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Magnetic Nano-Particles and Their Applications in Immunoassays
Horng Herng-Er,C. C. Wu,Hong Chin-Yih,Liao S.H.,Liu C.M.,Yang S.Y.,Yang H.C. 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
Biocompatible magnetic nano-particles show great potential in bio-magnetic applications, such as MRI contrast agents, drug delivery, magnetically labeled immunoassays, and so on. In this work, the feasibility of magnetically labeled immunoassay using bio-compatible magnetic nano-particles is investigated. To do this, we study the synthesis technologies for magnetic nano-particles of Fe3O4, as well as the coating of various bio-probes onto the magnetic nano-particles to detect the bio-targets avidin, such as, etc. Furthermore, different measurements, like magnetic relaxation and saturated magnetization, for the amounts of bio-targets are developed. In order to achieve an ultra-high sensitivity in magnetically labeled immunoassays, we used SQUIDs because SQUIDs are the most sensitive sensors for magnetic signals. The characterizations of these magnetically labeled immunological measurements are discussed.
Resonant-Frequency-Dependent Flux Noise of a High-TC rf SQUID Coupled to a Substrate Resonator
Ji-Cheng Chen,Hong-Chang Yang,Chiu-Hsien Wu,Herng-Er Horng,Jen-Tzong Jeng,Kuen-Lin Chen 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
In the recent development of a high-TC rf SQUID magnetometer, Zhang et al. used a SrTiO3 substrate resonator with a YBCO thin film flux concentrator on it. The effective area was improved by a flux concentrator. However, there was no study of the resonant frequency of the substrate resonator. In this work, the frequency-dependent flux noise of a high-TC rf SQUID coupled to a substrate resonator was investigated. The results were analyzed with the noise theory. The optimization of the SQUID with a substrate resonator and its flux noise are discussed.
Improving the Sensitivity of a High-Tc SQUID Magnetometer with a Serial Array
Chiu-Hsien Wu,Hong-Chang Yang,J. C. Chen,C. T. Chiang,C. Y. Chen,Herng-Er Horng,J. T. Jeng,K. L Chen,M. J. Chen 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.48 No.5I
To pursue a high-reproducibility and high-quality SQUID for high-Tc superconducting applications, we have designed and fabricated a flip-chip magnetometer as a sensor for measuring weak magnetic signals. The magnetometer consists of a serial SQUID magnetometer coupled to a flux focuser. The SQUIDs are connected in series, thereby increasing the peak-to-peak value of the voltage-flux transfer function, V. A flux focuser is employed to increase the effective area of the SQUID. The serial SQUID array has high-quality device characteristics. High-Tc SQUID magnetometers exhibiting a magnetic field sensitivity of 45 fT/Hz1/2 in the white region and 200 fT/Hz1/2 at 1 Hz have been demonstrated in this work. The flip-chip SQUID magnetometer shows a sufficiently high sensitivity to record magnetocardiograms.