성악골 절제술후 발생한 중앙부및 구개 결손부의 재건

김훈,임재석,최성원,김호겸,권종진,최미숙,김성문 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

There are various defects caused by trauma or resection of maignant tumor in the orofacial region, which can be reconstructed with various regional and pararegional flaps. Among these defects, it is very difficult to reconstruct palatal and midfacial defects after maxillectomy and patients have problems in speaking and swallowing of food. Therefore it is very important for surgeons to reconstruct these defects functionally and esthetically and to return the patients to the normal social activity. These defects are usually obturated with prosthodontic appliances to assist the phonation and swallowing. But nowadays surgical reconstruction by various flaps was considered and performed for better rehabilitation. For this purpose the forehead flap, the nasolabial flap, the tongue flap, the sternocleidomastoideous flap, the temporal flap, the latissimus dorsi flap, the scapular flap etc. are used. We reconstructed small-sized plalatal defects with tongue flap, medium-sized palatal and maxillary defects after maxillectomy with temporal myofascial flap and large midfacial defects including eyeball exenteration with latissimus dorsi myocutaneous flaps. Here we are to report 5 cases of these flaps used for the reconstruction of palatal and midfacial defects and consider the versatility, reliability and limitation in use of these flaps.

선천성 고혈압 흰쥐와 정상혈압 흰쥐의 혈관 평활근 세포의 성장 특성

정재군,정현주,김인겸,김중영 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

목적 : 선천성 고혈압 흰쥐(SHR)와 정상 혈압 흰쥐(WKY)의 혈관 평활근 세포를 배양하여, 그 성장 특성을 조사하였다. 대상 및 방법 : SHR 및 WKY를 pentobarbital(50㎎/㎏)로 마취하여 적출한 흉부대동맥으로부터 혈관평활근세포를 얻었으며 이 세포를 이차배양하여 일정한 시간간격으로 trypsin을 처리하여 세포를 떼어낸후 혈구계(hemocytometer)로 세포수를 헤아렸다. 결과 : SHR과 WKY에서 얻은 혈관평활근세포에서 형태학적 차이는 없었고, SHR이 WKY보다 밀생상태에 더 빨리 도달하며 밀생상태에 도달했을때 SHR이 WKY보다 세포밀도가 더 높게 나타났다. 결론: SHR이 WKY보다 증식속도와 증식밀도가 더 높게 나타나는 것으로 보아 SHR에 성장 억제 조절 기전의 장애가 있음을 시사한다. To study the generation and processes of hypertension, characteristics of vascular smooth muscle cell were observed in cultured aortic smooth mescle cell from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY). The degree of cell proliferation increased with escalating concentrations of fetal bovine serum(FBS) in cells of both SHR and WKY control rats. These results have shown that 10% FBS, which was the usual concentration in culture medium, was better concentration of medium in cell proliferation than 5% FBS, 10% calf serum, 10% horse serum, or 1% bovine serum albumin. There were no detectable differences in the morphology of cells obtained from SHR and WKY. Comparative studies have shown that cultured vascular smooth muscle cells from SHR proliferated to a higher cell number, grew to a greater density, and have greater specific growth rate than those of the WKY. These results provide possibility of a disturbances on inhibitory conrol to vascular smooth muscle cell growth in SHR.

감술제조에 관한 연구

안용근,편재영,김승겸,신철승 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

홍시를 살균처리하지 않은 것, 열처리 살균한 것, 염산처리 살균한 것과 염산처리 살균한 곶감 12%에 설탕 15% 용액을 17℃에서 36일간 발효시켰다. 무처리구와 염산처리구는 감에 부착되어 있던 유산균과 초산균으로 오염되어 산패되었다. 그래서 곶감의 산도는 4.4, 열처리한 것은 산도는 5.0, 산처리한 것은5.8, 무처리함 것은 13.5ml(0.1N NaOH/10ml sample)를 나타냈다. 에탄올 함량은 열처리구는 11.2%, 곶감은 10.0%, 산처리구는 9.4%무처리구는 6.1%였다. 가장 기호성과 안정성이 높은 것은 열처리하여 28일간 발효시킨 것이었다. 열처리구로 36일간 발효시킨 술은 총당 4.65%, 환원당 3.65%, 단백질, 0.03㎎/ml, 아미노산 0.17㎍/ml, pH 3.4, 펙틴 13.02㎍/ml, 균체수 5.75 logCFU/ml를 나타냈다. 곶감주도 기호성은 높았으나 발효속도가 낮았다. The possibility of wine making from soft and dried persimmon and the effects of treatment for persimmon on the quality of wine have been investigated. Soft persimmon was pretreated by two methods, of heat and hydrochloric acid treatment. Fermentation mash was composed of 12% persimmon and 15% of sucrose, and was fermented at 17℃ for 36 days. The fermentation using persimmons which were untreated and treated by acid was not successful because of contamination caused by lactic acid and acetic acid bacteria. Acidity of the fermented broth produced from boiled, dried, acid treated and untreated persimmon was 4.4, 5.0, 5.8 and 13.5ml(0.1N NaOH/10ml broth), respectively. Ethanol concentration of the fermented broth produced from boiled, dried, acid treated and untreated persimmon was 11.2, 10.0, 9.4 and 6.1%v/v, respectively. The wine fermented for 28day's fermentation using boiled persimmon as substrate had the best quality and stability. After 36 day's fermentation using boiled persimmon, following composition was obtained: 4.65% of total sugar, 3.65% of reducing sugar, 0.03㎎/ml of protein, 0.17 ㎍/ml of amino acid and 13.02 ㎍/m1 of pectin. The pH and yeast cell of the boiled persimmon broth were 3.4 and 5.75 logCFU/ml. Fermented wine using dried persimmon had also good quality but the fermentation rate was slow.

[PB-0089] Voltage-dependent anion channel (VDAC) functions in the GA biosynthesis pathway in monocot plant and affects seed germination

Tae Kyeom Kim(Tae Kyeom Kim),Jae Yoon Kim(Jae Yoon Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-

Case report of diseases in psittacine birds, South Korea, 2012-2021

Hye-Ryoung Kim(Hye-Ryoung Kim),Chung-Hyun Kim(Chung-Hyun Kim),Hye-Sun Song(Hye-Sun Song),Ji-Ye Kim(Ji-Ye Kim),Jae-Kyeom Kim(Jae-Kyeom Kim),Yong-Kuk Kwon(Yong-Kuk Kwon) 한국예방수의학회 2022 한국예방수의학회 학술대회자료집 Vol.2022 No.-

Clinical and molecular characteristics of pulmo-nary sarcomatoid carcinoma

( Jae Kyeom Sim ),( Sang Mi Chung ),( Jong Hyun Choi ),( Jee Youn Oh ),( Seung Heon Lee ),( Je Hyeong Kim ),( Kyung Hoon Min ),( Gyu Young Hur ),( Jae Jeong Shim ),( Kyung Ho Kang ),( Bong Kyung Shin 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4

Background/Aims: Pulmonary sarcomatoid carcinoma (PSC) is a poorly differentiated non-small cell lung cancer (NSCLC) that contains components of spindle or giant cells. Owing to its low prevalence, there are insufficient data regarding its clinical features, therapeutic strategies and prognosis. Methods: The medical records of 26 patients diagnosed with PSC from January 2009 to June 2015 were reviewed and analyzed for clinicopathological characteristics, treatment modality, and outcomes. Results: The median age was 69.5 years. Twenty-three patients (88%) were male. Twenty-four patients (92%) were smokers. The median time from symptom onset to diagnosis was one month. Eighteen patients (69%) were diagnosed at an advanced stage. Pleomorphic carcinoma was the most common subtype, and epidermal growth factor receptor (EGFR) mutation was positive in two of 11 patients. Among 13 patients tested for programmed death ligand 1 (PD-L1) immunohistochemistry assay, eight showed high expression of PD-L1. The median overall survival (OS) of all patients was 9.5 months. In total, 12 patients were treated with chemotherapy: nine with platinum-based doublet therapy, two with tyrosine kinase inhibitor, and one with docetaxel. Seven patients showed partial response or stable disease. The median OS and progression-free survival of patients who received chemotherapy were 8.7 and 2.8 months, respectively. Conclusions: PSC was more common in males, smokers, and the elderly, with worse prognosis than ordinary NSCLC; chemotherapy response was favorable, and EGFR mutation status and PD-L1 expression may offer more therapeutic options.

Apiaceous Vegetables and Cruciferous Phytochemicals Reduced PhIP-DNA Adducts in Prostate but Not in Pancreas of Wistar Rats

Jae Kyeom Kim,Marissa A. McCormick,Cynthia M. Gallaher,Daniel D. Gallaher,Sabrina P. Trudo 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.2

We previously showed rats fed with apiaceous vegetables, but not with their putative chemopreventive phytochemicals, reduced colonic DNA adducts formed by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary procarcinogen. We report here the effects of feeding apiaceous and cruciferous vegetables versus their purified predominant phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adduct formation. In experiment I, male Wistar rats received three supplemented diets: CRU (cruciferous vegetables), API (apiaceous vegetables), and CRU+API (both types of vegetables). In experiment II, rats received three diets supplemented with phytochemicals matched to their levels in the vegetables from experiment I: P + I (phenethyl isothiocyanate and indole-3-carbinol), FC (furanocoumarins; 5-methoxypsoralen, 8-methoxypsoralen, and isopimpinellin), and COMBO (P + I and FC combined). After 6 days of feeding, PhIP was injected (10 mg/kg body weight) and animals were killed on day 7. PhIP-DNA adducts were analyzed by LC-MS/MS. In prostate, PhIP-DNA adducts were reduced by API (33%, P < .05), P + I (45%, P < .001), and COMBO (30%, P < .01). There were no effects observed in pancreas. Our results suggest that fresh vegetables and purified phytochemicals lower PhIP-DNA adducts and may influence cancer risk.

The serotype-specific prevalence of pneumococci in hospitalized pneumonia patients with COPD: a prospective, multi-center, cohort study

( Jae Yeol Kim ),( Jae-woo Jung ),( Min-jong Kang ),( Deog Kyeom Kim ),( Hayoung Choi ),( Young-jae Cho ),( Seung Hun Jang ),( Chang-hoon Lee ),( Yeon Mok Oh ),( Ji Sook Park ) 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5

Background/Aims: The overall incidence of pneumococcal pneumonia is declining. However, the change in the pathogenic distribution of community-acquired pneumonia (CAP) in chronic obstructive pulmonary disease (COPD) patients and the serotype specificity of Streptococcus pneumoniae have not been evaluated in the post-era of pneumococcal vaccination in Korea. Methods: We conducted a prospective, multi-center, cohort study from seven University-affiliated hospitals. The primary objective was the identification of serotype-specific prevalence of pneumococcal pneumonia in COPD patients hospitalized for CAP. For the purpose, we conducted serotype-specific urine antigen detection (SS-UAD) assays for S. pneumoniae. The secondary objectives were other clinical characteristics of pneumonia including vaccination status. Results: The total number of participants was 349. Most of them were male (95.1%) with old ages (75.55 ± 8.59 y). The positive rate for S. pneumoniae was 9.2% with SS-UAD assay and the common serotypes were 22F, 6A, and 6B. In the sputum, Pseudomonas aeruginosa (5.0%) and Haemophilus influenzae (4.0%) were common pathogens. The vaccination rate was 78.8%, 53.0%, and 25.8% for influenza, pneumococcal polysaccharide vaccine 23 (PPV 23), and pneumococcal protein-conjugated vaccine 13 (PCV 13), respectively. Thirteen patients died during hospitalization (mortality rate; 3.7%). There was no difference in the respective rate of influenza vaccination (79.2% vs. 69.2%, p = 0.288) and PCV 13 vaccination (25.6% vs. 30.8%, p = 0.443) between survivors and the deceased. Conclusions: Serotypes 22F, 6A, and 6B, which are covered either by PPV 23 or by PCV 13, are still common pneumococcal serotypes in COPD pneumonia in the post-vaccination era in Korea.

The Need for a Well-Organized, Video-Assisted Asthma Education Program at Korean Primary Care Clinics

Kim, Yee Hyung,Yoo, Kwang Ha,Yoo, Jee-Hong,Kim, Tae-Eun,Kim, Deog Kyeom,Park, Yong Bum,Rhee, Chin Kook,Kim, Tae-Hyung,Kim, Young Sam,Yoon, Hyoung Kyu,Um, Soo-Jung,Park, I-Nae,Ryu, Yon Ju,Jung, Jae-Woo The Korean Academy of Tuberculosis and Respiratory 2017 Tuberculosis and Respiratory Diseases Vol.80 No.2

Background: The purpose of this study was to assess the effect of our new video-assisted asthma education program on patients' knowledge regarding asthma and asthma control. Methods: Adult asthmatics who were diagnosed by primary care physicians and followed for at least 1 year were educated via smart devices and pamphlets. The education sessions were carried out three times at 2-week intervals. Each education period lasted at most 5 minutes. The effectiveness was then evaluated using questionnaires and an asthma control test (ACT). Results: The study enrolled 144 patients (mean age, $56.7{\pm}16.7years$). Half of the patients had not been taught how to use their inhalers. After participating in the education program, the participants' understanding of asthma improved significantly across all six items of a questionnaire assessing their general knowledge of asthma. The proportion of patients who made errors while manipulating their inhalers was reduced to less than 10%. The ACT score increased from $16.6{\pm}4.6$ to $20.0{\pm}3.9$ (p<0.001). The number of asthmatics whose ACT score was at least 20 increased from 45 (33.3%) to 93 (65.3%) (p<0.001). The magnitude of improvement in the ACT score did not differ between patients who received an education session at least three times within 1 year and those who had not. The majority of patients agreed to the need for an education program (95.8%) and showed a willingness to pay an additional cost for the education (81.9%). Conclusion: This study indicated that our newly developed education program would become an effective component of asthma management in primary care clinics.

Characterization of Nutritional Composition, Antioxidative Capacity, and Sensory Attributes of <i>Seomae</i> Mugwort, a Native Korean Variety of <i>Artemisia argyi</i> H. Lév. & Vaniot

Kim, Jae Kyeom,Shin, Eui-Cheol,Lim, Ho-Jeong,Choi, Soo Jung,Kim, Cho Rong,Suh, Soo Hwan,Kim, Chang-Ju,Park, Gwi Gun,Park, Cheung-Seog,Kim, Hye Kyung,Choi, Jong Hun,Song, Sang-Wook,Shin, Dong-Hoon Hindawi Publishing Corporation 2015 Journal of analytical methods in chemistry Vol.2015 No.-

<P>Few studies have investigated <I>Seomae</I> mugwort (a Korean native mugwort variety of <I>Artemisia argyi</I> H. Lév. & Vaniot), exclusively cultivated in the southern Korean peninsula, and the possibility of its use as a food resource. In the present study, we compared the nutritional and chemical properties as well as sensory attributes of <I>Seomae</I> mugwort and the commonly consumed species <I>Artemisia princeps</I> Pamp. In comparison with <I>A. princeps, Seomae</I> mugwort had higher contents of polyunsaturated fatty acids, total phenolic compounds, vitamin C, and essential amino acids. In addition, <I>Seomae</I> mugwort had better radical scavenging activity and more diverse volatile compounds than <I>A. princeps</I> as well as favorable sensory attributes when consumed as tea. Given that scant information is available regarding the <I>Seomae</I> mugwort and its biological, chemical, and sensory characteristics, the results herein may provide important characterization data for further industrial and research applications of this mugwort variety.</P>