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Shao-Mei Yang,Fu-Nan Li,Zhi-Ning Huang,Zhong-Shi Zhou,Jin Hou,Man-Yi Zheng,Li-Juan Wang,Yu Jiang,Xin-Yi Zhou,Qiu-Yue Chen,Shan-Hua Li 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.10
To identify novel therapeutic agents to treatcancer, we synthesized a series of diaryl ether derivatives. Structure–activity relationship studies revealed that thepresence of a chlorine or hydroxyl at the para-position onthe phenyl ring (5h or 5k) significantly enhanced antitumoractivity. Compound 5h had stronger growth inhibitory activityin HepG2, A549, and HT-29 cells than compound 5k,with IC50 values of 2.57, 5.48, and 30.04 lM, respectively. Compound 5h also inhibited the growth of other cells lines,including Hep3B, PLC/PRF5, SMMC-7721, HeLa, andA375, with IC50 values of 2.76, 4.26, 29.66, 18.86, and10.21 lM, respectively. The antitumor activity of compound5h was confirmed by a colony forming assay. Further,our results indicated that the antitumor activity ofcompound 5h may be mediated by enhancing expression ofp21 and cl-caspase3, and leading to apoptosis of cancercells.
Xiao-Wei Tang,Ji-Lei Hu,Jiang-Nan Qiu 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.7
Soil liquefaction causes extensive damages to buildings and infrastructures during earthquakes. It is very important to identify the significant parameters controlling seismic liquefaction which will enhance the predictability of evaluation models. In order to identify the significant factors, 203 literatures about soil liquefaction are analyzed by bibliometrics, 12 significant factors, such as: magnitude, epicentral distance, duration of earthquake, fines content, particle size, grain composition, relative density, drainage condition, degree of consolidation, thickness of sand layer, depth of sand layer, groundwater table, are identified among 22 influence factors. And then the interrelationship among the 12 main factors was analyzed, and a multilevel structure hierarchy is developed by interpretive structural modeling, which would help understand more clearly about the relationships among these factors. The results show that: magnitude, epicentral distance, duration of earthquake and drainage condition have a direct impact on soil liquefaction, and fines content plays a key role in all factors. The results can provide guidelines for election of factors and the establishment of model in the risk evaluation of soil liquefaction.