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Ding, Yun,Choo, Jaebum,deMello, Andrew J. Springer-Verlag 2017 Microfluidics and Nanofluidics Vol.21 No.3
<P>Droplet-based microfluidic technologies have proved themselves to be of significant utility in the performance of high-throughput chemical and biological experiments. By encapsulating and isolating reagents within femtoliter-nanoliter droplet, millions of (bio) chemical reactions can be processed in a parallel fashion and on ultra-short timescales. Recent applications of such technologies to genetic analysis have suggested significant utility in low-cost, efficient and rapid workflows for DNA amplification, rare mutation detection, antibody screening and next-generation sequencing. To this end, we describe and highlight some of the most interesting recent developments and applications of droplet-based microfluidics in the broad area of nucleic acid analysis. In addition, we also present a cursory description of some of the most essential functional components, which allow the creation of integrated and complex workflows based on flowing streams of droplets.</P>
Recent advances in surface-enhanced Raman scattering detection technology for microfluidic chips
Chen, Lingxin,Choo, Jaebum WILEY-VCH Verlag 2008 Electrophoresis Vol.29 No.9
<P>Microfluidic chip devices and their application to sensitive chemical and biological analyses have attracted significant attention over the past decade. The miniaturization of reaction systems offers practical advantages over conventional benchtop systems. In this case, however, a highly sensitive on-chip detection method is important for the monitoring of chemical reactions as well as for the detection of analytes inside the channel because the detection volume in a micrometer-size channel is extremely small. Recently, a surface-enhanced Raman scattering (SERS) technique is being regarded as a potential candidate for the highly sensitive detection of analytes in a microfluidic chip. This review provides a general survey and an in-depth look at recent developments in SERS techniques for the biological/environmental analysis of minute analytes in a microfluidic chip.</P>
Choi, Junghyun,Choo, Jaebum,Chung, Hoeil,Gweon, Dae‐,Gab,Park, Jeunghee,Kim, Hyo Jin,Park, Sangyong,Oh, Chil‐,Hwan John Wiley & Sons, etc 2005 Biopolymers Vol.77 No.5
<P><B>Abstract</B></P><P>Raman spectroscopy has strong potential for providing noninvasive dermatological diagnosis of skin cancer. In this study, confocal Raman microscopy was applied to the dermatological diagnosis for one of the most common skin cancers, basal cell carcinoma (BCC). BCC tissues were obtained from 10 BCC patients using a routine biopsy and used for confocal Raman measurements. Autofluorescence signals from tissues, which interfere with the Raman signals, were greatly reduced using a confocal slit adjustment. Distinct Raman band differences between normal and BCC tissues for the amide I mode and the PO 2− symmetric stretching mode showed that this technique has strong potential for use as a dermatological diagnostic tool without the need for statistical treatment of spectral data. It was also possible to precisely differentiate BCC tissue from surrounding noncancerous tissue using the confocal Raman depth profiling technique. We propose that confocal Raman microscopy provides a novel method for dermatological diagnosis since direct observations of spectral differences between normal and BCC tissues are possible. © 2005 Wiley Periodicals, Inc. Biopolymers 77: 264–272, 2005</P>
유승교,주재범 漢陽大學校 自然科學硏究所 1997 自然科學論文集 Vol.16 No.-
9,10-Dihydroanthracene과 xanthane의 비평면 형태구조에 미치는 환산질량 효과를 고찰하기 위하여 결합 벡터 모델을 이용한 운동에너지 팽창함수를 계산하였다. 운동에너지 계산에 필요한 분자의 구조파라미터들은 분자역학 (MM3) 프로그램을 이용하여 계산하였으며, 이 화합물의 고리변환 진동운동에 대한 위치에너지 함수는 계산된 운동에너지 팽창함수와 이전에 보고된 분광데이터들 (제트-냉각 레이저 형광 여기 스펙트럼과 분산 스펙트럼)을 이용하여 결정하였다. 그 결과 운동에너지 팽창함수(환산질량 효과)를 고려하여 진동 Hamiltonian을 계산하였을 때, 이 함수를 고려하지않은 경우보다 정확한 위치에너지함수가 결정될 수 있음을 알 수 있었다. 특히, 전자바닥 상태에서 결정된 9,10-dihydroanthracene의 비평면 진동위치에너지 함수는 이 화합물의 평형구조가 평면구조라는 사실을 잘 설명해 준다. In order to understand the reduced mass effects for the out-of-plane conformational behaviors of 9,10-dihydroanthracene and xanthene, the vector-based kinetic energy expansion functions have been determined. The structural parameters for the kinetic energy functions have been calculated from molecular mechanics (MM3) program. The potential energy functions for the ring inversions of 9,10-dihydroanthracene and xanthene have been determined from the kinetic energy functions and previously reported spectral data; the jet-cooled laser-induced fluorescence excitation spectra for their S₁states and the dispersed spectra for for their ?? states. The quantum mechanical calculations including kinetic energy expansion functions made in possible to determine more accurate potential energy expansions for their out-of-plane vibrations. Especially, the ring inversion potential energy function of 9,10-Dihydroanthracene in its ?? state shows the fact that the equilibrium structure of this molecule is planar.