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PNF 상지패턴에 기초한 진동운동기구 훈련이 노인의 체간 안정성과 균형에 미치는 영향
이형수 ( Hyoungsoo Lee ),임정대 ( Jungdae Im ),이기훈 ( Gihun Lee ),이지성 ( Jiseong Lee ),이진욱 ( Jinwuk Lee ),손지윤 ( Yeonju Seo ),서연주 ( Jiyoon Son ),안효정 ( Hyojoeng An ),오현정 ( Hyunjeong Oh ),윤하늘 ( Haneul Youn ),이서연 대한통합의학회 2015 대한통합의학회지 Vol.3 No.3
Purpose : This study examines the effect of vibration exercise grafting PNF patterns for 6 weeks on upper body stability and equilibrium for seniors having fifteen or over of MMSE-K. Method : A total of 10 senior citizens participated in this study. Each participant performed PNF patterned exercises using vibration sports equipment for 30 minutes, once static a week, for six weeks. We measured trunk stability and balance degree before and after the six-week exercise program. Motor Assessment Scale (MAS) was used to measure trunk stability, while Functional Reach Test (FRT) and Timed Up and Go (TUG) was used to measure balance degree. The collected data was processed using paired t-test to confirm the difference between pre-program conditions and post-program conditions. Results: The results of our study show that post-program trunk stability measurements increased when compared to pre-program data; however, this increase was not statistically significant. pre and post-measurements for satatic balance and dynamic balance were statistically unchanged. Conclusion: Due to limitations in the number of participants, the procedural design of this experiment, and the limited amount of time participants actually controlled, this study failed to produce statistically significant results. However, further study should be conducted using a systematically implemented exercise program to show support for exercising with flexi-bar as an effective program for the elderly.
신생아 중환자실 개방면회와 개방면회에 대한 부모 불안, 간호사의 태도
이유나(Yu-nah Lee),김은숙(Eunsook Kim),박소현(Sohyun Park),김안나(An Na Kim),이지윤(Jiyoon Lee),이금문(Keum Moon Lee),최수정(Sujung Choi),이은정(Eun-jung Lee) 한국근거기반간호학회 2014 근거와 간호 Vol.2 No.1
Purpose: The purpose of this study was to survey the visitation conditions in the Neonatal Intensive Care Unit (NICU) and to evaluate parents’ anxiety and nurses’ attitude about the open visitation policy. Methods: One group pre-posttest design was used. After the approval of the institutional review board was obtained, 22 parents and 58 nurses in the NICU participated in the survey between January and February in 2014.The visitation conditions were the number of patients who had visitors in the NICU for a whole day, total visitation hours, mean visitation hours and total number of visitation in a day. Before and after the open visitations were applied, the anxiety level of the patients and attitudes of the nurses were measured. Results: After the open visitation, all visitation conditions significantly increased. Parents’ anxiety score also significantly decreased after experiencing the open visitation (p=.023). However, nurses’ attitude was not different (p=.851). Conclusion: The open visitation can relive parents’ anxiety in the NICU but still nurses have some conflicts for applying the open visitation. It is necessary to prepare environmental infrastructure and educate nurses and parents to activate the open visitation in the NICU.
Lee, Jiyoon,Jang, Hosung,Shin, Hosub,Choi, Woo Lee,Mok, Young Geun,Huh, Jin Hoe Oxford University Press 2014 Nucleic acids research Vol.42 No.18
<P>DNA methylation is a primary epigenetic modification regulating gene expression and chromatin structure in many eukaryotes. Plants have a unique DNA demethylation system in that 5-methylcytosine (5mC) is directly removed by DNA demethylases, such as DME/ROS1 family proteins, but little is known about the downstream events. During 5mC excision, DME produces 3′-phosphor-α, β-unsaturated aldehyde and 3′-phosphate by successive β- and δ-eliminations, respectively. The kinetic studies revealed that these 3′-blocking lesions persist for a significant amount of time and at least two different enzyme activities are required to immediately process them. We demonstrate that <I>Arabidopsis</I> AP endonucleases APE1L, APE2 and ARP have distinct functions to process such harmful lesions to allow nucleotide extension. <I>DME</I> expression is toxic to <I>E. coli</I> due to excessive 5mC excision, but expression of <I>APE1L</I> or <I>ARP</I> significantly reduces DME-induced cytotoxicity. Finally, we propose a model of base excision repair and DNA demethylation pathway unique to plants.</P>
Lee Yujin,Jang Jiyoon,Bibi Maimoona,Duggirala Krishna Babu,Ji Sang Hee,Lee Ji Hun,Ahn Sunjoo,Song Jin Sook,Chae Chong Hak,Kim Seong Hwan,Lee Kwangho 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.6
Apoptosis signal-regulating kinase 1 (ASK1) is a member of mitogen-activated protein kinase kinase kinase (MAP3K) family that involves downstream phosphorylation of MAP kinases, c-Jun N-terminal kinases, and p38 MAP kinases. ASK1 inhibitors could possibly be beneficial for ameliorating the development and progression of diseases. Especially, ASK1 has been of interest as one of therapeutic targets for nonalcoholic fatty liver disease as the most common chronic liver diseases including simple steatosis and nonalcoholic steatohepatitis. In this manuscript, novel ASK1 inhibitor lead KTA-29 which has an imidazo [1,2-b]pyridazine core with novel C6-bicycloheptaneimidazole is disclosed. With the novel imidazo[1,2-b] pyridazine core, structure-activity-relationship study for ASK1 potency is described and KTA-29 affinity toward ASK1 with molecular modeling study is explained.
Lee, Donmin,Jung, Yen-Sook,Heo, Youn-Jung,Lee, Sehyun,Hwang, Kyeongil,Jeon, Ye-Jin,Kim, Jueng-Eun,Park, Jiyoon,Jung, Gun Young,Kim, Dong-Yu American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.18
<P>Recently, many kinds of printing processes have been studied to fabricate perovskite solar cells (PeSCs) for mass production. Among them, slot-die coating is a promising candidate for roll-to-roll processing because of high-throughput, easy module patterning, and a premetered coating system. In this work, we employed mixed lead precursors consisting of PbAc<SUB>2</SUB> and PbCl<SUB>2</SUB> to fabricate PeSCs via slot-die coating. We observed that slot-die-coated perovskite films based on the mixed lead precursors exhibited well-grown and uniform morphology, which was hard to achieve by using only a single lead source. Consequently, PeSCs made with this precursor system showed improved device performance and reproducibility over single PbAc<SUB>2</SUB>. Lastly, a large-area module with an active area of 10 cm<SUP>2</SUP> was fabricated with a power conversion efficiency of 8.3%.</P> [FIG OMISSION]</BR>
Lee, Jiyoon,Kim, Dongwook,Oh, Hyejong,Lee, Sungin,Choi, Seok Hwa,Kim, Gonhyung The Korean Society of Veterinary Clinics 2022 한국임상수의학회지 Vol.39 No.3
The present study was performed to compare cranial tibial wedge osteotomy (CTWO) and tibial plateau leveling osteotomy (TPLO) through radiographic evaluation. The experiment was conducted with five cadaver dogs [mean (± SD) weight, 32.9 ± 4.1 kg; mean (± SD) age, 6 ± 2 years; three males and two females] euthanized for reasons unrelated to this study. The cadaver dogs consisted of German Shepherd (n = 3), Belgian Malinois (n = 1), and mixed breed (n = 1). CTWO and TPLO were carried out by the standard surgical method. Radiographic evaluation was performed by comparing several factors, including the flexion and extension angles, the anatomical mechanical axis angle (AMA-angle), tibial length, patellar height measurement using the Labelle-Laurin method, mechanical medial proximal tibial angle (mMPTA), mechanical medial distal tibial angle (mMDTA), and frontal plane alignment (FPA). Both the CTWO and the TPLO groups showed significantly increased flexion angles after surgery. Only the CTWO group had significantly increased extension angle. Although both groups showed significant decreases in the AMA-angle, the mechanical axis moved cranially against the anatomical axis only in the CTWO group. The patellar height was significantly lowered in the CTWO group. No significant differences were found in mMPTA, mMDTA, or FPA. In conclusion, radiographic comparison revealed more changes in CTWO group than in TPLO group.