Optimal cutoff level of serum squamous cell carcinoma antigen to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance

( Jinju Oh ),( Jin Young Bae ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.3

Objective The objective of this study was to determine the optimal cutoff level of serum squamous cell carcinoma antigen (SCC-Ag) to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance. Methods Between January 2000 and July 2014, a total of 158 women with cervical squamous cell carcinoma were treated with radiotherapy with or without concurrent chemotherapy at our department. A total of 1,550 serum SCC-Ag tests performed during post-treatment surveillance of the 158 patients were included in this retrospective study. Results During post-treatment surveillance, 53 patients were diagnosed as having recurrent cervical cancer based on biopsy or a radiological test showing progression of a lesion. Receiver operating characteristic (ROC) curve for serum SCC-Ag to diagnose recurrent cervical squamous cell carcinoma showed that the area under the ROC curve was 0.914 (95% confidence interval, 0.887-0.942; P<0.001). The best cutoff value for serum SCC-Ag to obtain the highest Youden's index was ≥2 ng/mL (sensitivity, 80.2%; specificity, 94.6%). Conclusion Serum SCC-Ag test was helpful in detecting recurrent cervical squamous cell carcinoma during post-treatment surveillance, and the optimal cutoff value was ≥2 ng/mL. The researchers recommend active imaging studies, when serum SCC-Ag level ≥2 ng/mL during post-treatment surveillance.

Clinical value of routine serum squamous cell carcinoma antigen in follow-up of patients with locally advanced cervical cancer treated with radiation or chemoradiation

( Jinju Oh ),( Hyun Joo Lee ),( Tae Sung Lee ),( Ju Hyun Kim ),( Suk Bong Koh ),( Youn Seok Choi ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4

Objective The objective of this study was to evaluate the clinical benefits of routine squamous cell carcinoma antigen (SCC-Ag) monitoring of patients with locally advanced cervical squamous cell carcinoma treated with radiation or chemoradiation. Methods A total of 53 patients with recurrent cervical squamous cell carcinoma treated with radiotherapy or chemoradiation were enrolled in this study. A retrospective review of medical records was conducted. The role of routine monitoring of serum SCC-Ag was evaluated in terms of cost effectiveness and effect on survival after diagnosis of recurrence. Results Serum SCC-Ag abnormality (≥2.5 ng/mL) was observed in 62.3% of patients when recurrent disease was diagnosed. The first indicator of relapse was abnormal serum SCC-Ag level in 21 patients (39.6%), 10 of whom had asymptomatic recurrent disease amenable to salvage therapy. Adding SCC-Ag measurement to the basic follow up protocol improved the sensitivity for detecting recurrence (The sensitivity of the basic protocol vs. addition of SCC-Ag: 49.1% vs. 88.7%, P<0.001). Twenty-three patients who were candidates for salvage therapy with curative intent showed better survival compared with those who were not candidates for therapy (5-year survival: 36.6% vs. 0%, P=0.012). Conclusion Surveillance with routine serum SCC-Ag monitoring can better detect asymptomatic recurrent disease that is potentially amenable to salvage therapy with curative intent. Early diagnosis of recurrent disease that can be treated with salvage therapy may lead to better survival.

Clinical significance of lymph node size in locally advanced cervical cancer treated with concurrent chemoradiotherapy

Oh, Jinju,Seol, Ki Ho,Choi, Youn Seok,Lee, Jeong Won,Bae, Jin Young Yeungnam University College of Medicine 2019 Yeungnam University Journal of Medicine Vol.36 No.2

Background: This study aimed to assess the in-field lymph node (LN) failure rate according to LN size and to investigate effect of LN size on the survival outcome of patients with locally advanced cervical carcinoma treated with concurrent chemoradiotherapy (CCRT). Methods: A total of 310 patients with locally advanced cervical carcinoma treated with CCRT were enrolled in retrospective study. LN status was evaluated by magnetic resonance imaging. All patients received conventional external beam irradiation and high-dose rate brachytherapy, and concurrent cisplatin-based chemotherapy. In-field LN failure rate according to LN size was analyzed. Results: The median follow-up period was 83 months (range, 3-201 months). In-field LN failure rate in patients with pelvic LN size more than 10 mm was significantly higher than that in patients with pelvic LN size less than 10 mm (p<0.001). A similar finding was observed in the infield para-aortic LN (PALN) failure rate (p=0.024). The pelvic and PALN size (${\geq}10mm$) was a significant prognostic factor of overall-survival (OS) and disease-free survival rate in univariate and multivariate analyses. The OS rate was significantly different between groups according to LN size (<10 mm vs. ${\geq}10mm$). Conclusion: A LN of less than 10 mm in size in an imaging study is controlled by CCRT. On the other hand, in LN of more than 10 mm in size, the in-field LN failure rate increase and the prognosis deteriorate. Therefore, a more aggressive treatment strategy is needed.

The cutoff level of serum squamous cell carcinoma antigen to detect recurrent cervical squamous cell carcinoma during post-treatment surveillance

( Jinju Oh ),( Tae Sung Lee ),( Suk Bong Koh ),( Ju Hyun Kim ),( Youn Seok Choi ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-

목적: The objective of this study was to determine the appropriate cutoff level of serum squamous cell carcinoma antigen (SCC-Ag) to diagnose recurrent cervical squamous cell carcinoma during post-treatment surveillance. 방법: Between January 2000 and July 2014, a total of 158 women with cervical squamous cell carcinoma were treated with radiotherapy with or without concurrent chemotherapy in our department. A total of 1550 serum squamous cell carcinoma antigen tests during post-treatment surveillance of the 158 patients were included in this retrospective study. 결과: During post-treatment surveillance, 53 patients have been diagnosed as recurrent cervical cancer based on biopsy or a radiological test showing progression of a lesion. Receiver operating characteristic curve (ROC) for serum SCC-Ag to diagnose recurrent cervical squamous cell carcinoma showed that the area under the ROC was 0.914 (95% confidence interval: 0.887 ~ 0.942, p-value < 0.001). The best cutoff value for serum SCC-Ag using Youden’s index was ≥2 ng/mL (sensitivity = 80.2%, Specificity = 94.6%). 결론: Serum SCC-Ag test during surveillance was helpful to detect recurrent cervical squamous cell carcinoma, and the best cutoff value was ≥2 ng/mL.

Prophylactic extended-field irradiation with concurrent chemotherapy for pelvic lymph node-positive cervical cancer

Oh, Jinju,Seol, Ki Ho,Lee, Hyun Joo,Choi, Youn Seok,Park, Ji Y.,Bae, Jin Young The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.4

Purpose: This study aimed to evaluate whether prophylactic extended-field pelvic radiotherapy (EF-PRT) yields better results than standard whole pelvic radiotherapy (WPRT) in patients with pelvic lymph node-positive cervical cancer treated with concurrent chemoradiotherapy (CCRT). Materials and Methods: A total of 126 cases of stage IB-IVA cervical cancer that had pelvic lymph node involvement in magnetic resonance imaging and were treated with CCRT between 2000 and 2016 were reviewed. None of the patients had para-aortic lymph node (PALN) metastases. The patients were classified to two groups, namely, those treated with EF-PRT, including prophylactic para-aortic radiotherapy, and those treated only with WPRT. The median dose to the PALN area in patients treated with EF-PRT was 45 Gy. All patients received concurrent cisplatin-based chemotherapy. Results: Overall, 52 and 74 patients underwent EF-PRT and WPRT, respectively. Patient characteristics and irradiated dose were not significantly different, except the dose to the para-aortic area, between the two groups. The median follow-up period was 75.5 months (range, 5 to 195 months). The 10-year cumulative recurrence rate of PALN for EF-PRT vs. WPRT was 6.9% and 10.1% (p = 0.421), respectively. The 10-year disease-free survival and overall survival for EF-PRT vs. WPRT were 69.7% vs. 66.1% (p = 0.748) and 71.7% vs. 72.3% (p = 0.845), respectively. Acute gastrointestinal complications were significantly higher in EF-PRT (n = 21; 40.4%) than WPRT (n = 26; 35.1%) (p = 0.046). Late toxicities were not significantly different in both groups. Conclusion: In this study, prophylactic radiotherapy for PALN does not have an additional benefit in patients with pelvic lymph node-positive cervical cancer treated with CCRT.

High expression of epidermal growth factor-like domain 7 is correlated with poor differentiation and poor prognosis in patients with epithelial ovarian cancer

Oh, Jinju,Park, Sung Hae,Lee, Tae Sung,Oh, Hoon Kyu,Choi, Jung-Hye,Choi, Youn Seok Asian Society of Gynecologic Oncology; Korean Soci 2014 Journal of Gynecologic Oncology Vol.25 No.4

<P><B>Objective</B></P><P>The purpose of this study was to evaluate the expression of epidermal growth factor-like domain 7 (EGFL7) in epithelial ovarian cancer, and to assess its relevance to clinicopathological characteristics and patients' survival.</P><P><B>Methods</B></P><P>A total of 177 patients with epithelial ovarian cancer were enrolled in the current study. For each patient, a retrospective review of medical records was conducted. Immunohistochemical staining for EGFL7 was performed using tissue microarrays made with paraffin-embedded tissue block. EGFL7 expression levels were graded on a grade of 0 to 3 based on the percentage of positive cancer cells. We analyzed the correlations between the expression of EGFL7 and various clinical parameters, and also analyzed the survival outcome according to the EGFL7 expression.</P><P><B>Results</B></P><P>The expression of EGFL7 in ovarian cancer tissues was observed in 98 patients (55.4%). High expression of EGFL7 (grade 2 or 3) was significantly correlated with pathologic type, differentiation, stage, residual tumor after debulking surgery, lymphovascular space involvement, lymph node metastasis, high cancer antigen 125, peritoneal cytology, and ascites. Among these clinicopathologic factors, differentiation was significantly correlated with EGFL7 expression in multivariate analysis (p<0.05). Survival analysis showed that the patients with high EGFL7 expression had a poorer disease free survival than those with low EGFL7 expression (p=0.002).</P><P><B>Conclusion</B></P><P>Our data suggest that EGFL7 expression is a novel predictive factor for the clinical progression of epithelial ovarian cancer, and may constitute a therapeutic target for antiangiogenesis therapy in patients with epithelial ovarian cancer.</P>

이륜자동차 온실가스 배출계수 개발

오진주(Jinju Oh),정윤재(Yunjae Jeong),강정중(Jeongjung Kang),정애라(Aera Jung),박용성(Yongsung Park) 한국자동차공학회 2013 한국자동차공학회 학술대회 및 전시회 Vol.2013 No.11

잠재프로파일 분석을 이용한 청소년의 사회적 관계의 질 유형과 주관적 행복의 차이

오진주 ( Oh Jinju ),이현민 ( Lee Hyunmin ) 한국조사연구학회 2021 조사연구 Vol.22 No.1

이 연구의 목적은 청소년이 지각하는 부모, 공교육 교사, 사교육 교사, 그리고 친구와의 관계의 질 유형을 탐색하고, 각 유형에 따라 주관적 행복에 어떠한 차이가 있는지 분석하여 청소년의 사회적 관계의 질 유형과 주관적 행복 사이의 연관성에 대하여 구체적인 이해를 하기 위함이다. 이를 위해 2019년 ‘어린이-청소년 행복지수조사’ 자료 중 아버지와의 관계, 어머니와의 관계, 공교육 선생님과의 관계, 사교육 선생님과의 관계, 친구와의 관계로 구성된 사회적 관계의 질에 대해 잠재프로파일 분석을 실시하고 각 유형에 따라 주관적 행복에 차이가 있는지를 분석하였다. 분석은 학교급에 따라 중학생과 고등학생으로 분리하여 실시하였다. 각 계층의 사회적 관계의 질은 5개의 잠재계층으로 나타났다. 중학생은 '어머니 의존 유형’, ‘친구 의존 유형’, ‘친구 중심 유형’, ‘원만한 관계 유형’, ‘친밀한 관계 유형’으로 명명하고 고등학생은 ‘어머니 의존 유형’, ‘친구 의존 유형’, ‘가정 외 중심 유형’, ‘원만한 관계 유형’, ‘친밀한 관계 유형’으로 명명하였다. 중학생과 고등학생의 사회적 관계의 질 유형에 따른 주관적 행복의 차이를 분석한 결과, 통계적으로 유의한 차이가 나타났다. 이에 이 연구는 잠재프로파일 분석을 이용하여 청소년이 지각하는 사회적 관계의 질 유형을 제시하고, 주관적 행복과의 연관성에 대한 시사점을 제공하였다는데 의의를 지닌다. The purpose of this study is to explore the types of quality of social relationships as perceived by adolescents and to analyze the difference in subjective happiness. To this end, we analyzed the potential parental profile of relationship with parents, public school teacher, private education teacher and friends among the data of Korean children and youth in harvested from the Korean Bangjunghwan Foundation and Yonsei University of 2019. The analysis of the detailed characteristics of the parental rearing attitudes of each class was named and characterized respectively. As a result of analyzing differences in subjective happiness according to the type of social relationship between middle and high school students, statistically significant differences were found. The results further demonstrate that it is important to suggest a practical method to improve the quality of social relationships as perceived by adolescents.

Inhibitory effects of Schizandrae Fructus on eotaxin secretion in A549 human epithelial cells and eosinophil migration

Oh, Bang-gul,Lee, Heekyung,Kim, Yangseok,Shin, Minkyu,Hong, Moochang,Jung, Sung-Ki,Kim, Jinju,Bae, Hyunsu Elsevier 2009 Phytomedicine Vol.16 No.9

<P><B>Abstract</B></P><P>Eosinophilia have been implicated in a broad range of diseases, most notably allergic conditions (e.g. asthma, rhinitis and atopic dermatitis) and inflammatory diseases. These diseases are characterized by an accumulation of eosinophils in the affected tissue. Defining the mechanisms that control the recruitment of eosinophil is fundamental to understanding how these diseases progress and identifying a novel target for drug therapy. Accordingly, this study was conducted to evaluate the regulatory effect of Schizandrae Fructus (SF) on the expression of eotaxin, an eosinophil-specific chemokine released in respiratory epithelium following allergic stimulation, as well as its effects on eosinophil migration.</P><P>To accomplish this, human epithelial lung cells (A549 cell) were stimulated with a combination of TNF-α (100ng/ml) and IL-4 (100ng/ml) for 24h. The cells were then restimulated with TNF-α (100ng/ml) and IL-1β (10ng/ml) to induce the expression of chemokines and adhesion molecules involved in eosinophil chemotaxis for another 24h. Next, the samples were treated with various concentrations of Schizandrae Fructus (SF) (1, 10, 100, 1000μg/ml) or one of the major constituents of SF, schizandrin (0.1, 1, 10, 100μg/ml), after which following inhibition effect assay was performed triplicates in three independence.</P><P>The levels of eotaxin in secreted proteins were suppressed significantly by SF (100 and 1000μg/ml, <I>p</I><0.01) and schizandrin (10 and 100μg/ml, <I>p</I><0.01). In addition, SF (1, 10, 100 and 1000μg/ml) decreased mRNA expression levels in A549 cells significantly (<I>p</I><0.01). Eosinophil recruitment to lung epithelial cells was also reduced by SF, which indicates that eotaxin plays a role in eosinophil recruitment. Furthermore, treatment with SF suppressed the expression of another chemokine, IL-8 (0.1 and 1μg/ml SF, <I>p</I><0.01), as well as intercellular adhesion molecule-1 (10 and 100μg/ml SF, <I>p</I><0.01) and vascular cell adhesion molecule-1 (0.1 and 1μg/ml SF, <I>p</I><0.05), which are all related to eosinophil migration. Taken together, these findings indicate that SF may be a desirable medicinal plant for the treatment of allergic diseases.</P>

Influences of Tobacco-Related Knowledge on Awareness and Behavior towards Smoking

Park, Jinju,Lim, Min Kyung,Yun, E Hwa,Oh, Jin-Kyoung,Jeong, Bo Yoon,Cheon, Yejin,Lim, Sujin The Korean Academy of Medical Sciences 2018 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.33 No.47

<P><B>Background</B></P><P>A considerable amount of research has shown that knowledge and appropriate awareness are essential for encouraging positive behaviors and promoting health. In Korea, the roles that behavioral changes play in the prevention of cancer have been an important issue since the introduction of the 10 codes for cancer prevention in 2006. Thus, the present study investigated the associations of tobacco-related knowledge with awareness and attitudes towards positive smoking-cessation behaviors.</P><P><B>Methods</B></P><P>The present study analyzed data from the 2010 national questionnaire survey (n = 1,006). This study evaluated sociodemographic characteristics, smoking status, self-rated health status, health-related interests, and the accuracy of 12 tobacco-related statements to determine knowledge level and to investigate its impact on awareness and behaviors related to smoking. These parameters were examined and staged using the Precaution Adoption Process Model.</P><P><B>Results</B></P><P>A higher level of tobacco-related knowledge was significantly associated with a positive attitude towards smoking cessation (5–8 correct answers: odds ratio [OR], 2.53; 95% confidence interval [CI], 1.57–4.08; ≥ 9 correct answers: OR, 3.90; 95% CI, 2.22–6.82; reference: ≤ 4 correct answers). Interestingly, among current smokers, only those who correctly responded to ≥ 9 of 12 tobacco-related statements were significantly associated with a positive attitude towards smoking cessation.</P><P><B>Conclusion</B></P><P>This study found that having a higher level of tobacco-related knowledge had a significant impact on positive attitudes towards smoking cessation. This suggests that there is a need to disseminate appropriate knowledge to the general population to encourage positive attitudes and promote healthful behaviors in terms of smoking.</P>