A mobile data caching synchronization strategy based on in-demand replacement priority

조진화(Jinhua Zhao),하영(Ying Xia),이순조(Soon-Jo Lee),배해영(Hae-Young Bae) 한국컴퓨터정보학회 2012 韓國컴퓨터情報學會論文誌 Vol.17 No.2

모바일 데이터 캐슁 기법은 로컬 데이터 전송 과정에서 속도를 향상시키거나 서버의 오버로드를 줄이기 위한 효과적인 기법으로 많이 사용되었고 모바일 컴퓨팅 환경의 저전력, 접속지연 및 간헐적인 인터넷 연결 등의 제약 사항의 해결을 위해 캐싱 기법을 사용하는 다수의연구가 진행되었다. 그러나 최근 스마트폰이 대량 보급되면서 서버 기반 어플리케이션 등 다양한 어플리케이션들에서 모바일 데이터베이스에서 전송해야 되는 데이터 량이 급증하는 등 문제가 발생하고 있으며, 이런 환경에서는 기존 기법들의 사용이 적합하지 않아 어플리케이션의 서버 대기 시간이 길어지는 등 서비스 품질 저하로 연결된다. 본 논문에서는 데이터 캐쉬의 사용률을 높이고 통신횟수를 줄이고 무선 통신망에서의 데이터 전송량을 줄이고 모바일 데이터베이스 시스템의 성능을 향상시키기 위하여 수요에 따른 교체 우선순위기반모바일동기화정책을제안한다. 또한성능평가를통하여제안기법이데이터전송량을줄이고데이터 전송 성공 확률을 향상시켜 모바일 클라이언트가 대량의 데이터의 전송을 요청할 때 데이터 전송 효율이 향상됨을 보인다. Mobile data caching is usually used as an effective way to improve the speed of local transaction processing and reduce server load. In mobile database environment, due to its characters - low bandwidth, excessive latency and intermittent network, caching is especially crucial. A lot of mobile data caching strategies have been proposed to handle these problems over the last few years. However, with smart phone widely application these approaches cannot support vast data requirements efficiently. In this paper, to make full use of cache data, lower wireless transmission quantity and raise transaction success rate, we design a new mobile data caching synchronization strategy based on in-demand and replacement priority. We experimentally verify that our techniques significantly reduce quantity of wireless transmission and improve transaction success rate, especially when mobile client request a large amount of data.

A detection method of Escherichia coli O157:H7 based on immunomagnetic separation and aptamers-gold nanoparticle probe quenching Rhodamine B’s fluorescence

Fengnan Lian,Dan Wang,Shuo Yao,Lirui Ge,Yue Wang,Yuyi Zhao,Jinbin Zhao,Xiuling Song,Chao Zhao,Jinhua Li,Yajuan Liu,Minghua Jin,Kun Xu 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.8

This research aimed to detect Escherichia coli O157:H7 in milk based on immunomagnetic probe separation technology and quenching effect of gold nanoparticles to Rhodamine B. Streptavidin-modified magnetic beads (MBs) were combined with biotin-modified antibodies to capture E. coli O157:H7 specifically. Gold nanoparticle (AuNPs) was incubated with sulfhydryl-modified aptamers (SH-Aptamers) to obtain the Aptamers-AuNPs probe. After magnetic beads captured target bacteria and formed a sandwich structure with the gold nanoprobe, Rhodamine B was added into complex to obtain fluorescent signal changes. Our results demonstrated that the established method could detect E. coli O157:H7 in the range of 101–107 CFU/mL, and the limit of detection (LOD) was 0.35 CFU/mL in TBST buffer (pH = 7.4). In milk simulation samples, the LOD of this method was 1.03 CFU/mL. Our research provides a promising approach on the detection of E. coli O157:H7.

Improved Received Signal Strength Ratio Based High Accuracy Indoor Visible Light Positioning Scheme

Zhijie Luo,JinHua Wang,WenWen Zhao,JianKun Luo,WeiNan Zhang,GuoFu Zhou 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.12

With the increasingly development of Light-emitting Diode (LED) lighting, in this paper, we proposed an Indoor Visible Light Positioning (VLP) Scheme by using visible LED lights for accurate localization. The basic idea of the position scheme is to improve received signal strength ratio algorithm. Received signal strength ratio (RSSR) is the relative ratio of optical powers detected between each LED and optical receiver. In this paper, we introduce concept of multiple LEDs selection to improve RSSR positioning algorithm. By three LEDs are reasonably selected from the multiple LEDs deployed in the room, the positioning accuracy of RSSR is improved. The system can be employed easily because it does not require additional sensors and occlusion problem in visible light would be alleviated. In addition, we performed the simulation experiments, and confirmed the feasibility of our proposed method.

Simulation of in-situ preheating of ni-based multi-layer and multi-pass coatings on H13 steel

Honggang Yin,Jinhua LI,Liwei Zhao,Fangping Yao 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.9

COMSOL was used to simulate the temperature field of the preheating and nonpreheating processes of the laser cladding multi-layer and multi-pass coating, and experimental verification was carried out. The results show that the temperature gradient value of the coating at the Z-axis is much larger than the value at the X and Y-axis, respectively. It indicates that the coating is sensitive to cracks at the Z-axis. After preheating, the quality of the coating is improved, and the results of the geometric morphology in experiments are basically consistent with the results of simulation. With increase in coating temperature, the cladding efficiency increased. The difference of temperature between the first and second layer was significantly reduced. The temperature gradient value at the Z-axis decreased. The coating grain structure presents as refined and well-distributed. The temperature gradient size in each layer decreased with the number of coatings increasing.

<i>S</i>-Adenosyl-<small>L</small>-methionine Activates Actinorhodin Biosynthesis by Increasing Autophosphorylation of the Ser/Thr Protein Kinase AfsK in <i>Streptomyces coelicolor</i> A3(2)

JIN, Ying-Yu,CHENG, Jinhua,YANG, Seung Hwan,MENG, Lingzhu,PALANIYANDI, Sasikumar Arunachalam,ZHAO, Xin-Qing,SUH, Joo-Won Japan Society for Bioscience, Biotechnology, and A 2011 Bioscience, biotechnology, and biochemistry Vol.75 No.5

<P><I>S</I>-Adenosyl-<SMALL>L</SMALL>-methionine (SAM) is one of the major methyl donors in all living organisms. The exogenous treatment with SAM leads to increased actinorhodin production in <I>Streptomyces coelicolor</I> A3(2). In this study, mutants from different stages of the AfsK-AfsR signal transduction cascade were used to test the possible target of SAM. SAM had no significant effect on actinorhodin production in <I>afsK</I>, <I>afsR</I>, <I>afsS</I>, or <I>act</I>II-open reading frame 4 (ORF4) mutant. This confirms that <I>afsK</I> plays a critical role in delivering the signal generated by exogenous SAM. The <I>afsK-pHJL-KN</I> mutant did not respond to SAM, suggesting the involvement of the C-terminal of AfsK in binding with SAM. SAM increased the <I>in vitro</I> autophosphorylation of kinase AfsK in a dose-dependent manner, and also abolished the effect of decreased actinorhodin production by a Ser/Thr kinase inhibitor, K252a. In sum, our results suggest that SAM activates actinorhodin biosynthesis in <I>S. coelicolor</I> M130 by increasing the phosphorylation of protein kinase AfsK.</P>

Biotransformation of Panax ginseng extract by rat intestinal microflora: identification and quantification of metabolites using liquid chromatography-tandem mass spectrometry

Dong, Wei-Wei,Zhao, Jinhua,Zhong, Fei-Liang,Zhu, Wen-Jing,Jiang, Jun,Wu, Songquan,Yang, Deok-Chun,Li, Donghao,Quan, Lin-Hu The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at $37^{\circ}C$ for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LC-MS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LC-MS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

Biotransformation of Panax ginseng extract by rat intestinal microflora

Wei-Wei Dong,Jinhua Zhao,Fei-Liang Zhong,Wen-Jing Zhu,Jun Jiang,Songquan Wu,Deok-Chun Yang,Donghao Li,Lin-Hu Quan 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4

Background: In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of P. ginseng by microflora are important for obtaining a better understanding of their biological effects. Methods: In vitro biotransformation of P. ginseng extract by rat intestinal microflora was investigated at 37C for 24 h, and the simultaneous determination of the metabolites and metabolic profile of P. ginseng saponins by rat intestinal microflora was achieved using LCeMS/MS. Results: A total of seven ginsenosides were detected in the P. ginseng extract, including ginsenosides Rg1, Re, Rf, Rb1, Rc, Rb2, and Rd. In the transformed P. ginseng samples, considerable amounts of deglycosylated metabolite compound K and Rh1 were detected. In addition, minimal amounts of deglycosylated metabolites (ginsenosides Rg2, F1, F2, Rg3, and protopanaxatriol-type ginsenosides) and untransformed ginsenosides Re, Rg1, and Rd were detected at 24 h. The results indicated that the primary metabolites are compound K and Rh1, and the protopanaxadiol-type ginsenosides were more easily metabolized than protopanaxatriol-type ginsenosides. Conclusion: This is the first report of the identification and quantification of the metabolism and metabolic profile of P. ginseng extract in rat intestinal microflora using LCeMS/MS. The current study provided new insights for studying the metabolism and active metabolites of P. ginseng.

Removal of methylene blue from aqueous solutions by adsorption onto chemically activated halloysite nanotubes

Peng Luo,Bing Zhang,Yafei Zhao,Jinhua Wang,Haoqin Zhang,Jindun Liu 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.3

This study examines the adsorption behavior of methylene blue (MB) from aqueous solutions onto chemically activated halloysite nanotubes. Adsorption of MB depends greatly on the adsorbent dose, pH, initial concentration,temperature and contact time. The Langmuir and Freundlich models were applied to describe the equilibrium isotherms and the Langmuir model agrees very well with experimental data. The maximum adsorption capacities for MB ranged from 91.32 to 103.63 mg·g^(−1 )between 298 and 318 K. A comparison of kinetic models applied to the adsorption data was evaluated for pseudo-first-order, pseudo-second-order, Elovich and intra-particle diffusion equation. The results showed the adsorption process was well described by the pseudo-second-order and intra-particle diffusion mode. Thermodynamic parameters suggest that the adsorption is spontaneous and endothermic. The obtained results indicated that the product had the potential to be utilized as low-cost and effective alternative for dye removal in wastewater.

Cell-Penetrating Peptide-Modified PLGA Nanoparticles for Enhanced Nose-to-Brain Macromolecular Delivery

Lu Yan,Huiyuan Wang,Yifan Jiang,Jinhua Liu,Zhao Wang,Yongxin Yang,Shengwu Huang,Yongzhuo Huang 한국고분자학회 2013 Macromolecular Research Vol.21 No.4

Macromolecular drugs become an essential part in neuroprotective treatment. However, the nature of ineffective delivery crossing the blood brain barrier (BBB) renders those macromolecules undruggable for clinical practice. Recently, brain target via intranasal delivery have provided a promising solution to circumventing the BBB. Despite the direct route from nose to brain (i.e. olfactory pathway), there still are big challenges for large compounds like proteins to overcome the multiple delivery barriers such as nasal mucosa penetration, intracellular transport along the olfactory neuron, and diffusion across the heterogeneous brain compartments. Herein presented is an intranasal strategy mediated by cell-penetrating peptide modified poly(lactic-co-glycolic acid) (PLGA) nanoparticles for the delivery of insulin to the brain, a potent therapeutic against Alzheimer’s disease. The results revealed that the cell-penetrating peptide can potentially deliver insulin into brain via the nasal route, showing a total brain delivery efficiency of 6%. It could serve as a potential treatment for neurodegenerative diseases.

Application of molecular dynamics simulation in self-assembled cancer nanomedicine

Xueli Xu,Ao Liu,Shuangqing Liu,Yanling Ma,Xinyu Zhang,Meng Zhang,Jinhua Zhao,Shuo Sun,Xiao Sun 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Self-assembled nanomedicine holds great potential in cancer theragnostic. The structures and dynamics of nanomedicine can be affected by a variety of non-covalent interactions, so it is essential to ensure the self-assembly process at atomic level. Molecular dynamics (MD) simulation is a key technology to link microcosm and macroscale. Along with the rapid development of computational power and simulation methods, scientists could simulate the specific process of intermolecular interactions. Thus, some experimental observations could be explained at microscopic level and the nanomedicine synthesis process would have traces to follow. This review not only outlines the concept, basic principle, and the parameter setting of MD simulation, but also highlights the recent progress in MD simulation for self-assembled cancer nanomedicine. In addition, the physicochemical parameters of self-assembly structure and interaction between various assembled molecules under MD simulation are also discussed. Therefore, this review will help advanced and novice researchers to quickly zoom in on fundamental information and gather some thoughtprovoking ideas to advance this subfield of self-assembled cancer nanomedicine.