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Jiaqi Zeng,Wenchao Li,Min Lei,Chunfa Dong,Kui Zhou 한국섬유공학회 2023 Fibers and polymers Vol.24 No.10
Polycaprolactone (PCL) exhibits limited applicability in the application of biological tissue engineering scaffolds due to its lower surface hydrophilicity and surface energy. In this paper, PCL crystal lamellae scaffolds with different surface roughness were fabricated by immersing electrostatic direct-written PCL scaffolds in PCL/Amyl acetate (AC) solution for 15 , 30 , 60 and 120 min, respectively, using solution incubation for crystallization. The rough scaffolds were subsequently coated with polydopamine (PDA) for 4 h, 8 h, 12 h and 16 h. Surface morphology, chemical properties and water contact angle tests were performed on both types of scaffolds. To evaluate the feasibility of the modified scaffold as a bionic scaffold, L929 mouse fibroblasts were inoculated on the surface of the scaffold and cultured for 1, 3 and 7 days. When compared to the untreated scaffolds, the surface of the scaffolds treated for 15 , 30 , 60 , and 120 min, respectively exhibited a distinct PCL crystal lamellae structure, accompanied by a significant increase in surface roughness and corresponding water contact angle elevation. In the cell experiments, the 30 min treatment group demonstrated superior cellular activity compared to the other experimental groups. The water contact angle of the PDA-modified scaffolds decreased over time with extended treatment durations, ultimately reaching 0°. In the cell experiments, the 8 h treatment scaffolds exhibited a more pronounced improvement in activity compared to the other groups. Based on these results, it can be concluded that the PDA-modified PCL crystal lamellae electrostatic direct-write scaffold promotes cell proliferation and differentiation, thereby facilitating tissue regeneration.
Jiaqi Zhang,Jiaxin Li,Xiao-Fei Zeng,Jie-Xin Wang,Yuan Le 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-
Bacterial infection is a general problem that increases the burden of wound treatment. It has been intenselyexpected to fabricate bioactive wound dressings with good antibacterial effect. In this work, doublelayerhybrid nanofiber membranes (DHNM) of PVA/COL@ZnONPs and PCL/Gt@TiO2NPs were built by continuouselectrospinning. The matrix membranes with acceptable tensile strength and moisture permeabilityproperty were obtained by optimizing the formulation and spinning conditions. The matrixmembranes exhibited Young’s modulus of 91.93 MPa and tensile stress of 2.61 MPa. The water vaportransmittance rate (WVTR) of matrix membranes was 1140.45 g/m2day. ZnONPs in the inner layer werereleased quickly in 2 hours to destroy the bacteria in the wound. TiO2NPs in the outer layer were sustainablyreleased within 7 days to resist the bacterial attack outsides. The double-layer membranes showedgood biocompatibility and enhanced the migration of cells. The cell migration rate of double-layer hybridmembranes (DHNM) was higher than that of single layer membranes. The double-layer membraneshowed 93% elimination of the wound specific P. aeruginosa, over 99% inhibition to E. coli and over 97%to S. aureus. This study provides a potential approach for wound dressings to improve antibacterial effect.
Shuai Yang,Li Li,Liqian Wang,Jiaqi Zeng,Yinglan Li 한국간호과학회 2020 Asian Nursing Research Vol.14 No.4
Purpose: This study explored the direct and indirect effects of risk factors of work-related musculoskeletaldisorders (WRMDs) in nurses working in intensive care units (ICUs). Methods: A cross-sectional study design was used. ICU nurses from 28 tertiary hospitals in the Hunanand Guangdong provinces participated in a survey conducted via a self-reported online questionnaire. Astructural equation model was used to fit the data and to evaluate associations among WRMDs and riskfactors. Results: Valid questionnaire samples were submitted by 984 ICU nurses. The prevalence of WRMDswithin the previous year among ICU nurses was 96.8%. A valid structural equation model was constructed,and a good fit was shown: Chi-square value/degrees of freedom ¼ 2.248; comparative fitindex ¼ .931; normal fit index ¼ .905; goodness-of-fit index ¼ .978; adjusted goodness-of-fit index ¼.966; and root mean square error of approximation ¼ .036. All regression coefficients for direct effectreached significant levels (critical ratio > 1.96 and p < .05). In the structural equation model, theoccurrence of WRMDs was directly affected by the following: physical factors, risk perception, and jobstress. Physical factors and a safe environment indirectly affected WRMDs through risk perception andjob stress. The strongest correlations with WRMDs were physical factors. Conclusion: The model provided a new perspective for understanding the associations among physicalfactors, workplace safety environment, risk perception, job stress, and WRMDs. To improve the practicesetting of the ICU, efforts should be made to help prevent WRMDs from physical, psychosocial, andenvironmental factors.
Zhenyu Xu,Ke Li,Kui Zhou,Shuiyuan Li,Hongwei Chen,Jiaqi Zeng,Rugang Hu 한국섬유공학회 2023 Fibers and polymers Vol.24 No.1
Silk Fibroin (SF) is a protein polymer with great biocompatibility, which can promote cell proliferation and differentiation,and enhance bone repair. In this paper, the effects of distinctive concentrations of SF solutions on the physicochemical andbiological properties of the SF-HA-SA scaffolds were investigated. The SF-HA-SA porous scaffolds were prepared utilizingthe pneumatic extrusion 3D printing technique, composed of hydroxyapatite (HA) and different concentrations of SF solution,and sodium alginate (SA) as a binder. The results shown the SF-HA-SA scaffolds can promote cell proliferation withthe increase of SF concentration in scaffolds, and the strength meets the necessities of trabecular bone defects of bone andcartilage repair. It provides an important reference for the application of SF in bone tissue engineering.