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      • KCI등재

        Development and application of high-performance compound salt drilling fluid

        Jian Wang,Hanxuan Song,Jian Guan,Hongyu Liu 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.5

        Due to the characteristics of deep burial, abnormal pressure, high bottom hole temperature, and abundant fractures, the tightoil reservoirs in the Leijia block of Liaohe Oilfield have many complex situations such as lost circulation and electricalresistance encountered, which seriously restricts the development of tight oil and gas resources in Leijia. Safe and efficientdevelopment. To solve this problem, firstly, the mechanism of the wellbore instability of the tight mud shale in the Leijia blockwas studied. Then, the formula of the composite salt base fluid was optimized by using the principle of activity balance, andthe nano-plugging with core-shell structure was developed in a targeted manner. Finally, a high-performance drilling fluidsystem with strong plugging, strong inhibition and strong lubrication was constructed. The temperature resistance of thesystem reaches 150 °C, the primary recovery rate of shale is 97.8%, the permeability is reduced by more than 50%, and HTHP(150 °C) is less than or equal to 8 mL. In the test of Well L77-HX in Leijia block, the accident complexity rate is 0, the successrate of electrical measurement is 100%, the ROP is increased by 40%, the drilling depth is 5000m, and the horizontaldisplacement is 1783m. This new compound salt high-performance drilling fluid system provides technical support.

      • Theoretical Overview of Method Research on Informatization Promoting Enterprise Competitiveness

        Jian Wang,Zhenji Zhang,Xiaolan Guan 보안공학연구지원센터 2014 International Journal of u- and e- Service, Scienc Vol.7 No.6

        The existing and competitive environment of enterprises faces severe challenges in the process of global economic integration, and how the enterprises win the competitive advantages in the market to achieve sustainable development has become the focus of attention. With the rapid development of internet, information construction and application have gradually become important means to win the competitive advantages for enterprises. This thesis summarizes the method research status of enterprise informatization promoting competitiveness conducted by domestic and foreign scholars through analysis from the perspective of driving force (namely, external environment, internal resource & capabilities and internal & external integration) of enterprise competitiveness, which is useful to the construction of enterprise informatization and the promotion of the competitive advantages and provides theoretical basis and policy suggestions for further study of enterprises informatization construction and competitive advantage.

      • KCI등재

        Quantitative Reduction of Basilar Invagination With Atlantoaxial Dislocation by a Posterior Approach

        Jian Guan,Fengzeng Jian,Qingyu Yao,Chenghua Yuan,Can Zhang,Longbing Ma,Zhenlei Liu,Wanru Duan,Xingwen Wang,Xuefeng Bo,Zan Chen 대한척추신경외과학회 2020 Neurospine Vol.17 No.3

        Objective: This study evaluated the feasibility and efficacy of quantitative reduction and fixation to treat basilar invagination (BI) with atlantoaxial dislocation (AAD). Methods: Posterior occipitocervical angle (POCA), occiput–C2 angle (Oc–C2A), clivusaxial angle (CAA), and C2–7 angle (C2–7A) were considered for quantitative reduction. Twelve patients with BI complicated with AAD received posterior interarticular release and individualized cage implantation to restore vertical dislocation. The POCA was adjusted using cantilever technology to further reduce the horizontal dislocation and adjust lower cervical vertebral angle. All patients received a radiological follow-up for ≥12 months. Improvements in spinal cord function were evaluated using Japanese Orthopedic Association (JOA) score. Results: All the patients received successful quantitative reduction for BI-AAD, and bony fusion was achieved without spinal cord injury after surgery for 12 months. The JOA score was improved significantly to 15.2 ± 0.9 twelve months after surgery (p < 0.01). Radiological follow-up revealed that individualized cage and POCA play vital roles in quantitative correction: (1) distance of the dens above McRae’s line and atlantodens interval were restored to normal level, respectively; (2) changes in Oc–C2 angle (ΔOc–C2A), C2–7 angle (ΔC2–7A), clivus-axial angle (ΔCAA), and POCA (ΔPOCA) were all caused by changes in axis tilt. Based on the changes of radiological parameter we deduced the formula for quantitative reduction by linear regression analysis: -ΔPOCA = ΔOc–C2A = -ΔC2–7A = ΔCAA. Conclusion: Quantitative posterior reduction by individualized cage and adjusting ΔPOCA is feasible for treating BI with AAD.

      • KCI등재

        Reconstruction of the Cervical Lateral Mass Using 3-Dimensional-Printed Prostheses

        Qiang Jian,Zhenlei Liu,Wanru Duan,Jian Guan,Fengzeng Jian,Zan Chen 대한척추신경외과학회 2022 Neurospine Vol.19 No.1

        Objective: This study aimed to investigate the outcome of using 3-dimensional (3D)-printed prostheses to reconstruct a cervical lateral mass to maintain cervical stability. Methods: We retrospectively analyzed data of 7 patients who underwent cervical lateral mass reconstruction using a 3D-printed prosthesis, comprising axial and subaxial lateral mass reconstruction in 2 and 5 patients, respectively. Bilateral mass was reconstructed in 1 patient and unilateral mass in the remaining 6 patients. Results: Using a 3D-printed lateral mass prosthesis, internal fixation was stable for all 7 patients postoperatively. No implant-related complications such as prosthesis loosening, displacement, and compression were observed at the last follow-up. Conclusion: Reconstruction of the lateral mass structure is beneficial in restoring load transfer in the cervical spine under physiological conditions. A 3D-printed prosthesis can be considered a good option for reconstruction of the lateral mass as fusion was achieved, with no subsequent complications observed.

      • Outcomes Based on Risk Assessment of Anastomotic Leakage after Rectal Cancer Surgery

        Gong, Jian-Ping,Yang, Liu,Huang, Xin-En,Sun, Bei-Cheng,Zhou, Jian-Nong,Yu, Dong-Sheng,Zhou, Xin,Li, Dong-Zheng,Guan, Xin,Wang, Dong-Feng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

        Purpose: Anastomotic leakage (AL) is associated with high morbidity and mortality, high reoperation rates, and increased hospital length of stay. Here we investigated the risk factors for AL after anterior resection for rectal cancer with a double stapling technique. Patients and Methods: Data for 460 patients who underwent primary anterior resection with a double stapling technique for rectal carcinoma at a single institution from 2003 to 2007 were prospectively collected. All patients experienced a total mesorectal excision (TME) operation. Clinical AL was defined as the presence of leakage signs and confirmed by diagnostic work-up according to ICD-9 codes 997.4, 567.22 (abdominopelvic abscess), and 569.81 (fistula of the intestine). Univariate and logistic regression analyses of 20 variables were undertaken to determine risk factors for AL. Survival was analysed using the Cox regression method. Results: AL was noted in 35 (7.6%) of 460 patients with rectal cancer. :Median age of the patients was 65 (50-74) and 161 (35%) were male. The diagnosis of AL was made between the 6th and 12th postoperative day (POD; mean 8th POD). After univariate and multivariate analysis, age (p=0.004), gender (p=0.007), tumor site (p<0.001), preoperative body mass index (EMI) (p<0.001), the reduction of TSGF on 5th POD less than 10U/ml (p=0.044) and the pH value of pelvic dranage less than or equal to 6.978 on 3rd POD (p<0.001) were selected as 6 independent risk factors for AL. It was shown that significant differences in survival of the patients were AL-related (p<0.001), high ASA score related (p=0.036), high-level EMI related (p=0.007) and advanced TNM stage related <p<0.001). Conclusions: AL after anterior resection for rectal carcinoma is related to advanced age, low tumor site, male sex, high preoperative EMI, low pH value of pelvic drainage on POD 3 and a significant reduction of TSGF on POD 5. In addition to their high risk of immediate postoperative morbidity and mortality, AL, worse physical status, severe obesity and advanced TNM stage have similarly negative impact on survival.

      • KCI등재

        Location Distribution of Fistulas and Surgical Strategies for Spinal Extradural Meningeal Cysts: A Retrospective Analysis of 30 Cases at a Single Center

        Qiang Jian,Gang Song,Zhenlei Liu,Wanru Duan,Jian Guan,Fengzeng Jian,Zan Chen 대한척추신경외과학회 2022 Neurospine Vol.19 No.1

        Objective: This study aimed to illustrate the features of fistula location distribution, surgical strategies, and outcomes in spinal epidural meningeal cysts (SEMCs). Methods: The authors searched and reviewed the medical records for cases of SEMCs. Imaging features, operative reports, and media were reviewed to accurately describe the surgical techniques employed. We recorded the level and laterality of the fistula according to the operative report and the media. Consistency analysis was performed on the dominant laterality of the cyst on preoperative axial magnetic resonance imaging and laterality of the fistula in the operative media or report. When cyst and fistula lateralities were the same, they were considered consistent. Finally, the Japanese Orthopedic Association (JOA) score was used to obtain patient-reported results at each follow-up. Results: Thirty patients with SEMCs were identified. Fistula repair was performed in all patients. Two patients experienced cyst recurrence after surgery and were repaired during the second surgery. Based on imaging findings, SEMCs mostly occurred in the thoracolumbar junction. Most of the fistulas (87.88%) were at the T12 or L1 levels. In patients with multiple adjacent SEMCs, the fistula may be at one end of the cyst rather than in the middle level of the cyst. A fistula laterality of 72.72% was consistent with cyst laterality. The JOA improvement rate was 61.84% ± 26.63%. Conclusion: Most fistulas were always located at the T12–L1 level as well as the middle level of the cyst, which is always consistent with cyst laterality. In patients with multiple adjacent SEMCs, the fistula may be at one end of the cyst. Cleft closure is key to healing SEMCs.

      • 『法度随时变 江山教我画论写生在关山月艺术创作中的重要性』

        关坚 ( Guan Jian ) 인문사회과학예술융합학회 2018 인문사회과학예술융합학회지 Vol.2 No.2

        速写写生作品, 是画家生涯、艺术积累的见证, 同时也是研究其艺术变化、作品构成和风格特征的重要依据。作为折衷派新国画的追随者, 关山月自抗战时期起稳步地进入艺术界, 短短几年即由一位寂寂无闻的艺术爱好者成长成为一位具有独立思考、能够迅速把握当下艺术主流思想的艺术家。纵观其一生的从艺历程, 我们不难发现, 适时调整自己的艺术方向、提升技巧的表达水准与和内容的思想性, 乃是基因于其不间断地深入生活、深入自然中去写生, 从中描绘大量的速写作品。

      • KCI등재

        Mitochondrial citrate accumulation drives alveolar epithelial cell necroptosis in lipopolysaccharide-induced acute lung injury

        Yang Hui-Hui,Jiang Hui-Ling,Tao Jia-Hao,Zhang Chen-Yu,Xiong Jian-Bing,Yang Jin-Tong,Liu Yu-Biao,Zhong Wen-Jing,Guan Xin-Xin,Duan Jia-Xi,Zhang Yan-Feng,Liu Shao-Kun,Jiang Jian-Xin,Zhou Yong,Guan Cha-Xi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

        Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We found an accumulation of mitochondrial citrate (citratemt) in lipopolysaccharide (LPS)-treated AECs because of the downregulation of Idh3α and citrate carrier (CIC, also known as Slc25a1). shRNA- or inhibitor–mediated inhibition of Idh3α and Slc25a1 induced citratemt accumulation and necroptosis in vitro. Mice with AEC-specific Idh3α and Slc25a1 deficiency exhibited exacerbated lung injury and AEC necroptosis. Interestingly, the overexpression of Idh3α and Slc25a1 decreased citratemt levels and rescued AECs from necroptosis. Mechanistically, citratemt accumulation induced mitochondrial fission and excessive mitophagy in AECs. Furthermore, citratemt directly interacted with FUN14 domain-containing protein 1 (FUNDC1) and promoted the interaction of FUNDC1 with dynamin-related protein 1 (DRP1), leading to excessive mitophagy-mediated necroptosis and thereby initiating and promoting ALI. Importantly, necroptosis induced by citratemt accumulation was inhibited in FUNDC1-knockout AECs. We show that citratemt accumulation is a novel target for protection against ALI involving necroptosis.

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