全蝎 抽出物의 抗癲癎效果에 關한 硏究

신현철,윤철호,김종대,정지천,신억섭,허근 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

In convulsion state by PTZ in rat, anticonvulsive effect and some γ-aminobutyric acid (GABA)-related mechanisms of Bythus extract in brain was experimented. It was ingibited GABA-T activity, lipid peroxide generation and xanthine oxidase activity as scheduled administration in vitro and vivo. And the content of brain gutathione was increased as scheduled administration in rat. In convulsion state by PTZ of previously managed rat by Buthus extract, onset eime and duration were non-specific changes but recovery time and severity was remarkably reduced. In conclusion speculated that Buthus extract inhibits convulsion by control of GABA content in brain.

震顫痲痺에 對한 文獻的 考察

申鉉喆,金鍾?,鄭智天 동국대학교 한의학연구소 1995 東國韓醫學硏究所論文集 Vol.4 No.-

This study is that examine ana readjust cause - pathology, symptom, treatment, clinical reports recorded in western medicine, successive literature of oriental medicine and recent literatures and journals of chinese medicine about Paralysis agitans. The results was followed ; 1. Paralysis agitans is similar with symptoms of Jinjeon, Qi, Gyeong, Gyejong, Lyeon and Pyengo, Tantan, Jungbu, Jungpung. 2. There are runs, Hwa, Dam, Eo in the causes of disease, Gansinyinheo, Qihyeolyangheo, Jeokyeoldamhwa, Qichehyeoleo, Ganpungnaedong etc in clinical types, to be concerned with liver, kidney, heart and spleen in Jangbu. Gansinyinheo and Qihyeolyangheo are concerned wiyh idopathic paralysis agitans, Jeokyeoldamhwa and Qichehyeoloe successive it, Ganpungnaedong both idiopathic and successive. 3. Treatments are Jayinjamyang, Pyeonggansikpung, Ikqiyanghyeol, Sikpunghwallak, Seoganhaewool, Hwalhyeoltonglak etc, and prescriptions are Yukmi, Chunmagudeongum, Paljintang, Tonggyuhwalhyeoltang, Hyeoltbuchukeotang etc. 4, In caring, it is necessary to live pleasantly, to be temperate sexual intercourse, to control diet, to do suitable exercises, for example Qigong, Physical exercises, Walking etc. 5. In clinical reports, this disease frequently occurs more than 50 years, male is more than female, and there are many complications as hypertension and arteriosclerosis etc. The majority of causes are Gansinyinheo, Qichehyeoleo, and the others are Qihyeolyangheo, Damhwa, Ganpungnaedong, Qigiulche, Yeolyoesimsin etc, the majority of care Jabogansin, Yukyinsikpung, Hwalhyeolhwaeo, and the others Ikqiyanghyeol, Haldamtonglak, Seoganhaewool. Curing period is generally from 2 to 3 months. In effectiveness rate, successive Qichehyeoleo type is the highest, and idiopathic Qihyeolyangheo type is the lowest. Effectiveness of rigidity is higher than tremor.

조혈모세포이식 후 발생한 주폐포자층 폐렴에 대한 고찰

주지현,최정현,이동건,백지연,고윤호,이혜정,김세희,신호진,박윤희,박지영,김유진,신완식,김춘추 대한감염학회 2001 감염 Vol.33 No.4

Background : Pneumocytitis cainii pneumonia (PCP) can occur in immunocompromised hosts especially such as AIDS or cancer patients. Although recent research had focused on PCP in AIDS patients, few studies have described the clinical presentations of PCP in recipients of stem cell transplantation (SCT). We evaluated the clinical manifestations of PCP in SCT patients admitted at St. Mary's hospital, Seoul, Korea. Methods : The medical records of 17 PCP patients undergoing SCT between Feb. 1998 and Feb. 2000 were reviewed. The diagnosis of PCP was confirmed through the demonstration of Pneumocytitis cainii via either cytology of brochoalveolar lavage (BAL) or histological technique of lung biopsy. CMV disease and CMV infection were confirmed by BAL culture and antigenemia respectively . Results : Seventeen patients were all recipients of allogeneic SCT and 7 of 17 patients were performed non-sibling SCT. Patients presented with symptoms including brief period (4 ∼23 days) of fever (76%), dyspnea (70%), cough (64%), and signs such as rare(58.8%), Sixteen patients (94%) had been receiving immunosuppressive agent such as cyclosporine A (64%) or Fk506 (35%) without PCP prophylaxis. Eleven patients (64%) were treated with corticosteroid with mean dose of 16 mg/day prednisolone and mean duration of 4.6 months after post-SCT period. Twelve patients were co-infected with CMV. Another co-infected miCroorganisms were Pseudomonas aeruginosa, Mycobacterium tuberculosis, herpes simplex virus, parainfluenza virus, Average duration of treatment with trimethoprim-sulfamethoxazole (TMP/SMX) was 21 ±9 days. Four patients died, and three of them were related with PCP. Conclusion : PCP developed frequently in patients who were taking immunosuppressive drug due to graft versus host disease or were not taking TMP/SMX prophylaxis. High risk patients showing fever, cough, or dyspnea should be considered to take early bronchoscopic intervention for detection of PCP. When treat for PCP, it also be considered to the possibility of coinfection such as CMV. (Korean J Infect Dis 33:273∼279, 2001)

골수염으로 발현된 재발성 콕시디오이데스 진균증 1예

백지현,박은영,정윤숙,홍재원,채윤태,진성준,최희경,신소연,한상훈,진범식,김창오,최준용,송영구,조남훈,김준명 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Coccidioidomycosis is a fungal infection that results from inhaling the airborne arthroconidia of the Coccidioides species. It is an endemic disease in the southwest part of North America and rarely diagnosed in Korea. As tourism to endemic areas and the number of immunocompromised patients have been increasing, the incidence of this infection has increased in non-endemic areas. Treatment is usually successful with antifungal agents; however, recurrence is common. It is difficult to decide when to discontinue the antifungal treatment especially in non-endemic areas where doctors are not familiar with the disease. We report a case of recurrent coccidioidomycosis manifesting as osteomyelitis after the treatment of the patient for disseminated coccidioidal infection. The complement fixation test was a useful tool for the assessment of patient response and to evaluate suspected recurrence.

The early effects of different LED (light-emitting diode) therapy on the viability and migration of human biceps tendon fibroblast cells

Ji Hyeon Ryu,Suk-Woong Kang,Jisu Park,Ji Won Kim,Yong-Il Shin 대한견주관절의학회 2022 대한견주관절학회 학술대회논문집 Vol.2022 No.4

UV-illuminated chemical bath deposition of CdS buffer layer for CIGSSe solar cells

Hyeon-ji Baek,Ji A. Oh,Young-Eun Seo,Hye-Jin Shin,Sung-Wook Cho,Chan-Wook Jeon 한국물리학회 2020 Current Applied Physics Vol.20 No.1

In this paper, we compare the performance of Cu(In,Ga)(S,Se)2 (CIGSSe) thin film solar cells with a CdS buffer layer grown by chemical bath deposition (CBD) with UV irradiation of 365 nm or 254 nm at an output power of 8 W. The effects of UV light irradiation on the CBD-CdS thin film deposition mechanism were investigated through chemical and electro-optical studies. UV light irradiation during the solution process promotes the hydrolysis of thiourea, thereby inhibiting the formation of the intermediate products being developed on the reaction pathways and decreasing the solution pH. Therefore, the efficiency of the CdS/CIGSSe solar cells was improved because of the increased elemental ratio of S/(S + O) in the CdS thin film. This very simple and effective approach can be used to control the S/O ratio of the CdS thin film fabricated by the CBD process without artificially controlling the process temperature, solution pH or concentration.

The Effect of Pneumococcal Polysaccharide Vaccine in a Mouse Model of Allergic Rhinitis

Shin, Ji-Hyeon,Kim, Boo Young,Park, Hyang Rim,Kim, Sung Won,Kim, Soo Whan SAGE Publications 2013 Otolaryngology-head and neck surgery Vol.148 No.3

<P>This study aimed to determine if pneumococcal polysaccharide vaccine (PPV) could suppress allergic inflammation in an allergic rhinitis mouse model and to explore whether differences exist regarding the effect of PPV according to timing of administration.</P>

2,3-Dehydrosilybin Suppresses IL-31-Associated Pruritus Factors in Astrocytes and Microglia

Ji Hyeon Park,Jae Young Shin,Feng Wang,Suping Hao,Da Jeong Shin,Seon Il Jang,Byoung Ok Cho 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Chronic pruritus is the main symptom that increases the suffering of patients in hypersensitivity disorder disease. IL-31 is a pruritic cytokine with a primary objective to control itch. A 2,3-dehydrosilybin (DHS) is a type of flavonoid extracted from the seeds of milk thistle. DHS has been reported to have hepatoprotective, angiogenic, and antioxidant effects. This study investigated the effect of DHS pretreatment on IL-31-associated pruritus in astrocytes and microglia. Pretreatment with DHS inhibited the production of IL-31 by lipopolysaccharide (LPS) and interferon gamma (IFN-γ) stimulation in microglia. Pretreatment with DHS inhibited the phosphorylation of MAPK, STAT1 and NF-κB by LPS plus IFN-γ stimulation in microglia. In addition, DHS suppressed the expression of IL-31 receptor A in IL-31-treated astrocytes. DHS also inhibited lipocalin2 production in IL-31 stimulated astrocytes. Taken together, DHS has potential as a therapeutic agent for symptom relief by down-regulating the IL-31-mediated pruritus mechanism in microglia and astrocytes.

Exploring the Effects of 630 nm Wavelength of Light-Emitting Diode Irradiation on the Proliferation and Migration Ability of Human Biceps Tendon Fibroblast Cells

Ji Hyeon Ryu,Jisu Park,Ji Won Kim,Yong-Il Shin,Sang Don Lee,Young Kwang Oh,Suk-Woong Kang 대한정형외과학회 2023 Clinics in Orthopedic Surgery Vol.15 No.1

Background: Light-emitting diode (LED)-based photobiomodulation is used as an inducer of cell regeneration. Although numerous in vitro and in vivo orthopedic studies have been conducted, the ideal LED wavelength range for tendon healing has not yet been determined. This study, thus, focused on the effects of LED of a 630 nm wavelength on the cell viability, proliferation, and migration of human biceps tendon fibroblast cells. Methods: Human tendon fibroblast cell culture was performed using the biceps tendon of patients who had undergone biceps tenodesis. Human biceps tendon fibroblasts from two patients (male, aged 42 and 69 years) were isolated and cultured. The cell type was confirmed by a morphological analysis and using tendon and fibroblast specific markers. They were then split into three groups, with each receiving a different irradiation treatment: no LED treatment (control), 630 nm LED, and 630 nm + 880 nm LED for 20 minutes each. After the LED treatment, cell viability, proliferation, and migration assays were performed, and the results were compared between the groups. Results: Twenty-four hours after LED treatment, cell viability and proliferation were significantly increased in the 630 nm LED and 630 nm + 880 nm LED treatment groups compared to that in the control group (p < 0.05). Under the same conditions, compared with the control group, the 630 nm LED alone treatment group showed a 3.06 ± 0.21 times higher cell migration rate (p < 0.05), and the 630 nm + 880 nm LED combination treatment group showed a 2.88 ± 0.20 times higher cell migration rate (p < 0.05) in threedimensional migration assay. Conclusions: In human tendon fibroblast cells, 20 minutes of LED treatment at 630 nm and 630 nm + 880 nm exhibited significant effects on cell proliferation and migration. Our findings suggest the potential of LED therapy as an adjuvant treatment for tendon healing, and hence, further research is warranted to standardize the various parameters to further develop and establish this as a reliable treatment regimen.

A Novel Intragenic Riboswitch-regulated Gene Expression in Yeast

Ji-Hyeon SHIN,Jong-Shik SHIN 한국생물공학회 2012 한국생물공학회 학술대회 Vol.2012 No.4