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Kim, Young Jin,Go, Min Jin,Hu, Cheng,Hong, Chang Bum,Kim, Yun Kyoung,Lee, Ji Young,Hwang, Joo-Yeon,Oh, Ji Hee,Kim, Dong-Joon,Kim, Nam Hee,Kim, Soeui,Hong, Eun Jung,Kim, Ji-Hyun,Min, Haesook,Kim, Yeonj Nature Publishing Group, a division of Macmillan P 2011 Nature genetics Vol.43 No.10
To identify the genetic bases for nine metabolic traits, we conducted a meta-analysis combining Korean genome-wide association results from the KARE project (n = 8,842) and the HEXA shared control study (n = 3,703). We verified the associations of the loci selected from the discovery meta-analysis in the replication stage (30,395 individuals from the BioBank Japan genome-wide association study and individuals comprising the Health2 and Shanghai Jiao Tong University Diabetes cohorts). We identified ten genome-wide significant signals newly associated with traits from an overall meta-analysis. The most compelling associations involved 12q24.11 (near MYL2) and 12q24.13 (in C12orf51) for high-density lipoprotein cholesterol, 2p21 (near SIX2-SIX3) for fasting plasma glucose, 19q13.33 (in RPS11) and 6q22.33 (in RSPO3) for renal traits, and 12q24.11 (near MYL2), 12q24.13 (in C12orf51 and near OAS1), 4q31.22 (in ZNF827) and 7q11.23 (near TBL2-BCL7B) for hepatic traits. These findings highlight previously unknown biological pathways for metabolic traits investigated in this study.
Resonant-Frequency-Dependent Flux Noise of a High-TC rf SQUID Coupled to a Substrate Resonator
Ji-Cheng Chen,Hong-Chang Yang,Chiu-Hsien Wu,Herng-Er Horng,Jen-Tzong Jeng,Kuen-Lin Chen 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
In the recent development of a high-TC rf SQUID magnetometer, Zhang et al. used a SrTiO3 substrate resonator with a YBCO thin film flux concentrator on it. The effective area was improved by a flux concentrator. However, there was no study of the resonant frequency of the substrate resonator. In this work, the frequency-dependent flux noise of a high-TC rf SQUID coupled to a substrate resonator was investigated. The results were analyzed with the noise theory. The optimization of the SQUID with a substrate resonator and its flux noise are discussed.
Inter-comparison of Radar Data Assimilation Systems for ICE-POP 2018 Snowfall Cases
Ji-Won Lee,Ki-Hong Min,Kao-Shen Chung,Cheng-Rong You,GyuWon Lee 한국기상학회 2021 한국기상학회 학술대회 논문집 Vol.2021 No.10
Gangwon-do (GWD) has complex topography and land-surface characteristics due to its location to the East Sea and the Taebaek Mountain range. This coastal location and rugged terrain can amplify snowfall mechanisms, which makes it difficult to predict the amount and location accurately. This study compares two different methods in assimilating radar data and analyze snowfall prediction results. The two methods that are compared are, a) three dimensional variational (3D-Var) and b) a Local Ensemble Transform Kalman Filter (LETKF) data assimilation (DA). 3D-Var considers only the covariance of the climatic background error, but LETKF can consider model errors changing with time/space. The latter can consider the effect of DA corresponding to the current flow of the atmosphere. In 2018, for the purpose of understanding snowfall in the GWD region and support the Pyeongchang Winter Olympic and Paralympic Games, a long-term heavy snow observation campaign was carried out. The International Collaborative Experiments for 2018 Pyeongchang Olympic Games RDP/FDP Projects (ICE-POP 2018) data are utilized to study and verify the numerical experiment results. The results of performing precipitation verification for two snowfall cases showed that 3D-Var and LETKF methods have similar skills in forecasting winter precipitation. However, the dynamics and thermodynamic characteristics leading to snowfall formation show much differences. More detailed analysis will be presented to understand the cause of these differences.
Ji, Yu-Bin,Chen, Ning,Zhu, Hong-Wei,Ling, Na,Li, Wen-Lan,Song, Dong-Xue,Gao, Shi-Yong,Zhang, Wang-Cheng,Ma, Nan-Nan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Alkaloids are the most extensively featured compounds of natural anti-tumor herbs, which have attracted much attention in pharmaceutical research. In our previous studies, a mixture of major three alkaloid components (5, 6-dihydrobicolorine, 7-deoxy-trans-dihydronarciclasine, littoraline) from Hymenocallis littoralis were extracted, analyzed and designated as AHL. In this paper, AHL extracts were added to human liver hepatocellular cells HepG-2, human gastric cancer cell SGC-7901, human breast adenocarcinoma cell MCF-7 and human umbilical vein endothelial cell EVC-304, to screen one or more AHL-sensitive tumor cell. Among these cells, HepG-2 was the most sensitive to AHL treatment, a very low dose ($0.8{\mu}g/ml$) significantly inhibiting proliferation. The non-tumor cell EVC-304, however, was not apparently affected. Effect of AHL on HepG-2 cells was then explored. We found that the AHL could cause HepG-2 cycle arrest at G2/M checkpoint, induce apoptosis, and interrupt polymerization of microtubules. In addition, expression of two cell cycle-regulated proteins, CyclinB1 and CDK1, was up-regulated upon AHL treatment. Up-regulation of the Fas, Fas ligand, Caspase-8 and Caspase-3 was observed as well, which might imply roles for the Fas/FsaL signaling pathway in the AHL-induced apoptosis of HepG-2 cells.
RASAL1 Attenuates Gastric Carcinogenesis in Nude Mice by Blocking RAS/ERK Signaling
Chen, Hong,Zhao, Ji-Yi,Qian, Xu-Chen,Cheng, Zheng-Yuan,Liu, Yang,Wang, Zhi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer. However, whether or not RASAL1 suppresses tumor growth in vivo remains to be determined. In the present study, we investigated the role of RASAL1 in gastric carcinogenesis using an in vivo xenograft model. A lentiviral RASAL1 expression vector was constructed and utilized to transfect the human poorly differentiated gastric adenocarcinoma cell line, BGC-823. RASAL1 expression levels were verified by quantitative real-time RT-PCR and Western blotting analysis. Then, we established the nude mice xenograft model using BGC-823 cells either over-expressing RASAL1 or normal. After three weeks, the results showed that the over-expression of RASAL1 led to a significant reduction in both tumor volume and weight compared with the other two control groups. Furthermore, in xenograft tissues the increased expression of RASAL1 in BGC-823 cells caused decreased expression of p-ERK1/2, a downstream moleculein the RAS/RAF/MEK/ERK signal pathway. These findings demonstrated that the over-expression of RASAL1 could inhibit the growth of gastric cancer by inactivation of the RAS/RAF/MEK/ERK pathway in vivo. This study indicates that RASAL1 may attenuate gastric carcinogenesis.
Peng, Cheng,Mansour, Alaa M.,Wu, Chunfa,Zuccolo, Ricardo,Ji, Chunqun,Greiner, Bill,Sung, Hong Gun Techno-Press 2018 Ocean systems engineering Vol.8 No.4
Floating Production Storage and Offloading (FPSO) units have the advantages of their ability to provide storage and offloading capabilities which are not available in other types of floating production systems. In addition, FPSOs also provide a large deck area and substantial topsides payload capacity. They are in use in a variety of water depths and environments around the world. It is a good solution for offshore oil and gas development in fields where there is lack of an export pipeline system to shore. However due to their inherently high motions in waves, they are limited in the types of risers they can host. The Low Motion FPSO (LM-FPSO) is a novel design that is developed to maintain the advantages of the conventional FPSOs while offering significantly lower motion responses. The LM-FPSO design generally consists of a box-shape hull with large storage capacity, a free-hanging solid ballast tank (SBT) located certain distance below the hull keel, a few groups of tendons arranged to connect the SBT to the hull, a mooring system for station keeping, and a riser system. The addition of SBT to the floater results in a significant increase in heave, roll and pitch natural periods, mainly through the mass and added mass of the SBT, which significantly reduces motions in the wave frequency range. Model tests were performed at the Korea Research Institute of Ships & Ocean Engineering (KRISO) in the fall of 2016. An analytical model of the basin model (MOM) was created in Orcaflex and calibrated against the basin-model. Good agreement is achieved between global performance results from MOM's predictions and basin model measurements. The model test measurements have further verified the superior motion response of LM-FPSO. In this paper, numerical results are presented to demonstrate the comparison and correlation of the MOM results with model test measurements. The verification of the superior motion response through model test measurements is also presented in this paper.
Yue Cheng,Li-Xiang Huang,Li Zhang,Ming Ma,Shuang-Shuang Xie,Qian Ji,Xiao-Dong Zhang,Gao-Yan Zhang,Xue-Ning Zhang,Hong-Yan Ni,Wen Shen 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.2
Objective: To evaluate the spontaneous brain activity alterations in liver transplantation (LT) recipients using resting-state functional MRI. Materials and Methods: Twenty cirrhotic patients as transplant candidates and 25 healthy controls (HCs) were included in this study. All patients repeated the MRI study one month after LT. Amplitude of low-frequency fluctuation (ALFF) values were compared between cirrhotic patients (both pre- and post-LT) and HCs as well as between the pre- and post-LT groups. The relationship between ALFF changes and venous blood ammonia levels and neuropsychological tests were investigated using Pearson’s correlation analysis. Results: In the cirrhotic patients, decreased ALFF in the vision-related regions (left lingual gyrus and calcarine), sensorimotor-related regions (left postcentral gyrus and middle cingulate cortex), and the default-mode network (bilateral precuneus and left inferior parietal lobule) were restored, and the increased ALFF in the temporal and frontal lobe improved in the early period after LT. The ALFF decreases persisted in the right supplementary motor area, inferior parietal lobule, and calcarine. The ALFF changes in the right precuneus were negatively correlated with changes in number connection test-A scores (r = 0.507, p < 0.05). Conclusion: LT improved spontaneous brain activity and the results for associated cognition tests. However, decreased ALFF in some areas persisted, and new-onset abnormal ALFF were possible, indicating that complete cognitive function recovery may need more time.
Guo, Cheng-Xian,Yang, Guo-Ping,Pei, Qi,Yin, Ji-Ye,Tan, Hong-Yi,Yuan, Hong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: A number of association studies have been carried out to investigate the relationship between genetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment of patients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study was to assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response in rectal cancer patients treated with neoadjuvant chemoradiation. Materials and Methods: Studies were retrieved by searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted a meta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treated with neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs). Results: Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487, XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with the response in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05). Conclusions: This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated with the radiotherapy-based multimodality treatment in rectal cancer patients.