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웨이브렛 신경회로망을 이용한 비선형 시스템의 안정한 직접 적응 제어
서재용,연정흠,원경재,서승진,전홍태 중앙대학교 생산공학연구소 1998 생산공학연구소 논문집 Vol.7 No.2
이 논문에서는 웨이브렛 신경회로망을 사용하여 알려지지 않은 비선형 시스템을 안정하게 적응 제어하는 문제를 다룬다. 비선형 시스템의 정확한 제어는 함수를 근사화하는 데 상용된 함수 근사화기의 정확성과 효율성에 의존한다. 이에 기준 함수의 선택이 자유롭고 함수 근사화 능력이 뛰어난 웨이브렛 신경회로망을 비선형 시스템 제어에 사용한다. 초기 웨이브렛 신경회로망 제어기를 설정하는 방법은 먼저 제어기 입력의 시-주파수 특성을 분석해서 웨이브렛 신경회로망 변수인 신축과 이동을 구하고, 다음에 Lyapunov 안정성 이론에 기초한 적응 법칙을 사용하여 연결 강도를 조절하는 것이다. 이 직접 적응 웨이브렛 신경회로망 제어기를 불안정한 비선형 시스템인 역 진자 시스템을 제어하는 데 적용한다. In this paper, we deal with the problem of controlling an unknown nonlinear dynamical system, using wavelet network. Accurate control of the nonlinear systems depends critically on the accuracy and efficiency of the function approximator used to approximate the function. Thus, we use wavelet network which shows high capability of approximating the functions and includes the free-selection of the basis functions for the control of the nonlinear system. The method of constructing an initial adaptive wavelet network controller is that we find the dilation and translation that are wavelet network parameters by analyzing the time-frequency characteristics of the controller's input, and then, the weight is adjusted by the adaptive law based on the Lyapunov stability theory. We apply this direct adaptive wavelet network controller to control the inverted pendulum system which is an unstable system.
재조합 BMP-7 유전자가 전달된 HEK 293 세포에 의한 누드 마우스에서의 뼈형성
정수연,장원태,장연실,안면환,김재룡,송인환 영남대학교 의과대학 2003 Yeungnam University Journal of Medicine Vol.20 No.2
To induce bone formation at ectopic site by tissue engineering and gene therapy, we transplanted collagen sponges containing rhBMP-7 transduced HEK 293 cells in the hypodermis of nude mice. Bone formation was investigated by histological and electron microscopic method at 3, 6, and 9 weeks after transplantation. At 9 weeks after transplantation, eosinophilic bony tissue was observed in the implanted collagen sponge and was confirmed as bone tissue by Von Kossa stain. In the transmission electron microscopic observation, the cells in newly formed bone tissue had eccentrically located nucleus and well developed rough endoplasmic reticulum (rER). Therefore, the cells were evaluated as osteoblasts. Those results suggest that it is possible to form a bone tissue in the ectopic site by transplantation of rhBMP-7 transduced HEK 293 cells. This will be contributed to push more advanced gene therapy for bone formation. However, the HEK 293 cell is unable to apply to the clinical gene therapy. Therefore it is worth to find more compatible cells for clinical application. In addition, collagen sponge is considered as an excellent scaffold and/or carrier for gene therapy and a good biomaterial for tissue engineering.
수술적으로 치료한 통증을 동반한 흉추부의 후외상성 Schmorl씨 결절 : 2례 보고 Report of Two Cases
신병준,이재철,송화용,정석봉,권계원,조영일,김연일 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Study Design : Two patients who had painful Schmorl's node at thoracic level from acute trauma were adopted and taken operation for its treatment Objectives : To document the effect of operation for the treatment of painful Schmorl's node at thoracic level summary of background data : Schrmorl's nodes are common spinal lesion generally believed to be asymptomatic, but in some cases there were painful symptom by Schmorl's node. This case report is to explain the effect of operative treatment for the painful Schmorl's node. Methods : Two patients were adopted who had traumatic painful Schmorl's node at thoracic level for our case report. They were treated conservative methods at first but it's effect were poor, so they were taken anterior decompression and fusion, and checked back pain symptom. Result : In all two patients, the symptom of back pain by Schmorl's nodes at thoracic level was almost subsided. conclusion : For the treatment of traumatic painful Schmorl's node, most of surgeon says that conservative treatments were treatment of choice, but operative treatments are also benefit to subsidence of back pain by Schmorl's node.
Effect of age and sex on retinal layer thickness and volume in normal eyes
Won, Jae Yon,Kim, Sung Eun,Park, Young-Hoon Wolters Kluwer Health 2016 Medicine Vol.95 No.46
<P><B>Abstract</B></P><P>The aim of the study was to evaluate the effect of sex and age on the thickness of the retinal layer in normal eyes using spectral-domain optical coherence tomography (SD-OCT).</P><P>Fifty healthy subjects between the ages of 20 and 80 had their retinal layers measured using SD-OCT at Seoul St. Mary's Hospital. Mean thickness and volume were measured for 9 retinal layers in the fovea, the pericentral ring, and the peripheral ring. The differences of sex- and age-related thickness and volume in each retinal layer were analyzed.</P><P>The retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), and outer plexiform layer (OPL) were thinnest in the fovea area, whereas the outer nuclear layer (ONL), photoreceptor layer (PHL), and retinal pigment epithelium (RPE) were thickest at similar locations. Mean thickness of the RNFL, GCL, IPL, and OPL was significantly greater in men than women. However, mean thickness of the ONL was greater in women than in men. When compared between patients < 30 years and > 60 years of age, the thickness and volume of peripheral RNFL, GCL, and pericentral and peripheral IPL were significantly larger in the younger group than the older group. Conversely, the thickness and volume of foveal INL and IR were larger in the older group than in the younger group.</P><P>The thickness and volume of the retinal layer in normal eyes significantly vary depending on age and sex. These results should be considered when evaluating layer analysis in retinal disease.</P>
Won, Jae Yon,Kim, Mirinae,Park, Young-Hoon Wolters Kluwer Health 2017 Medicine Vol.96 No.19
<P><B>Abstract</B></P><P>The aim of the study was to investigate the thickness and volume profiles of each retinal layer in postoperative patients with epiretinal membranes.</P><P>Twenty-four patients who underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling for epiretinal membrane were included. The best corrected visual acuity, thickness, and volume were recorded from the medical records through a retrospective review. Spectral domain optical coherence tomography was used to measure the average thickness and volume of each retinal layer before surgery and 6 months postoperatively.</P><P>All 24 patients were monitored for 60 months after surgery. In all Early Treatment Diabetic Retinopathy Study (ETDRS) subfields, the thickness and volume of the retinal nerve fiber layer and the inner retinal layer decreased significantly. In contrast, the thickness and volume of the ganglion cell layer, inner nuclear layer, inner plexiform layer, and outer plexiform layer only decreased in some ETDRS subfields. Finally, there was no significant change in the thickness or volume of the outer nuclear layer (ONL), retinal pigment epithelium (RPE), and photoreceptor layers in all ETDRS subfields.</P><P>The thickness and volume of the inner retina layer decreased significantly after pars plana vitrectomy using ILM peeling. However, there was no significant change in the thickness and volume of the outer retinal layers (ONL, RPE, and photoreceptor) after surgery.</P>