혈액투석 중인 만성 신부전 환자에서 G 형 간염 바이러스의 감염률 및 임상적 의의

최규완,백승운,김정룡,이준혁,고광철,이종철,이윤하,김윤구,오하영,이효석 대한소화기학회 1999 대한소화기학회지 Vol.33 No.1

Background/Aims: We aimed to elucidate the prevalence and risk factors of HGV infection in patients with chronic renal failure undergoing hemodialysis, and to define the potential etiologic-role of HGV in the development of chronic liver disease. Methods: One-hundred and seventy-eigh patients with chronic renal failure undergoing hemodialysis were included. After extraction of RNA from serum, reverse transcription polymerase chain reaction was performed using the primers from the NS5a region. The PCR products were analyzed by liquid hybridization. Results: The prevalence was 9.0% (16/178). The prevalence rates were not statistically different according to the presence (8.5%) or abscence (10.8%) of past history of blood transfusion, patient's age or maintenance duration of hemodialysis (p$gt;0.05). Anti-HBc-positive patients (12.4%, 16/129) showed significantly higher prevalence rate (p=0.01) of HGV infection than anti-HBc-negative patients (0%, 0/49). Twelve of the 14 HGV positive patients without co-infection showed persistently normal ALT level during a year of follow-up. Conclusions: The prevalence of HGV in patients with chronic renal failure undergoing hemodialysis is significantly higher than that of volunteer blood donors. HGV may share the route of transmission with adulthood HBV infection. The etiologic-role of HGV in the development of chronic liver disease may be considerably poor. (Kor J Gastroenterol 1999;33:78 - 89)

eLoran Signal Strength and Atmospheric Noise Simulation over Korea

Rhee, Joon Hyo,Seo, Jiwon The Institute of Positioning 2013 Journal of Positioning, Navigation, and Timing Vol.2 No.2

GPS is the most widely-used Positioning, Navigation, and Timing (PNT) system. Since GPS is an important PNT infrastructure, the vulnerability of GPS to signal jamming has received significant attention. Especially, South Korea has experienced intentional high-power jamming from North Korea for the past three years, and thus realized the necessity of a complementary PNT system. South Korea recently decided to deploy a high-power terrestrial navigation system, eLoran, as a complementary PNT system. According to the plan, the initial operational capability of the Korean eLoran system is expected by 2016, and the full operational capability is expected by 2018. As a necessary research tool to support the Korean eLoran program, an eLoran performance simulation tool for Korea is under development. In this paper, the received signal strength, which is necessary to simulate eLoran performance, from the suggested Korean eLoran transmitters is simulated with the consideration of effective ground conductivities over Korea. Then, eLoran signal-to-noise ratios are also simulated based on atmospheric noise data over Korea. This basic simulation tool will be expanded to estimate the navigation performance (e.g., accuracy, integrity, continuity, and availability) of the Korean eLoran system.

저가형 연석탐지 시스템 개발을 위한 다중 초음파 센서 기반 하드웨어 플랫폼 구축

이준효(Joon Hyo Rhee),서지원(Jiwon Seo) 대한전자공학회 2016 대한전자공학회 학술대회 Vol.2016 No.6

Hairy roots induction of Oriental melon (Cucumis melo) by A. rhizogenes and propagation of the root-knot nematode

Hyo Kyung Pak,Joon Soo Sim,Hyo Rim Ko,Sun Hwa Ha,Chan Ho Kang,Yong Rhee,Suk Chan Lee,Yong Hwan Kim,Bum Soo Hahn 한국육종학회 2008 한국육종학회 학술발표회 발표요지 Vol.40 No.1

Navigation-Assisted Total Knee Arthroplasty for Patients with Extra-Articular Deformity

( Seung Joon Rhee ),( Chang Hyo Seo ),( Jeung Tak Suh ) 대한슬관절학회 2013 대한슬관절학회지 Vol.25 No.4

Purpose: Since the existence of an extra-articular deformity seriously alters the normal geometry and kinetics around the knee joint, difficulties are often encountered in total knee arthroplasty (TKA) using a standard surgical technique. The purpose of this study was to evaluate the usefulness of surgical navigation system as a treatment option for osteoarthritic knees with extra-articular deformity. Materials and Methods: The authors retrospectively reviewed medical records of the patients who underwent primary TKA between 2007 and 2012. Knees with preoperative radiography showing an angular deformity within the region from the middle third of the femur to the middle third of the tibia in the ipsilateral limb of the arthritic knees were considered as cases having extra-articular deformity. Thirteen knees of the 13 patients were found to have undergone TKA using a navigation system for osteoarthritis with ipsilateral extra-articular deformity. The hip-knee-ankle angle, Knee Society score (KSS), and range of motion were measured before and after the operation to evaluate the improvement. Results: The mean hip-knee-ankle angle in the coronal plane was improved to 0.2o±4.5o in valgus alignment postoperatively. The KSS was improved to 89.6±4.6 points postoperatively at the last follow-up, with over 90% of good and excellent results. The range of motion was improved to 118.5o±10.5o postoperatively. Conclusions: Navigation-assisted TKA is a good treatment option of osteoarthritic knees with extra-articular deformity.

Antibacterial Action of Norfloxacin Combined with Penicillin, Gentamicin, Amikacin, Tylosin, Trimethoprim, Tetracycline or Colistin

Yun, Hyo-in,Park, Seung-chun,Jiang, Cheng-zhe,Huh, Won,Rhee, Jae-chin,Park, Jong-myung,Choi, Sang-ho,Cho, Joon-hyoung 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.2 No.-

세균 감염증으로 인한 돼지 설사증의 효과적인 치료 및 예방을 위해 돼지 설사 분변으로부터 분리한 E coli 와 S typhimurium을 시험균주로 하여 norfloxacin과 국내 가축 치료에 주로 이용되고 있는 여러 항생제를 실험실적 방법으로 병용투여시 두 항생제 간의 상호작용을 checkerboard method를 이용하여 실험하였다. E coli를 시험균주로 실험한 결과, norfloxacin과 colistin의 두 항생제간의 상호작용은 상승작용을 나타내었다. 그러나 norfloxacin과 tetracycline의 병용 처치 실험에서는 길항작용을 보여주었다. S typhimurium을 시험균주로 실험한 결과, norfloxacin과 colistin의 병용 처치 실험에서는 E coli에서와 마찬가지로 상승 작용을 나타내었다. Norfloxacin과 colistin에서의 배합 비율에 따른 E coli에 대한 FIC 값은 norfloxacin이 0.08 그리고 colistin이 0.78일 때 0.38로 가장 항균 작용이 높았으며, S typhimurium에 대한 FIC 값은 E coli에서와 같은 비율에서 가장 활성이 높은 0.25를 보여주어 두 항생제의 항균력은 배합 비율에 따라서 차이가 있음을 알 수 있었다.

난소암에서 종양억제유전자들의 Multiple Methylator Phenotypes

류효충,조치흠,권상훈,박준철,서민애,정선욱,이정호,김종인,윤성도,차순도 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.3

지금까지 알려진 바로는 종양억제유전자와 관련해서 CpG island의 methylation 이상으로 종양억제유전자의 기능 변화가 암 형성에 관여한다고 알려져 있다. 최근의 연구 결과 대장암이나 유방암에서 이러한 hypermethylation이 진단적 지표자로서의 사용가능성을 제시하였다. 따라서 난소암 환자에서 이러한 있는 종양억제유전자들의 CpG islands의 methylation의 변화를 알아보고자 하는 연구가 시도되고 있다. 지금까지 난소암에서 methylation에 관한 연구는 많이 행해져 있지 않아 본 연구자는 난소암에서 종양억제 유전자인 BRCA1, p15, p16, p21, p73, hMLH1의 methylation유무를 알아보고자 연구를 계획하였다. 난소암 13예와 정상 난소 조직 7예를 이용하여 p15, p16, p21, p73, BRCA1, hMLH1유전자들에 대한 MSPCR을 시행하였다. p15 유전자는 난소암과 정상 난소에서 모두가 methylation을 보이지 않았고, hMLH1에서는 모두에서 같은 methylation을 보여 의의가 없었다. p21 유전자는 양군 모두에서 같은 정도의 methylation을 보였고, p73 유전자는 난소암 13예 중에서 11예에서 methylation이 관찰되었으며, 정상 난소에서는 모두에서 methylation이 있었으나, 난소암에서 보다는 methylation이 적었다. p16 유전자는 난소암에서 13예 중 10예에서 methylation이 보였으나 정상에서도 methylation이 모두 관찰되었다. BRCA1 유전자는 난소암에서 11/13 (85%)에서 methylation이 있었고, 정상에서는 4/7 (57%)에서 methylation이 나타나 차이를 확인하였다. 이상의 결과로 저자가 확인한 난소암에서의 methylation 이상은 BRCA1 유전자에서 정상과 비교하여 차이를 확인하였으며, BRCA1 유전자의 methylation 변화가 난소암의 암화 과정에 관계한다는 것을 유추할 수 있겠다. 그러나 표본 수가 적은 관계로 향후 좀더 많은 난소암과 대조군을 가지고 이러한 MSPCR 방법을 이용해 종양억제유전자의 변이나 발현 감소를 적절한 표적 CpG islands를 찾아 시행하면 좋은 결과를 보게 되리라 생각된다. Objective : Recent evidence suggests that aberrant methylation of CpG islands is a major pathway leading to the inactivation of tumor suppressor genes and development of cancer. The purpose of this study was to detect the methylation in ovarian cancer. Methods : Recent studies on colorectal and breast cancer have defined a CpG island methylator phenotype, which involves the targeting of multiple genes by promotor hypermethylation. Little is currently known about the role of methylation in ovarian cancer. To detect the methylation in ovarian cancer, we have investigated the methylation status of 13 primary ovarian cancers at six genes using methylation specific polymerase chain reaction compared with 7 normal ovaries. Results : Six of tumor suppressor genes (p15, p16, p21, p73, BRCA1, and hMLH1) were evaluated to see the methylation status. Methylation of p15, p21, p73, and hMLH1 did not detect in ovarian cancers compared with normal ovaries. Ten of 13 ovarian cancers showed methylation of p16 gene and all normal ovaries showed hypermethylation. The BRCA1 gene was methylated in 11 (85%) of 13 ovarian cancers, 4 (57%) of 7 normal ovaries. Conclusion : Methylation of the BRCA1 gene is common alteration in ovarian cancers, and may paly a part of role in pathogenesis of ovarian cancer.

Hairy root induction in Oriental melon (Cucumis melo) by Agrobacterium rhizogenes and reproduction of the root-knot nematode (Meloidogyne incognita)

Pak, Hyo-Kyung,Sim, Joon-Soo,Rhee, Yong,Ko, Hyo-Rim,Ha, Sun-Hwa,Yoon, Mun-Sup,Kang, Chan-Ho,Lee, Sukchan,Kim, Yong-Hwan,Hahn, Bum-Soo Springer-Verlag 2009 Plant cell, tissue and organ culture Vol.98 No.2

Construction of the Radio Map with Defective GPS Position Information

Taewon Kang,Joon Hyo Rhee 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11

The basic idea of RSS-based indoor positioning is to estimate the receiver location by matching the measured received signal strength indicator (RSSI) with preestablished RSSI collections with corresponding locations, known as the radio map. Hence, constructing an accurate radio map directly relates to accurate positioning performance in RSS-based indoor positioning. RSS-based indoor positioning can be easily conducted with a radio map that surveys every location, but a complete radio map cannot be constructed when the map area includes locations that are physically impossible to reach or denied access. In addition, measurement errors or device problems can occur during the survey, resulting in degradation of the radio map. We analyzed incidents that occurred in actual RSSI surveys that could disrupt the construction of the radio map and proposed methods to construct a more accurate radio map.

A Direct Determination of Resistances and Capacitances for PolysiIicon Emitter Bipolar Transistors Using Simple Expressions of z Parameters

Lee,Seong Hearn,Rhee,Heung Soo,Ryum,Byung R.,Kang,Sang Won,Kwon,Oh Joon,Lee,Jin Hyo 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1

We propose a direct determination method for resistances and capacitances of advanced polysilicon emitter bipoloar transistors using the simple expressions of Z parameters. This method does not require any other independent measurements or special test structures to determine device resistances and capacitances of these devices. In order to investigate the validity of this method, the extracted values of emitter and collector resistances are compared with do measured ones, and show reasonable agreement with them. Since analytical Z parameter equations are simple and compact, this method allows us to extract the resistances and capacitances of PSA bipolar transistors with greate accuracy and faster extraction.