만성 신부전증 환자의 중중 고혈당에 따른 의식 변화 결정에 대한 연구

위형중,이창범,박성광,강성귀,임천규,박은주,윤경택,한상웅,안유헌,김호중· 대한신장학회 2000 대한신장학회잡지 Vol.19 No.6

절제된 위암의 병리학적 분류

강구,신형식,이민철,박영의,김주섭,박철재,배수동 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.1

디지털 제어에 의한 단상유도전동기의 범용 기동기 설계

최창주,서강성,박수강,조금배,백형래,임병옥 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.2

Single phase induction motor(SPIM) is one of the most widely used type of low power AC motors in the world, especially for domestic or commercial applications where a three phase power supply is not available. Fractional horse power single phase induction motors have no starting torque their own. So there are several ways of starting single phase induction motors. The most common type is the starting capacitor installed in series with the auxiliary winding to increase the starting torque. Also, the auxiliary winding is disconnected once the speed of the motor reaches 70 to 80% of the rated speed. In the conventional systems, this function is conducted by a centrifugal switch. But the mechanical centrifugal switch has many problems such as switch malfunction. This paper presents the new methods of universal starting switch by digital controller to overcome these shortcomings of centrifugal switch.

Mirizzi 증후군의 변형된 분류와 치료

김형철,강길호,채만규,김성용,백무준,이문수,박상흠,이문호,김창호,송옥평,조무식,박희주 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Purpose : The Mirizzi syndrome is relatively rare and preoperative diagnosis of this disease is difficult. In 1978, Morelli suggested the subclassification of the Mirizzi syndrome into acute or chronic form. We experienced 5 cases of acute form. We analysed clinical features, preoperative radiologic findings and operative findings of 18 cases including acute forms which were diagnosed as Mirizzi syndrome and should suggest the modified classification of Mirizzi syndrome for choice of appropriate treatment. Method : From January 1995 to December 1998, 18 cases, of which 8 cases were diagnosed at Soonchunhyang University Chunan Hospital, and 10 cases were reported in the Korean Journal were retrospectively analysed with regard to clinical features, preoperative radiologic findings and operative findings. According to the clinical features, whole cases were divided into type Ⅰ(acute form) and type Ⅱ(chronic form) and then each type of cases were subclassified according to preoperative radiologic findings and operative findings. Results : Of 18 cases there were 5 cases in type Ⅰ(27.8%), 13 cases in type Ⅱ(72.2%). Type Ⅱb was most common. Type Ⅰa cases were treated only with cholecystectomy. We applied cholecystectomy, T-tube choledochostomy and patch technique in type Ⅰb and thpe Ⅰc cases. Cholectystectomies including removal of gallstones and internal drainage procedures were done in type Ⅱ chronic forms. Conclusion : The acute form(Type Ⅰ) of Mirizzi syndrome was suggested by Morelli might be subclassified into typeⅠa,Ⅰb and Ⅰc following the presence of the necrotic defect in common hepatic duct. Through the modified classification of Mirizzi syndrome based on clinical feature, preoperative radiologic findings and operative findings, we can choice appropriate treatment.

景觀 Simulation 技法을 이용한 環景計劃 ·設計의 適用에 관한 硏九 : (컴퓨터 그래픽 기법을 중심으로)

이주형,강승호 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

본 연구에서는 경관시뮬레이션 技法중 컴퓨터 技法을 이용하여 環境計劃 및 設計를 수행하였다. 연구 진행방법은 3段階로 이루어진다. 1段階 : 데이타베이스의 構策-環境을 이루고 있는 각종 自然的 要素와 人爲的으로 만들어 나가는 人工的 要素를 컴퓨터에 畵像이나 3次元 圓形으로 貯藏하고, 라이브러리화 한다. 2段階 : 대상지의 분석-계획대상지에 적지분석 및 공간분석을 수행하는데 있어서 LANDCADD를 이용하였다. 적지 및 공간분석은 각 시설의 설치 기준에 합당한 屬性을 입력하여 圖面重??法으로 분석하였다. 3段階 : 대상지의 계획 및 설계―몇가지 방법을 이용하여 사실적 이미지을 작성하였고, 계획시설의 레이트레이싱 畵像을 背景畵像 위에 合成하는 방법을 체계화 시켰다. 이러한 방법에 의해 나타나는 결과물은 LANDCADD와 컴퓨터 그래픽을 이용한 사실적 표현과 이해하기 쉬운 정보의 可視化에 의해 계획에 관계되는 예측 평가의 정도를 향상시키고, 개발계획에 관련된 사람들의 의견을 수렴하기 위한 미디어로 유효하며, 존재하지 않는 경관을 계획한대로 만들어 낼 수 있는 造作成을 경관평가의 실험적 통제에 적용하는 방법을 제시한다. This study applied the techiniques of computer among landscape simulation techiniques to environment planning and design. The progress of this study comprises three stage. First stage : Construction of database―Computer saves natural and artificial factors in the shape of image or 3 dimension model and make library Second stage : The analysis of site―The analysis of suitable site and space is performed by LANDCADD. Suitable attribute of design criteria are analysed with overlay techinique Third stage : Planning and design for site Some methods are used to build realistic images. The raytracing image of planning building are composed on the background image. The result output by landcadd and computer graghics improves the prediction degree of the related planning and is the useful aggreregation media of inhabitant opinions and present the method used exprimental control of landscape evaluation.

셀레콕시브 및 그 합성유도체들의 항암활성 스크리닝

박정란,강진형,구효정,노지영,류형철,박상욱,고동현,조일환,이주영,황다니엘,김인경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Selective COX (cyclooxygenase)-2 inhibitors including celecoxib have been shown to induce apoptosis and cell cycle changes in various tumor cells. New inhibitors are recently being developed as chemomodulating agents. We evaluated celecoxib and screened 150 synthetic compounds for anti-proliferative activities in vitro. Effects of celecoxib on COX activity, cell growth, cell cycle distribution, and apoptosis induction were determined in A549 COX-2 overexpressing human non-small cell lung cancer (NSCLC) cells. The COX inhibition of celecoxib increased with concentration up to 82% at 1μM after 24 hr exposure. Forty μM and 50μM of celecoxib induce G_1 arrest, and TUNEL-positive apoptotic cells, respectively. Among 150 compounds, several compounds were selected for having greater COX-2 inhibitory activity and higher selectivity than celecoxib with growth inhibitory activity. Celecoxib showed concentration-dependent COX inhibitory activity, and ability to induce cell cycle arrest and apoptosis in human NSCLC cells in vitro. Among synthetic analogues screened, several compounds showed promising in vitro activity as COX-2 inhibitory anticancer agents, which warrant further evaluation in vitro and in vivo.

굴 養殖場 水域의 基礎生産 硏究

李秉暾,姜亨求,姜龍柱 동의대학교 기초과학연구소 1992 基礎科學硏究論文集 Vol.2 No.1

The primary production of phytoplankton in oyster farming bays were seasonally measured by ^14C method in Hansan-Koje Bay and Kamagyang Bay for one year period. In Hansan-Koje Bay, mean daily primary production was 0.52gC/㎡/day(0.22∼1.02gC/㎡/day), and it was relatively high in summer and low in winter. Annual primary production was estimated to be 189gC/㎡/yr. Mean chlorophyll α content was 1.70mg/㎥, and it was relatively high in summer. In Kamagyang Bay, mean daily primary production was 0.91gC/㎡/day(0.11∼3.61gC/㎡/day), and it was maximum in summer and minimum in fall. Annual primary production was estimated to be 334gC/㎡/yr. Mean chlorophyll α concentration was 2.34mg/㎥, and it was maximum in summer and relatively high in winter. Considering the water area of the two osyter farming bays, annual carbon production by phytoplankton were 9,450 ton in Hansan-Koje Bay and 37,000 ton in Kamagyang Bay. In general pattern of primary production in these bays, high production occurs in summer with increasing trend since spring.

뇨(尿)중 3-Methylhistidine 함량의 측정과 이용

정수현,서형주,김윤숙,이효구,강덕호 한국식품영양학회 1996 韓國食品營養學會誌 Vol.9 No.2

기존의 방법을 일부 수정하여 뇨중 3-methylhistidine을 분석하였다. 뇨중 3-methylhistidine을 fluorescamine 유도체화하여 HPLC에 주입하고 C_18 column과 10 mM acetonitrile/sodium phosphate buffer(pH 7.5)로 분리·용출시켜 형광검출기로 측정하였다. 3-methylhistidine의 체류시간은 7분 이내이었으며, histidine과의 분리상태도 서로 간섭함이 없이 양호하였다. 뇨에 3-methylhistidine을 첨가하고 이를 분석하였을 때의 회수율은 93∼106%로 높은 수준이었다. 체육학과 남학생중 웨이트 트레이닝 단련자와 비단련자를 대상으로 조사한 단기간의 웨이트 트레이닝에 따른 뇨중 3-methylhistidine 함량의 변화는 두 집단 모두 웨이트 트레이닝후의 3-methylhistidine 분비량이 유의하게 증가하였다. A modified method is given for the precolumn derivatization and subsequent high-pressure liquid chromatographic seperation of 3-methylhistidine from urine. The elution contained isocratic solution with acetonirile and 10 mM sodium phosphate(pH 7.5) requires less than 7 min. The recoveries of 3-methylhistidine from urine control were 93% to 106%. 3-Methylhistidine determinations were performed on urine samples from volunteers who were both male trained and non-trained physical undergraduates. As the result, urinary 3-methylhistidine content of volunteers increased significantly after weight training.

Natural Toxin의 안전성 평가연구 : Ochratoxin A의 면역독성 Immunotoxicity of ochratoxin A

김주일,한형미,정혜주,김형수,김환묵,정승태,박재현,강선경,김진호 식품의약품안전청 1997 식품의약품안전청 연보 Vol.1 No.-

Ocllratoxin A는 fenicl'flrium과 rtsr☞rgiffus 속 등의 곰팡of가 생성하는 mycotoxin으로서 세포매기성 및 체액성 면역기능에 슨상을 일으키는 것으로 알려져 있다. 본 연구는 OTA가 면역계에 미치는 영향과 OTA의 면역 독성 억제 효과가 있는 물질을 검색하기 위하며 6~7 주령의 Balb/c mice 비장세핀에 T 및 B 세포의 mitogen인 Con A와 LPS로 처리하고 3일간 배양한 후 비장세포의 분화정도를 MTS를 처리하여 관찰하였으며, OTA를 투여한 마우스의 면역장기 형리조직학적 견화를 관찰하였다. 마우스의 비장세포 (2xtD6cel1/rnf)에 OTA(1~6μg/ml)를 상에서 혼합하여 Con A와 LPS로 자극시킨 결과 임파구는 Sfg/mf이상에서 거의 모든 세포가 분화되지 않았다. mice에 OTA (1,5 및 10mg/11g)를 2일 간격으로 6회 복갚 주사한 후 비장세포를 분리하여 Con A와 LPS로 처리한 결과 Smg 투여군에서는 6회 투여 혼에 분화가 억제되었고, 10mg 투여군에서는 3회 및 6회 투여군에서 분화가 억제되었단. Ochratoxin A의 면역독성 억제 효과가 있는 물질을 검색하기 위하여 in vitro 실험에서 마우스의 비장세포 (2×10" cell/mf)에 OTA (3fg/mf)와 L-phenylalanine, indole-3-carbinol, L-ascorbic acid,piroxicaTn, curcumin 및 arethylsalicylic acid를 혼합하고 동일 처리한 결과 L-ascorbic acid, L-phenylala-nine 및 Indole-3-carbinol은 OTA의 면역독성 발현을 운의성 있게 억제하였다. Balt/c mice에 OTA (10mg/kg)와 l'n pifro실험에서 억제효파가 확인된 L-ascorbic acfd, L-phenylalanine 및 indole-3-carbinol을 2일 간격으로 동시에 3회 복강주사하여 관찰한 결과 indote-3-carbine께서 엮제효과를 관찰할수 있었다. Ochratoxin A를 투여할 마우스의 비장 및 홍선에서는 임파구의 빈도가 줄었으며 특히 비장제서는 starry-sky 세포가 증가됨을 관찰할 수 있었다. 이러한 결자로 OTA는 비장세포의 T 및 B 임파구의 분열능을 억제시 키며, 면역장기의 임파구에 손상 야기시키므로서 면역기능을 저하시키고 OTA에 의한 면역독성은 indole-3-carbinol이 경감시킴을 관찰하엿다. Ochratoxin A (OTA) is a Tnyeotoxin produced by several fungal species iBcluded the genera fs4pergiffug and f☞HiciHiHuL and known as one of the major environmental contaminants. Tn thepresent study, the effects of OTA on the imraune system and the prevention of the OTA-inducedimmunosuppression by protective agents were studied in Balb/c rnicf:. Splenocytes were isolated and theproliferative responses to concanavalin A (Con A) and lipopolysaccharide (LPS) were measured in thepreseEce of 1 to 6fg/mf OTA. Sfg/mf OTA completely btocked both Con A and LPS-stimulatedmitogenic responses, causing approximately 50% inhibition at 3fe/mf OTA. This suppression of mitogen-induced proliferative resplonses observed id uifro was reproduced in mice treated with ☞rA in rioafntraperitoneal administration of 5, IDmg/kg OTA 3 to etimes every other day significantly decreasedboth Con A- aud LPS-inttuced mitegenic responses. The effects of possible protective agents on theOTA-induced suppression c)』 mitogenic responses were examined both in uifro and in viua Amoag 6 pos-sible protective agents (1,-phenylalanine, L-ascorbic acid, indole-3- carbinol, curcumin, firoxicam,acethylsaricylic acid) employed in the present study, L-phenylalanine (100ff), L-ascorbic acid (100#M) and iBdote-3-carbinel t 10Df) showed significantly protective effects on the OTA-iBduced suppres-sion of mitogenic responses id uifro. Howeuer, when the protective of·fects of these agents were examinedin rr'ua only indole-3-carbinol showed significantly protective respoases. It has been ebserved that Iyin-phatic cell population in thc spleen and thymus was decreased in raice given OTA by hematoBylin-eosinstaining. These data indicate that OTA suppresses the cell-mediated and humoral immune functioBsand this OTA-iBduced supflression of immune functions can he alleviated by indole-3-carbinol.

Iridium Complexes with Cyclometalated 2-Cycloalkenyl-Pyridine Ligands as Highly Efficient Emitters for Organic Light-Emitting Diodes

Kang, Dong Min,Kang, Jae-Wook,Park, Jong Won,Jung, Sung Ouk,Lee, Se-Hyung,Park, Hyung-Dol,Kim, Yun-Hi,Shin, Sung Chul,Kim, Jang-Joo,Kwon, Soon-Ki WILEY-VCH Verlag 2008 ADVANCED MATERIALS Vol.20 No.10

<B>Graphic Abstract</B> <P>Iridium complexes containing cyclometalated 2-cyclohexenylpyridine derivatives with rigid and bulky cyclohexene units are synthesized, and found to be highly efficient materials in EL devices (see figure). Devices based on these iridium complexes emit yellowish- green light with the very high external quantum efficiency of 18.7%. <img src='wiley_img/09359648-2008-20-10-ADMA200702558-content.gif' alt='wiley_img/09359648-2008-20-10-ADMA200702558-content'> </P>