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Anti-cariogenic Characteristics of Rubusoside
Jeesoo Kim,Thi Thanh Hanh Nguyen,Juhui Jin,Iis Septiana,Gyu-Min Son,Gang-Hee Lee,You-Jin Jung,Dilshad Qureshi,목일균,Kunal Pal,Soo-Yeon Yang,Seong-Bo Kim,Doman Kim 한국생물공학회 2019 Biotechnology and Bioprocess Engineering Vol.24 No.2
Streptococcus mutans plays an important role in the development of dental caries in humans by synthesizing adhesive insoluble glucans from sucrose by mutansucrase activity. To explore the anti-cariogenic characteristics of rubusoside (Ru), a natural sweetener component in Rubus suavissimus S. Lee (Rosaceae), we investigated the inhibitory effect of Ru against the activity of mutansucrase and the growth of Streptococcus mutans. Ru (50 mM) showed 97% inhibitory activity against 0.1 U/mL mutansucrase of S. mutans with 500 mM sucrose. It showed competitive inhibition with a Ki value of 1.1 ± 0.2 mM and IC50 of 2.3 mM. Its inhibition activity was due to hydrophobic and hydrogen bonding interactions based on molecular docking analysis. Ru inhibited the growth of S. mutans as a bacteriostatic agent, with MIC and MBC values of 6 mM and 8 mM, respectively. In addition, Ru showed synergistic anti-bacterial activity when it was combined with curcumin. Therefore, Ru is a natural anti-cariogenic agent with antimutansucrase activity and antimicrobial activity against S. mutans.
이지수(Jeesoo Lee),송시몬(Simon Song),조지현(Jee-Hyun Cho) 한국가시화정보학회 2014 한국가시화정보학회지 Vol.12 No.1
Magnetic resonance velocimetry (MRV) is a versatile flow visualization technique using magnetic resonance imaging machine developed for the medical purpose. Recently, MRV is often utilized to analyze engineering flows due to its superior features of MRV such as capabilities of measuring flows with complicated, opaque flow geometry unlike optical techniques, 3-dimensional volumetric velocity vectors within a few hours, and etc. The purpose of this study was to validate the MRV data and evaluate the accuracy of the mean velocity profiles that we acquired for a turbulent flow in a circular pipe using a MR machine installed in Korea Basic Science Institute, Ochang, Korea. In addition, we briefly describe a procedure of parameter optimization for the operation of MRV. The results indicate that the MRV measurements provided well resolved mean velocity fields with a quite reasonable accuracy according to the inner and outer layer scaling laws of the turbulent pipe flows.
Chae Jeesoo,Jung Seung-Hyun,Choi Eun Ji,Kim Jae Woong,Kim Na Yung,Moon Sung Won,Lee Ji Youl,Chung Yeun-Jun,Lee Sug Hyung 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
This study aimed to identify somatic mutations in nontumor cells (NSMs) in normal prostate and benign prostatic hyperplasia (BPH) and to determine their relatedness to prostate cancer (PCA). From 22 PCA patients, two prostates were sampled for 3-dimensional mapping (50 normal, 46 BPH and 1 PCA samples), and 20 prostates were trio-sampled (two normal or BPH samples and one PCA sample) and analyzed by whole-genome sequencing. Normal and BPH tissues harbored several driver NSMs and copy number alterations (CNAs), including in FOXA1, but the variations exhibited low incidence, rare recurrence, and rare overlap with PCAs. CNAs, structural variants, and mutation signatures were similar between normal and BPH samples, while BPHs harbored a higher mutation burden, shorter telomere length, larger clone size, and more private NSMs than normal prostates. We identified peripheral-zonal dominance and right-side asymmetry in NSMs, but the asymmetry was heterogeneous between samples. In one normal prostate, private oncogenic RAS-signaling NSMs were detected, suggesting convergence in clonal maintenance. Early embryonic mutations exhibited two distinct distributions, characterized as layered and mixed patterns. Our study identified that the BPH genome differed from the normal prostate genome but was still closer to the normal genome than to the PCA genome, suggesting that BPH might be more related to aging or environmental stress than to tumorigenic processes.
자기공명유속계를 이용한 진공청소기 노즐 아래 카펫 내부 유동의 3차원 가시화
이지수(Jeesoo Lee),양병권(Byungkuen Yang),송시몬(Simon Song) 한국가시화정보학회 2015 한국가시화정보학회 학술발표대회 논문집 Vol.2015 No.12
3D mean flow field inside a carpet induced by a suction nozzle of a vacuum cleaner was visualized using magnetic resonance velocimetry (MRV). Nozzle with three different shape of nozzle lips were tested and their effects on a flow distribution within carpet were analyzed. Measured data were validated by comparing flow rate computed from MRV data with flow meter value measured during experiments. We successfully observed distinct flow patterns caused by the geometry of each nozzle at least qualitatively. Distributions of incoming velocities along the carpet depth under the boundary of nozzles were investigated for the qunatitative analysis. We found that the nozzle with longer lips tends to generate relatively uniform profile than the nozzle with shorter lips. Furthermore the shorter lips induces stronger incoming flow at near the carpet surface.
전방위적분법과 속도장을 이용한 3 차원 다공성 유동의 압력장 예측
이지수(Jeesoo Lee),송시몬(Simon Song) 대한기계학회 2016 대한기계학회 춘추학술대회 Vol.2016 No.12
We have developed a method to estimate 3D static pressure fields in porous media using omnidirectional integration method to a given velocity field data. A magnetic resonance velocimeter is used to obtain 3D 3C velocity vectors of a flow inside a carpet experimentally. 3D pressure gradient field were then computed using the Darcy-Forchheimer’s model which describes the relation between differential pressure and velocity of a flow through a porous medium. Finally, the pressure field were obtained by numerically integrating the pressure gradient along arbitrary paths. An omnidirectional integration method is used to derive the pressure independent of integration paths. The detailed procedure and validation of the method will be given in the presentation.