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다양한 형태의 사물데이터 질의 처리를 위한 단일 색인 및 시각화 방안
한진주(Jinju Han),나철원(Chul-Won Na),이다희(Dahee Lee),이도훈(Do-Hoon Lee),온병원(Byung-Won On),이용(Ryong Lee),박민우(Min-Woo Park),이상환(Sang-Hwan Lee) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.9
Recently, a variety of IoT data is collected by attaching geosensors to many vehicles that are on the road. IoT data basically has time and space information and is composed of various data such as temperature, humidity, fine dust, Co2, etc. Although a certain sensor data can be retrieved using time, latitude and longitude, which are keys to the IoT data, advanced search engines for IoT data to handle high-level user queries are still limited. There is also a problem with searching large amounts of IoT data without generating indexes, which wastes a great deal of time through sequential scans. In this paper, we propose a unified spatial index model that handles both grid and trajectory queries using a cell-based space-filling curve method. also it presents a visualization method that helps user grasp intuitively. The Trajectory query is to aggregate the traffic of the trajectory cells passed by taxi on the road searched by the user. The grid query is to find the cells on the road searched by the user and to aggregate the fine dust. Based on the generated spatial index, the user interface quickly summarizes the trajectory and grid queries for specific road and all roads, and proposes a Web-based prototype system that can be analyzed intuitively through road and heat map visualization.
Lee, Dong-Sung,Ko, Wonmin,Yoon, Chi-Su,Kim, Dong-Cheol,Yun, Jinju,Lee, Jun-Kyung,Jun, Ki-Young,Son, Ilhong,Kim, Dong-Woung,Song, Bong-Keun,Choi, Seulah,Jang, Jun-Hyeog,Oh, Hyuncheol,Kim, Sungchul,Kim, Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P>The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases. Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases. KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants. In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia. KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE<SUB>2</SUB>) in LPS-stimulated BV2 microglia. It also reduced tumor necrosis factor-<I>α</I> (TNF-<I>α</I>), interleukin-1<I>β</I> (IL-1<I>β</I>), and IL-6 production. This effect was correlated with the suppression of inhibitor of nuclear factor kappa B-<I>α</I> (I<I>κ</I>B-<I>α</I>) phosphorylation and degradation and nuclear factor kappa B (NF-<I>κ</I>B) translocation and DNA binding. Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia. Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression. Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.</P>
Lee, Jinju,Ahn, Hyung Jun Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Although siRNA-mediated downregulation technology has been highly successful in suppressing the expression of any disease-related gene, systemic delivery of siRNA for the clinical applications remains challenging, especially in the use of cancer therapy. DC-Chol/DOPE cationic liposomes as one of the most attractive vehicles for gene delivery have been widely exploited for transfection of siRNA into cells, but complexity of systemic delivery has allowed only their direct injection into local targets due to the formation of aggregations with negatively-charged blood components. Herein, we demonstrate the effects of PEGylation on DC-Chol/DOPE cationic liposomes for systemic siRNA delivery in cancer therapy. In contrast to non-PEGylated DC-Chol/DOPE-siRNA lipoplexes, PEGylated DC-Chol/DOPE-siRNA lipoplexes reduce the excretion by kidneys and scavenging in liver, prolonging the circulation time <I>in vivo</I>, and ultimately increase their preferential tumor accumulation. Therefore, systemic injection of PEGylated DC-Chol/DOPE liposomes loaded with siRNA against kinesin spindle protein (KSP) gene exhibited a high level of target gene silencing at tumor sites and substantial suppression of tumor growth. Furthermore, systemically administered PEGylated lipoplexes did not lead to any activation of innate immune responses in the immunocompetent mice. These results suggest the potential of PEGylated DC-Chol/DOPE liposomes as a systemic delivery carrier for siRNA-mediated cancer therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
( Jinju Oh ),( Hyun Joo Lee ),( Tae Sung Lee ),( Ju Hyun Kim ),( Suk Bong Koh ),( Youn Seok Choi ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4
Objective The objective of this study was to evaluate the clinical benefits of routine squamous cell carcinoma antigen (SCC-Ag) monitoring of patients with locally advanced cervical squamous cell carcinoma treated with radiation or chemoradiation. Methods A total of 53 patients with recurrent cervical squamous cell carcinoma treated with radiotherapy or chemoradiation were enrolled in this study. A retrospective review of medical records was conducted. The role of routine monitoring of serum SCC-Ag was evaluated in terms of cost effectiveness and effect on survival after diagnosis of recurrence. Results Serum SCC-Ag abnormality (≥2.5 ng/mL) was observed in 62.3% of patients when recurrent disease was diagnosed. The first indicator of relapse was abnormal serum SCC-Ag level in 21 patients (39.6%), 10 of whom had asymptomatic recurrent disease amenable to salvage therapy. Adding SCC-Ag measurement to the basic follow up protocol improved the sensitivity for detecting recurrence (The sensitivity of the basic protocol vs. addition of SCC-Ag: 49.1% vs. 88.7%, P<0.001). Twenty-three patients who were candidates for salvage therapy with curative intent showed better survival compared with those who were not candidates for therapy (5-year survival: 36.6% vs. 0%, P=0.012). Conclusion Surveillance with routine serum SCC-Ag monitoring can better detect asymptomatic recurrent disease that is potentially amenable to salvage therapy with curative intent. Early diagnosis of recurrent disease that can be treated with salvage therapy may lead to better survival.
Jinju Lee,Youngsin Han,조현희,김미란 대한폐경학회 2019 대한폐경학회지 Vol.25 No.2
Sleep disorders are one of the main symptoms of menopause. Symptoms of sleep disorders that menopausal women complain about include falling asleep, frequent awakening and/or early morning awakening. There are many possible causes of sleep disorders in postmenopausal women, including vasomotor symptoms, ovarian hormone changes, restless legs syndrome, periodic leg movement syndrome, and obstructive sleep apnea. In this review, we discuss the relationship between menopause and sleep disorders.
MicroRNA genes are transcribed by RNA polymerase II
Lee, Yoontae,Kim, Minju,Han, Jinju,Yeom, Kyu-Hyun,Lee, Sanghyuk,Baek, Sung Hee,Kim, V Narry Wiley (John WileySons) 2004 The EMBO journal Vol.23 No.20
<P>MicroRNAs (miRNAs) constitute a large family of noncoding RNAs that function as guide molecules in diverse gene silencing pathways. Current efforts are focused on the regulatory function of miRNAs, while little is known about how these unusual genes themselves are regulated. Here we present the first direct evidence that miRNA genes are transcribed by RNA polymerase II (pol II). The primary miRNA transcripts (pri-miRNAs) contain cap structures as well as poly(A) tails, which are the unique properties of class II gene transcripts. The treatment of human cells with alpha-amanitin decreased the level of pri-miRNAs at a concentration that selectively inhibits pol II activity. Furthermore, chromatin immunoprecipitation analyses show that pol II is physically associated with a miRNA promoter. We also describe, for the first time, the detailed structure of a miRNA gene by determining the promoter and the terminator of mir-23a approximately 27a approximately 24-2. These data indicate that pol II is the main, if not the only, RNA polymerase for miRNA gene transcription. Our study offers a basis for understanding the structure and regulation of miRNA genes.</P>
Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics
Lee, Min Hee,Sharma, Amit,Chang, Min Jung,Lee, Jinju,Son, Subin,Sessler, Jonathan L.,Kang, Chulhun,Kim, Jong Seung The Royal Society of Chemistry 2018 Chemical Society reviews Vol.47 No.1
<P>Theranostic systems are receiving ever-increasing attention due to their potential therapeutic utility, imaging enhancement capability, and promise for advancing the field of personalized medicine, particularly as it relates to the diagnosis, staging, and treatment of cancer. In this Tutorial Review, we provide an introduction to the concepts of theranostic drug delivery effected <I>via</I> use of conjugates that are able to target cancer cells selectively, provide cytotoxic chemotherapeutics, and produce readily monitored imaging signals <I>in vitro</I> and <I>in vivo</I>. The underlying design concepts, requiring the synthesis of conjugates composed of imaging reporters, masked chemotherapeutic drugs, cleavable linkers, and cancer targeting ligands, are discussed. Particular emphasis is placed on highlighting the potential benefits of fluorogenic reaction-based targeted systems that are activated for both imaging and therapy by cellular entities, <I>e.g.</I>, thiols, reactive oxygen species and enzymes, which are present at relatively elevated levels in tumour environments, physiological characteristics of cancer, <I>e.g.</I>, hypoxia and acidic pH. Also discussed are systems activated by an external stimulus, such as light. The work summarized in this Tutorial Review will help define the role fluorogenic reaction-based, cancer-targeting theranostics may have in advancing drug discovery efforts, as well as improving our understanding of cellular uptake and drug release mechanisms.</P>