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      • KCI등재

        A New Interleaved Double-Input Three-Level Boost Converter

        Jianfei Chen,Shiying Hou,Tao Sun,Fujin Deng,Zhe Chen 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

        This paper proposes a new interleaved double-input three-level Boost (DITLB) converter, which is composed of two boost converters indirectly in series. Thus, a high voltage gain, together with a low component stress and a small input current ripple due to the interleaved control scheme, is achieved. The operating principle of the DITLB converter under the individual supplying power (ISP) and simultaneous supplying power (SSP) mode is analyzed. In addition, closed-loop control strategies composed of a voltage-current loop and a voltage-balance loop, have been researched to make the converter operate steadily and to alleviate the neutral-point imbalance issue. Experimental results verify correctness and feasibility of the proposed topology and control strategies.

      • KCI등재

        An Interleaved Five-level Boost Converter with Voltage-Balance Control

        Jianfei Chen,Shiying Hou,Fujin Deng,Zhe Chen,Jian Li 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5

        This paper proposes an interleaved five-level boost converter based on a switched-capacitor network. The operating principle of the converter under the CCM mode is analyzed. A high voltage gain, low component stress, small input current ripple, and self-balancing function for the capacitor voltages in the switched-capacitor networks are achieved. In addition, a three-loop control strategy including an outer voltage loop, an inner current loop and a voltage-balance loop has been researched to achieve good performances and voltage-balance effect. An experimental study has been done to verify the correctness and feasibility of the proposed converter and control strategy.

      • SCIESCOPUSKCI등재

        An Interleaved Five-level Boost Converter with Voltage-Balance Control

        Chen, Jianfei,Hou, Shiying,Deng, Fujin,Chen, Zhe,Li, Jian The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5

        This paper proposes an interleaved five-level boost converter based on a switched-capacitor network. The operating principle of the converter under the CCM mode is analyzed. A high voltage gain, low component stress, small input current ripple, and self-balancing function for the capacitor voltages in the switched-capacitor networks are achieved. In addition, a three-loop control strategy including an outer voltage loop, an inner current loop and a voltage-balance loop has been researched to achieve good performances and voltage-balance effect. An experimental study has been done to verify the correctness and feasibility of the proposed converter and control strategy.

      • SCIESCOPUSKCI등재

        A New Interleaved Double-Input Three-Level Boost Converter

        Chen, Jianfei,Hou, Shiying,Sun, Tao,Deng, Fujin,Chen, Zhe The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

        This paper proposes a new interleaved double-input three-level Boost (DITLB) converter, which is composed of two boost converters indirectly in series. Thus, a high voltage gain, together with a low component stress and a small input current ripple due to the interleaved control scheme, is achieved. The operating principle of the DITLB converter under the individual supplying power (ISP) and simultaneous supplying power (SSP) mode is analyzed. In addition, closed-loop control strategies composed of a voltage-current loop and a voltage-balance loop, have been researched to make the converter operate steadily and to alleviate the neutral-point imbalance issue. Experimental results verify correctness and feasibility of the proposed topology and control strategies.

      • KCI등재

        Study on liquid-solid jet erosion characteristics of 316L stainless steel

        Guan Wang,Qianfeng Gao,Linyuan Kou,Pei Zhang,Wenhui Wang,Jianfei Deng,Xuejun Zhu 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4

        The essence of erosion is the dynamic damage and material loss process of a material caused by particle impact. The failure mechanism of erosion is the result of the interaction of multiphase flow, particle characteristics, material properties, particle impact process, and other factors. This paper employs experimental and numerical simulation methods to investigate the erosion behavior of a solid-liquid two-phase flow of 316L stainless steel jet from the angle of erosion, to explain the erosion behavior from both macroscopic and microscopic perspectives. The results discovered that the kinetic energy of the fluid is converted into pressure potential energy, which changes the kinematic characteristics of the particles and influences how they erode. The particles erode the target material by plowing and impacting at various erosion angles, and the erosion rate exhibits an increasing-decreasing-increasing tendency as the erosion angle increases, the 45° corresponds to the maximum erosion rate. Due to the particles to harden the target surface, the erosion effect is diminished in the time dimension. Comparing to high erosion angles, the reduction rate of the erosion rate in the late experiment stage is small for slow erosion angles. In the last 3 hours of the experiment, the total erosion of 316L stainless steel at 90° erosion angle was only 35 %. This provides a theoretical foundation for failure prevention in transport components containing solid particles.

      • KCI등재

        Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate

        Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

        Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.

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