Simultaneous Single-Position Oblique Lateral Interbody Fusion Combined With Unilateral Percutaneous Pedicle Screw Fixation for Single-Level Lumbar Tuberculosis: A 3-Year Retrospective Comparative Study

Jinyue He,Jiezhong Deng,Yusheng Yang,Tingting Zheng,Fei Luo,Jianzhong Xu,Zehua Zhang 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To illustrate a simultaneous single-position oblique lateral interbody fusion (SPOLIF) combined with unilateral percutaneous pedicle screw fixation in treating single-level lumbar tuberculosis, compared with posterior-only approach in clinical and radiographic evaluations. Methods: Consecutive patients who had undergone surgeries for single-level lumbar tuberculosis from January 2018 to December 2020 were retrospectively reviewed. The patients included were divided into SP-OLIF and posterior-only groups according to surgical methods applied, with follow-up for at least 36 months. Outcomes included estimated blood loss, operative time, and complications for safety evaluation; visual analogue scale (VAS), Oswestry Disability Index (ODI) for efficacy evaluation; erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) for evaluating tuberculosis activity; x-ray and computed tomography scan were used for radiographic evaluation. Results: A total of 136 patients had been enrolled in the study (60 for SP-OLIF and 76 for Posterior-only). The median operative time, blood loss, and hospital stay in SP-OLIF group were significantly less, with a lower complication rate. Meanwhile, the SP-OLIF group showed substantially lower VAS in 1 and 7 days and decreased ODI in the first month postoperatively, without significant difference afterward. Similarly, the median CRP and ESR in SP-OLIF group were significantly lower in 3 and 7 days postoperatively. All indicators had reduced to normal after 3 months. No recurrence had been reported throughout the whole follow-up. Conclusion: SP-OLIF was an efficient minimally invasive protocol for single-level lumbar tuberculosis, facilitating earlier clinical improvement, with decreased blood loss, operative time and hospital stay compared with posterior-only approach.

Experimental Study on the Motion Process of Radial Retractable Roof Structures

JinYu Lu,Jie Liao,Gan-Ping Shu,Tao Zhang 한국강구조학회 2016 International Journal of Steel Structures Vol.16 No.4

In recent years, the use of retractable roofs is increasing to meet the demand of holding big-scale events. This article introduces a class of radial retractable roofs based on the foldable bar structure (FBS) mechanism. A radial retractable roof structure whose moveable section consisted of 6 segments and 6 rigid linkages was designed with appropriate parameters. An experimental study of a radial retractable roof was carried out. A scale model with a 3 metre diameter was constructed to study the roof deflection and vibration during the deployment process under four different load cases. Furthermore, based on the multi-flexible body dynamics theory, an ADAMS-ANSYS co-simulation was applied to simulate the motion process of the radial retractable roof structure. The experimental results were consistent with the numerical simulations. This indicates that the dynamic and fluctuation phenomena of structural behaviour are universal. The structural vibration was increased with the increase of external loads, and the vibration amplitude increased significantly when the roof was starting and braking. With the closing of the movable roof, the deflection of the fixed roof increased significantly. In the motion process, the bending moment of the fixed roof gradually increases, while that of the moving roof varies little. Vertical vibration is significant in the motion process by reason of the complex wheel-rail contact.

Progressive Collapse Behavior of Large-span Truss String Structures Subjected to Cable Failure

Haiying Zhang,JinYu Lu,Xiaolong Wu,Na Li 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.4

Cables play an important role in truss string structures, and their sudden failure can lead to massive damage and even collapse of the structures. This paper studies the dynamic response of a 72 m span truss string structure, the progressive collapse numerical simulation of the structure is carried out under different load conditions, the displacement and force responses of the structure after cable failure are investigated, the dynamic amplification factor is calculated, and the collapse mechanism is revealed. The effect of individual factor changes on the structural response is analyzed and compared. Results showed that after cable failure, the stress state of the upper truss changed from an arch to a simply supported beam, when reaching collapse load, the structure collapsed within 5s instead of reaching new equilibrium positions. Moreover, the structure with stiffer elastic support exhibited higher resistance to collapse. The critical member of the truss, which first buckled under compression, shifted from the mid-span to the lower chord at the end, leading to rapid structural collapse. Increasing the cable's cross-sectional area can hardly reduce the structure's dynamic response. However, when the instantaneous failure time of the cable exceeded 0.1s, a significant alleviation of the structure's dynamic response was observed.

Spinosin Inhibits Aβ_1-42 Production and Aggregation via Activating Nrf2/HO-1 Pathway

( Xiaoying Zhang ),( Jinyu Wang ),( Guowei Gong ),( Ruixin Ma ),( Fanxing Xu ),( Tingxu Yan ),( Bo Wu ),( Ying Jia ) 한국응용약물학회 2020 Biomolecules & Therapeutics(구 응용약물학회지) Vol.28 No.3

The present research work primarily investigated whether spinosin has the potential of improving the pathogenesis of Alzheimer’s disease (AD) driven by β-amyloid (Aβ) overproduction through impacting the procession of amyloid precursor protein (APP). Wild type mouse Neuro-2a cells (N2a/WT) and N2a stably expressing human APP695 (N2a/APP695) cells were treated with spinosin for 24 h. The levels of APP protein and secreted enzymes closely related to APP procession were examined by western blot analysis. Oxidative stress related proteins, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) were detected by immunofluorescence assay and western blot analysis, respectively. The intracellular reactive oxygen species (ROS) level was analyzed by flow cytometry, the levels of Aβ_1-42were determined by ELISA kit, and Thioflavin T (ThT) assay was used to detect the effect of spinosin on Aβ_1-42aggregation. The results showed that ROS induced the expression of ADAM10 and reduced the expression of BACE1, while spinosin inhibited ROS production by activating Nrf2 and up-regulating the expression of HO-1. Additionally, spinosin reduced Aβ_1-42production by impacting the procession of APP. In addition, spinosin inhibited the aggregation of Aβ_1-42. In conclusion, spinosin reduced Aβ_1-42 production by activating the Nrf2/HO-1 pathway in N2a/WT and N2a/ APP695 cells. Therefore, spinosin is expected to be a promising treatment of AD.

Hounsfield Units as an Independent Predictor of Failed Percutaneous Drainage of Spinal Tuberculosis Paraspinal Abscess Under Computed Tomography Guidance

Yu Xiang,Jinyue He,Ruonan Bai,Huorong Gou,Fei Luo,Xuequan Huang,Zehua Zhang 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To investigate the value of Hounsfield units (HUs) as an independent predictor of failed percutaneous drainage of spinal tuberculosis paraspinal abscess under computed tomography (CT) guidance. Methods: A retrospective analysis was conducted on 61 patients who underwent CT-guided percutaneous drainage for spinal tuberculosis paraspinal abscess between October 2017 and October 2020. Preoperative CT scans were used to measure the HUs of the abscess. Patients were categorized into successful drainage (n = 49) and failed drainage (n = 12) groups. Statistical analysis involved independent sample t-tests and chi-square tests to compare between the 2 groups. Binary logistic regression was performed to identify independent predictive factors for drainage failure. Receiver operating characteristic (ROC) curves were employed to ascertain risk factor thresholds and diagnostic performance. Results: Among the patients, 49 experienced successful drainage while 12 faced drainage failure. The mean HUs of abscesses in the failed drainage group were significantly higher than those in the successful drainage group (p < 0.001). ROC analysis revealed an area under the curve of 0.897 (95% confidence interval, 0.808–0.986) for predicting drainage failure based on HUs. The optimal HU cutoff value for predicting drainage failure was 22.3, with a sensitivity of 91.7% and specificity of 69.4%. Conclusion: HUs are an independent predictor of failed percutaneous drainage of spinal tuberculosis paraspinal abscess under CT guidance. The HU value of 22.3 can be used as an initial screening threshold for predicting the success or failure of drainage.

Ordinal Optimization Theory Based Planning for Clustered Wind Farms Considering the Capacity Credit

Wang, Yi,Zhang, Ning,Kang, Chongqing,Xu, Qianyao,Li, Hui,Xiao, Jinyu,Wang, Zhidong,Shi, Rui,Wang, Shuai The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.5

Wind power planning aims to locate and size wind farms optimally. Traditionally, wind power planners tend to choose the wind farms with the richest wind resources to maximize the energy benefit. However, the capacity benefit of wind power should also be considered in large-scale clustered wind farm planning because the correlation among the wind farms exerts an obvious influence on the capacity benefit brought about by the combined wind power. This paper proposes a planning model considering both the energy and the capacity benefit of the wind farms. The capacity benefit is evaluated by the wind power capacity credit. The Ordinal Optimization (OO) Theory, capable of handling problems with non-analytical forms, is applied to address the model. To verify the feasibility and advantages of the model, the proposed model is compared with a widely used genetic algorithm (GA) via a modified IEEE RTS-79 system and the real world case of Ningxia, China. The results show that the diversity of the wind farm enhances the capacity credit of wind power.

Ordinal Optimization Theory Based Planning for Clustered Wind Farms Considering the Capacity Credit

Yi Wang,Ning Zhang,Chongqing Kang,Qianyao Xu,Hui Li,Jinyu Xiao,Zhidong Wang,Rui Shi,Shuai Wang 대한전기학회 2015 Journal of Electrical Engineering & Technology Vol.10 No.5

Wind power planning aims to locate and size wind farms optimally. Traditionally, wind power planners tend to choose the wind farms with the richest wind resources to maximize the energy benefit. However, the capacity benefit of wind power should also be considered in large-scale clustered wind farm planning because the correlation among the wind farms exerts an obvious influence on the capacity benefit brought about by the combined wind power. This paper proposes a planning model considering both the energy and the capacity benefit of the wind farms. The capacity benefit is evaluated by the wind power capacity credit. The Ordinal Optimization (OO) Theory, capable of handling problems with non-analytical forms, is applied to address the model. To verify the feasibility and advantages of the model, the proposed model is compared with a widely used genetic algorithm (GA) via a modified IEEE RTS-79 system and the real world case of Ningxia, China. The results show that the diversity of the wind farm enhances the capacity credit of wind power.

Physically-Based Constitutive Modelling of As-Cast CL70 Steel for Hot Deformation

Fei Chen,Xiaodong Zhao,Jinyu Ren,Huiqin Chen,Xiaofeng Zhang 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.6

In order to conduct numerical simulation of plasticity forming and confirm the processing parameters of heat deformationfor as-cast CL70 steel, the hot deformation behaviors of as-cast CL70 steel were studied by isothermal compression testswhich used a Gleeble-1500D thermal mechanical simulation tester for the deformation temperatures ranging from 1173 to1523 K and the strain rates ranging from 0.001 to 1 s−1. Flow stress curves of the steel were obtained under high temperature. The flow stress constitutive models of the work hardening-dynamical recovery period and dynamical recrystallizationperiod were established for as-cast CL70 steel. In work hardening-dynamic recovery period, the flow stress was predicted byemploying the evolution rule of dislocation density in the constitutive model. In dynamic recrystallization period, the flowstress after the critical strain was predicted by employing the dynamic recrystallization kinetics in the constitutive model. To improve the prediction accuracy of the model, the dynamic recovery coefficient is modified in the traditional physicallybasedconstitutive model. The results indicate that the proposed physically-based constitutive model has high accuracy inpredicting the flow stress under hot deformation for as-cast CL70 steel.

The transcription factor PjERF1 enhances the biosynthesis of triterpenoid saponins in Panax japonicus

Chen Qin,Yu Yilin,Zhang Xiang,Zhao Ren,Zhang Jinyu,Liu Diqiu,Cui Xiuming,Ge Feng 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.5

The ERF-type transcription factors (TFs) play vital roles in plant secondary metabolism. ERF TFs simultaneously regulate the expression levels of key enzyme genes involved in the biosynthesis of secondary metabolites due to its “multi-point control” function. In this study, one gene of ERF TFs from Panax japonicus (PjERF1) was cloned. The open reading frame of PjERF1 was 801 bp and encoded 266 amino acids. Phylogenetic analysis showed that PjERF1 belonged to ERF subfamily with a typical conserved domain. Subcellular localization found that PjERF1 protein might be located in eukaryotic cell nucleus. Yeast one-hybrid assay demonstrated that PjERF1 could bind to the promoters of PjβAS, PjCAS, and PjSE specifically and regulate the expression levels of such key enzyme genes involved in the triterpene saponins biosynthesis. Therefore, in the PjERF1 overexpression cell lines, the expression levels of some key enzyme genes involved in the triterpenoid saponins biosynthesis were significantly increased compared with those in non-transgenic cell line. As a result of it, the biosynthesis of chikusetsusaponin IV and IVa, and other ginsenosides (Rd, Rb1, Re, and R0) were also promoted in the PjERF1 over- expression cell lines. This study indicated that PjERF1 could regulate the biosynthesis of saponins in P. japonicus through controlling the expression levels of key enzyme genes related to the biosynthesis of triterpenoid saponins.

Thunderstorm Cloud Localization Algorithm and Performance Analysis of a Three‑Dimensional Atmospheric Electric Field Apparatus

Hongyan Xing,Xu Yang,Jinyu Zhang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.6

In order to accurately obtain the location of thunderstorm cloud and improve the accuracy and stability of thunderstorm cloud localization, a thunderstorm cloud localization algorithm of a three-dimensional atmospheric electric feld apparatus is proposed. An electric feld measurement model is established, and the localization parameters are defned based on the model. According to the theory of mirror method, the potential distribution of the thunderstorm cloud at the atmospheric electric feld apparatus is obtained. Using the potential distribution formula, the three-dimensional electric feld components are derived and the thunderstorm cloud coordinates are obtained. The relationship between the electric feld component measurement error, the azimuth angle, the elevation angle and the ranging and direction-fnding accuracy is given, and the localization performance is analyzed. The results show that the method has a ranging error rate of about 5% and a directionfnding error rate of about 3%, which has a good localization efect.