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지구성 운동이 중추신경제 세로토닌과 TH 발현에 미치는 영향
공선아,유승희,임백빈,김연정,정주호,김홍,김영표,김성수,김창주 대한스포츠의학회 2000 대한스포츠의학회지 Vol.18 No.2
The purpose of this study was to investigate the effects of aerobic exercise training on serotonin and TH expression in CNS of rats. The 28 Sprague-Dawle rats of 200-300g were used and were divided into four groups: 1 week control group and 4 weeks control group which lead a sedentary life during the whole training period, and 1 week exercise group with 30 min treadmill training five times per a eek for 1 week and 4 weeks exercise group with 30 min exercise five times per week for four weeks. After treadmill training, each group was fixated with PFA and 40㎛ thickness slices was made by cryostat. To evaluate the effect of aerobic exercise on serotonin and TH(tyrosine hydroxylase) expression, immunohistochemistry technique was performed. The result of the study were as followed: 1. Serotonin expression of 1 week exercise group was significantly increased in dorsal raphe(P<.001). Serotonin expression of 4 weeks exercise group was significantly decreases in dorsal raphe(P<.001). 2. Serotonin expression of 1 week exercise group was significantly increased in raphe magnus(P<.001). Serotonin expression of 4 weeks exercise group was significantly increased in raphe magnus(P<.001). 3. TH expression of 1 week exercise group was significantly increased in substantia.
Kim, Ji-young,Alam, Farzana,Chung, Seung Woo,Park, Jooho,Jeon, Ok Cheol,Kim, Sang Yoon,Son, Woo Chan,Byun, Youngro Wolters Kluwer Health | Lippincott Williams Wilkin 2014 ANTICANCER DRUGS Vol.25 No.9
To achieve a clinically rational regimen for cancer chemoprevention with improved efficacy and safety, the combination effect of celecoxib and newly developed oral angiogenesis inhibitor, LHD4, on chemoprevention was evaluated. The chemopreventive effects of celecoxib, LHD4, and the combination of celecoxib and LHD4 were evaluated in a murine colorectal carcinogenesis model. After 17 experimental weeks, mouse colon tissues were collected and examined in terms of polyp volume and degree of carcinogenesis, inflammation, and angiogenesis. Mice in the celecoxib-treated or LHD4-treated groups had total polyp volumes of 47.0±9.7 and 120.1±45.2 mm, respectively, which represented decreases of 65.6 and 22.3% from the control (154.5±33.5 mm). However, the polyp volume in the combination group was 22.8±9.3 mm, a decrease of 85.2% from the control. In the comparison of carcinogenesis, the percentage of normal tissue (i.e. excluding proliferative tissue) was found to be 40.6% in the control, 51.7% in the celecoxib, 56.9% in the LHD4, and 81.7% in the combination group. In accordance with attenuated carcinogenesis, both inflammation and angiogenesis were also well controlled. Together, these results suggest that the combinatory use of celecoxib and a newly developed oral heparin conjugate could be a promising regimen for chemoprevention by intervening in both inflammation and angiogenesis.
김종우,김주한,김홍기,박래현,박석윤,이낙영,이석훈,이주호,정현용 충남대학교 기초과학연구소 1999 忠南科學硏究誌 Vol.26 No.1
In the 1998 academic year, 33 college junior in the department of statistics who are taking the course of sample theory are divided into 7 groups. And each group conducts a survey which contains all the process of sampling design, such as typing text, customizing color, using icons and clip art and even adding their favorite link The result is an attractive colorful website. [http://stat.chungnam.ac.kr/~sypark]
Modulation of Chelidonii herba on GABA Activated Chloride Current in Rat PAG Neurons
Kim, Younjung,Shin, Minchul,Chung, Jooho,Kim, Eehwa,Koo, Gyosung,Lee, Choongyeol,Kim, Changju 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2001 No.-
Modulation of Chelidonii herba on γ-aminobutyric acid(GABA) activated chloride current in the acutely dissociated periaqueductal gray (PAG) neuron was studied by nystatin-perforated patch-clamp technique. High concentrations of Chelidonii herba elicited ion current, that was blocked by bicuculline. Low concentrations reduced the GABA activated current in PAG. Two types of inhibitory action of Chelidonii herba on GABA activated current have been implicated in PAG. One is the inhibitory action of Chelidonii herba on GABA was abolished by naltrexone and the other is that of Chelidonii herba was potentiated by naltrexone. In addition, all of two types of action of Chelidonii herba are linked to pertussis toxin=sensitive GTP-binding proteins. These results suggest that the inhibitory modulation of Chelidonii herba on GABA activated current via G-proteins in PAG neuron in an important analgesic mechanism.
Kim Eunsoo,Kim Hyunchul,Bae Changdeuck,Lee Daehee,Moon Jooho,김주선,신현정 나노기술연구협의회 2017 Nano Convergence Vol.4 No.31
We describe a fabrication strategy for preparing yttria-stabilized zirconia nanotube (YSZ-NT) arrays embedded in porous alumina membranes by means of template-directed atomic layer deposition (ALD) technique. The individual YSZ-NTs have a high aspect-ratio of well over 120, about ~ 110 nm in diameter, and ~ 14 µm in length. Interfacing the tube arrays with porous Pt was also introduced on the basis of partial etching technique in order to construct Pt/YSZ-NTs/Pt membrane electrode assembly (MEA) structures. The resulting YSZ-NTs MEAs show a 7 mm in diameter with a roughness factor of ~ 2. Area specific resistance was measured up to 1.84 Ω cm2 at 400 °C using H2 as fuel.
All Solution-Processed, Fully Transparent Resistive Memory Devices
Kim, Areum,Song, Keunkyu,Kim, Youngwoo,Moon, Jooho American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.11
<P>We fabricated all-solution processed, fully transparent resistive random access memory (<I>sol</I>-TRRAM) with a configuration of ITO/GaZnO(GZO)/ITO. All layers, including an active layer and top and bottom ITO electrodes, were deposited on a glass substrate by either spin coating or inkjet printing using a sol–gel solution. Our <I>sol</I>-TRRAM was transparent, with 86.5% transmittance at 550 nm. An initial forming process is unnecessary for the production of transparent memory due to the presence of sufficient inherent nonlattice oxygen ions in the solution-processed GZO layer. The <I>sol</I>-TRRAM also showed reasonable bipolar resistance switching with a low operation current (<100 μA) and excellent cycle endurance properties (>300 cycles). The main conduction mechanism during the set process can be explained by the trap-controlled space-charge limited conduction, and the resistance change occurred by the modification of the potential barrier height because of the charge injection by Fowler–Nordheim tunneling.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-11/am201215e/production/images/medium/am-2011-01215e_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am201215e'>ACS Electronic Supporting Info</A></P>
Kim, Dongha,Lee, Daehee,Kim, Joosun,Moon, Jooho American Chemical Society 2012 ACS APPLIED MATERIALS & INTERFACES Vol.4 No.10
<P>The SnO<SUB>2</SUB> anode is a promising anode for next-generation Li ion batteries because of its high theoretical capacity. However, it exhibits inherent capacity fading because of the large volume change and pulverization that occur during the charge/discharge cycles. The buffer matrix, such as electrospun carbon nanofibers (CNFs), can alleviate this problem to some extent, but SnO<SUB>2</SUB> particles are thermodynamically incompatible with the carbon matrix such that large Sn agglomerates form after carbonization upon melting of the Sn. Herein, we introduce well-dispersed nanosized SnO<SUB>2</SUB> attached to CNFs for high-performance anodes developed by Ni presence. The addition of Ni increases the stability of the SnO<SUB>2</SUB> such that the morphologies of the dispersed SnO<SUB>2</SUB> phase are modified as a function of the Ni composition. The optimal adding composition is determined to be Ni:Sn = 10:90 wt % in terms of the crystallite size and the distribution uniformity. A high capacity retention of 447.6 mA h g<SUP>–1</SUP> after 100 cycles can be obtained for 10 wt % Ni-added SnO<SUB>2</SUB>–CNFs, whereas Ni-free Sn/SnO<SUB>2</SUB>–CNFs have a capacity retention of 304.6 mA h g<SUP>–1</SUP>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2012/aamick.2012.4.issue-10/am301328u/production/images/medium/am-2012-01328u_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am301328u'>ACS Electronic Supporting Info</A></P>
Kim, Kyujin,Kim, Inhyuk,Oh, Yunjung,Lee, Daehee,Woo, Kyoohee,Jeong, Sunho,Moon, Jooho The Royal Society of Chemistry 2014 Green Chemistry Vol.16 No.9
<P>Copper zinc tin sulfide (CZTS) has attracted significant attention in the past few years as a next-generation absorber material, and is a promising candidate for the mass production of thin-film solar cells with high efficiencies. Here, we demonstrate a non-toxic solvent-based hybrid-ink approach for the fabrication of a high-quality CZTS absorber layer with a thickness of 1.3 μm and micrometer-scale grains (∼1 μm), resulting in an efficiency of 8.17%. In particular, we investigate the effects of the solid-state Zn metal or ZnS precursor on both the phase transformation and the device performance, which clearly suggests that the low-melting-point Zn phase effectively facilitates the phase-pure, high-performance CZTS absorber layer without the formation of secondary phases that have been observed in most cases of CZTS solar cells derived from wet chemical processes. We believe that our environmentally friendly approach will pave the way toward achieving low-cost, scalable solar cells with high efficiencies.</P> <P>Graphic Abstract</P><P>A Cu<SUB>2</SUB>ZnSnS<SUB>4</SUB> solar cell with an efficiency of 8.17% was fabricated using a non-toxic solvent-based hybrid-ink without the involvement of a complex synthesis, toxic solvents or harmful post-selenization. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4gc00896k'> </P>