Appaloosa 신생망아지의 방광파열 1례

양재혁,정종태,이주명,황규계,임윤규,Yang, Jaehyuk,Cheong, Jongtae,Lee, Joo-Myoung,Hwang, Kyu-Kye,Lim, Yoon-Kyu 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.4

A 3-day-old Appaloosa colt was examined because of acute onset of ataxia, left-sided head tilt, fever and heart murmur. The foal continued to nurse but became increasingly depressed and mild colic. On plain radiological examination, the foal was normal. Uroperitoneum was diagnosed following abdominocentesis. Postmortem examination revealed bladder rupture. The lesion was in the dorsomedial part of the bladder wall. We suggested that the cause of bladder rupture was parturient trauma. Even though the rupture was associated with trauma, the margin of rupture of bladder was clearly smooth and regular.

Evaluation of the Biocompatibility of Cuttlebone in Mouse

원상철,이주명,정종태,박현정,서종필,Won, Sangcheol,Lee, Joo Myoung,Cheong, Jongtae,Park, Hyunjung,Seo, Jongpil The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2

골대체재는 지연유합이나 유합부전 그리고 골절술과 관절고정술 시 골편의 연속성 확립이 필요한 경우 골절의 주요 결손부위를 채우는데 주로 활용되고 있다. 자가골을 대체할 수 있는 천연 골이식재의 대표적인 것이 calcium carbonate (CC)이며, 갑오징어의 오적골(Cuttlebone, CB) 또한 천연 CC로 이루어져 있다. 본 연구에서는 오적골의 다양한 전처리 후 직경 5 mm 두께 2 mm의 형태로 가공하여 생체적합성을 평가하고자 하였다. 조직검사에서 결합조직 두께는 2, 4주차 모두 CBHA군에서 가장 유의성 있게 얇았다 (p < 0.05). 이상의 결과들은 CBHA가 생체 내에 적용하는 골대체재로서 생체적합성이 매우 높은 것으로 나타났다. 따라서 CBHA는 편평골에 있어 생체적합성이 뛰어난 골대체재로 그 가치가 있는 것으로 생각되며, 수의 임상에 있어서 활용성이 매우 높을 것으로 사료된다. Bone grafting is widely used to bridge major bone defects or to promote bone union. Natural calcium carbonate (CC) has been used as a bone substitute material and used to scaffold for bone morphogenetic protein (BMP). The aims of this study is to evaluate the biocompatibility of cuttlebone (CB) and hydroxyapatite from CB (CBHA). Each material was shaped into disks (5 mm in diameter and 2 mm in thickness). To test biocompatibility, the disks were implanted into the dorsal subcutaneous tissue in mice. Fibrous capsule thickness around each disk was evaluated histologically at 2 and 4 weeks after implantation. Concerning biocompatibility, fibrous capsule thickness of CBHA was significantly thinner than that of CB and CHA (p < 0.05) at 2 and 4 weeks after implantation. Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB.

Evaluation of the Bone Defect Regeneration after Implantation with Cuttlebone in Rabbit

원상철,이주명,박현정,서종필,정종태,Won, Sangcheol,Lee, Joo-Myoung,Park, Hyunjung,Seo, Jongpil,Cheong, Jongtae The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2

골대체제는 지연유합이나 유합부전 그리고 골절술과 관절고정술 시 골편의 연속성 확립이 필요한 경우 골절의 주요 결손부위를 채우는데 주로 활용되고 있다. 본 연구에서는 오적골의 다양한 전처리 후 직경 5 mm 두께 2 mm의 형태로 가공하여 rhBMP-2의 담체로써 골전도력과 골유도력을 평가하고자 하였다. 결합조직의 두께는 2, 4주차 모두 오적골유래 hydroxyapatite 적용군(CBHA)에서 가장 유의성 있게 얇았다(p < 0.05). Radiologic gray-level histogram의 측정에서는 4주차에서 CBHA군이 산호유래 hydroxyapatite 적용군(CHA)군보다 유의성 있게 높게 나타났으며(p < 0.05), 12주차에서는 CHA군의 변화율이 가장 적었다. 전체 12주 동안의 변화율에서는 CBHA가 가장 많은 변화를 보였다. 폐쇄율에 있어서는 4, 8, 12주차 모두 CHA군이 다른 군에 비해 유의성 있게 높게 나타났으며(p < 0.05), 8주차에서는 bmp를 적용한 오적골 적용군(CB1bmp)이 CBHA군보다 유의성 있게 높게 나타났다(p < 0.05). 이상의 결과들은 CBHA가 생체 내에 적용하는 골대체재로서 골유도능력이 우수한 것으로 나타났다. 따라서 CBHA는 편평골에 있어 생체적 합성이 뛰어난 골대체재로 그 가치가 있는 것으로 생각되며, 수의 임상에 있어서 활용성이 매우 높을 것으로 사료된다. Bone grafting is widely used to bridge major bone defects or to promote bone union. In the evaluation of bone defect regeneration, 5 mm-diameter defects were created in rabbit calvaria. Concerning biocompatibility, fibrous capsule thickness of CBHA (hydroxyapatite from cuttlebone) was significantly thinner than that of CB (cuttlebone) and CHA (hydroxyapatite from coral) (p < 0.05) at 2 and 4 weeks after implantation. Concerning 12-week total changes of radiologic gray-level histogram, CBHA was significantly higher than CHA (p < 0.05). In the evaluation of bone defect regeneration, bone formation of CHA was significantly higher than that of CB and CBHA (p < 0.05). Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB. It is suggested that CBHA is a valuable bone graft material.

개에서 땀샘 선암종과 유선 복합형 선종의 동시 발생

박지성,정지열,조숙희,정종태,강태영,김재훈,Park, Ji-Sung,Jung, Ji-Youl,Jo, Suk Hee,Cheong, Jongtae,Kang, Tae-Young,Kim, Jae-Hoon 대한수의학회 2008 大韓獸醫學會誌 Vol.48 No.3

A 7-year-old female Shih Tzu dog with lots of masses in the whole mammary gland was presented to the surgery department of the Veterinary Teaching Hospital in the Cheju National University. After surgical excision, all mammary samples were referred to Pathology Department of Veterinary Medicine. Grossly, masses were measuring up to $6.5{\times}4{\times}1cm$ and on cut surface of masses in right 1st, 3rd, 4th, 5th and left 1st, 3rd, 4th, 5th mammary masses were well delineated and firm, sulphur yellow, solid round to oval shape. Microscopically, most neoplastic sweat glands were severely proliferated in dermis and subcutis. Most tubules were lined by round to oval shaped epithelium with eosinophilic cytoplasm, hyperchromatic nuclei with high mitotic figures and severe central necrosis. The neoplastic epithelium also had PAS-positive diastase-resistant cytoplasmic granules, but negative with Perls iron stain. The left 2nd mass was well delineated, and had several dark brown areas and yellowish white glittered areas. Mass was well circumscribed with dense connective tissue. Neoplastic areas contained irregular sized mammary gland with papillary grown luminal epithelial cells in single or double cells layer with mitotic figures and small amounts of proliferated myoepithelial cells. Proliferated myoepithelial cells also produced slightly basophilic mucinous materials. Based on the gross, histopathologic and special staining characteristics, this dog was diagnosed as 90% of apocrine sweat gland aenocarcinoma and 10% mammary. complex adenomas in mammary masses. In our best knowledge, this is the first report for concurrent occurrence of apocrine sweat gland adenocarcinoma and mammary gland complex adenoma in mammary masses of the same dog.

개 특발성 혈소판감소증 1례

김소라,조창석,김민재,강태영,이주명,박현정,정종태,이경갑,윤영민,Kim, So-La,Cho, Chang-Seok,Kim, Min-Jae,Kang, Tae-Young,Lee, Joo-Myoung,Park, Hyun Jung,Cheong, Jongtae,Lee, Kyoung-kap,Yun, Young-min 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.4

A 4-year-old spayed female, Yorkshire terrier dog with a history of petechial and ecchymotic hemorrhages on the face, trunk and hind limb was referred to Veterinary Medical Teaching Hospital, Cheju National University. The complete blood count revealed a marked thrombocytopenia ($96{\times}10^3/{\mu}l$). The biochemical profile showed only slightly increased glucose. The coagulation profile such as prothrombin time and activated partial thromboplastin time, was within the reference range. In Giemsa staining, there were no endoparasites like as Babesia spp. on the RBC. This case was diagnosed as a idiopathic thrombocytopenia in a Yorkshire terrier dog. She was treated with prednisone (1 mg/kg BW, IM q 12 h) and cephalosporin (10 mg/kg BW, IM, q 12 h). When rechecked on day 6, the platelet was within reference range ($507{\times}10^3/{\mu}l$) and also petechial and ecchymotic hemorrhages on the body were gradually improved without any complications. The dose of prednisone was decreased to 0.5 mg/kg BW, q 24 h. On day 17, we finished treatment because all the clinical signs, blood and serum chemistry were reference range and platelet count was dramatically increased.

개의 비강 내 이행암종 증례

강화정,강상철,정지열,조숙희,노인순,이주명,정종태,김정훈,안민찬,배종희,김재훈,Kang, Hwa-Jung,Kang, Sang-Chul,Jung, Ji-Youl,Jo, Suk-Hee,Roh, In-Soon,Lee, Joo-Myung,Cheong, Jongtae,Kim, Jung-Hun,An, Min-Chan,Bae, Jong-Hee,Kim, Jae-Hoon 대한수의학회 2008 大韓獸醫學會誌 Vol.48 No.3

A 10-year-old female Yorkshire terrier with the clinical signs of nasal swelling, epistaxis and nasal discharge was presented to the Veterinary Teaching Hospital in the Cheju National University. Abnormal nasal mass was detected in physical examination and radiographic findings. After surgical excision, the sample of nasal mass was referred to Pathology Department of Veterinary Medicine. Grossly, the mass was soft, friable, and $2.5{\times}4cm$ cm in size. Histopathologically, the mass was composed of mediumsized non-keratinizing columnar to polyhedral cells arranged in anastomosing ribbon and large nest. It has complex in-folding of thick epithelial layers separated by fibrovascular septa. Tumor cells showed characteristic palisading arrangement of columnar cells, and perpendicularly distributed to the basement membrane. The cells had pale basophilic cytoplasm, oval nucleus and one or more nucleoli, and indistinct cellular border. Many tumor cell emboli were presented in lymphatics. Immunohistochemistry revealed that tumor cells were cytokeratin (CK) 19 and CK clone MNF116 positive and but CK7 and CK high molecular weight negative. Based on the gross, histopathologic, and immunohistochemical findings, the mass was diagnosed as transitional carcinoma in nasal cavity. In our best knowledge, this is the first report of transitional carcinoma originated from transitional zone of canine nasal cavity in Korea.

랫드에서 hyaluronic acid에 의한 유착 방지 효과에 관한 연구

이종훈,이주명,윤영민,강태영,우호춘,강윤호,김남중,김희석,이경갑,정종태,Lee, Jong hoon,Lee, Joo Myoung,Yun, Young min,Kang, Tae young,Woo, Ho choon,Kang, Yoon ho,Kim, Nam joong,Kim, Hee seok,Lee, Kyoung kap,Cheong, Jongtae 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4

This study was conducted to investigate the effect of hyaluronic acid (HA) on prevention of abdominal adhesions depending on various concentrations thereof by inducing an abrasion experimentally in the cecum of rats. Each group was consisted of 10 rats, and 40 rats were divided into 4 groups comprising the saline treatment group, HA 0.4% treated group, 0.6% treated group, and 0.8% treated group. And abrasion was caused in the cecum by using dry gauze and thereby, adhesion was induced. On 7 days after the operation, adhesions of each region were evaluated into the range of 0-4. Significant difference was found in the adhesion score between the control group and each experimental group (P<0.05). Also, HA 0.4% treatment group showed the lowest adhesion score (P<0.05). In the light of the above results, HA 0.4% solution was more effective on prevention of adhesion than HA 0.6% and 0.8% solution.