단기간의 저용량 Cytosine arabinoside 치료에 반응하였던 Down 증후군에 병발한 급성골수성백혈병 1례

김현수,이정호,이정찬,강정현,곽상혁,김철희,배광봉,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The incidence of hematologic disorders in patients with Down's syndrome is significantly increased, about 14∼30 - fold higher than in general population and includes neonatal transient abnormal myelopoieis and acute leukemias. The age of onset of leukemia in Down's syndrome is peaking first in the newborn period and then under 4 years of age. Down's syndrome with acute leukemia above the age of 20 is very rare and it's treatment oucome is unclear. The treatment of Down's syndrome with leukemia has been controversial because of toxicity and associated congenital cardiac and other abnormalities. But if treated adequately, children with Down's syndrome show a favorable response to anti-leukemia therapy. A 24-year-old man with Down's syndrome was first seen for the evaluation of anemia and thrombocytopenia. The peripheral blood morphology and bone marrow study revealed acute myelogenous leukemia, cytogenetic study of bone marrow showed trisomy 21. Beacuse of his sicioeconomic condition and medical abnormalities including deafness, visual loss, he was treated with low dose subcutaneous cytosine arabinoside(Ara-C) for 11 days. Complete remission was obtained after 37 days. The complete remission lasted for 5 months. He subsequently relapsed, and died 6 months later.

紫胡淸肝湯이 CCI₄ 中毒白鼠의 肝損傷에 미치는 影響에 ?하여

金德鎬,金定濟,金秉蕓,禹弘楨 慶熙大學校韓醫科大學韓醫學硏究所 1980 慶熙韓醫大論文集 Vol.3 No.-

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

水稻 主要品種의 窒素反應 試驗

金正敎,河浩成 진주농과대학 1971 진주농과대학 연구논문집 Vol.- No.10

몇가지 主要 水稻 品種-農林6號, 八錦, 시라누이, 기비요시, 金南風, Calady40을 供試하여 이들 品種이 10, 13, 16, 19kg/10a의 질소 수준에서 질소비료에 對한 反應程度를 알아보기 위하여 試驗한 結果를 要約하면; 1. 窒素 施肥量의 增加에 따라 대체로 16kg/10a까지는 收量이 增加하였으며 處理間에는 有意性이 認定되었다. 2. 各 品種의 施肥量에 對한 反應은 같지 않으며, 金南風, 八錦, Calady40, 農林6號는 13kg/10a 水準에서, 시라누이, 기비요시는 16kg/10a 水準에서 最大의 收量을 나타내었으며 각 品種의 收量差에는 高度의 有意性이 認定되었다. 3. 草長과 分蘖數는 질소비료의 增施에 따라 증가하였으며, 그중 極短稈種인 시라누이의 分蘖數는 현저한 增加를 나타내었으나 長稈 品種인 Calady40은 增肥에 따라 별로 큰 差異가 없었다. 4. 稈長은 品種에 따라 그 差異가 심하며 질소비료량을 增加함에 따라 各 品種 모두 길어진 편이었다. 5. 穗長은 질소비료의 증가에 따라 一定한 경향을 나타내지 않았으며 品種別로는 Calady40과 기비요시가 길었고 시라누이가 가장 짧았다. 6. 穗數는 질소 增施에 따라 增加된 경향이며 穗當 粒數는 一定한 경향이 없었다. 7. 倒伏은 질소 增肥에 따라 增加하였으며 農林6號 八錦, Calady40이 질소 16kg/10a에서 19kg/10a에 이르기까지 그 倒伏度가 約3에서 5程度로 增加하였으며 短稈인 시라누이는 질소 19kg/10a에서도 倒伏이 일어나지 않았다. 8. 病蟲害는 增肥에 따라 例外없이 그 被害度가 增加하였으며 蟲害에 比하여 病害가 特히 질소비료의 증시에 따라 그 被害度가 높았다. This experiment was conducted to evaluate the responses of nitrogen on the several leading varities of rice, Oryza sativa L. The varieties used in this experiment were Norin 6, Palkeum, Shiranui, Kibjyoshi, Kimmaze and Calady 40, which were consisted of short, medium and long culm length. The nitrogen levels applied were 10, 13, 16 and 19 kg/10 a, and 8 kg/10 a of ?? and 10 kg/10 a of K₂O were also applied at each nitrogen level. The results obtained in this experiment were summarized as follows: 1. The yields was increased by increasing the nitrogen level at 16 kg/10 a and highly significant differences were noticed between the different nitrogen levels applied. 2. Even though there were not found any trends among the responses of variety to the nitrogen levels, Kimmaze, Palkeum, Calady 40 and Norm 6 showed the highest yields at the level of 13 kg/10a, and shiranui and Kibjyoshi at 16 kg/10a of nitrogen. And the varietal differences of yields were highly significant. 3. Plant height and No. of tillers were increased by increasing the nitrogen level, and the No. of tillers of Shiranui was more increased than that of Calady 40, the former is a variety which has an extra short culm, and the latter long culm. 4. Panicle length and No. of grains per panicle were not shown any trends in each variety at the different nitrogen levels, while No. of panicles were increased a little. And No. of grains per panicle was shown the maximum at 13 kg/10a for Norm 6, Palkeum, and Kimmaze, at 16 kg/10a for Shiranui and Kibiyoshi, and at 19kg/10a for Calady 40. 5. Lodging indices of Norm 6, Palkeum and Calady 40 were increased from 3 to 5 by increasing the nitrogen level from 16 kg to 19 kg/10 a, however, a short varity, Shiranui, showed no lodging at the highest nitrogen level of 19 kg/10a. 6. Disease and insect damage were increased by increasing the nitrogen amounts in every varity and the disease damage was more serious than insect one.

회전체 균열과 진동신호와의 상관관계 연구

김정태,조성호 弘益大學校 科學技術硏究所 1996 科學技術硏究論文集 Vol.7 No.1

Application of instantaneous frequency analysis is implemented to investigate a crack inside a rotor. As important parameters of rotor crack detection, rotation speed and gravitational effect are studied. During the study, maximun crack size is increased up to 5% of the rotor radius and the rotating speed is changed from 40% to 50% and 60% of the critical frequency. The investigated results are as follow; (1) At 50 % of critical frequency, harmonic component of 2x is most sensitive to a crack. Also, the output of the instataneous frequency analysis shows stable pattern, whether it is in gravitation or horezental direction. (2) At a sub-critical speed, the amplitude of 2x component is larger than that of 1x. Also, the signal in gravitation direction becomes stable compared to the horizontal direction. Therefore, the vibration monitoring for a rotor craction crack detection is recommended to use the signal measured in the gravitational direction.

벼 大單位 增産團地栽培에 關한 經營實態調査 : 慶南地方의 5個 團地를 中心으로

金厚根,金正敎,尹泰圭,河湖成,張權烈 慶尙大學校 1975 論文集 Vol.14 No.-

Recently large scale cooperative rice production system has been promoted. This cooperative rice production system is intended to promote introducing a set of new technology which may not be suitable for individual small scale farms to adopt. And this system is believed to be one of important public programs to achieve productivity growth policy goal in Korea. Nevertheless, there seem to exist several problems for this public program to widely introduce to over-all nation. This is one of main objectives that this study intends to investigate. In order to study comparative characteristics of the large scale rice cooperative farm in terms of resource base and organization 99 farms which are member farms and 100 farms which are non-member individual farms have been selected and interviewed from five large scale cooperative farm areas in Gyeong-Nam Province in 1974. The important findings can be summarized as follows: 1) Most of operators af both classes belong to age cohert 40∼50, but the average educational level for member farm operators is higher than that for non-member. 2) The average scale Of rice paddy for member farms, 13.1 tanbO, is larger than that for non-member, 10.6, and the same thing is true for average size of rice paddy plots which is, respectively, 805 pyeong and 690. 3) Completely irrigated paddy for member farms is 99 percent of total paddy owned whereas that for non-member is 81, and consolidated paddy for member farms is 67 percent while that for non-member is 26.4. On the other hand, technically improved paddy other than indicated above for member farms is 32 percent, but that for non-member is only 8.3. 4) Number of rice varieties adopted is 9 for both classes. The most popular variety for member farm is Akibare(36%) whereas that for non-member is Sadominori(29.3%) and Akibare (28.4%). 5) Labor used is 13.5 man per tanbo for member farms and 12.4 for non-member. More labor is used for improving soil quality and protection for member farms whereas less labor is used for preparatory works such as seed bed, sterilization, and water management in the case of the member farm. 6) In the case of member farms, the type of work which is achieved cooperatively by more than 70 percent is purchasing or exchaging seeds, sterilization, and plant protection. Despite seed bad, water management, transplanting and the like being more or less suitable for cooperative work, the proportion of those works done cooperatively is relatively small as compared to what we expected. 7) According to farmers interviewed, variety selection, plant protection, seed bed, transplanting fertilization, water management, and harvesting works are more easier for cooperation, in order importance. 8) Cooperative farmers were cultivating a leading variety, Tongil, which showed higher yields than ordinary varieties and had a desire to be released a new high yielding variety which has a characteristics of highly resistance to dsease and insect. 9) Cooperative farmers were forced to begin the nusery bed earlier than the individual farmers and to emphasize on the disease and insect control with more frequencies. 10) Cooperative farmers had benefits in the seedling transplanting earlier and higher planting density than individual farmers. 11) Cooperative farmers had an intention to apply a deep fertilization method arid to dress heavier nitrogen with a reasonable ratio of the basal fertilization to the top dressing. 12) Cooperative farmers had a convenient irrigation system and were available to adopt a summer drainage method. 13) Cooperative farmers controlled the weed with agricultural chemicals arid recognized the control effect of weedcides. 14) In general, it was recognized that there happened somewhat benefit result in disease control in the cooperative farm while a reasonable control effect was not found in heavy prevailing case. The dominant diseases found in the cooperative farm were sheath bright, strip disease and they were to he prevented with a strong efforts. 15) Rice stem borer and grass leaf roller were effelctivey controlled in the cooperative farm, however, plant hoppers was not completely controlled by the usual method because of its unexpected prevalence. 16) The most difficult thing to cooperate they indicate is to supply an adequate amount of labor at appropriate time in tire labor peak season. In this sense, it seems necessary to introduce field machinary in order to achieve the objective of large scale cooperative rice production. 17) Farmers interviewed believe that technology concerning yield increase is most important. in this respect, it is important to develop such new technology, to diseminate its results and to train good quality extension workers. 18) 42 percent of member farm operators indicate that the cooperative system was successful and 25 percent indicate failed. 29 percent of non-member farmers think that the cooperative farm system was successful and 7 percent of them think failed. Thus 55 percent of non-member farmers indicate they are willing to join to the system in the next year, 7 percent of them are not and others have not decided yet. 19) 60 percent of member farmers think that the scale and number of members of the system were too much large to successfully cooperate and 67 percent of them believe that cooperation among members were not very developed, and 42 percent of members suppose what the leader of individual active farms were not very well functioning. 20) Number of member farmers who believe that the yield level in this year is increased as compared that before joining to the system is 3,4 percent, and no one indicated that the yield level is decreased. On the other hand, 22 percent of them believe that by participating to the system the same quality of paddy could produce more rice. 21) About 93 percent of member farmers believe that the system may not lie survived without support of government and i priority must be given to yield technology. 22) About 80 percent of member operators indicate that they would partioipate to the program in the next production year and 23 percent of them indicate that they would participate with the same amount of paddy land as this year. 23) The rice yield level for member and non-member farms is, respectively, 406kg and 346 per tanbo, and the former is 17.3 percent higher than the latter. 24) The cash expenses per tanbo for member and non-member farms is, respectively, 12,311 won and 10,398. 25) The gross revenud per tanbo for both classes is, respectively, 60,024 won, and 51,303 when evaluated by the official price level, and the net income is, respectively, 47,713 won and 40,905. As seen above, the fact that the rice yield level of member farmers, hence, the income level turns out to be higher seems to stem from two basic factors; that is, on the average, the member farmers are operating farm with an improved resource base and they seem to use more the so called conventional inputs with a better yield technology and management. Thus we may conclude that it is important to invest to improve resource quality, to innovate new yield technology and diseminate this innovation. At the same time, in order to more promote the cooperative system, it seems desirable to solve the following problem areas: 1) Number of member farms and paddy area covered by one cooperaitve unit seems better not to he very large. This seems so because there is on much scale economies owing to the nature of technology available to adopt, whereas a large member unit may restrict opportunity of individual members to deeply involve in the process of decision making. Thus we recommend to continue to study finding an optimum size of the unit. 2) As implied already, quality as well as quantity of extension workers and other local officers who lead this program area crucial factor to expand number of unit of the system and hence to achieve the objective of the program. 3) In order to get rid of labor deficit, especially in the labor peak season farm mechanization seems necessary. For this matter, it is worthwhile to promote, first of all, to invent suitable field machinery, secondly, land consolidation and other land improvement projects, and thirdly to innovate a new technology system suitable to mechanized farming. At any rate, it is also necessary for the government to supply an adequate amount of credit and other administrative support.

이비인후과 영역의 급성 감염성 질환에 있어서 Tosugloxacin의 임상적 효과

김희남,김은서,이정권,이호기,김시찬 최신의학사 1996 最新醫學 Vol.39 No.1

제주도 연안 해양환경 중에서 유기인계 농약의 잔류

김정호,오윤근,김정배 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

제주도 연안의 수산물 생산력 향상을 위해서는 연안 해양환경 보전이 무엇보다 중요하다. 특히 골프장의 농약 오염원이 연안환경과 수산생물에 미치는 영향을 규명할 필요가 있다. 따라서 제주도의 농업 오염물질 중 유기인계 농약에 의한 연안해역의 오염을 규명하고자, 1997년 7월과 8월에 남제주도에 위치한 중문골프장에 인접한 색달동과 대포동 근해 해양환경시료에서 monocrotophos와 EPN 유기인계 농약 잔류를 조사하였다. GC-FPD에 의한 monocrotophos와 EPN의 시료중 최소 검출농도는 동ㆍ식물의 고체시료에서는 0.024ng/g, 0.020ng/g이었다. 또한 해수에서는 각각 0.012ng/mL, 0.010ng/mL이었다. 식물시료인 우뭇가사리와 미역, 동물시료인 소라와 성게에 대한 유기인계 농약의 잔류량 조사 결과 모든 시료에서 monocrotophos와 EPN이 검출되지 않았다. monocrotophos와 EPN은 색달동과 대포동에서의 해수와 저니토에서도 검출되지 않았으며, 이러한 결과는 7월, 8월에서도 동일하였다. 따라서 남제주도 중문골프장 근해 해양 환경 중에서는 monocrotophos와 EPN의 유기인계 농약오염은 없는 것으로 나타났다. To investigate the residue of organophosphorus pesticides such as Monocrotophos[Dimethyl-l -methyl-2-methyl carbamoylvinylphosphate] and EPN[O-ethyl-O-4-nitnophenyl phenylphosphonothioate] in the coatal environmen of Cheju island, samples of sea organism, water and sediment were collected at the Sackdaldong and Daepodong near the Jungmoon golf course in July and Aug. 1997. The qualified detection limit of monocrotophos and EPN by GC-FPD were 0.024 ng/g and 0.020 ng/g in the sea organism, respectively. Neither Monocrotophos nor EPN was detected in seaweed cava(Ecklonia cava), Agar(Gelidium amansii), turban sell (Batillus cornutus) and sea urchin (Anthocidaris Crassispina). They were not detected in seawater and sediment either. These results showed that the coastal area near the Jungmoon golf course in the Cheju island was not polluted by the organophosphorus pesticides such as Monoc개tophos and EPN.