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Prognosis of HER2 overexpression in small T1N0M0 breast cancer: A single center experience in Korea
( Jihong Bae ),( Hee Kyung Ahn ),( Kwan Il Kim ),( Heung Kyu Park ),( Yong Soon Chun ),( Young Saing Kim ),( Inkeun Park ),( Junshik Hong ),( Sun Jin Sym ),( Jinny Park ),( Eun Kyung Cho ),( Jae Hoon 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1
Introduction: A role of adjuvant treatment in patients with T1abN0M0 human epidermal growth factor receptor 2 (HER2)-positive breast cancer remains controversial. In this study, we investigated the prognosis of pT1abN0M0 breast cancer according to HER2 and hormone-receptor status. Methods: We retrospectively reviewed consecutive 536 patients diagnosed with T1a-cN0M0 breast cancer between 2003 and 2012 in a single center. Invasive disease free survival (IDFS), distant recurrence free survival (DRFS), and overall survival (OS) were estimated and compared by Kaplan-Meier method and log-rank test. Results: With a median estimated potential follow-up of 53 months, 5-year IDFS rate was 96.1% (92.3% in T1abN0, 97.3% in T1cN0), DRFS rate 98.3% (97.6% in T1abN0, 98.5% in T1cN0), and OS rate 98.4% (97.6% in T1abN0, 98.6% in T1cN0). Among 142 patients with T1abN0M0, IDFS in HER2 (+) disease (n=31, 5-year IDFS rate 73.2%, 5-year DRFS rate 96.3%) was significantly inferior to those with HR (+)/HER2 (-) disease (n=63, 5-year IDFS rate 98.4%, no distant recurrence has occurred during follow-up period) or TN (n=14, no recurrence has occurred during follow-up period). IDFS in HER2 (+) T1abN0 disease was not significantly different by HR status (5-year IDFS rate 64.1% in HR (+) HER2 (+) vs. 40.0% in HR (-) HER2 (+), p=0.104). Conclusions: In Korean patients with T1abN0M0 breast cancer, HER2 overexpression was associated with worse IDFS.
Jihong Park,Nicole L. Cosby 대한견주관절의학회 2016 대한견주관절학회지 Vol.19 No.2
Background: Arthroscopic surgical repair is a better intervention than non-operative (conservative) treatment for patients with shoulder dislocations. This systematic review determined the numbers-needed-to-treat (NNT) and relative risk reduction (RRR) associated with arthroscopic surgical repair versus non-operative treatment in reducing recurrence rates among patients with first-time traumatic anterior shoulder dislocations. Methods: We searched Google Scholar, MEDLINE, SPORTDiscus, and CINAHL from inception in 2015. All articles had to compare arthroscopic surgical repair and non-operative treatment and be written in English. We used the total number of subjects and the number of recurrent dislocations within each treatment to calculate the NNT and RRR for each study and the pooled data. Results: Six articles were selected and all clearly demonstrated that the arthroscopic surgical repair was more effective than non-operative treatment in reducing the recurrence episodes. The pooled NNT was 1.76 (95% confidence interval [CI]=NNT to benefit 1.50–2.13) and the pooled RRR was 86.0% (95% CI=77.0%–92.0%) among individuals who underwent arthroscopic repair. The average follow-up time was 56 months. Conclusions: A Strength of Recommendation Taxonomy level of evidence of 1 with a grade A recommendation supports the use of arthroscopic surgical repair over non-operative treatment in prevention of first-time traumatic anterior shoulder dislocations. We suggest that sports medicine practitioners consider the patients’ age, occupation, and physical activity level when making a clinical decision.
( Jihong Park ),( Kyeongtak Song ),( Sae Yong Lee ),( Hohyung Ryu ) 한국운동생리학회(구 한국운동과학회) 2020 운동과학 Vol.29 No.3
PURPOSE: We examined the immediate effect on ankle or knee joint cooling on the lower-extremity activation during a single-leg drop jump. METHODS: Twenty healthy adults randomly completed three data collection sessions (a 20-minute ankle or knee joint cooling, or control). Two wireless surface electromyography (EMG, 2,000 Hz) electrodes were attached over the vastus medialis (VM) and the medial gastrocnemius (MG) on their right limb. Subjects were asked to drop down from a wooden box (a 30-cm height) on their right foot onto the force platform (2,000 Hz) and then performed an immediate jump as high as they could. Whole EMG signals (normalised by the mean EMG value recorded during a reference position) within the preactivation (100-ms prior to contact) and the ground contact (on the force platform) during the drop jump task were analysed using functional linear models (p=.05, Cohen’s d effect size: ES). RESULTS: After knee joint cooling, (1) the VM activation was decreased during the ground contact (6 to 14%, 30 to 45%, 60 to 90% for ES of 0.50, 0.47, and 0.61, respectively) and (2) the MG activation was increased during the preactivation (84- to 29-ms prior to initial contact, ES=1.30) and the ground contact (59 to 100%, ES=1.40). No changes were observed under the condition of ankle joint cooling or control. CONCLUSIONS: A 20-minute unilateral knee joint cooling may result in an ipsilateral quadriceps inhibition during a drop jump task. The gastrocnemius appears to increase activation as a compensatory strategy responding to the quadriceps inhibition. The altered neuromuscular activations do not seem to put an individual at risk of injury, resulting from compressive forces in the sagittal plane.
The Impact of Acute Phase Domain-Specific Cognitive Function on Post-stroke Functional Recovery
Park, Jihong,Lee, Gangpyo,Lee, Shi-Uk,Jung, Se Hee Korean Academy of Rehabilitation Medicine 2016 Annals of Rehabilitation Medicine Vol.40 No.2
<P><B>Objective</B></P><P>To assess whether the cognitive function in the acute stage evaluated by domain-specific neuropsychological assessments would be an independent predictor of functional outcome after stroke.</P><P><B>Methods</B></P><P>Forty patients underwent 4 domain-specific neuropsychological examinations about 3 weeks after the onset of stroke. The tests included the Boston Naming Test (BNT), the construction recall test (CRT), the construction praxis test (CPT), and the verbal fluency test (VFT). The Korean version of Modified Barthel Index (K-MBI) at 3 months and the modified Rankin Scale (mRS) at 6 months were investigated as functional outcome after stroke. Functional improvement was assessed using the change in K-MBI during the first 3 months and subjects were dichotomized into 'good status' and 'poor status' according to mRS at 6 months. The domain-specific cognitive function along with other possible predictors for functional outcome was examined using regression analysis.</P><P><B>Results</B></P><P>The z-score of CPT (p=0.044) and CRT (p<0.001) were independent predictors for functional improvement measured by the change in K-MBI during the first 3 months after stroke. The z-score of CPT (p=0.049) and CRT (p=0.048) were also independent predictors of functional status at post-stroke 6 months assessed by mRS.</P><P><B>Conclusion</B></P><P>Impairment in visuospatial construction and memory within one month after stroke can be an independent prognostic factor of functional outcome. Domain-specific neuropsychological assessments could be considered in patients with stroke in the acute phase to predict long-term functional outcome.</P>
Jihong Park,Seong-Lyun Kim,Zander, Jens IEEE 2016 IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS Vol.15 No.6
<P>The forthcoming 5G cellular network is expected to overlay millimeter-wave (mmW) transmissions with the incumbent micro-wave (mu W) architecture. The overall mm-mu Wresource management should, therefore, harmonize with each other. This paper aims at maximizing the overall downlink (DL) rate with a minimum uplink (UL) rate constraint, and concludes: mmWtends to focus more on DL transmissions while mu W has high priority for complementing UL, under time-division duplex (TDD) mmW operations. Such UL dedication of mu W results from the limited use of mmW UL bandwidth due to excessive power consumption and/or high peak-to-average power ratio (PAPR) at mobile users. To further relieve this UL bottleneck, we propose mmW UL decoupling that allows each legacy mu Wbase station (BS) to receive mmW signals. Its impact on mm-mu W resource management is provided in a tractable way by virtue of a novel closed-form mm-mu W spectral efficiency (SE) derivation. In an ultra-dense cellular network (UDN), our derivation verifies mmW (or mu W) SE is a logarithmic function of BS-to-user density ratio. This strikingly simple yet practically valid analysis is enabled by exploiting stochastic geometry in conjunction with real three-dimensional (3-D) building blockage statistics in Seoul, South Korea.</P>
Overuse Capsuloligamentous Injury of the First Metatarsophalangeal Joint: A Case Report
Park, Jihong,Grindstaff, Terry L. Korean FootAnkle Society 2015 대한족부족관절학회지 Vol.1 No.2
Capsuloligamentous injury at the first metatarsophalangeal (MTP) joint is a common traumatic injury during physical activity, particularly on artificial turf. Mechanism of injury include excessive flexion, extension, or valgus stress. We report a non-operatively treated capsuloligamentous injury at the first MTP joint, which did not occur traumatically but developed by a stress-related mechanism in a collegiate rower.