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Sung Min Bae,Tae Young Shin,Young Soon Jun,Seung Hee Lee,Won Seok Kwak,Yong Oh Ahn,Dong Jun Kim,See Nae Lee,In Hee Kim,Soo Dong Woo 한국응용곤충학회 2015 한국응용곤충학회 학술대회논문집 Vol.2015 No.10
Insects are among the most diverse groups of animals on the planet, representing more than half of all known living organisms. These insects are found in nearly every environment. Although humans regard certain insects as pests and attempt to control them using insecticides, most insects perform complex ecological functions, and provide either direct or indirect economic benefits to humans. Recently, the importance of insects used as food sources or as pets has increased in many countries, including Korea. In addition, several insects have a strong influence on people's emotion. Insect-mediated mental healthcare program is designed to help people who have disorders with physical, behavior and development. Children who have mental disorder, the experimental group that was provided with an insect-mediated mental healthcare program over a total of 8 sections, one section per week, 60 minutes per section, followed by pre-test and post-test. They responded to therapeutic effect after the completion of the program. Further research on the basis of this study is expected to help children with emotional therapy in other areas.
Lee, Nae Yoon,Kim, Youn Sang Hu@thig & Wepf 2007 Macromolecular Rapid Communications Vol.28 No.20
<P>This work reports a facile method to fabricate multi-tiered polymer nanopatterns on SU-8 by the combination of imprint- and photo-lithography. First, SU-8 is imprint patterned using a polymeric flexible mold with an anti-adhesion coating that is deposited on a transparent and flexible substrate, at room temperature under low pressure. Next, the resulting SU-8 nanopatterns are exposed to UV light through a chromium mask by a photolithographic process. Removal of the unexposed SU-8 leaves behind multi-tiered structures. The use of a hemispherical poly(dimethylsiloxane) pad facilitates the evacuation of trapped air during the imprinting process. Line/space patterns of 500 nm with the smallest line width of 200 nm were homogeneously imprint-patterned on SU-8 on a large flexible substrate, and three-tiered structures, ranging in thickness from 300 nm to 2 µm, were successfully formed.</P><P> <img src='wiley_img/10221336-2007-28-20-MARC200700362-gra001.gif' alt='wiley_img/10221336-2007-28-20-MARC200700362-gra001'> </P>
A poly(dimethylsiloxane)-coated flexible mold for nanoimprint lithography
Lee, Nae Yoon,Kim, Youn Sang IOP Pub 2007 Nanotechnology Vol.18 No.41
<P>In this paper, we introduce an anti-adhesion poly(dimethylsiloxane) (PDMS)-coated flexible mold and its applications for room-temperature imprint lithography. The flexible mold is fabricated using an ultraviolet-curable prepolymer on a flexible substrate, and its surface is passivated with a thin layer of PDMS to impart an anti-adhesion property. The highly flexible mold enables conformal contact with a substrate on which a low-viscosity polymer resist is spin-cast in a thin layer. Large-area imprinting is then realized at room temperature under significantly reduced pressure. The mold was durable even after repetitive imprinting of over 200 times. Also, we show a double imprinting on the substrate with a PDMS-coated replica polymeric mold having 500 nm line patterns. This enables the formation of matrix patterns with varying feature heights in less than 7 min. </P>
Lee, Si Nae,Lee, Kyung Hee,Chung, Seok,Nam, Hae Sung,Cho, Jae Hwa,Ryu, Jeong Seon,Kwak, Seung Min The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.5
Pancreaticothoracic fistula is a rare complication of acute or chronic alcoholic pancreatitis. It may present with various symptoms, like dyspnea, abdominal pain, cough, chest pain, fever, back pain, hemoptysis, fatigue, or orthopnea. Pancreaticothoracic fistula can be detected by magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), or computed tomography. MRCP has high sensitivity and fewer side effects, and thus it has recently been recommended as the first choice for the detection of pancreaticothoracic fistula. On the other hand, ERCP enables the detection and treatment of pancreaticothoracic fistula and allows for stent insertion; for this reason it is a commonly used modality in pancreaticothoracic fistula cases. Herein, the authors describe a case of pancreaticothoracic fistula detected by ERCP and MRCP that manifested only respiratory symptoms, namely hemoptysis and pneumothorax without abdominal pain, which commonly accompanies pancreatitis.
( Nae Yun Heo ),( Young Suk Lim ),( Woochang Lee ),( Minkyung Oh ),( Jiyun An ),( Dan Bi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Dong Jin Suh2 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. Methods: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. Results: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. Conclusions: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients. (Clin Mol Hepatol 2014;20:177-184)
Highly sensitive stretchable transparent piezoelectric nanogenerators
Lee, Ju-Hyuck,Lee, Keun Young,Kumar, Brijesh,Tien, Nguyen Thanh,Lee, Nae-Eung,Kim, Sang-Woo The Royal Society of Chemistry 2013 Energy & environmental science Vol.6 No.1
<P>Here we report a new type of stretchable transparent piezoelectric nanogenerator (NG) using an organic piezoelectric material consisting of poly(vinylidene fluoride trifluoroethylene) [P(VDF-TrFE)] sandwiched with mobility-modified chemical vapor deposition-grown graphene electrodes by ferroelectric polarization into P(VDF-TrFE). This new type of NG has a very high sensitivity and mechanical durability with fully flexible, rollable, stretchable, foldable, and twistable properties. We also investigated the mobility-modified graphene electrodes with ferroelectric P(VDF-TrFE) remnant polarization, and a mechanism is proposed for switching the mobility of the carriers by the ferroelectric remnant polarization. Upon exposure to the same input sound pressure, the measured output performance of the stretchable NG with a thin polydimethylsiloxane stretchable rubber template is up to 30 times that of a normal NG with a plastic substrate. Upon exposure to an air flow at the same speed, the measured output voltage from the stretchable NG is about 8 times larger than that of the normal NG.</P> <P>Graphic Abstract</P><P>Highly sensitive stretchable transparent piezoelectric nanogenerators have been developed using P(VDF-TrFE) sandwiched with mobility-modified graphene electrodes. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2ee23530g'> </P>
Lee, Jongseok,Armstrong, Derek T.,Ssengooba, Willy,Park, Jeong-ae,Yu, Yeuni,Mumbowa, Francis,Namaganda, Carolyn,Mboowa, Gerald,Nakayita, Germine,Armakovitch, Sandra,Chien, Gina,Cho, Sang-Nae,Via, Laur American Society for Microbiology 2014 Antimicrobial Agents and Chemotherapy Vol.58 No.1
<P>For <I>Mycobacterium tuberculosis</I>, phenotypic methods for drug susceptibility testing of second-line drugs are poorly standardized and technically challenging. The Sensititre MYCOTB MIC plate (MYCOTB) is a microtiter plate containing lyophilized antibiotics and configured for determination of MICs to first- and second-line antituberculosis drugs. To evaluate the performance of MYCOTB for <I>M. tuberculosis</I> drug susceptibility testing using the Middlebrook 7H10 agar proportion method (APM) as the comparator, we conducted a two-site study using archived <I>M. tuberculosis</I> isolates from Uganda and the Republic of Korea. Thawed isolates were subcultured, and dilutions were inoculated into MYCOTB wells and onto 7H10 agar. MYCOTB results were read at days 7, 10, 14, and 21; APM results were read at 21 days. A total of 222 isolates provided results on both platforms. By APM, 106/222 (47.7%) of isolates were resistant to at least isoniazid and rifampin. Agreement between MYCOTB and APM with respect to susceptibility or resistance was ≥92% for 7 of 12 drugs when a strict definition was used and ≥96% for 10 of 12 drugs when agreement was defined by allowing a ± one-well range of dilutions around the APM critical concentration. For ethambutol, agreement was 80% to 81%. For moxifloxacin, agreement was 83% to 85%; incorporating existing DNA sequencing information for discrepant analysis raised agreement to 91% to 96%. For MYCOTB, the median time to plate interpretation was 10 days and interreader agreement was ≥95% for all drugs. MYCOTB provided reliable results for <I>M. tuberculosis</I> susceptibility testing of first- and second-line drugs except ethambutol, and results were available sooner than those determined by APM.</P>
Detection of Mycobacterium tuberculosis Antigens in Sputum Samples from Tuberculosis Patients
( Sang Nae Cho ),( Sun Hee Baik ),( Sun Park ),( Joon Chang ),( Se Kyu Kim ),( Sung Kyu Kim ),( Won Young Lee ),( Yun Sop Chong ),( Chul Ho Cho ),( Jin Joo Kim ),( Joo Deuk Kim ) 대한결핵 및 호흡기학회 1994 Tuberculosis and Respiratory Diseases Vol.41 No.6