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RISS 인기검색어
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- 저자 : Zhang Jieping (검색결과 4 건)
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Shuai Zhang,Yongxiang Zhang,Jieping Zhu 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.2
A new approach is proposed to quickly determine the optimal band-pass filter for the resonant demodulation of rolling element bearings. The combined wavelet filter is joined with quantum-behaved particle swarm optimization for optimal filtering. The correlated kurtosisis used as an evaluation index to identify the optimal filtered signal. The proposed approach possesses good band-pass filteringproperties and improves optimal filtering speed and effect to converge rapidly to an optimal solution. Simulation and experiment resultsshow that this approach can generate fault features that are superior to those produced with the classic algorithm. It also shortens the timespent on the same filtering effect in comparison.
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The Transition of Molecular Alignment of Poly(ethylene oxide) Film via Thermal Annealing
Hangyu Zhang,Guangzhu Ding,Kun Wu,Chenguang Cai,Jieping Liu 한국고분자학회 2022 Macromolecular Research Vol.30 No.4
The molecular alignment of polymer film has attracted a lot of attentions due to its complicated process affected by processing conditions and dominating polymer applications. Here we demonstrate that the annealing process can not only change the surface morphology of annealed poly(ethylene oxide) (PEO) film significantly but also induce the formation of highly oriented lamellar structure. It indicates that sheaf-like and cluster banding morphology can be both found obviously on the surface of pristine film. However, there is only sheaf-like morphology and sporadical cluster banding cannot be found obviously on the surface of annealed film. Then, there are both tilt and flat-on orientations of PEO crystalline for pristine film. But, single flat-on orientation of PEO crystalline is present and tilt orientation mode is absent for annealed films. Furthermore, the transition of molecular alignment of PEO film via thermal annealing cannot be affected by the thickness and temperature.
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Qing Chen,Guohui Zhang,Kaixuan Wang,Chao Wang,Guangzhu Ding,Jieping Liu 한국고분자학회 2017 Macromolecular Research Vol.25 No.4
The growth of spherulites is an intricate process and the final morphology is dependent on many process conditions. The spherulitic morphologies of poly(3-hydroxybutyrate) (PHB) crystallized from melt film are observed under various crystallization temperature gradient (the non-isothermal crystallization) in this work. Characterization reveals that the crystal morphologies (banded or nonbanded spherulites) of PHB film are determined significantly by nucleation temperature (not growth temperature). Interestingly, banded spherulites, nucleated between 60-135 oC, are able to grow completely above growth temperature 135 oC or below 60 oC yet and non-banded shperulites nucleated at above 135 oC can also develop steadily till below growth temperature 135 oC under temperature gradient condition. Therefore, the conclusion drawn from the temperature gradient or non-isothermal process is novel and different from the result of isothermal crystallization (morphology mainly depending on the growth temperature). In addition, the growth and evolution kinetics of banded and non-banded spherulites are both investigated for some polymer thin films under the temperature gradient in detail.
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Shi Si,Gu Huijie,Xu Jinyuan,Sun Wan,Liu Caiyin,Zhu Tong,Wang Juan,Gao Furong,Zhang Jieping,Ou Qingjian,Jin Caixia,Xu Jingying,Chen Hao,Li Jiao,Xu Guotong,Tian Haibin,Lu Lixia 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor beta (GMFB) is considered a growth and differentiation factor for both glia and neurons. Here, we demonstrated that Gmfb deficiency effectively ameliorated the phenotype of T1D-OP in rats by inhibiting osteoclast hyperactivity. In vitro assays showed that GMFB participated in osteoclast activation rather than proliferation. Gmfb deficiency did not affect osteoclast sealing zone (SZ) formation but effectively decreased the SZ area by decreasing actin depolymerization. When GMFB was overexpressed in Gmfb-deficient osteoclasts, the size of the SZ area was enlarged in a dose-dependent manner. Moreover, decreased actin depolymerization led to a decrease in nuclear G-actin, which activated MKL1/SRF-dependent gene transcription. We found that pro-osteoclastogenic factors (Mmp9 and Mmp14) were downregulated, while anti-osteoclastogenic factors (Cftr and Fhl2) were upregulated in Gmfb KO osteoclasts. A GMFB inhibitor, DS-30, targeting the binding site of GMFB and Arp2/3, was obtained. Biocore analysis revealed a high affinity between DS-30 and GMFB in a dose-dependent manner. As expected, DS-30 strongly suppressed osteoclast hyperactivity in vivo and in vitro. In conclusion, our work identified a new therapeutic strategy for T1D-OP treatment. The discovery of GMFB inhibitors will contribute to translational research on T1D-OP.
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