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- 저자 : Jieun Han (검색결과 264 건)
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Jieun Han,박민정,안뜰에봄,Jong-Hyun Park,오단이,Kyeong Han Kim,Soo-Hyun Sung 대한약침학회 2021 Journal of pharmacopuncture Vol.24 No.2
Objectives: We aimed to compare the external herbal dispensary (EHD) evaluation criteria for pharmacopuncture and the Korea Good Manufacturing Practice (KGMP) sterile medicine standards to contribute to the establishment of quality control criteria for pharmacopuncture. Methods: We obtained the KGMP standards from the Ministry of Food and Drug Safety and the pharmacopuncture certification criteria from the Ministry of Health and Welfare of South Korea. The EHD evaluation items were classified into three categories: facilities, quality control, and validation. The evaluation items were compared with the KGMP sterile medicine criteria to determine their conformance with each other, followed by a discussion among the committee of six experts and their consensus to suggest the items to complement the EHD evaluation criteria. Results: Among the KGMP sterile medicine criteria, 44 were related to the management of the facilities, and 32 pharmacopuncture evaluation items corresponded to these KGMP items (66.7%). Fifty-eight KGMP criteria were related to quality management, and 42 pharmacopuncture evaluation items corresponded to these KGMP items (72.4%). Twentyfive KGMP sterile medicine criteria were related to validation, and 11 pharmacopuncture evaluation items corresponded to these KGMP items (44.0%). Sixteen items under the pharmacopuncture EHD criteria corresponded to the KGMP sterile medicine criteria based on the consent of the experts. Among these, 4 were related to facility management, 6 were related to quality control, and 6 were related to validation. Conclusion: For the safety and quality control of pharmacopuncture, there is a need to select the criteria for the mandatory items among the proposed pharmacopuncture-EHD criteria laws and systems to ensure that the pharmacopuncture materials are produced under the pharmacopuncture-EHD in compliance with the relevant requirements. More studies are needed to secure the safety level of pharmacopuncture materials corresponding to that of conventional medicine.
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Jieun Han,Jihye Kim,Kyeong Han Kim,Ji-Yeon Lee,Soo-Hyun Sung 대한약침학회 2022 Journal of pharmacopuncture Vol.25 No.1
Objectives: This study is a comparative analysis of the satisfaction and recognition characteristics for traditional Korean medicine (TKM) in people with disabilities and the general population of Korea. Methods: Here, 5,000 subjects were categorized into two groups based on a disability rating using the data from the 2017 National Survey for the Usage of Korean Medicine. The relationships among the sociodemographic characteristics, TKM usage status, recognition of TKM usage, and recognition of the effectiveness of the TKM treatment were analyzed based on the disease. The response reliability was verified using the chi-square test analysis method. Results: Disabilities corresponded with low rates of high school or higher education (44%, 83.5%) and no jobs (56.9%, 33.5%), mostly the status of the low-income class with a monthly household income of < 1,500 USD (50.9%, 10.5%), poor health conditions (55.2%, 9.8%), high chronic disease prevalence rate (69.0%, 19.9%), high medical care rate (11.2%, 0.5%), and low commercial health insurance subscription rate (44%, 74.2%). Furthermore, people with disabilities visited TKM institutions more often (88.8%, 74.1%) with a high frequency TKM usage rate of ≥ 1-2 times a month (26.2%, 15.3%). They also reported that the cost of using the TKM was very high (14.7%, 8.8%) and that primarily the application of insurance benefits should be improved (52.6%, 47.5%). The treatment effectiveness for diseases was high for musculoskeletal disorders for both people with disabilities and the general population. Conclusion: Preferential application of insurance benefits for musculoskeletal diseases must be extended to the TKM treatment as well, as people with disabilities have a high recognition for these conditions with TKM. It is difficult to perform randomized controlled trials on people with disability. Therefore, large-scale observational and cohort studies should be conducted. We hope this study will help establish a suitable TKM policy for people with disabilities.
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Han, Jieun,Na, Kun Elsevier 2019 Journal of industrial and engineering chemistry Vol.80 No.-
<P><B>Abstract</B></P> <P>For effective gene therapy using Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL), which is a protein that selectively induces cancer cell apoptosis through human mesenchymal stem cells (hMSCs), low cytotoxicity branched polyethyleneimine (bPEI) 25k carbon dots (bPEI25k CDs) were investigated as a TRAIL–GFP gene (plasmid TRAIL–GFP, pTRAIL–GFP) carrier for delivery into hMSCs. bPEI25k CDs were prepared using one-step microwave-assisted pyrolysis, which has the advantage of low cytotoxicity and allows for bioimaging after gene delivery. The bPEI25k CDs had lower cytotoxicity levels at all tested concentrations, whereas the raw bPEI25k were cytotoxic in proportions up to a concentration by 25%. The complex containing bPEI25k CDs and pTRAIL–GFP was safely internalized and transfected into the hMSCs. It also revealed a cellular fluorescence imaging property induced by a unique characteristic of CDs. The amount of secreted TRAIL from bPEI25k CDs/pTRAIL–GFP@hMSCs was 25-fold higher than that from bPEI25k/pTRAIL–GFP@hMSCs, leading to a higher cytotoxic effect against the lung cancer cells. Therefore, bPEI25k CDs are recommended as an effective gene carrier for successful cancer gene therapy mediated through hMSCs.</P>
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( Han-sung Kwon ),( Seo-yeon Kim ),( Jieun Park ),( Han-sung Hwang ),( In-sook Sohn ) 대한주산의학회 2017 Perinatology Vol.28 No.4
Objective: To compare perinatal outcomes of gestational diabetic women with a family history of type 2 diabetes mellitus (DM), who were diagnosed through early or late screening. Methods: After 2010, women with a family history of DM underwent 2-step screening at the initial visit, mostly before 16 weeks of gestation. The perinatal outcomes were compared with those of historical cohort screened at 24-28 weeks of gestation between 2005 and 2009. The primary outcomes were complications associated with maternal hyperglycemia such as primary cesarean delivery, large for gestational age (LGA), neonatal hypoglycemia, and fetal anomaly. Results: The risk of gestational diabetes mellitus (GDM) was 20.8% (67/322) in women with a history of DM in a first-degree relative. Women who were screened before 16 weeks of gestation were more likely to have a high level of hemoglobin A1C at diagnosis and receive insulin therapy for glycemic control than the Late-screen group. But odds ratios of LGA, primary cesarean delivery and fetal anomalies compared with normal control were highest in the Late-screen group than in the Early screen group and the Low risk GDM group. Conclusion: Some perinatal outcomes may be more favorable in women with GDM and a family history of DM who were screened before 16 weeks of gestation rather than routinely.
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Jieun HAN,Wooram PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Microspheres are useful in various fields because they can deliver active pharmaceutical ingredients and sustainably release them. However, the acidic byproduct produced by the biodegradable polymer causes inflammation and cytotoxicity. Here, magnesium hydroxide (MH) was encapsulated in microspheres capping with ricinoleic acid (RA) for use as an acid neutralizing regulator. The encapsulation efficiency of RA capped MH (RA-MH) was higher than that of the pristine MH. Furthermore, the microspheres containing RA-MH have excellent acid neutralization effect compared to the control. We have demonstrated that the cytotoxicity of the microspheres containing RA-MH was improved by the acid neutralization in in vitro test. Also, the anti-inflammatory effect was also evaluated the secretion the anti-inflammatory cytokines. As a result, we believe that microspheres containing RA-MH can be applied to drug delivery and tissue engineering for various diseases treatment.
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( Jieun Kang ),( Jisun Park ),( Dawn Chung ),( San Hui Lee ),( Eun Young Park ),( Kyung-hee Han ),( Seoung Jin Choi ),( In-bai Chung ),( Hyuck Dong Han ),( Yeon Soo Jung ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4
Objective To describe the clinical outcomes of frozen-thawed embryo transfer (FET) with artificial preparation of the endometrium, using a combination of estrogen (E2) and progesterone (P4) with or without a gonadotropin-releasing hormone agonist (GnRHa), and the modified natural cycle (MNC) with human chorionic gonadotropin (hCG) trigger. Methods In this retrospective study, we evaluated 187 patients during 3 years (February 2012-April 2015). The patients were allocated to the following treatment groups: group A, comprising 113 patients (181 cycles) who received GnRHa+E2+P4; group B, comprising 49 patients (88 cycles) who received E2+P4; and group C, comprising 25 patients (42 cycles) who received hCG+P4. The inclusion criteria were regular menstrual cycles (length 24-35 days) and age 21-45 years. Results The primary outcome of the study ― implantation rate (IR) per embryo transferred ― was not statistically different among the 3 groups. Similar results were found for the IRs with fetal heartbeat per embryo transferred (68/181 [37.6%] in group A vs. 22/88 [25.0%] in group B vs. 14/42 [33.3%] in group C) and for the live birth rates (LBRs) per embryo transferred (56/181 [30.9%] in group A vs. 18/88 [20.5%] in group B vs. 11/42 [26.2%] in group C). Conclusion Although the pregnancy outcomes were better in the hormone therapy with GnRHa group, hormone therapy FET with GnRHa for pituitary suppression did not result in significantly improved IRs and LBRs when compared with hormone therapy FET without GnRHa or MNC FET.
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Han, Jieun,Park, Wooram,Park, Sin-jung,Na, Kun American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.12
<P>Photodynamic therapy (PDT) is a widely used clinical option for tumor therapy. However, the clinical utilization of conventional small-molecule photosensitizers (PSs) for PDT has been limited by their low selectivity for disease sites, and undesirable photoactivation. To overcome these limitations, we demonstrated a tumor-specific and photoactivity-controllable nanoparticle photomedicine based on a combination of PS-biomacromolecule conjugates and polydopamine nanoparticles (PD-NP) for an effective tumor therapy. This novel photomedicine consisted of a PD-NP core and a PS-conjugated hyaluronic acid (PS-HA) shell. The PD-NP and the PS-HA play roles as a quencher for PSs and a cancer targeting moiety, respectively, The synthesized PS-HA-shielded PD-NPs (PHPD-NPs) had a relatively narrow size distribution (approximately 130 nm) with uniform spherical shapes. In response to cancer-specific intracellular enzymes (e.g., hyaluronidase), the PHPD-NPs exhibited an excellent singlet oxygen generation Capacity for PDT. Furthermore, an efficient photothermal conversion ability for photothermal therapy (PTT) was also shown in the PHPD-NPs system. These properties provide superior therapeutic efficacy against cancer cells. In mice tumor model, the photoactive restorative effects of the PHPD-NPs were much higher in cancer microenvironments compared to that in: the normal tissue. As a result, the PHPD-NPs showed a significant antitumor activity in in vivo mice tumor model. The nanoparticle photomedicine design is a novel strategy for effective tumor therapy.</P>
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