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OECD QSAR Application Toolbox를 이용한 화학물질의 건강유해성 및 생태독성 예측
김정곤,서정관,김탁수,김현경,박상희,김필제,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Kim, Hyun-Kyung,Park, Sanghee,Kim, Pil-Je 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.2
Objectives: The OECD QSAR Application Toolbox was developed by the Organisation for Economic Cooperation and Development (OECD) to facilitate the practical use of QSAR approaches in regulatory contexts as well as to reduce the need for additional animal testing. In this study, human health and the ecotoxicity of chemicals were predicted by applying the OECD QSAR Application Toolbox and the results were compared with experimental data in order to evaluate the applicability of this program. Methods: Read-across, trend analysis, and QSAR of OECD QSAR Application Toolbox were used for the prediction of toxicity. Results: The toxicity prediction was conducted on 6,354 chemicals for which toxicity data have been produced on the six endpoints of skin sensitization, skin irritation, eye irritation, mutagenicity, and acute toxicities of fish and Daphnia. From the total of 6,354, we obtained prediction results for 1,621 chemicals (25.5%). Conclusions: The predicted properties of mutagenicity, skin sensitization, and acute aquatic toxicities were reasonably good when compared with experimental data, but other endpoints were not due to the limitation of applicable chemical groups.
어린이용품에 함유된 휘발성유기화합물의 비발암 위해성평가
김정곤,서정관,김탁수,박건호,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Park, Gun-Ho 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.3
Background: This study was conducted to assess health risks in regard to exposure by children to volatile organic compounds (VOCs) in children's products. Methods: Ten VOCs were measured by head-space gas chromatography in children's products, including toys, oil pastels, sign pens, furniture, ball pools, and playmats. We estimated the average daily dose (ADD) via inhalation during the use of these children's products and calculated hazard quotient (HQ) by dividing ADD by reference dose of VOCs. Results: Among the measured VOCs, five compounds were identified in children's products: benzene, ethylbenzene, styrene, toluene, and xylene. The detection rates of VOCs in toys, ball pools, furniture, playmats, sign pens, and oil pastels were 85%, 100%, 100%, 30%, 100%, and 60%, respectively. The maximum levels of VOCs were 0.18 mg benzene/kg in toys, 5.92 mg toluene/kg in playmats, 10.37 mg ethylbenzene/kg in ball pools, 24.85 mg xylene/kg in toys, and 118.29 mg styrene/kg in ball pools. From exposure levels of VOCs in the children's products HQs were calculated within a range of $5.71{\times}10^{-10}$ to $4.77{\times}10^{-4}$. The HQ of xylene was the highest for children aged 0-6 playing on the playmats. However, the HQ via inhalation exposure to VOCs in individual products did not exceed 1.00. Conclusion: Based on the results, it was concluded that the use of these children's products do not pose health risks to children.
어린이용품 함유 유해인자의 위해성평가를 위한 노출계수 조사
김정곤,서정관,김탁수,박건호,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Park, Gun-Ho 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.1
Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.
화학사고 장외영향평가 지원 프로그램(KORA)의 활용도 증대를 위한 제언
김정곤(Jungkon Kim),류지성(Jisung Ryu),류태권(Taekwon Ryu),곽솔림(Sollim Kwak),임형준(Hyeongjun Lim),최우수(Woosoo Choi),정진희(Jinhee Jung),이지은(Jieun Lee),임동연(Dongyeon Lim),윤준헌(Junheon Yoon) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.2
Objectives: All enterprises intending to install and operate hazardous chemical handling facilities should prepare an off-site risk assessment (ORA) report that evaluates the impact of potential chemical accidents on the surrounding environment and population. This study was conducted to introduce the process of development and the functioning of the Korea Off-site Risk Assessment support tool (KORA) developed by the National Institute of Chemical Safety and to suggest manners to increase its utilization. Additionally, this article provided an overview of KORA. Methods: In order to identify problems with and refinements for KORA, the required items for each phase of KORA were derived by analyzing the Chemical Control Act and related administrative regulations. Results: The functions of KORA made receptor-considered assessment of chemical accidents possible, but several limitations were found in particular phases, such as the analysis of impact range, consideration of sensitive receptors, and assessment of environmental receptors. Conclusion: In this study, we suggested manners to increase the utilization of KORA. It is anticipated that the further research suggested in the study could contribute to the stabilization of the KORA system.
Ivermectin, praziquantel, tamiflu, triclosan의 환경위해성평가
류태권(Taekwon Ryu),김정곤(Jungkon Kim),김경태(Kyungtae Kim),이재우(Jaewoo Lee),김지은(Jieun Kim),조재구(Jaegu Cho),윤준헌(Junheon Yoon),이재안(Jaean Lee),김필제(Pilje Kim),류지성(Jisung Ryu) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.2
Objectives: The purpose of this study was to assess environmental risk on the emerging contaminants of concern, such as ivermetin, parziquantel, tamiflu and triclosan. Furthermore, we tried to provide a more efficient management practice and a basis for future studies of risk assessment on those substances. Methods: Predicted no effect concentration (PNEC) and predicted environmental concentration (PEC) were determined through modeling and literature reviews. Environmental risk assessment was evaluated by calculating HQ (hazard quotient) by a comparison of PEC (or measured environmental concentration (MEC)) and PNEC. Results: HQ value of tamiflu calculated from MEC was 1.9E-03. For ivermectin and triclosan, the HQ values were not available because these were not detected in the aquatic environment. The toxicity of ivermectin and triclosan showed a very low value, indicating a high level of HQ. However, praziquantel can be categorized into the material that do not require management since they have less than HQ 1. Conclusion: Based on the results of the initial risk assessment, it is assumed that the ivermectin and triclosan have potential to cause direct adverse effects on the aquatic environment. To conduct an accurate environmental risk assessment, the further study on PEC estimation of such contaminants should be actively carried out.
화학사고 시 수용체 보호를 위한 독성끝점 농도와 급성독성 자료를 활용한 우려농도 예측값 조사
이지윤(Jiyun Lee),김순신(Sunshin Kim),양원호(Wonho Yang),윤준헌(Junheon Yoon),류지성(Jisung Ryu),김정곤(Jungkon Kim),지경희(Kyunghee Ji) 한국환경보건학회 2018 한국환경보건학회지 Vol.44 No.1
Objectives: To protect individuals working at the site as well as the surrounding general population from a chemical accident, several emergency exposure guidance levels have been used to set alevel of concern for certain chemicals. However, a level of concern has not been established for many substances that are frequently used or produced in large quantities in Korean workplaces. In the present study, we investigated the guidance levels for protecting populations from chemical exposure and the estimation of level of concern using acute inhalation and oral toxicity data. Methods: The number of chemicals to which emergency exposure guidance levels (e.g., ERPG-2, AEGL-2, PAC-2, and IDLH) can be applied were determined among 822 hazardous chemicals according to the ‘Technical Guidelines for the Selection of Accident Scenarios (revised December 2016)’. The ERPG and AEGL values were compared across all three tiers for the 31 substances that appeared on both lists. We examined the degree of difference between the emergency exposure guidance levels and the estimates of level of concern calculated from acute inhalation or acute oral toxicity data. Results: Among the 822 hazardous chemicals, emergency exposure guidance levels can be applied to 359 substances, suggesting that the estimates of level of concern should be calculated using acute toxicity data for 56.3% of the hazardous chemicals. When comparing the concordance rates of ERPG and AEGL for 31 substances, the difference between the two criteria was generally small. However, about 40% of the substances have values diverging by more than three-fold in at least one tier. Such discrepancies may cause interpretation and communication problems in risk management. The emergency exposure guidance levels were similar to the estimates of level of concern calculated using acute inhalation toxicity data, but the differences were significant when using acute oral toxicity data. These results indicate that the level of concern derived from acute oral toxicity data may be insufficient to protect the population in some cases.Conclusion: Our study suggests that the development of standardized guidance values for emergency chemical exposure in the Korean population should be encouraged. It is also necessary to analyze acute toxicity data and fill the information gaps for substances that are important in Korean workplace situations.