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An Empirical Analysis of Factors Influencing the Information Service Quality of Recruitment Websites
Feng Hu,Zhiyi Rao,Jieping Li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.12
The online recruitment industry has developed rapidly under the Internet Plus environment, but the job hunters are rarely satisfied to the overall information service quality of recruitment websites. In order to improve the information service quality of recruitment websites, and maintain the competitive advantages of the industry, we conduct an empirical analysis of the factors influencing the information service quality of recruitment websites. Based on synthesizing the service quality evaluation indicators from both domestic and foreign studies,we propose the research model and hypotheses from the perspective of job hunters. We then conduct an online survey, and perform descriptive analysis, reliability analysis, factor analysis, variance analysis, correlation analysis and regression analysis on the sample data to test the research model and hypotheses with SPSS. The results show that the information content quality, reliability, ease of use, personalization and interactivity all have significantly positive correlation with the information service quality of recruitment websites.
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Shi Si,Gu Huijie,Xu Jinyuan,Sun Wan,Liu Caiyin,Zhu Tong,Wang Juan,Gao Furong,Zhang Jieping,Ou Qingjian,Jin Caixia,Xu Jingying,Chen Hao,Li Jiao,Xu Guotong,Tian Haibin,Lu Lixia 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor beta (GMFB) is considered a growth and differentiation factor for both glia and neurons. Here, we demonstrated that Gmfb deficiency effectively ameliorated the phenotype of T1D-OP in rats by inhibiting osteoclast hyperactivity. In vitro assays showed that GMFB participated in osteoclast activation rather than proliferation. Gmfb deficiency did not affect osteoclast sealing zone (SZ) formation but effectively decreased the SZ area by decreasing actin depolymerization. When GMFB was overexpressed in Gmfb-deficient osteoclasts, the size of the SZ area was enlarged in a dose-dependent manner. Moreover, decreased actin depolymerization led to a decrease in nuclear G-actin, which activated MKL1/SRF-dependent gene transcription. We found that pro-osteoclastogenic factors (Mmp9 and Mmp14) were downregulated, while anti-osteoclastogenic factors (Cftr and Fhl2) were upregulated in Gmfb KO osteoclasts. A GMFB inhibitor, DS-30, targeting the binding site of GMFB and Arp2/3, was obtained. Biocore analysis revealed a high affinity between DS-30 and GMFB in a dose-dependent manner. As expected, DS-30 strongly suppressed osteoclast hyperactivity in vivo and in vitro. In conclusion, our work identified a new therapeutic strategy for T1D-OP treatment. The discovery of GMFB inhibitors will contribute to translational research on T1D-OP.
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