Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

정신분열병 환자의 뇌파를 대상으로 한 혼도의 정량화

신철진 용인정신의학연구소 1995 용인정신의학보 Vol.2 No.2

C형 간염 바이러스 core 단백의 대장균내 발현

신현진,김철중,신광순 충남대학교 수의과대학 동물의과학연구소 1995 動物醫科學硏究誌 Vol.3 No.-

C형 간염 바이러스(HCV)의 구조 유존자중 core 유전자를 fusion protein vector인 pGEX-2T vector에 cloning하여 core단백질을 발현시켜서 항원성을 증가시키고자 하였다. HCV의 core gene을 PCR (polymerase chain reaction) 기법을 이용하여 증폭한 후, 약 0.57kb 정도의 증폭된 core gene을 TA cloning vector에 cloning 한 후, restriction exzyme BamH I으로 잘라, gel elution method로 elution하여 pGEX-2T vector의 BamH I site에 cloning 시켰다. Cloning된 plasmid를 E coli cell인 JM105에 transformation시킨 후, IPTG에의해 protein induction 하였다. pGEX-2T에서 발현된 HCV core 단백질은 SDSPAGE및 Western-blotting 분석 결과, 양성 C형 간염 환자의 serum및 monoclonal antibody와 특이적으로 반응하였다.

동하중을 받는 FRAME 구조물의 확률유한요소해석 및 신뢰성해석

신재철,김진홍,정인수,한성호 충남대학교 산업기술연구소 2003 산업기술연구논문집 Vol.18 No.1

Most dynamic systems have various random properties in excitation and system parameters. Therefore, in this paper, reliability analysis for structural response is proposed fro the linear dynamic system with random properties in both excitation and system parameters. The system parameters and responses with random properties are modeled by the perturbation technique. A displacement and bending moment of frame structure is acquired in Stochastic Finite Element Method Program(SFEMP) and Dynamic Stochastic Finite Element Method Program(DSFEMP) using perturbation method, and Direct Monte Carlo Simulation Program(DMCSP) is used to verify and compare previous results. Comparing outputs of SFEMP and DSFEMP with them of DMCSP, it show that they are similar to each other. Also DMCSP need much time to analyze a complicated structure, but SFEMP and DSFEMP can reduce quite time. In this study, it is assumed that excitations, system parameters and response are Gaussian. The results of response for the analysis are compared to those of numerical simulation. Also the probability of failure are calculated for using Advanced First Order Second Moment(AFOSM) of the general reliability analysis method.

정신병적 증상을 동반한 기면병 1례

신일선,양종철,윤진상 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

저자들은 정신병적 증상이 동반된 기면병 환자를 경험하였다. 본 증례에서 정신병적 증상은 methyl-phenidate에 의해 유발 및 악화되었지만, 또한 기면병과는 별개로 서서히 진행되어온 정신분열병의 증상이기도 하였다. 진단 및 치료 특히 약물치료와 관련된 어려움을 외국문헌의 고찰과 함께 보고한다. The case of a 19-year-old man with coexistent narcolepsy and psychotic symptoms was presented. The psychotic symptoms were induced and / or exacerbated by methylphenidate. In addition, they were considered as symptoms of schizophrenia which had been developed regardless of the use of methylphenidate. The case illustrates the difficulties in diagnosing and treating, in particular, pharmacotherapy.

비디오시스템과의 일체형 지면반력 Windows 프로그램 개발

신인식,문영진,정철수,이기청 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.2

The study was designed to develop the window version force platform from the former program operated in DOS version. The window version program was developed utilizing a visual-basic program of Microsoft Inc. The characteristics of the program are as follows: 1.The compatibility among the board was enhanced so that all AD board of Data Translation Inc. can be utilized. 2.The program can be operated with the connection to the image analysis system which consists of force platform and D-5100 Panasonic Video Camera. 3.The automation of analysis was achieved so that the variable can be analyzed immediately after the button on the force platform was pressed. 4.Multi-file processing was adopted so that several files can be performed simultaneously for the analysis. 5.The program was designed in user-friendly mode. The program can be operated by even novice because the main menu was composed in flowchart format. There were not significant differences between the values obtained utilizing the program developed in the present study and the former program. The present results suggest that the program developed in this study may have advantage with regard to conveniency and economical efficiency over the expensive programs imported from the foreign countries.

하악 매복 지치의 외과적 발거시 Methylprednisolone의 안면 부종 감소 효과에 대한 임상적 연구

신지훈,박진배,한지용,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : The third molars, expecially mandibular wisdom teeth, are commonly obliquely impacted, and surgical procedure with odontomy and osteotomy is necessary for their extraction. The surgical extracion of impacted wisdom teeth occasionally in duces variable discomfort. Especially, postoperative swelling, pain and limitation of mouth opening determine the degree of discomfort. For the reduction of these complicaions, drug therapy(antihistamine, enzyme, steroid), cole pack and pressure technique have been studied. It is known that the steroids are the most effective. Methods and Meterial : We selected fifty patients in their twenties, who visited Department of Dentistry, Pusan Paik Hospital from March to August in 1998. All of 50 patients has no other medical problems. Total 50 patients were randomly divided to 30 of experimental group and 20 of control group. The experimental group had orally administration of methyprednisolone 5㎎ every 8 hours 2 times preoperatively and 7 times postoperatively. Five points were marked on the patients' face, and the distances between the points were measured just before operation and 48 hours after operation. Results : Methyprednisolone reduces swelling about 50% after surgical extraction of obliquely impacted mandibular third molars with osteotomy and odontomy. The difference in the amount of tissue edema between experimental and control group was significant(p<0.01). However, there was no significant difference according to the operation time. Conclusion : It seems that the use of methylprednisolone is effective to reduce postoperative swelling following surgical extraction of third molars.

정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

성인 남자의 식습관과 혈중 지질 농도에 관한 연구

신승렬,황보진향,박동철 慶山大學校 1997 論文集 Vol.15 No.1

This paper was carried out to study on the food & daily habit score and lipid contents in serum of adult man as basal research for research on the effects of food & daily habits on the lipid contents in serum of adult man. The number of normal, dangerous leval and hypercholesterolemia was each 133(60.5%), 62(28.2%) and 25(11.3%) of adult man. respectively. The mean age. weight. Broca's index(RBW) and Quetelet index(BMI) was 48.4 9.5. 67.7 10.2. 109.1 14.3, 23.6 3.0. respectively. The numbers of good food habits was 5.4 percentage, but those of bad food habits was 35.5 percentage, It was appeared to bad the mode of dietary and hormony of food. The contents of trigryceride and cholesterol in serum was 115.8 and 192.4mg/dℓ, respectively. The numbers of triglyceride contents(90∼120mg/dℓ in serum was 53(24.1%) of the subjects of research, and those of triglyceride contents (150-210mg/dℓ) in serum was 133(60.5%) of the adult man.

TV媒體가 兒童의 攻擊性 發達에 미치는 影響

申允澈,裵珍洙 진주교육대학교 1986 論文集 Vol.30 No.1

Few tropics have attracted as much theoretical and empirical attention over the past score as the development and regulation of aggressive behavior permeated by the TV viloence viewing. In this pacer we intended to overview the ambivalent effects of TV-media, the relationship between TV violence viewing and aggressive behavior development of the children through the literatures according to the types of research, and after that suggest some implipications to decrease and prevention of aggression. In light of the review we draw the following conclusions. 1) Research has demonstrated that TV plays a role in the positive effect and negative effect as well according to the TV programs, 2) Although multiple theories have been explored to explain the development of aggression derived from the TV violence viewing, only one theory can't be done it completely. 3) Though the results gained from the laboratory experiments about the effects of TV violence viewing and the viewer's aggression are inconsistent, they have helped to identify the range of circumstamces under which it is possible to find an effect on viewer aggression. 4) While field experiments haute found either no effect or awn effect of less aggression in the group that viewed violence compared to a group that viewed neutral films, the remaining majority of these studies has provided qualified evidence that viewing of violence leads to an increase in viewer aggression. 5) Most of the correlational study have not reached the conclusion that there is a consistent or, small positive correlation between viewing TV violence and aggression. But there is little evidence that in natural settings viewing TV violence cause people to be more aggressive. 6) There are many intervening variables in determining the TV violence viewing and aggressive behavior, that is, age, sex-typing, identification and fantasy wish the TV characters, viewer's predisposition, parents influence, etc.