2014년 영천시의 한 물놀이장에서 유행한 피부 질환 역학조사

박지혁 ( Ji Hyuk Park ),임현술 ( Hyun Sul Lim ),이관 ( Kwan Lee ),하경임 ( Gyoung Yim Ha ),정태선 ( Taesun Jeong ) 대한보건협회 2015 대한보건연구 Vol.41 No.2

Objective: An outbreak of skin rash illness was reported from people who had been to a water park located in Yeongcheon-si. Epidemiologic investigation was performed to elucidate the cause of this outbreak and to prevent a recurrence. Methods: Medical records of clinics and hospitals in Yeongcheon-si were reviewed to find cases of skin rash illness. The manager of the water park was interviewed, and the collected water samples were analyzed and tested for bacterial culture. Results: Seventy-one cases, consisted of 42 men (59.2%) and 29 women (40.8%), were experienced skin rash illness. Most of the cases (98.6%) were children under 20 years and all cases went to the water park. A swimming pool for adults used underground and lake water, and residual chlorine was not detected. The water samples were positive for various bacteria, including Aeromonas sobria and Pseudomonas putida. Conclusion: This outbreak was linked to the contaminated water of swimming pools. The water park was reopened after appropriate chlorine disinfection, and another outbreak was not reported until late 2014. Chlorine disinfection of water in swimming pools should be conducted, and enhanced chlorine monitoring is needed.

[SP1-4] Genes Regulated in the High-Fat-Die-Induced Obesity

Taesun Park 한국식품영양과학회 2007 한국식품영양과학회 학술대회발표집 Vol.2007 No.10

Piperine, a Componentof Black Pepper, Inhibits Adipogenesisby Antagonizing PPARγ Activity in 3T3-L1 Cells

Park, Ui-Hyun,Jeong, Hong-Suk,Jo, Eun-Young,Park, Taesun,Yoon, SeungKew,Kim, Eun-Joo,Jeong, Ji-Cheon,Um, Soo-Jong American Chemical Society 2012 Journal of agricultural and food chemistry Vol.60 No.15

<P>This study investigated the antiadipogenic activity of black pepper extract and its constituent piperine in 3T3-L1 preadipocytes as well as the underlying molecular mechanisms. Both black pepper extract and piperine, without affecting cytotoxicity, strongly inhibited the adipocyte differentiation of 3T3-L1 cells. The mRNA expression of the master adipogenic transcription factors, PPAR gamma, SREBP-1c, and C/EBP beta, was markedly decreased. Intriguingly, mRNA levels of PPAR gamma target genes were also down-regulated. Moreover, a luciferase reporter assay indicated that pipierine significantly represses the rosiglitazone-induced PPAR gamma transcriptional activity. Finally, GST-pull down assays demonstrated that piperine disrupts the rosiglitazone-dependent interaction between PPAR gamma and coactivator GBP. Genome-wide analysis using microarray further supports the role of piperine in regulating genes associated with lipid metabolism. Overall, these results suggest that piperine, a major component of black pepper, attenuates fat cell differentiation by down-regulating PPAR gamma activity as well as suppressing PPAR gamma expression, thus leading to potential treatment for obesity-related diseases.</P>

Polyphenolic compounds from Korean <i>Lonicera japonica</i> Thunb. induces apoptosis via AKT and caspase cascade activation in A549 cells

Park, Kwang Il,Park, Hyeonsoo,Nagappan, Arulkumar,Hong, Gyeong Eun,Yumnam, Silvia,Lee, Ho Jeong,Kim, Eun Hee,Lee, Won Sup,Shin, Sung Chul,Kim, Jin A,Lee, Sang Joon,Ma, Jin Yeul,Min, Taesun,Heo, Jeong D.A. Spandidos 2017 Oncology letters Vol.13 No.4

<P><I>Lonicera japonica</I> Thunb. (<I>L. japonica</I> T.) has historically been used in Korean herbal medicine due to its anticancer and protective effects on the respiratory system. In the present study, the polyphenolic compounds in <I>L. japonica</I> T. were investigated using high-performance liquid chromatography coupled with tandem mass spectrometry, and its anticancer effects on A549 non-small-cell lung cancer cells were studied. Polyphenolic compounds potentially inhibit A549 cells in a dose-dependent manner. Flow cytometry and western blot analysis demonstrated that polyphenolic compounds induce apoptosis by regulating the protein expression levels of caspases, poly-(ADP-ribose) polymerase and the B-cell lymphoma-2-associated X-protein/B-cell lymphoma-extra large ratio. Furthermore, polyphenolic compounds inhibited mitochondrial membrane potential activity. Caspase-3 activity was increased in a dose-dependent manner and polyphenolic compounds inhibited the activation of protein kinase B by dephosphorylation. These results suggest that polyphenolic compounds in A549 cells indicate the anticancer activity through the induction of apoptosis.</P>

G-Protein Coupled Receptors as Novel Targets for Treating Obesity and Metabolic Diseases

Taesun Park 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

Hepatic and Renal Cysteine Sulfinic Acid Decarboxylase Activities in Cats Fed Different Levels of Dietary Protein and Taurine

Taesun Park,Quinton R. Rogers 한국식품영양과학회 1999 Preventive Nutrition and Food Science Vol.4 No.1

In order to evaluate the dietary regulation of cysteine sulfinic acid decarboxylase (EC 4.1.1.29) in cats, activity and protein content of CSAD were assessed in the liver and kidney of cats fed different levels of dietary protein, with and without taurine. Four groups of cats were fed one of the following diets for 5 weeks: 20% protein and taurine-free diet (LPOT); 20% protein and 0.15% taurine diet (LPNT); 60% protein and taurine-free diet (HPOT); and 60% protein and 0.15% taurine diet (HPNT). CSAD activity was determined in the liver and kidney of cats by measuring ¹⁴CO₂ released from [1-¹⁴C]-L cysteine sulfinic acid. CSAD protein was quantified using an immunochemical method. CSAD activity was extremely low in cat tissues, among which kidney showed the highest activity which was 0.118±0.050, and 0.377±0.056 nmolㆍmin^(-1)ㆍ㎎ soluble protein^(-1) in animals fed LPOT and HPOT, respectively. Even though renal CSAD protein content was 18-55% of the hepatic CSAD protein content, renal CSAD activity was 1.3~6.5 times of the hepatic CSAD activity. Renal CSAD activities of cats fed 60% protein were about 1.6~3.2 times those of animals fed 20% protein, and hepatic CSAD activity was not significantly affected by the dietary level of protein. Taurine depletion significantly elevated both hepatic and renal CSAD activities above the values for cats having normal taurine status most probably as an adaptive response.

Octacosanol Supplementation Increases Running Endurance Time and Improves Biochemical Parameters After Exhaustion in Trained Rats

Taesun Park,Hyunjung Kim,Sunghee Park,Dae Suk Han 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.4

This study evaluated the effects of octacosanol on runing performance and related biochemical parameters inexercise-trained rats run to exhaustion on a treadmill. Male Sprague Dawley rats were randomly assigned to one of threegroups sedentary control group (SC), exercise-trained control group (EC), and exercise-trained, octacosanol-suplementedgroup (EO) and raised on either control or octacosanol (0.75%)-supplemented diet with (or without for SC rats) exercise-traing for 4 weeks. EC rats ran 184% longer until exhaustion than SC rats (P, .01), while octacosanol-suplemented trainedrats ran 46% longer than EC rats (P, .05). Under the exhausted state immediately following the runing performance test,EO rats exhibited significantly higher plasma ammonia and lactate concentrations compared with the values for EC rats (P,.05). Although EO rats ran significantly longer until exhausted, their plasma glucose level and gastronecmius muscle glyco-gen concentration were not significantly different from those of EC rats. Dietary suplementation of octacosanol resulted insignificantly higher creatine phosphokinase activity in plasma (44% increase, P, .01) and citrate synthase activity in mus-cle (16% increase, P, .01) of exercise-trained rats. These results sugest that the ergogenic properties of octacosanol includethe sparing of muscle glycogen stores and increases in the oxidative capacity in the muscle of exercise-trained rats.

Oleuropein attenuates hepatic steatosis induced by high-fat diet in mice

Park, Soyoung,Choi, Youngshim,Um, Soo-Jong,Yoon, Seung Kew,Park, Taesun Elsevier 2011 Journal of hepatology Vol.54 No.5

<P><B>Background & Aims</B></P><P>Oleuropein, a secoiridoid derived from olives and olive oil, has been known to possess antimicrobial, antioxidative, and anticancer activities. The purpose of the present study was to determine whether oleuropein has a protective effect against hepatic steatosis induced by a high fat diet (HFD) and to elucidate its underlying molecular mechanisms in mice.</P><P><B>Methods</B></P><P>Male C57BL/6N mice were fed a normal diet (ND), HFD, or an oleuropein-supplemented diet (OSD) for 10weeks. The plasma and hepatic lipid levels were determined, and the hepatic gene and protein expression levels were analysed via RT-PCR and Western blotting, respectively.</P><P><B>Results</B></P><P>The supplementation of HFD with oleuropein reversed the HFD-induced increases in liver weight along with plasma and hepatic lipid levels in mice. The expression of Wnt10b inhibitor genes, such as secreted firizzed-related sequence protein 5 and dickkopf homolog 2, was downregulated, whereas the β-catenin protein expression was upregulated in the liver of OSD-fed mice compared to HFD-fed mice. Fibroblast growth factor receptor 1 (FGFR1), phosphoextracellular-signal-regulated kinase 1/2, cyclin D, and E2F transcription factor 1, along with several key transcription factors and their target genes involved in adipogenesis, were downregulated by oleuropein. OSD-fed mice exhibited decreased expression of the toll-like-receptor-(TLR)-mediated signaling molecules (TLR2, TLR4, and myeloid differentiation primary-response gene 88) and proinflammatory cytokines, in their livers, as compared to HFD mice.</P><P><B>Conclusions</B></P><P>These results suggest that the protective effects of oleuropein against HFD-induced hepatic steatosis in mice appear to be associated with the Wnt10b- and FGFR1-mediated signaling cascades involved in hepatic lipogenesis, along with the TLR2- and TLR4-mediated signaling implicated in hepatic steatosis.</P>

Educational and interactive informed consent process for treatment of unruptured intracranial aneurysms

Park, Jaechan,Son, Wonsoo,Park, Ki-Su,Kang, Dong-Hun,Lee, Joomi,Oh, Chang Wan,Kwon, O-Ki,Kim, Taesun,Kim, Chang-Hyun American Association of Neurological Surgeons 2017 Journal of Neurosurgery Vol.126 No.3

<B>OBJECTIVE</B><P>For patients with unruptured intracranial aneurysms (UIAs), the information transfer that precedes informed consent needs to be in-depth and detailed, as most patients with a UIA have no symptoms, yet the risks related to treatment are relatively high. Thus, in this study an educational and interactive program was proposed for patients with UIAs to improve the informed consent process and assess the level of comprehension.</P><B>METHODS</B><P>A total of 110 patients with UIAs underwent the proposed educational and interactive informed consent (EIIC) process and were enrolled in this study. The EIIC process combines patient education using information booklets, a cartoon book, a video, an initial physician-patient interview, answering a questionnaire, a second physician-patient interview based on the questionnaire results, and finally consent. After the first physician-patient interview that provides the patient with specific information, including his or her angiographic characteristics, medical condition, and recommended treatment, the patient is requested to answer a questionnaire composed of 3 parts: demographic information, including the patient's age, sex, and years of education; 13 medical questions to assess the patient's knowledge about his or her UIA; and an evaluation of the usefulness of the educational resources. The control group consisted of 65 patients from 3 other tertiary university hospitals where the EIIC process was not used.</P><B>RESULTS</B><P>The questionnaire scores of the EIIC group ranged from 7 to 13 (mean ± SD: 11.9 ± 1.3) and were significantly higher than those for the controls (10.2 ± 1.9, p < 0.001). The better comprehension of the patients in the EIIC group was remarkable as they were significantly older than those in the control group (62.7 ± 8.3 years vs 55.9 ± 10.5 years, respectively; p < 0.001). For both the EIIC group and the control group, a Pearson correlation analysis revealed a positive correlation (r = 0.232 for the EIIC group, r = 0.603 for controls) between the years of education and the questionnaire score (p = 0.015 for the EIIC group, p < 0.001 for the controls), whereas no correlation was found between the patient age and the questionnaire score. For the EIIC group, the verbal information from the attending physician was selected by 90 patients (81.8%) as the most useful and informative educational method, while the most effective reinforcement of this verbal communication was the video (n = 86; 78.2%), information booklets (n = 16; 14.5%), the Internet (n = 7; 6.4%), and the cartoon book (n = 1; 0.9%).</P><B>CONCLUSIONS</B><P>The proposed standardized EIIC process resulted in good patient comprehension about UIAs. The verbal information from the attending physician was the most informative, and the video was the most effective reinforcement of the verbal communication. The patient level of comprehension was shown to be correlated with years of education.</P>

On the Causes of Passives in English, Korean and Chinese from a Corpus-Based Approach

Taesun Park(박태선) 언어과학회 2020 언어과학연구 Vol.0 No.93

This study examines the factors of passive voice in Korean, English, and Chinese from authentic data through the use of a corpus. The corpora used in this study are NIKLC for Korean, BNC for English, and ECPC for Chinese. The result shows that in English, topicality is the highest factor, connectedness is the second factor, and circumstances dependency is the third factor. In Korean, topicality is the highest factor, circumstances dependency is the second factor and connectedness is the third factor. In Chinese, affectedness is the highest factor, connectedness is the second factor, and topicality is the third factor. Agent omission phenomenon is a common characteristic in the three languages. Circumstances dependency, which is characteristic of Korean passive, is the lowest in English. Though the corpora used in this study may not be completely perfect in their content, this research has its value in the fact that it tries to compare the three languages through the use of a corpus.