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RISS 인기검색어
- 검색키워드
- 저자 : Joung Younju (검색결과 2 건)
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Lu Mengdan,Joung Younju,Jeon Chang Su,김선주,Yong Dongeun,장효원,Pyun Sung Hyun,강태준,Choo Jaebum 나노기술연구협의회 2022 Nano Convergence Vol.9 No.39
Since COVID-19 and flu have similar symptoms, they are difficult to distinguish without an accurate diagnosis. Therefore, it is critical to quickly and accurately determine which virus was infected and take appropriate treatments when a person has an infection. This study developed a dual-mode surface-enhanced Raman scattering (SERS)-based LFA strip that can diagnose SARS-CoV-2 and influenza A virus with high accuracy to reduce the false-negative problem of the commercial colorimetric LFA strip. Furthermore, using a single strip, it is feasible to detect SARS-CoV-2 and influenza A virus simultaneously. A clinical test was performed on 39 patient samples (28 SARS-CoV-2 positives, 6 influenza A virus positives, and 5 negatives), evaluating the clinical efficacy of the proposed dual-mode SERS-LFA strip. Our assay results for clinical samples show that the dual-mode LFA strip significantly reduced the false-negative rate for both SARS-CoV-2 and influenza A virus.
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Nanoplasmonic assay platforms for reproducible SERS detection of Alzheimer’s disease biomarker
Hajun Dang,Younju Joung,Chaehyeon Jeong,Chang Su Jeon,Sung Hyun Pyun,Sung-Gyu Park,조재범 대한화학회 2023 Bulletin of the Korean Chemical Society Vol.44 No.5
With the recent developments in high-sensitivity optical detection technologies, many studies have been conducted to accurately detect biomarkers with low concentrations of 1.0 pM or less as well as apply them to in vitro diagnostics. The tubulin-associated unit (tau-381) protein, a biomarker of Alzheimer’s disease, is one such representative example, and its cut-off value reported in clinical practice is 5.5 fM. Therefore, a robust sensing technology that can stably detect such low concentrations of biomarkers is needed. In this study, tau- 381 was detected with high sensitivity and reproducibility by a plasmonic Au nanopopcorn substrate fabricated via thermal evaporation. Here, aptamer DNAs labeled with Raman reporters on the terminal were used as the receptors. The plasmonic nanopopcorn substrate used in this study is composed of uniform gold nanoparticles (AuNPs) of average size 64 nm. The reproducibility was significantly improved through more uniform nanogaps than those formed by aggregation of AuNPs in solution. An assay was conducted by first reacting tau-381 with the corresponding aptamers, and the remaining aptamer DNAs were then reacted with capture DNAs immobilized on the surface of the Au substrate. The assay results for tau-381 showed a limit of detection value of 2.2 fM, which is below the cut-off value (5.5 fM).
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