은 ELISA kit를 활용하여 procollagen type Ⅰ생합성과 MMP-1 저해활성을 측정하였다. 측정결과 procollagen type Ⅰ생합성과 MMP-1 저해활성 결과 모두 arctiin이 가장 우수한 결과를 보였다. 이와 같은 결과를 통해 우방자에서 분리한 리그난 화합물들을 이용하여 주름개선 소재로 개발할 수 있을 것으로 사료 된다. This study was carried out to discover the skin wrinkle reducing components in the seeds of Arctium lappa. The isolation of a methylene chloride-soluble fraction of 70% ethanol extract from the seeds of Arctium lappa using a procollagen type-1 synthesis and MMP-1 activity resulted in the isolation and identification of four lignin compounds: arctiin, arctigenin, matairesinol, and diarctigenin. All structures were confirmed via NMR and MS spectroscopic data. To determine cell viability and procollagen type-1 synthesis, human dermal fibroblasts were treated with 10-100 μM. As a result, none of the four compounds showed cytotoxicity up to 50 μM. We also investigated their procollagen type-1 synthesis and MMP-1 inhibition activity and found that arctiin had the highest activity in terms of both procollagen synthesis and MMP-1 inhibition among all four compounds. Putting all the data together, we suggest that arctiin be used in cosmetics as an anti-wrinkle material.