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Two New Cytotoxic Spirostane‐Steroidal Saponins from the Roots of <i>Bletilla striata</i>
Park, Jong Eel,Woo, Kyeong Wan,Choi, Sang Un,Lee, Je Hyun,Lee, Kang Ro WILEY‐VCH Verlag 2014 Helvetica chimica acta Vol.97 No.1
<P><B>Abstract</B></P><P>Two new spirostane‐steroidal saponins, bletilnoside A (<B>1</B>) and bletilnoside B (<B>2</B>), together with five known compounds, <B>3</B>–<B>7</B>, were isolated from the roots of <I>Bletilla striata</I> (<SMALL>Thunb</SMALL>.) <SMALL>Reichb</SMALL>. F. The structures of the new compounds were determined based on their 1D‐ and 2D‐NMR spectral data. The isolated compounds <B>1</B>–<B>7</B> were tested for cytotoxicity against four human tumor cells (A549, SK‐OV‐3, SK‐MEL‐2, and HCT15) <I>in vitro</I> using a sulforhodamin B bioassay, and compounds <B>1, 2</B>, and <B>5</B> showed significant cytotoxicities against all tested tumor cell lines with <I>IC</I><SUB>50</SUB> values ranging from 3.98±0.16 to 12.10±0.40 μ<SMALL>M</SMALL>.</P>