http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Pro-Apoptotic Activity of 4-Isopropyl-2-(1-Phenylethyl) Aniline Isolated from Cordyceps bassiana
Kim, Mi Seon,Lee, Yunmi,Sung, Gi-Ho,Kim, Ji Hye,Park, Jae Gwang,Kim, Han Gyung,Baek, Kwang Soo,Cho, Jae Han,Han, Jaegu,Lee, Kang-Hyo,Hong, Sungyoul,Kim, Jong-Hoon,Cho, Jae Youl The Korean Society of Applied Pharmacology 2015 Biomolecules & Therapeutics(구 응용약물학회지) Vol.23 No.4
Cordyceps species including Cordyceps bassiana are a notable anti-cancer dietary supplement. Previously, we identified several compounds with anti-cancer activity from the butanol fraction (Cb-BF) of Cordyceps bassiana. To expand the structural value of Cb-BF-derived anti-cancer drugs, we employed various chemical moieties to produce a novel Cb-BF-derived chemical derivative, KTH-13-amine-monophenyl [4-isopropyl-2-(1-phenylethyl) aniline (KTH-13-AMP)], which we tested for anti-cancer activity. KTH-13-AMP suppressed the proliferation of MDA-MB-231, HeLa, and C6 glioma cells. KTH-13-AMP also dose-dependently induced morphological changes in C6 glioma cells and time-dependently increased the level of early apoptotic cells stained with annexin V-FITC. Furthermore, the levels of the active full-length forms of caspase-3 and caspase-9 were increased. In contrast, the levels of total forms of caspases-3, caspase-8, caspase-9, and Bcl-2 were decreased in KTH-13-AMP treated-cells. We also confirmed that the phosphorylation of STAT3, Src, and PI3K/p85, which is linked to cell survival, was diminished by treatment with KTH-13-AMP. Therefore, these results strongly suggest that this compound can be used to guide the development of an anti-cancer drug or serve as a lead compound in forming another strong anti-proliferative agent.
Kim, Jaegu,Kim, Jae-Hyun,Cho, Sung-Hak,Whang, Kyung-Hyun Springer-Verlag 2016 APPLIED PHYSICS A MATERIALS SCIENCE AND PROCESSING Vol.122 No.4
<P>Selective laser lift-off of GaN from a sapphire substrate was demonstrated using 266-nm diode-pumped solid-state laser irradiation. To fabricate a single GaN light-emitting diode (LED) with a size of 100 mu m 9 100 mu m, we used a simple direct scanning technique with a defocused beam and investigated the liftoff parameter in terms of the intensity. Two processing windows corresponding to lower- and higher-intensity regimes were observed experimentally. In the lower-intensity regime, the larger beam size worked better than with the higher regime. Although fluence is generally explained as a processing condition, the total input fluence for a single LED was not crucial to lift-off in case of the scanning technique using a defocused laser beam. However, an intensity of similar to 37 kW/cm(2) was required to initiate the thermal decomposition reaction in GaN at any sample position.</P>
Yoon, Min-Ah,Kim, Chan,Hur, Min,Kang, Woo Seok,Kim, Jaegu,Kim, Jae-Hyun,Lee, Hak-Joo,Kim, Kwang-Seop Elsevier 2018 APPLIED SURFACE SCIENCE - Vol.428 No.-
<P><B>Abstract</B></P> <P>The adhesion between a stamp and thin film devices is crucial for their transfer on a flexible substrate. In this paper, a thin adhesive silicone layer on the stamp was treated by atmospheric pressure plasma to locally control the adhesion strength for the selective transfer. The adhesion strength of the silicone layer was significantly reduced after the plasma treatment, while its surface energy was increased. To understand the inconsistency between the adhesion strength and surface energy changes, the surface properties of the silicone layer were characterized using nanoindentation and X-ray photoelectron spectroscopy. These techniques revealed that a thin, hard, silica-like layer had formed on the surface from plasma-enhanced oxidation. This layer played an important role in decreasing the contact area and increasing the interfacial slippage, resulting in decreased adhesion. As a practical application, the transfer process was demonstrated on GaN LEDs that had been previously delaminated by a laser lift-off (LLO) process. Although the LEDs were not transferred onto the treated adhesive layer due to the reduced adhesion, the untreated adhesive layer could readily pick up the LEDs. It is expected that this simple method of controlling the adhesion of a stamp with a thin adhesive layer would enable a continuous, selective and large-scale roll-to-roll selective transfer process and thereby advance the development of flexible, stretchable and wearable electronics.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A thin adhesive silicone layer was treated by atmospheric pressure plasma to control the adhesion strength. </LI> <LI> The adhesion strength of the layer was reduced after the plasma treatment, while its surface energy was increased. </LI> <LI> It was confirmed that a thin, hard, silica-like layer had formed on the surface from plasma-enhanced oxidation. </LI> <LI> The silica-like layer played an important role in increasing the interfacial slippage, resulting in decreased adhesion. </LI> <LI> The usefulness of the plasma treatment was demonstrated for the selective transfer process of GaN LEDs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ivermectin, praziquantel, tamiflu, triclosan의 환경위해성평가
류태권(Taekwon Ryu),김정곤(Jungkon Kim),김경태(Kyungtae Kim),이재우(Jaewoo Lee),김지은(Jieun Kim),조재구(Jaegu Cho),윤준헌(Junheon Yoon),이재안(Jaean Lee),김필제(Pilje Kim),류지성(Jisung Ryu) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.2
Objectives: The purpose of this study was to assess environmental risk on the emerging contaminants of concern, such as ivermetin, parziquantel, tamiflu and triclosan. Furthermore, we tried to provide a more efficient management practice and a basis for future studies of risk assessment on those substances. Methods: Predicted no effect concentration (PNEC) and predicted environmental concentration (PEC) were determined through modeling and literature reviews. Environmental risk assessment was evaluated by calculating HQ (hazard quotient) by a comparison of PEC (or measured environmental concentration (MEC)) and PNEC. Results: HQ value of tamiflu calculated from MEC was 1.9E-03. For ivermectin and triclosan, the HQ values were not available because these were not detected in the aquatic environment. The toxicity of ivermectin and triclosan showed a very low value, indicating a high level of HQ. However, praziquantel can be categorized into the material that do not require management since they have less than HQ 1. Conclusion: Based on the results of the initial risk assessment, it is assumed that the ivermectin and triclosan have potential to cause direct adverse effects on the aquatic environment. To conduct an accurate environmental risk assessment, the further study on PEC estimation of such contaminants should be actively carried out.