Plasmonic Nanoantennae Fabricated by Focused Ion Beam Milling

Jiang-Tao Lv,Yuan Yan,Wei-Kang Zhang,Yun-Hui Liu,Zi-Yu Jiang,Guang-Yuan Si 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

We show a novel approach to fabricate plasmonic nanoantennae based on a maskless focused ion beam nanoring patterning process. Antenna nanoarrays with desired outlines are achieved by precisely controlling the geometric parameters during the milling process. Various nanoantenna designs of bow-tie, nanoclusters (pentamers), and ellipsoid shaped satellites surrounded particle lattices arerealized. The whole fabrication method is programmable and monolithic since only a one-step milling process is involved. The opticalproperties are experimentally characterized. Such nanoantennae may find extensive applications in chemical/bio-sensing due toremarkably enhanced near field intensity at the plasmon resonance.

An Energy-Efficient Multicast Algorithm with Maximum Network Throughput in Multi-hop Wireless Networks

Jiang, Dingde,Xu, Zhengzheng,Li, Wenpan,Yao, Chunping,Lv, Zhihan,Li, Tao The Korea Institute of Information and Commucation 2016 Journal of communications and networks Vol.18 No.5

Energy consumption has become a main problem of sustainable development in communication networks and how to communicate with high energy efficiency is a significant topic that researchers and network operators commonly concern. In this paper, an energy-efficient multicast algorithm in multi-hop wireless networks is proposed aiming at new generation wireless communications. Traditional multi-hop wireless network design only considers either network efficiency or minimum energy consumption of networks, but rarely the maximum energy efficiency of networks. Different from previous methods, the paper targets maximizing energy efficiency of networks. In order to get optimal energy efficiency to build network multicast, our proposed method tries to maximize network throughput and minimize networks' energy consumption by exploiting network coding and sleeping scheme. Simulation results show that the proposed algorithm has better energy efficiency and performance improvements compared with existing methods.

An Energy-Efficient Multicast Algorithm with Maximum Network Throughput in Multi-hop Wireless Networks

Dingde Jiang,Zhengzheng Xu,Wenpan Li,Chunping Yao,Zhihan Lv,Tao Li 한국통신학회 2016 Journal of communications and networks Vol.18 No.5

Energy consumption has become a main problem of sus-tainable development in communication networks and how to com-municate with high energy efficiency is a significant topic that re-searchers and network operators commonly concern. In this paper,an energy-efficient multicast algorithm in multi-hop wireless net-works is proposed aiming at new generation wireless communica-tions. Traditional multi-hop wireless network design only consid-ers either network efficiency or minimum energy consumption ofnetworks, but rarely the maximum energy efficiency of networks. Different from previous methods, the paper targets maximizingenergy efficiency of networks. In order to get optimal energy ef-ficiency to build network multicast, our proposed method triesto maximize network throughput and minimize networks’ energyconsumption by exploiting network coding and sleeping scheme. Simulation results show that the proposed algorithm has better en-ergy efficiency and performance improvements compared with ex-isting methods.

Risk Factors for Early Recurrence of HBV-related Hepatocellular Carcinoma Meeting Milan Criteria after Curative Resection

Zhu, Wen-Jiang,Huang, Chu-Ying,Li, Chuan,Peng, Wei,Wen, Tian-Fu,Yan, Lv-Nan,Li, Bo,Wang, Wen-Tao,Xu, Ming-Qing,Yang, Jia-Yin,Jiang, Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background: The prognosis of patients with hepatocellular carcinoma (HCC) after curative resection varies greatly. Few studies had investigated the risk factors for early recurrence (recurrence-free time ${\leq}$ 1 year) of hepatitis B virus (HBV)-related HCCs meeting Milan criteria. Methods: A retrospective analysis was performed on the 224 patients with HCC meeting Milan criteria who underwent curative liver resection in our center between February 2007 and March 2012. The overall survival (OS) rate, recurrence-free survival (RFS) rate and risk factors for early recurrence were analyzed. Results: After a median follow-up of 33.3 months, HCC reoccurred in 105 of 224 patients and 32 died during the period. The 1-, 3- and 5-year OS rates were 97.3%, 81.6% and 75.6% respectively, and the 1-, 3- and 5-year RFS rates were 73.2%, 53.7% and 41.6%. Cox regression showed alpha-fetoprotein (AFP) > 800 ng/ml (HR 2.538, 95% CI 1.464-4.401, P=0.001), multiple tumors (HR 2.286, 95% CI 1.123-4.246, P=0.009) and microvascular invasion (HR 2.518, 95% CI 1.475-4.298, P=0.001) to be associated with early recurrence (recurrence-free time ${\leq}$ 1-year) of HCC meeting Milan criteria. Conclusions: AFP > 800 ng/ml, multiple tumors and microvascular invasion are independent risk factors affecting early postoperative recurrence of HCC. In addition resection appears capable of replacing liver transplantation in some situations with safety and a better outcome.

VEGF‐incorporated biomimetic poly(lactide‐<i>co</i>‐glycolide) sintered microsphere scaffolds for bone tissue engineering

Jabbarzadeh, Ehsan,Deng, Meng,Lv, Qing,Jiang, Tao,Khan, Yusuf M.,Nair, Lakshmi S.,Laurencin, Cato T. Wiley Subscription Services, Inc., A Wiley Company 2012 Journal of biomedical materials research. Part B, Vol.b100 No.8

<P><B>Abstract</B></P><P>Regenerative engineering approaches utilizing biomimetic synthetic scaffolds provide alternative strategies to repair and restore damaged bone. The efficacy of the scaffolds for functional bone regeneration critically depends on their ability to induce and support vascular infiltration. In the present study, three‐dimensional (3D) biomimetic poly(lactide‐<I>co</I>‐glycolide) (PLAGA) sintered microsphere scaffolds were developed by sintering together PLAGA microspheres followed by nucleation of minerals in a simulated body fluid. Further, the angiogenic potential of vascular endothelial growth factor (VEGF)‐incorporated mineralized PLAGA scaffolds were examined by monitoring the growth and phenotypic expression of endothelial cells on scaffolds. Scanning electron microscopy micrographs confirmed the growth of bone‐like mineral layers on the surface of microspheres. The mineralized PLAGA scaffolds possessed interconnectivity and a compressive modulus of 402 ± 61 MPa and compressive strength of 14.6 ± 2.9 MPa. Mineralized scaffolds supported the attachment and growth and normal phenotypic expression of endothelial cells. Further, precipitation of apatite layer on PLAGA scaffolds resulted in an enhanced VEGF adsorption and prolonged release compared to nonmineralized PLAGA and, thus, a significant increase in endothelial cell proliferation. Together, these results demonstrated the potential of VEGF‐incorporated biomimetic PLAGA sintered microsphere scaffolds for bone tissue engineering as they possess the combined effects of osteointegrativity and angiogenesis. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.</P>

Risk of Trastuzumab-Related Cardiotoxicity in Early Breast Cancer Patients: A Prospective Observational Study

Jian Xue,Zefei Jiang,Fan Qi,Shuanghong Lv,Shaohua Zhang,Tao Wang,Xiaozhong Zhang 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4

Purpose: In the present study, we investigated the incidence ofcardiotoxicity within 5 years of trastuzumab treatment and evaluatedpotential risk factors in clinical practice. Methods: The studycohort included 415 patients diagnosed with early breast cancer(EBC). Cardiotoxicity incidence was evaluated in patients receivingtrastuzumab and those who did not. Multivariate Cox proportionalhazards regression models were used to estimate hazardratios and 95% confidence intervals of potential risk factorsfor trastuzumab-related cardiotoxicity after appropriate adjustments. Results: Incidence of cardiotoxicity in patients treatedwith trastuzumab was significantly higher than that in controls(23.7% vs. 10.8%, p<0.001). This result was adjusted for factorsthat might increase the risk of cardiotoxicity, such as historyof coronary artery diseases or the use of anthracyclines for morethan four cycles. Conclusion: Our findings indicated that treatmentwith trastuzumab was strongly associated with cardiotoxicityin EBC patients.

Genetic Polymorphism of GSTP1: Prediction of Clinical Outcome to Oxaliplatin/5-FU-based Chemotherapy in Advanced Gastric Cancer

Qing-Fang Li,Ru-Yong Yao,Ke-wei Liu,Hong-Ying Lv,Tao Jiang,Jun Liang 대한의학회 2010 Journal of Korean medical science Vol.25 No.6

The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile105Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. Patients with advanced gastric cancer accepted oxaliplatin/5-FU-based chemotherapy as first-line chemotherapy were investigated. GSTP1 Ile105Val polymorphism was detected by TaqMan-MGB probe allelic discrimination method. Response to treatment was assessed by disease controlled rate. Time to progression, overall survival and toxicities were recorded. Final patient outcomes were as follows: the allele frequencies of GSTP1 were 105Ile/105Ile 52%, 105Ile/105Val 41% and 105Val/105Val 7%. For patients with 105Ile/105Ile and those with at least one 105Val allele, disease control rate was 39% and 71% (P=0.026), respectively;median time to progression was 4.0 and 7.0 months (P=0.002); median overall survival time was 7.0 and 9.5 months (P=0.002). Neurological toxicity was more frequently occurred in patients with two 105Ile alleles (P=0.005). In conclusion, patients with at least one 105Val allele have better prognosis and response to oxaliplatin/5-FUbased regimen as first-line treatment for patients with advanced gastric cancer.