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Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Kim, Mira,Jeon, Jiyoung,Baek, Jongouk,Choi, Jaeyul,Park, Eun Ju,Song, Jiyeon,Bang, Hyojeong,Suh, Kwee Hyun,Kim, Young Hoon,Kim, Jongmin,Kim, Doran,Min, Kyung Hoon,Lee, Kwang-Ok Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
Kim, Jigeon,Koo, Bonkee,Kim, Wook Hyun,Choi, Jongmin,Choi, Changsoon,Lim, Sung Jun,Lee, Jong-Soo,Kim, Dae-Hwan,Ko, Min Jae,Kim, Younghoon Elsevier 2019 Nano energy Vol.66 No.-
<P><B>Abstract</B></P> <P>Fully inorganic CsPbI<SUB>3</SUB> perovskite quantum dots (CsPbI<SUB>3</SUB>-PQDs) are known as the best-performing photovoltaic absorber in colloidal quantum dot solar cells. This is achieved by improving the cubic-phase-stabilization and electronic-coupling in CsPbI<SUB>3</SUB>-PQD solids. In conventional approaches, the hydrolysis of methyl acetate (MeOAc) resulting in acetic acid and methanol as intermediate substances plays a key role in replacing long-chain hydrocarbons with short-chain ligands, which improves charge transport in the CsPbI<SUB>3</SUB>-PQD solids. However, CsPbI<SUB>3</SUB>-PQDs suffer from lattice distortion and instability under acidic conditions including protons and polar media, leading to CsPbI<SUB>3</SUB>-PQD fusion and poor photovoltaic performance. Herein, we report that electronic coupling and photovoltaic performance of CsPbI<SUB>3</SUB>-PQD solids are improved by efficient removal of long-chain oleate ligands using a solution of sodium acetate (NaOAc) in MeOAc, which results in the direct generation of OAc ions without forming protons and methanol. NaOAc-based ligand exchange of CsPbI<SUB>3</SUB>-PQDs enables preservation of their nanocrystal size without fusion and minimization of surface trap states originating from metal hydroxide formation on their surfaces. Consequently, the best solar cell comprising NaOAc-treated CsPbI<SUB>3</SUB>-PQDs shows an improved device performance with a power conversion efficiency (<I>PCE</I>) of 13.3%, as compared with a lead nitrate-treated control device (12.4% <I>PCE</I>).</P> <P><B>Highlights</B></P> <P> <UL> <LI> NaOAc directly generates short-chain OAc ions to exchange the oleate ligands of CsPbI<SUB>3</SUB>-PQDs. </LI> <LI> Our strategy enables minimizing the formation of protons and methanol during the ligand exchange. </LI> <LI> NaOAc-based ligand exchange enables preserving nanocrystal size and minimizing surface traps. </LI> <LI> Resultant CsPbI<SUB>3</SUB>-PQD solids show enhanced electronic coupling with improved charge transport. </LI> <LI> NaOAc-treated CsPbI<SUB>3</SUB>-PQD solar cells show improved photovoltaic performance up to 13.33% PCE. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We demonstrate that sodium acetate (NaOAc) directly generates short-chain OAc ions to exchange the long-chain oleate ligands of CsPbI<SUB>3</SUB> perovskite quantum dots (CsPbI<SUB>3</SUB>-PQDs). NaOAc-based ligand exchange enables preservation of CsPbI<SUB>3</SUB>-PQD size, minimization of surface trap states, and enhancement of electronic coupling in the resultant CsPbI<SUB>3</SUB>-PQD solids. Consequently, NaOAc-treated CsPbI<SUB>3</SUB>-PQD solar cells show improved device performance with 12.4% power conversion efficiency.</P> <P>[DISPLAY OMISSION]</P>
Kim Jongmin,Shin Kyung-Hwa,Kim Hyerim,Kim Hyung-Hoi,Lee Hyun-Ji 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.5
Background: The currently recommended pre-transfusion testing techniques for patients with autoantibodies are complex, time-consuming, and labor-intensive. Therefore, although the red blood cell (RBC) selection method using crossmatched RBC agglutination reaction grades (i.e., the “least incompatible” transfusion) is discouraged, many institutions still use it. We aimed to evaluate the effectiveness of this method combined with Rh subgroup phenotyping. Methods: We retrospectively investigated RBC transfusions from January 2019 to December 2021 in patients presenting as auto-control-positive via antibody identification (auto-control (+) group), where Rh subgroup phenotype-matched RBCs were selected based on the agglutination reaction grades of crossmatched units. For each study patient, an auto-control-negative patient was matched based on age, sex, department, and pre-transfusion Hb levels (auto-control (−) group). The mean Hb change per unit, transfusion-associated symptom/sign reports, and agglutination reaction grades upon crossmatching were analyzed. Results: In the auto-control (+) group, the Hb change per unit among different agglutination reaction grades of transfused RBCs and among different relative grades of transfused RBCs and crossmatching auto-controls was not significantly different (P=0.392 and P= 0.132, respectively). No significant difference was observed in Hb changes and transfusion-associated symptom/sign occurrence between the auto-control (+) and auto-control (−) groups (P=0.121 and P=0.822, respectively). In addition, no definite evidence of hemolysis in the auto-control (+) group was observed in the medical record review. Conclusions: Together with Rh subgroup phenotyping, selecting the RBC unit with the lowest agglutination reaction grade upon crossmatching does not adversely affect transfusion efficiency.
Reversible self-bending soft hydrogel microstructures with mechanically optimized designs
Kim, Jongmin,Kim, Cheolgyu,Song, YoungShin,Jeong, Seong-Geun,Kim, Taek-Soo,Lee, Chang-Soo Elsevier 2017 Chemical Engineering Journal Vol.321 No.-
<P><B>Abstract</B></P> <P>A rational design methodology for materials with optimal mechanical properties is a prerequisite for developing programmable soft matter that undergoes structural changes in response to external stimuli. The goals of this study are to experimentally characterize the capabilities of a self-bending reconfigurable microstructure, provide fundamental information in engineering design, and validate simulations of physics-based models. In this study, the self-bending behavior of hydrogel bilayers, composed of an active layer and a passive layer, is investigated experimentally and theoretically. This self-bending is completely reversible and allows the structure to fold and unfold without permanent deformation. Experimentally, the effects of design parameters on the self-bending behavior of the microstructures of hydrogel bilayers are explored by varying the extrinsic geometric variables. The study of finite element method (FEM) simulations shows that the final shape of the bilayer sheet is governed by intrinsic properties, including the elastic modulus and the swelling ratio, and extrinsic geometrical factors, such as the thickness ratio of the bilayer and the aspect ratio of the structure. Therefore, the self-bending behavior of the planar hydrogel bilayer was confirmed by experiments and simulations in which multiple values were assigned for each of the primary design parameters in origami-based engineering.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The capabilities of self-folding reconfigurable microstructure are characterized. </LI> <LI> The finite element method (FEM) provides information in engineering design. </LI> <LI> A rational design methodology for programmable soft materials is provided. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Pitna,Park, Jin Hee,Choi, Chang Soon,Choi, Inah,Joo, So Hyun,Kim, Min Kyoung,Kim, Soo Young,Kim, Ki Chan,Park, Seung Hwa,Kwon, Kyoung Ja,Lee, Jongmin,Han, Seol-Heui,Ryu, Jong Hoon,Cheong, Jae Hoo Kluwer Academic/Plenum Publishers 2013 Neurochem Res Vol.38 No.3
<P>Prenatal exposure to alcohol has consistently been associated with adverse effects on neurodevelopment, which is collectively called fetal alcohol spectrum disorder (FASD). Increasing evidence suggest that prenatal exposure to alcohol increases the risk of developing attention deficit/hyperactivity disorder-like behavior in human. In this study, we investigated the behavioral effects of prenatal exposure to EtOH in offspring mice and rats focusing on hyperactivity and impulsivity. We also examined changes in dopamine transporter and MeCP2 expression, which may underlie as a key neurobiological and epigenetic determinant in FASD and hyperactive, inattentive and impulsive behaviors. Mouse or rat offspring born from dam exposed to alcohol during pregnancy (EtOH group) showed hyper locomotive activity, attention deficit and impulsivity. EtOH group also showed increased dopamine transporter and norepinephrine transporter level compared to control group in the prefrontal cortex and striatum. Prenatal exposure to EtOH also significantly decreased the expression of MeCP2 in both prefrontal cortex and striatum. These results suggest that prenatal exposure to EtOH induces hyperactive, inattentive and impulsive behaviors in rodent offspring that might be related to global epigenetic changes as well as aberration in catecholamine neurotransmitter transporter system.</P>
Synthesis of Vinyl Sulfone-tethered Proline Derivatives as Highly Selective Cathepsin S Inhibitors
Mira Kim,Jiyoung Jeon,Jongouk Baek,Jaeyul Choi,Eun Ju Park,Jiyeon Song,Hyojeong Bang,Kwee-Hyun Suh,Young Hoon Kim,Jongmin Kim,Doran Kim,민경훈,Kwang-Ok Lee 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2