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유건성(Geon Sung Yoo),변재훈(Jae Hoon Byeon) 한국체육교육학회 2009 한국체육교육학회지 Vol.14 No.1
The purpose of this study was self-identity of individuals with physical disabilities participating in physical activity. Subjects included 198(male: 143 female: 58) with individuals with physical disabilities. The questionnaire that was developed by Park Ah-Chung(1996) was used self-identity scale of Korean. It was revised by Lee Sung-Guk(1999) which consisted of 6 factors, 48 items. Construct validity of the instrument was checked by Factor analysis. Reliability of questions was confirmed by Cronbach`s α value(.783). The data analysis were Independent t-test, one-way ANOVA, and multiple regression analysis. The results were as follows; First, job and incomes had significant effects on self-identity of individuals with physical disabilities. Second, physical instructors, mass media, and friends had significant effects on self-identity of individuals with physical disabilities. Third, physical activity period, group exercise, and athletes with disabilities had significant effects on self-identity of individuals with physical disabilities. Fourth, high understanding of disability traits significant difference than low understanding of disabilities traits on self-identity of individuals with physical disabilities. These results implied that individuals with physical disabilities participation in physical activity had significant effects on their self-identity according to socio-demographic variables, significant other, type of physical activity, participation type of physical activity, and understanding of disability traits.
Inhibitory actions of the antidepressant/antipanic drug phenelzine on brain GABA transaminase
Yoo, Byung-Kwon,Hong, Joung-Woo,Suk, Jae-Wook,Ahn, Jee-Yin,Yoo, Jeong-Suk,Lee, Kil-Soo,Cho, Sung-Woo,Choi, Soo-Young The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.6
Brain GABA transaminase is inactivated by preincubation with antidepressant/antipanic drug pheneizine (${\beta}$ethylphenylhydrazine) (mixing molar ratio 10:1) at pH 7.4. The reaction of enzyme with phenelzine was monitored by absorption and fluorescence spectroscopic methods. The inactive enzyme was fully reconstituted by addition of cofactor pyridoxal-5-phosphate. This result implies that the blocking of 1 mol of pyridoxal-5-phosphate per enzyme dimer is needed for inactivation of the enzyme. The time course of the reaction is significantly affected by the substrate .alpha.-ketoglutarate, which afforded complete protection against the loss of catalytic activity. The kinetic studies shows that phenelzine reacts with the cofactor of enzyme with a second-order rate constant of $2.1{\times}10^3M^{-1}s^{-1}$. It is postulated that the antidepressant/antipanic drug phenelzine is able to elevate the neurotransmitter GABA levels in central nervous system by inhibitory action on GABA degradative enzyme GABA transaminase.
Jae Yeong Cho,Dong-Hyuk Cho,Jong-Chan Youn,Darae Kim,Sang Min Park,Mi-Hyang Jung,Junho Hyun,Jimi Choi,Hyun-Jai Cho,Seong-Mi Park,Jin-Oh Choi,Wook-Jin Chung,Byung-Su Yoo,Seok-Min Kang 대한심장학회 2023 Korean Circulation Journal Vol.53 No.4
The Korean Society of Heart Failure guidelines aim to provide physicians with evidence-based recommendations for diagnosing and managing patients with heart failure (HF). In Korea, the prevalence of HF has been rapidly increasing in the last 10 years. HF has recently been classified into HF with reduced ejection fraction (EF), HF with mildly reduced EF, and HF with preserved EF (HFpEF). Moreover, the availability of newer therapeutic agents has led to an increased emphasis on the appropriate diagnosis of HFpEF. Accordingly, this part of the guidelines will mainly cover the definition, epidemiology, and diagnosis of HF.
Yoo, Chae-Kyoung,Cho, In-Cheol,Lee, Jae-Bong,Jung, Eun-Ji,Lim, Hyun-Tae,Han, Sang-Hyun,Lee, Sung-Soo,Ko, Moon-Suck,Kang, Taeyoung,Hwang, Joon-Ho,Park, Yong Sang,Park, Hee-Bok American Physiological Society 2012 PHYSIOLOGICAL GENOMICS Vol.44 No.13
<P>Clinical-chemical traits are essential when examining the health status of individuals. The aim of this study was to identify quantitative trait loci (QTL) and the associated positional candidate genes affecting clinical-chemical traits in a reciprocal F(2) intercross between Landrace and Korean native pigs. Following an overnight fast, 25 serum phenotypes related to clinical-chemical traits (e.g., hepatic function parameters, renal function parameters, electrolyte, lipids) were measured in >970 F(2) progeny. All experimental samples were subjected to genotyping analysis using 165 microsatellite markers located across the genome. We identified eleven genome-wide significant QTL in six chromosomal regions (SSC 2, 7, 8, 13, 14, and 15) and 59 suggestive QTL in 17 chromosomal regions (SSC 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 13, 14, 15, 16, 17, and 18). We also observed significant effects of reciprocal crosses on some of the traits, which would seem to result from maternal effect, QTL on sex chromosomes, imprinted genes, or genetic difference in mitochondrial DNA. The role of genomic imprinting in clinical-chemical traits also was investigated. Genome-wide analysis revealed a significant evidence for an imprinted QTL in SSC4 affecting serum amylase levels. Additionally, a series of bivariate linkage analysis provided strong evidence that QTL in SSC 2, 13, 15, and 18 have a pleiotropic effect on clinical-chemical traits. In conclusion, our study detected both novel and previously reported QTL influencing clinical-chemical traits in pigs. The identified QTL together with the positional candidate genes identified here could play an important role in elucidating the genetic structure of clinical-chemical phenotype variation in humans and swine.</P>
Sang Hoon Chae,Jae Yeon Won,Jae Chul Yoo 대한견주관절학회 2020 대한견주관절학회지 Vol.23 No.2
Background: Atelocollagen has been studied for restoration of rotator cuff tendon. In this study, we attempted to evaluate the clinical outcome of ultrasound-guided atelocollagen injection in an outpatient clinic for patients with partial rotator cuff tear. Methods: We recruited 42 outpatients who visited our hospital from May 2019 to September 2019. Atelocollagen injection was performed in patients with partial rotator cuff tear diagnosed by magnetic resonance imaging and ultrasound. American Shoulder and Elbow Surgeons (ASES), Constant, Korean Shoulder Score (KSS) and Simple Shoulder Test (SST) scores, and range of motion were assessed before injection and after two months. Statistically, we analyzed the clinical results using the Wilcoxon signed rank test. Results: Finally, 15 patients were enrolled for analysis. There was no significant difference between pre- and post-injection in terms of range of motion, ASES (57.0 vs. 60.4), Constant (56.4 vs.58.9), KSS (64.6 vs.68.5), and pain-visual analog scale (4.2 vs.3.7), except function-visual analog scale (F-VAS; 6.3 vs.7.1) and SST (6.6 vs.6.9). A significant difference was found in SST (P=0.046) and F-VAS (P=0.009). According to the ultrasound results at 2 months, we found hyperechoic materials in three of seven patients. The most common complication of atelocollagen injection was post-injection pain (53%, 8/15). Conclusions: Ultrasound-guided atelocollagen injection for partial rotator cuff tear showed no significant change in terms of clinical outcomes, except for F-vas and SST score. Tendon regeneration was not clear due to the remnants of atelocollagen present at 2-month follow-up ultrasound. There seems to be alarming post-injection pain for 2 to 3 days in the patients who received atelocollagen injection in an outpatient clinic.
Jae-hee Han,Byung-Sik Moon,Won-Suk Yang,Ji-Beom Yoo,Chong-Yun Park,In-Taek Han,Nae-Sung Lee,Chong-Min Kim,Tae-Il Kim 한국진공학회(ASCT) 1999 Journal of Korean Vacuum Science & Technology Vol.3 No.2
Vertically well aligned multiwall carbon nanotubes were grown on nickel coated different substrates by plasma enhanced hot filament chemical vapor deposition at low temperatures below 650℃. Acetylene and ammonia gas were used as the carbon source and a catalyst. The surface roughness of nickel layer increased as NH₃ etching time increased. The diameters of the nanotubes decreased and the density of nanotubes increased as NH₃ etching time increased. Diameter of nanotube was 30 to 70 ㎚. Nickel cap was observed on the top of the grown nanotube and very thin carbon amorphous layer was found on the nickel cap.