유방암 환자에서 bcl-2 단백 발현의 예후 인자로서의 의의

류진우,박종권,정민,박동국,김정택,이두선,이찬영,전호진 단국대학교 1998 論文集 Vol.32 No.-

Breast cancer in women pose a problem, and it can be difficult at times to evaluate the possibility of the cancer recurrence in node negative early cancer. The reliable prognostic markers are needed in breast cancer management to help clinicians identify the patient with the high risk of recurrence and arrive at more rational decisions for proper treatment. In order to investigate the prognostic significance of bcl-2, an immunohis-tochemical staining was performed in 35 tissue sections from paraffin blocks of primary breast cancer. Bcl-2 positivity was 43%. No relation could be observed between bcl-2 expression and known prognostic factors(tumor size, lymph node metastasis state, histologic grade, and nuclear grade), There was strong relation between bcl-2 expression and estrogen receptor positivity (ER) (P〈0.05). No relation is found between bcl-2 expression and c - erbB - 2 expression. These results suggest that bcl-2 expression is associated with a favorable prognostic factor(ER) but it is of no value as independent prognostic factor to the clinician in identifying the patients with high risk of recurrence.

한국여성의 정치참여확대를 위한 여성단체의 역할

류진선 朝鮮大學校 社會科學硏究所 2005 社會科學硏究 Vol.26 No.1

미용업 종사자들의 근골격계증상유병률 및 관련요인

유선미,임진주,강명근,박종 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

Background and Objectives: This study identified beauty designers and skin specialists' complaints of subjective symptoms in bones and sinews over necks, shoulders, arms, fingers, knees, waists, and legs, and the whole area in which six physical areas are combined, and related factors, It was intended to prevent disorder in bones and sinews of beauty designers and contribute to health promotion. Methods: For the purpose, it targeted 203 beauty designers who work at beauty and skin shops in Gwangju, and they were interviewed using questionnaire with short answer questions. Results: When complaints of subjective symptoms(Pain, anesthesia, and stiffness) over bones and sinews were examined, 12.3% complainted pain in neck, 30.5% in shoulders, 11.3% in arms, 11.3% in back, 15.8% in fingers, and 12.3% in knees. And the prevalence rate of the whole area was 44.9%. As a result of multivariate logistic regression analysis, it was found that the subjective symptom complaint odds ratio of the group who graduated from universities had 0.39 times lower (95% confidence interval 0.20-0.73) than that of the group who graduated from high schools or below. For those who had smoking exerience, It was 5.23 times higher than that of non-smokers. Depending on occupational stress score, it increased 1.05 (95% confidence interval 1.01-27.15) times. Conclusion: It was demonstrated that subjective symptoms complaints over bones and sinews of beauty designers were greatly affected by health behaviors and occupational characteristics such as smoking and stress, therefore, it was thought that to reduce the complaints, excessive working hours should be prevented and a certain period of rest should be assured.

5-Fluorouracil 투여가 점막염 발생에 미치는 영향

이진환,류선열 전남대학교 치과대학 1990 전남치대논문집 Vol.2 No.1

This study was done to investigate the effects of 5-Fluorouracil(5-FU) and transient superficial mechanical irritation on the cheek, intestinal mucosa and bone marrow of golden syrian hamster. Each group of animals were treated with 5-FU(60㎎/㎏) followed by mechanical irritation. On the days 0, 2, 5, 7, 10, 12, 15, 17 and 20 after treatment, the animals were sacrificed for blood leukocyte and platelet count and microscopic examination of the cheek pouch and intestinal mucosa. The results obtained from this study were as follows : 1. The mucositis and ulceration with central areas of necrosis were not observed on the left cheek mucosa without irritation and intestinal mucosa but observed on the right cheek mucosa with irritation macroscopically. 2. Histologically, inflammatory cell infiltration and epithelial disruption characterized by frank ulceration with central areas of necrosis were observed at early stages in the 5-FU treated group. The induced mucositis was healed at late stages. 3. White blood cell counts were nadir on the 10th day after the initial injection of 5-FU, with subsequently gradual recovery, but platelet counts were not changed during experimental period significantly. 4. About 18% of weight loss was noted by 5-FU injection. These results suggest that the mucositis was induced by 5-FU injection combined with mechanical irritation and its severity was closely related with the decrease of leukocyte counts.

구강 편평세포암종에서 p53 단백과 증식성 세포핵항원 발현에 대한 면역조직화학적 연구

이진환,류선열 전남대학교 치과대학 1998 전남치대논문집 Vol.10 No.1

The present study was aimed at investigating the usefulness of clinical stage, degree of histopatphological malignancy, p53 protein and PCNA labeled indices in deciding the prognosis, proliferation and infiltration of oral squamous cell carcinoma (SCC). Twenty-seven cases of SCC (seven were recurrent cases) were analyzed and 10 cases of non-specific inflammatory lesion served as control. Malignant scores were obtained with the Anneroth's classification. Proliferative activity of SCC in oral cavity was examined by means of proliferaling cell nuclear antigen (PCNA) and p53 protein immunostaining using DO7, PC10 (Novostra Co., U.K.) as primary antibody and biotinylated linked antibody (LSAB kit, Dako Co., U.S.A.) as secondary antibody. The labeled indices of PCNA and p53 were calculated by computer image analysis system in 400 multiplication microscopic fields. Results obtained were as follows; 1. The mean age of SCC group was 61.2 years. Seven of 20 cases had recurrence in 4 months after the operation, in which no significant correlations were noted between pre- and postoperative clinical stage, malignant scores, p53 protein and PCNA indices. 2. Positive immunostaining was noted in 65% (13 of 20 cases) on p53 protein and in 80% (16 of 20 cases) on PCNA. 3. Mean p53 protein and PCNA labeled indices were 24.71±27.86% and 41.49±2.51% in SCC group. They were high in SCC group than those in control group, although there was no significant correlation between the two indices. 4. Mean malignant score was 15.22±0.64 in SCC group. There was no correlation between malignant score and clinical stage, and between malignant score p53 protein or PCNA indices. 5. There was no significant correlation between SCC and recurrent SCC groups in malignant scores, p53 protein or PCNA indices. These results suggest that p53 and PCNA labeled indices have only limited usefulness in deciding the prognosis, proliferation and infiltration of oral squamous cell carcinoma.

일부 미용업사자의 건강증진행위 실천도와 관련요인

임진주,유선미,류소연,박종 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.1

Background and Objectives:This study identified the performance degree of health promotion behaviors of the workers who are engaged in beauty business, and related factors in order to obtain basic data for development of health promotion program and health education. Method: This study targeted 103 hair dressers and 100 skin specialists who work in Gwangju, and they were interviewed using questionnaire with short answer questions in October 2003. The data collected were analysed using the following devices: descriptive statistics, t-test, ANOVA, Pearson's correlation analysis, and multiple-regression analysis. Results: 1. Health promotion behaviors had 2.76±0.95 when total score was four, which indicated that they had a relatively good management of health promotion behaviors. When specified health promotion behaviors were examined, self-realization had the highest score(2.98±0.58), and exercise had the lowest score(2.03±0.75). 2. When health promotion behaviors of the subjects were examined, there was a statistically significant difference depending on age(P=.025), marriage (P=.000), Position(P=.027), smoking(P=.041), and dhnking(P=.006). 3. It was found that the lower occupational stress of the subjects(r=-0.22, P=.001), the higher the social support(r=0.24, P=.001), and the higher se1f-efficacy(r=0.39, P=.000), the better health promotion behaviors. 4. The predicting factors of health promotion behaviors were smoking, drinking, social support, and self-efficacy, and they explained for 38.1% of health promotion behaviors, Conclusion: Health promotion behaviors of the workers who are engaged in beauty business were affected by various factors. Therefore, in developing future health promotion programs, a careful consideration to reduce stress caused by work and behaviors harmful to health should be given. And to encourage health promotion behaviors, socio-psychological approach through enrichment of social support and self-efficacy should be applied.

한국 회나무(Euonymus planipes), 참회나무(E. oxyphyllus)와 나래회나무(E. macropterus)의 잎의 형질비교

장계선,장진성,임효인,류진아 서울大學校農業生命科學大學附屬樹木園 2008 서울大學校 樹木園 硏究報告 Vol.- No.26

한반도에 분포하는 참회나무, 회나무, 나래회나무의 영양기관에서의 유효 식별 형질을 확인하기 위하여 166점의 표본 조사를 통해 단변량 분석을 실시하였다. 3종을 대상으로 4개의 정량형질(잎의 길이, 잎의 너비, 엽두의 길이, 엽병의 길이)을 측정하였다. 형질 분석 결과 3종에 대한 잎의 형질은 종간 차이를 보이지 않아 종간 식별에 도움이 되지는 않았다. 따라서 본 분류군에 있어서 잎의 형질만을 가지고 종을 식별하는 것은 타당하지 않고 반드시 꽃이나 열매가 있어야 이 분류군을 인식할 수 있다고 판단된다. 분포에 있어서 회나무는 강원도에서 평안도에 걸쳐 분포하고, 참회나무는 백두대간을 중심으로 한반도 북부까지 분포하며 나래회나무는 한반도 남쪽지역을 중심으로 분포하는 양상으로 보여 분류군 간에 다소 차이가 있지만 대부분 강원도를 중심으로 분포가 겹친다. Leaves of 166 specimens were sampled to investigate patterns of interspecific variation and to evaluate recognition of Euonymus planipes, E. oxyphyllus. and E. macropterus using four leaf characters (length, width, apex length, and petiole length). This study suggested that these leaf characters were not useful to identify these taxa. Therefore, it is only possible to identify these closely related taxa based on flower and fruit characters unlike other horticulturists' view.

感作 및 過敏性쇼크가 생쥐 腸 形質細胞에 미치는 영향

劉一晟,劉基善,鄭鎭雄 최신의학사 1968 最新醫學 Vol.11 No.10

The authors present here the following results_ showing the. effect of horse serum to plasma cells in lamina, propria. of duodenal vwi, using adult male mice seized with antibody-formation and anaphylactic shock ` by a normal horse serum injection. 1 . In normal group the plasma cells, counted 47.0 on an average in duodenal villi of mice, Type A of which counted 39.8; Type B 6.6; Type CO. 6. 2.In sensitized group the plasma cells counted 52.9, Types, A, B and C of which counted 44.9, _7.3 and 0.7 respectively, increasing by about 10% compared with normal group: 3. In anaphylactic shock group the plasma cells counted 42. 1, Types A, B and C of which counted 35. 8, 5.6 and 0.7, decreasing by about 10% compared with normal group.

건강가정지원센터 가정생활교육 프로그램 운영 및 성과 : 용산구·숙명여자대학교 시범사업을 중심으로

김명자,계선자,박미석,장진경,김연화,한은주,류진아 한국가족관계학회 2005 한국가족관계학회지 Vol.10 No.1

The purpose of this study is to propose a model for service programs and management strategies for the division of family education in Healthy Families Center. For the purpose, the researchers find out demands for the family education programs of people in Yong-San Gu, Seoul, exam the effect of each family education program of Yong-San Gu & Sookmyung Women's University Healthy Families Center from June to December, 2004. According to the results, people in Yong-San Gu need economic education service mostly, and they want to study at Saturday afternoon. The programs show positive effect on the improvement of family health.

유아교육기관의 운영관리 및 유아기 프로그램 평가

이소은,하진희,류혜선,박영주,주은혜,이종순 충북대학교 교육생활연구소 2001 생활과학연구논총 Vol.4 No.-

This purposes of this study were to assess the state of current administration and program contents in early childhood institutes. Using APECP(Assessnt Profile for Early Childhood Programs), assesment data were gathered from 27 apprentices in child care centers and 6 apprentices in Kindergarten in Cheongju. Descriptive statistics and Mann-Whitney test were used to analyze data. The result were as follows : (1) The distribution of percentile rate in administration was from 55% to 78%, and the area of Program Development scored the lowest. The assessments for Kindergarten were higher than those of child care center in the areas of Physical Facility, Food Service, and Program Management. (2) As for the program contents, percentile rate was from 62% to 80%, and generally the assessments for Kindergarten were higher than those of child care center. It appears that the certification and assessment system for ealry childhood institutions should be supervised more strongly in order to improve the qulaity of those institutions.