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Inter-Domain QoS Routing Scheme Using BGP Information in Global Internet
Jin Ju Lee,Seung-Hyuk Choi,Min Young Chung,Mijeong Yang,Taeil Kim,Jaehyung Park 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
In order to provide end-to-end Quality of Service (QoS) in the Internet, each connection should be satisfied with QoS requirements in both intra-domain and inter-domain. However, since Border Gateway Protocol (BGP) is an inter- Autonomous System (AS) routing protocol based on path vector, it is hard to guarantee end-to-end QoS in multi-domain environments. To overcome difficulty of inter-domain routing and maintain backward compatibility, Path Computation Element (PCE) is introduced to manage link state information and compute QoS paths. In this paper, we propose an inter-domain QoS routing scheme using BGP information to reduce connection setup delay in the Internet with PCE. We also compare the performance of the proposed scheme with those of conventional PCE structures. The results show that the performance of the proposed scheme is superior to the those of conventional ones.
Olfactory marker protein regulation of glucagon secretion in hyperglycemia
Oh Ju Hun,Han Ye Eon,Bao Ya Ru,Kang Chan Woo,Koo JaeHyung,Ku Cheol Ryong,Cho Yoon Hee,Lee Eun Jig 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
The olfactory marker protein (OMP), which is also expressed in nonolfactory tissues, plays a role in regulating the kinetics and termination of olfactory transduction. Thus, we hypothesized that OMP may play a similar role in modulating the secretion of hormones involved in Ca2+ and cAMP signaling, such as glucagon. In the present study, we confirmed nonolfactory α-cell-specific OMP expression in human and mouse pancreatic islets as well as in the murine α-cell line αTC1.9. Glucagon and OMP expression increased under hyperglycemic conditions. Omp knockdown in hyperglycemic αTC1.9 cells using small-interfering RNA (siRNA) reduced the responses to glucagon release and the related signaling pathways compared with the si-negative control. The OMPlox/lox;GCGcre/w mice expressed basal glucagon levels similar to those in the wild-type OMPlox/lox mice but showed resistance against streptozotocin-induced hyperglycemia. The ectopic olfactory signaling events in pancreatic α-cells suggest that olfactory receptor pathways could be therapeutic targets for reducing excessive glucagon levels.
Zhiming Cui,Jaehyung Ju 대한기계학회 2022 대한기계학회 춘추학술대회 Vol.2022 No.11
Mechanical couplings such as axial–shear and axial–bending have great potential in designing active mechanical metamaterials with directional control of input and output loads in sensors and actuators. However, the current ad hoc design of mechanical coupling without theoretical support of elasticity cannot provide design guidelines for mechanical coupling with lattice geometries. Moreover, the correlation between mechanical coupling effects and geometric symmetry is not yet clearly understood. In this work, we systematically search for all possible mechanical couplings in 2D lattice structures by determining the nonzero diagonal terms in the decomposed micropolar elasticity tensor. We also correlate the mechanical couplings with the point-group symmetry of 2D lattices by applying the symmetry operation to the decomposed micropolar elasticity tensor. The decoupled micropolar constitutive equation uncovers eight coupling effects for 2D lattice structures. The symmetry operation of the decoupled micropolar elasticity tensor reveals the correlation of the mechanical coupling with the point groups. Our findings can strengthen the design of mechanical metamaterials with potential applications in areas including sensors, actuators, soft robots, and active metamaterials for elastic/acoustic wave guidance and thermal management.