http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Taurine Possesses In vitro Antimutagenic Activity Comparable to Major Antioxidants
Mi-Kyung Sung,Hye-Seung Jeon,Taesun Park 한국식품영양과학회 1999 Preventive Nutrition and Food Science Vol.4 No.1
Taurine is known to suppress oxidant-induced tissue injury by stabilizing biomembrane and scavanging free radicals. The purpose of this study was to determine the antioxidative and antimutagenic activities of taurine, and to compare those activities with major antioxidants. For the measurement of antioxidative capacity, 0.05, 0.1, 0.5 and 1.0 ㎎/ml of taurine, L-ascorbic acid, alpha-tocopherol, and BHT (dibutyl hydroxy toluene) were prepared and tested for their ability to donate electrons to DPPH (1,1-diphenyl-2-picryl-hydrazyl). Antimutagenic activity was examined using the Ames salmonella test system at concentrations of 600, 900, and 1200 ㎍/ml. Results indicated that taurine possesses electron-donating capacity, however, the degree of donation was very weak compared to the major antioxidants tested. However, taurine was evaluated as a potent mutation suppressor. Antimutagenic capacity was in increasing order BHT>taurine>L-ascorbic acid>alpha-tocopherol at concentrations of 600 and 900 ㎍/ml. There was a dose-dependent increase in antimutagenicity of these compounds, however, antimutagenicity of the 900 ㎍ taurine/plate was not significantly different from that of 1200 ㎍ taurine/plate. These results indicate that taurine effectively suppresses the mutagenicity of AFB₁ without noticeable electron donating ability.
Mi-Song Kim(김미송),Won Sik Hong(홍원식),Sang Yeop Kim(김상엽),Sung Min Jeon(전성민),Jeong Tak Moon(문정탁) 대한용접·접합학회 2021 대한용접·접합학회지 Vol.39 No.4
Gold-coated silver wire was developed to alleviate the high cost of Au wire used in semiconductor packaging. Ball-bonding and stitch-bonding techniques were used to fabricate the dummy packaging material, comprising 97.3 % Ag, 97.3% Au-Coated Ag, and 99.99 %Au wires. The wire ball shear test (BST), the wire ball pull test (BPT), and the microstructural attributes of the ultrasonic bonding interfaces were compared with the initial properties, both before and after the highly accelerated stress test (HAST), conducted at 130 ℃ and 85% relative humidity (RH). The initial bonding strength for all the wire variants was ≈23~24 gf. Following the HAST, the bonding strength of the Ag wire, the Au-coated Ag wire, and the Au wire decreased by approximately 75 %, 47 %, and 17 %, respectively. The microstructure analysis revealed that cracks developed and propagated at the ends of the interface and that the Au-rich Au-Al intermetallic compound (IMC) inhibited the propagation of the crack at the ACA/Au wire interface. Additionally, it was discovered that the presence of the Ag-Au-Al IMC at the interface of the ACA wire reduced Kirkendall voids, which act as a barrier to Au-Al interdiffusion.
( Mi Young Jeon ),( Beom Kyung Kim ),( Jae Seung Lee ),( Hye Won Lee ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang-hyub Han ),( Seung Up Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Chronic hepatitis B (CHB) patients with immune tolerant (IT)-phase is not generally indicative of antiviral therapy (AVT). We assessed the risk of hepatocellular carcinoma (HCC) during untreated IT-phase stringently defined by lower FIB-4 index, compared to those undergoing AVT. Methods: Among initially screened 125 untreated patients with hepatitis B e antigen positive, HBV-DNA>20,000 IU/ml, and normal alanine aminotransferase from 2012 to 2018, those with FIB-4 index<1.45 were defined as IT-group (n=91). The cumulative probability of HCC was estimated using Kaplan-Meier analysis. Those with history of HCC or cirrhosis were excluded at baseline. Enrolled patients were followed up till HCC development (intention-to-treat [ITT] analysis), whereas those whose follow-up for HCC development was censored at the time when experiencing phase switch (per-protocol [PP] analysis). Results: Cumulative probabilities of HCC at 1-, 3-, and 5-years among IT-group were all 0.0% in (n=91), compared to AVT-treated patients with FIB-4 index<1.45 during the same period (n=928); 0.2%, 0.6%, and 1.4%, respectively (P=0.264 for ITT analysis and P=0.533 for PP analysis). Among initially screened 125 untreated patients, those with FIB-4 index≥1.45 (n=26) had the higher risk of HCC compared to IT-group (n=91) (P=0.005). Furthermore, among AVT-treated patients, those with FIB-4 index≥1.45 (n=1,052) had the higher risk of HCC compared to their counterpart (n=928) (P<0.001). Conclusions: The risk of HCC is almost negligible among IT-group stringently defined through lower FIB-4 index. However, given that the still higher HCC risk among untreated patients with higher FIB-4, appropriate criteria for AVT should be established.
Jeon, Hye-Mi,Ahn, Yong-Woo,Jeong, Sung-Hee,Ok, Soo-Min,Choi, Jeomil,Lee, Ju-Youn,Joo, Ji-Young,Kwon, Eun-Young Korean Academy of Periodontology 2017 Journal of Periodontal & Implant Science Vol.47 No.4
Purpose: The purpose of the present study was to perform a pattern analysis in patients with temporomandibular disorder (TMD) resulting from unilateral mastication due to chronic periodontitis. Methods: Thirty participants with signs or symptoms of TMD who engaged in unilateral mastication due to periodontitis-related discomfort (test group) were selected. Another 30 subjects exhibiting signs or symptoms of TMD resulting from unilateral mastication not due to chronic periodontitis (control group) were also recruited. An interview-based questionnaire was administered, and an examination of the temporomandibular joint (TMJ) with determination of periodontal status was performed. Results: The duration of unilateral mastication was significantly longer in the control group than in the test group. There was a significant negative correlation between the duration of unilateral mastication and the Community Periodontal Index score. Using the Research Diagnostic Criteria for TMD (RDC/TMD) axis I algorithms, all the subjects were assigned to 3 main groups. The test group exhibited significantly a higher diagnostic distribution of group III (arthralgia, osteoarthritis, or osteoarthrosis), and in both the test and control groups, the number of diagnoses was larger for the non-chewing side. The control group showed a significantly higher diagnostic distribution of group I (myofacial pain), and in both the test and control groups, the number of diagnoses was larger for the chewing side. Conclusions: The results of the present study indicate that unilateral mastication due to chronic periodontitis could induce not only pain but also structural TMJ changes if adequate treatment is not administered and supported within a short time from the onset of the condition. Therefore, immediate treatment of chronic periodontitis is recommended to prevent not only the primary progress of periodontal disease, but also secondary TMJ-related problems. Furthermore, subjects who have suffered chronic long-term periodontitis without treatment should be urged to undergo a TMJ examination.
( Mi Ra Kim ),( Sang Soo Kim ),( Jung Eun Huh ),( Byung Joo Lee ),( Jin Choon Lee ),( Yun Kyung Jeon ),( Bo Hyun Kim ),( Seong Jang Kim ),( Soo Geun Wang ),( Yong Ki Kim ),( In Joo Kim ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.1
Background/Aims: Obesity is correlated with numerous diseases, including thyroid cancer, but the clinical significance of obesity with regard to the clinical characteristics of thyroid cancer remains unclear. Neck circumference is an index of upper-body adipose tissue distribution. Methods: In total, 401 patients with papillary thyroid carcinoma (PTC) measuring ≤ 2 cm were included. Neck circumference was measured horizontally at the level just below the thyroid cartilage on preoperative neck computed tomographic images. Results: Neck circumference correlated significantly with tumor size in men (p = 0.001) but not in women (p = 0.930). Body mass index (BMI) did not significantly correlate with tumor size in either sex. Neck circumference was significantly larger in men with lateral lymph node (LN) metastasis than in those without (p = 0.004). Neck circumference and BMI did not differ significantly in women according to other factors such as tumor size, multifocality, extrathyroid extension, and LN metastasis. Tumor size and the prevalence of lateral LN metastasis in men tended to increase in the middle/large neck circumference subgroup compared with those in the low neck circumference subgroup. Multivariate logistic regression analysis revealed that neck circumference (p = 0.009) was a predictor for the presence of lateral LN metastasis in men. BMI was not a predictive factor for lateral LN involvement in either sex. Conclusions: Neck circumference, an indicator of central or visceral obesity but not BMI, may be associated with some prognostic factors in men with small PTC.
Jeon Young Hun,Lee Ji Ye,Yoo Roh-Eul,Rhim Jung Hyo,Lee Kyung Hoon,Choi Kyu Sung,Hwang Inpyeong,Kang Koung Mi,Kim Ji-hoon 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.9
Objective: This study aimed to validate the risk stratification system (RSS) and biopsy criteria for cervical lymph nodes (LNs) proposed by the Korean Society of Thyroid Radiology (KSThR). Materials and Methods: This retrospective study included a consecutive series of preoperative patients with thyroid cancer who underwent LN biopsy, ultrasound (US), and computed tomography (CT) between December 2006 and June 2015. LNs were categorized as probably benign, indeterminate, or suspicious according to the current US- and CT-based RSS and the size thresholds for cervical LN biopsy as suggested by the KSThR. The diagnostic performance and unnecessary biopsy rates were calculated. Results: A total of 277 LNs (53.1% metastatic) in 228 patients (mean age ± standard deviation, 47.4 years ± 14) were analyzed. In US, the malignancy risks were significantly different among the three categories (all P < 0.001); however, CTdetected probably benign and indeterminate LNs showed similarly low malignancy risks (P = 0.468). The combined US + CT criteria stratified the malignancy risks among the three categories (all P < 0.001) and reduced the proportion of indeterminate LNs (from 20.6% to 14.4%) and the malignancy risk in the indeterminate LNs (from 31.6% to 12.5%) compared with US alone. In all image-based classifications, nodal size did not affect the malignancy risks (short diameter [SD] ≤ 5 mm LNs vs. SD > 5 mm LNs, P ≥ 0.177). The criteria covering only suspicious LNs showed higher specificity and lower unnecessary biopsy rates than the current criteria, while maintaining sensitivity in all imaging modalities. Conclusion: Integrative evaluation of US and CT helps in reducing the proportion of indeterminate LNs and the malignancy risk among them. Nodal size did not affect the malignancy risk of LNs, and the addition of indeterminate LNs to biopsy candidates did not have an advantage in detecting LN metastases in all imaging modalities.