益胃升陽湯 및 加減方이 家兎의 摘出腸管 運動에 미치는 影響

李學宰,盧永範,柳道坤,韓宗鉉,康舜洙 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

In order to investigate the action of Radix Bupleuri and Radix Cimicifugae in Yikwiserugyangtang(益胃升陽湯), Yikwiseungyangtang was divided into six samples : Sample Ⅰ : Yikwiseungyangtang Sample Ⅱ : Water extract of Yikwiseungyangtang excluded R.Bupleuri and R.Cimicifugae. Sample Ⅲ : Water extract of Yikwiseungyangtang excluded R.Cimicifugae. Sample Ⅳ : Water extract of Yikwiseungyangtang excluded R.Bupleuri. Sample Ⅴ : Water extract of Yikwiseungyangtang increased R.Bupleuri and R.Cimicifugae to 3.75g Sample Ⅵ : Water extract of R.Bupleuri and R.Cimicifuage. Effects of Yikwiseungyangtang and its variants on the contractile force of isolated rabbit ileums are as follows : 1. Yikwiseungyangtang was significantly increased the contractile force of isolated rabbits ileum. 2. The contractile of Yikwiseungyangtang was significantly inhibited by atropine. 3. The contractile force of Yikwiseungyangtang was not inhibited by cyproheptadine. 4. In the contraction of Norepinephrine(10^-3M), Sample Ⅱ, Sample Ⅵ and Sample Ⅴ were increased the contractile force than that of Sample Ⅰ. 5. In the contraction of acetylcholine (10^-3M), no change observed in contractile force than that of Sample Ⅰ.

흰쥐에서의 카르복시메칠셀룰로오스나트륨과 겔란검 혼합겔의 유착방지 효과

권윤환,이시범,이정권,박용덕,박정숙,황성주 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

The aim of the present study was to investigate the efficacy of a mixed gel formulation composed of sodium carboxymethyl cellulose and gellan gum (Na-CMC gel) for the prevention of adhesions after laminectomv. The anti-adhesive effect of the Na-CMC gel was tested in a controlled randomized study using an animal model of lumbar laminectomv. The animals (60 female Sprague-Dawlev rats) were randomly allocated into two treatment groups to receive the Na-CMC gel on the injured area or no gel (control). The incidence of adhesions and their grade were blindly evaluated at 4. 8 and 12 weeks after surgery. The amount of scar tissue and tenacity were grossly reduced by the Na-CMC gel at postoperative 4. 8. and 12 weeks. The mean adhesion scores were 0.75. 125. and 1.38 at 4. 8. and 12 weeks in the gel-treated group. respectively. No significant inflammatory reaction was observed and the healing of wound was not affected by the Na-CMC gel. The Na-CMC gel reduced the amount of scar formation and tenacity in rat laminectomv model without affecting the healing of operation wound and other complications. Therefore. the Na-CMC gel may be the potential to prevent postsurgical adhesions in clinical state.

Performance Improvement of Grid-Connected Inverter Systems under Unbalanced and Distorted Grid Voltage by Using a PR Controller

Lee, Jong-Hyun,Jeong, Hae-Gwang,Lee, Kyo-Beum The Korean Institute of Electrical Engineers 2012 Journal of Electrical Engineering & Technology Vol.7 No.6

This paper proposes a control method for grid-connected inverter systems under unbalanced and distorted grid voltage. The proposed method can reduce the power ripple caused by the unbalanced condition and compensate for the low-order harmonics of the output currents caused by the distortion of grid voltage. To reduce the power ripple, our method replaces the two conventional PI controllers with one PR controllers in the stationary frame. PR controllers can implement selective harmonic compensation without excessive computational requirements; the use of these controllers simplifies the method. Both the simulated and experimental results agree well with the theoretical analysis.

Performance Improvement of Grid-Connected Inverter Systems under Unbalanced and Distorted Grid Voltage by Using a PR Controller

Jong-Hyun Lee,Hae-Gwang Jeong,Kyo-Beum Lee 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.6

This paper proposes a control method for grid-connected inverter systems under unbalanced and distorted grid voltage. The proposed method can reduce the power ripple caused by the unbalanced condition and compensate for the low-order harmonics of the output currents caused by the distortion of grid voltage. To reduce the power ripple, our method replaces the two conventional PI controllers with one PR controllers in the stationary frame. PR controllers can implement selective harmonic compensation without excessive computational requirements; the use of these controllers simplifies the method. Both the simulated and experimental results agree well with the theoretical analysis.

New Platform for Cytochrome P450 Reaction Combining in Situ Immobilization on Biopolymer

Lee, Jae Hyung,Nam, Dong Heon,Lee, Sahng Ha,Park, Jong Hyun,Park, Si Jae,Lee, Seung Hwan,Park, Chan Beum,Jeong, Ki Jun American Chemical Society 2014 Bioconjugate chemistry Vol.25 No.12

<P>We describe an efficienct chemical conversion platform with in situ immobilization of P450-BM3 on poly(3-hydroxybutyrate) granules. Through fusion with phasin, P450-BM3 is easily immobilized on poly(3-hydroxybutyrate) granules in <I>Escherichia coli</I>. In our work, the immobilized P450 exhibited higher stability and catalytic activity compared to free P450 against changes of pH, temperature, and concentrations of urea and ions. Through quick recovery of immobilized enzyme, the P450–P(3HB) complex successfully catalyzed an O-dealkylation reaction several times with maintained activity. Using the robust P450–P(3HB) complex, we performed a P450-catalyzed reaction on a preparative reactor scale (100 mL) and high-level production (12.3 μM) of 7-hydroxycoumarine from 7-ethoxycoumarin could be achieved.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bcches/2014/bcches.2014.25.issue-12/bc500404j/production/images/medium/bc-2014-00404j_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/bc500404j'>ACS Electronic Supporting Info</A></P>

The Microencapsulated Ascorbic Acid Release in vitro and Its Effect on Iron Bioavailability

Lee, Jun-Beum,Ahn, Joung-Jwa,Lee, Jong-Hwi,Kwak, Hae-Soo The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.10

The present study was carried out to examine the stability of microencapsulated ascorbic acid in simulated-gastric and intestinal situation in vitro and the effect of microencapsulated ascorbic acid on iron bioavailability. Coating materials used were polyglycerol monostearate (PGMS) and medium-chain triacylglycerol (MCT), and core materials were L-ascorbic acid and ferric ammonium sulfate. When ascorbic acid was microencapsulated by MCT, the release of ascorbic acid was 6.3% at pH 5 and 1.32% at pH 2 in simulated-gastric fluids during 60 min. When ascorbic acid was microencapsulated by PGMS, the more ascorbic acid was released in the range of 9.5 to 16.0%. Comparatively, ascorbic acid release increased significantly as 94.7% and 83.8% coated by MCT and PGMS, respectively, for 60 min incubation in simulated-intestinal fluid. In the subsequent study, we tested whether ascorbic acid enhanced the iron bioavailability or not. In results, serum iron content and transferring saturation increased dramatically when subjects consumed milks containing both encapsulated iron and encapsulated ascorbic acid, compared with those when consumed uncapsulated iron or encapsulated iron without ascorbic acid. Therefore, the present data indicated that microencapsulated ascorbic acid with both PGMS and MCT were effective means for fortifying ascorbic acid into milk and for enhancing the iron bioavailability.

Cofactor-free Light-driven Whole-cell Cytochrome P450 Catalysis

Jong Hyun PARK,Sahng Ha LEE,Gun Su CHA,Da Som CHOI,Dong Heon NAM,Jae Hyung LEE,Jung-Kul LEE,Chul-Ho YUN,Ki Jun JEONG,Chan Beum PARK 한국생물공학회 2015 한국생물공학회 학술대회 Vol.2015 No.4

Low-cost and energy-efficient asymmetric nickel electrode for alkaline water electrolysis

Kim, Jong-Hoon,Lee, Jung-Nam,Yoo, Chung-Yul,Lee, Kyo-Beum,Lee, Woong-Moo Elsevier 2015 International journal of hydrogen energy Vol.40 No.34

<P><B>Abstract</B></P> <P>Porous nickel electrodes for alkaline water electrolysis were made in simple manner by sintering nickel powder that was first compressed into nickel foam. The pores inside the sintered body show asymmetrical distribution in size, small pores (∼5 μm) existing near one surface and open structure (pore size: 100–200 μm) at the other surface. Such asymmetric body performs the dual role such that one surface has the electro-catalytic layer for the electrochemical reactions and the other surface has the escaping route of gas/electrolyte mixture. A nickel electrode stack was assembled by incorporating the sintered bodies, polymer separators and multi-functional light-weight gaskets. Two nickel electrodes with a separator between them were enclosed to make a unit cell in the gasket frame which plays the multi-role of electrolyte supply, exit of produced gas and sealing agent. By applying 1.8 V per unit cell, an electrolyzer made of such stacks with electrodes of 200 cm<SUP>2</SUP> surface area displays current of over 80 A at 80 °C over 400 h.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Porous nickel electrodes for alkaline water electrolysis were fabricated. </LI> <LI> Nickel powder was first compressed into nickel foam and then sintered. </LI> <LI> The pores inside the sintered body show asymmetrical distribution in size. </LI> <LI> A nickel electrode stack was assembled by incorporating the sintered Ni bodies. </LI> <LI> The electrolyzer made of the stack displayed current density of 0.5 A cm<SUP>−2</SUP> at 80 °C. </LI> </UL> </P>

비례공진 제어기를 이용한 계통연계형 인버터의 고조파 왜곡보상

이종현(Jong-Hyun Lee),이교범(Kyo-Beum Lee) 전력전자학회 2011 전력전자학술대회 논문집 Vol.2011 No.11

순차적 레이블링을 위한 ACE와 Self-Attention을 활용한 인공 신경망에 관한 연구

이종민(Jong-Min Lee),최준희(Joon-Hee Choi) 한국지능시스템학회 2021 한국지능시스템학회논문지 Vol.31 No.2

최근 자연어 처리 분야의 순차적 레이블링을 위해 복수의 단어 임베딩 모델과 Recurrent Neural Network(RNN) 기반의 순차 모델을 이용한 인공 신경망이 보편적으로 사용되고 있다. 이로 인해 신경망 모델에 적합한 임베딩 벡터의 결합을 찾는 것과 순차 모델의 역전파 과정 중 발생하는 기울기 소실 문제를 해결하는 것은 중요한 연구 주제가 되었다. 본 논문은 복수의 임베딩 벡터들 중 일부를 사용하여 최적의 임베딩 결합을 찾는 Automated Concatenation of Embeddings(ACE)와 기울기 소실 문제를 해결하기 위해 셀프 어텐션을 활용하는 방법을 제안한다. 제안 방식의 성능을 검증하기 위해 순차적 레이블링 문제의 일종인 품사 태깅과 개체명 인식에서 다양한 데이터셋을 사용해 실험을 수행하였다. 그 결과 현재 최고의 성능을 내는 논문의 모델들 보다 향상된 성능을 보인다. Recently multiple word embedding models and sequence models based on RNN have been widely used for sequence labeling in the field of natural language processing. It is essential to find optimal embedding vectors for concatenation. Also, we should address the vanishing gradient problem during the backpropagation. This paper proposes a method using self-attention and ACE for solving the problems. We verified the performance of our proposed method on datasets for sequence labeling such as part of speech tagging and named entity recognition. Our proposed model shows better performance than the state of the art models.