고혈압치료제의 in vitro및 in vivo 이용률간의 상관성 연구(Ⅱ)

서수경,강현구,조재민,박인숙,안미령,이선우,최흥석,유태무,손수정,이용복,양지선 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

의약풍이 생체내로 흡수되는_파정에서 생리학적 인자 및 제제학적 인자들에 의해 생체이용률이 달라져 약물의 흡수과정을 연구함으로써 약물의 생체이용률을 예측하는 것이 가능하다. 그러나 제제학적 측면에서 용출시험과 흡수과정인. 장관막 투과도 나아가서 생체이용률간의 띤구가 미흡한 상태이다. 따라서 약물의 흡수과정을 연구하벼 생체이용률을 예측하기 위하여 장관막 투과도 및 혈중농도사이의 상관관계를 예견할 수 있는 모델을 개발하고자 1999년도 연구사업으로 고혈압치료제중 베타-차단약 (아테놀올, 메토프롤올, 프라프라놀꼴)을 선택하여 웅출시험과 장관막 투과도계수를 측정하여 사람의 흡수을을 예측할 수 있는 장관막 투파도 모델을 확림하였고, 2000년도에는 계속사업으로서 각 약물에 대한 횐쥐에서의 생체이용를 파라메타를 측정하고 1999년도 연구사업결과에서 얻은 장관막 투과도 시험결과를 가지고 생체이용률과의 상관섞을 구하고자 하였다. 각 베타-차단약을 경구 및 정맥투여하고 시간별로 채혈한 후 분리한 혈장으로부터 각 약물에 대한 EfLC를 이용한 분석준건을 확지하여 혈중농도를 측정하고 생체이용률 파라메타(AUC, Cma, Tme, 등)를 구하였다. 횐쥐의 소장을 이용하여 diffusion chamber 법으로 측정한 장관막 투과도계수와 각 생체이용률 파라미터 사이의 상관성을 구찬 결과 양호한 상관관계를 보였다. 이와 같은 연구결과를 통하여 약물의 특성에 따라 동물의 장관막 투도. 모델을 이용하여 사람의 생체이용률도 예측할 수 있을 것으로 사료된다. A biopharmaceutics drug classification system for correlation f'H uf'fro dissolution and rH ui'ㄴo bio3vailabi3ity is proposed based on recognizing that drug dissolution andgastrointestinal permeability are the fundamental parameters controlling rate and extent of drugabsorption. The objective of this stud)· was to assess whether partition coefficient and intestinalPermeabilit)'can be rorrelateo with l'H vluo bioalFaifability. Beta-blockers were administeredorall? and intrauenousl)· to rats and pkarrnacokinetlc parameters were calculated. The goodcorre)ations between fermeability and log P (n~octanol/buffer) was demonstrated in previous ratexpenments performed in our laboratory. In this study, good correlations were obseFYedbetuTeen panitlon coefficient and permeabilit)·· or I'n ui'vo bioayilability These resuats indiEatethat rat intestinal perme3bilit3T model couBd be used to predict intestinal absorption ofbeta-blockeTs f'H uiuo.

Self-assembled block copolymer micelles with silver-carbon nanotube hybrid fillers for high performance thermal conduction

Choi, Jae Ryung,Yu, Seunggun,Jung, Haejong,Hwang, Sun Kak,Kim, Richard Hahnkee,Song, Giyoung,Cho, Sung Hwan,Bae, Insung,Hong, Soon Man,Koo, Chong Min,Park, Cheolmin The Royal Society of Chemistry 2015 Nanoscale Vol.7 No.5

<P>The development of polymer-filled composites with an extremely high thermal conductivity (TC) that is competitive with conventional metals is in great demand due to their cost-effective process, light weight, and easy shape-forming capability. A novel polymer composite with a large thermal conductivity of 153 W m(-1) K(-1) was prepared based on self-assembled block copolymer micelles containing two different fillers of micron-sized silver particles and multi-walled carbon nanotubes. Simple mechanical mixing of the components followed by conventional thermal compression at a low processing temperature of 160 C produced a novel composite with both structural and thermal stability that is durable for high temperature operation up to 150 C as well as multiple heating and cooling cycles of δT = 100 C. The high performance in thermal conduction of our composite was mainly attributed to the facile deformation of Ag particles during the mixing in a viscous thermoplastic medium, combined with networked carbon nanotubes uniformly dispersed in the nanoscale structural matrix of block copolymer micelles responsible for its high temperature mechanical stability. Furthermore, micro-imprinting on the composite allowed for topographically periodic surface micropatterns, which offers broader suitability for numerous micro-opto-electronic systems.</P>

Studies on Microwave Shielding Composites Based on FeCo Hollow Fiber Filled Polymer in the X-Band Frequency

Jae Ryung Choi,Ka Hyun Park,Byung Mun Jung,Sang-Kwan Lee,Sang Bok Lee 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Detection of occult primary tumors in patients with cervical metastases of unknown primary tumors: comparison of (18)F FDG PET/CT with contrast-enhanced CT or CT/MR imaging-prospective study.

Lee, Jae Ryung,Kim, Jae Seung,Roh, Jong-Lyel,Lee, Jeong Hyun,Baek, Jung Hwan,Cho, Kyung-Ja,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon Radiological Society of North America 2015 Radiology Vol.274 No.3

<P>Purpose: To assess diagnostic accuracy of fluorine 18 (F-18) fluorodeoxyglucose (FDG) combined positron emission tomography (PET) and computed tomography (CT) in the detection of occult primary tumors and determination of optimal care in patients with cervical metastasis of an unknown primary tumor (CUP) compared with contrast material-enhanced CT alone or combined contrast-enhanced CT and magnetic resonance (MR) imaging (CT/MR imaging). Materials and Methods: Institutional review board approval and written informed consent were obtained. In total, 56 patients with initially undetected tumors after endoscopic or physical examination were prospectively assessed with F-18 FDG PET/CT and contrast-enhanced CT or contrast-enhanced CT/MR imaging. The contrast-enhanced CT/MR images were read in combination. Results of guided biopsy with general anesthesia served as the reference standard. Diagnostic values of F-18 FDG PET/CT, contrast-enhanced CT, and contrast-enhanced CT/MR imaging were compared with the McNemar test. Results: Primary tumors were detected at 32 sites in 31 (55%) of 56 patients. There were 26 tumors in the palatine tonsil, two in the hypopharynx, two in the base of the tongue, and two in the nasopharynx. PET/CT depicted 22 (69%) of 32 primary tumors, but it failed to depict primary tumors in 10 (31%) of 32 cases. Overall, sensitivity of PET/CT (69%) in detection of primary tumors was higher than that of contrast-enhanced CT (16%) (P < .001) or contrast-enhanced CT/MR imaging (41%) (P = .039), while specificity of these methods did not differ (88%, 76%, and 59% for PET/CT, contrast-enhanced CT, and contrast-enhanced CT/MR imaging, respectively; P > .4). Diagnostic performance (area under the receiver operating characteristics curve [AUC] = 0.759) of PET/CT in tumor detection was significantly better than that of contrast-enhanced CT alone (AUC = 0.531) (P = .001) or contrast-enhanced CT/MR imaging (AUC = 0.537) (P = .036). PET/CT depicted primary tumors in eight (50%) of 16 cases of false-negative CT/MR imaging findings, one distant metastatic case, and two cases of synchronous cancer. Conclusion: F-18 FDG PET/CT is more sensitive in detection of primary tumors than is contrast-enhanced CT or contrast-enhanced CT/MR imaging in patients with CUP; therefore, it may lead to improved therapeutic planning in these patients. (C) RSNA, 2014</P>

Short Reports : A Simple Assay Method for Melanosome Transfer

( Hye Ryung Choi ),( So Hee Park ),( Jae Woo Choi ),( Dong Seok Kim ),( Kyung Chan Park ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1

Pigmentation is induced by production of melanin in specialized organelles termed melanosomes and by transfer of these organelles from melanocytes to surrounding keratinocytes. The chemical basis of melanogenesis is relatively well known but the mechanism of melanosome transfer is not well studied. Various pigmentary disorders and cosmetic applications require the use of depigmenting agents. Currently available topical agents used for the reduction of pigmentation mainly include tyrosinase inhibitors and/or melanocyte-cytotoxic agents. Recently, several agents have been introduced to inhibit melanosome transfer from melanocytes to keratinocytes. However, an experimental model for melanosome transfer is not well established. In this study, a simple assay method using flow cytometry is described. (Ann Dermatol 24(1) 90∼93, 2012)

중소기업의 가업승계관련 상속세 부담 및 담세능력 분석: 상속재산의 포트폴리오 특성을 중심으로

최재령 ( Jae-ryung Choi ) 한국중소기업학회 2016 中小企業硏究 Vol.38 No.3

본 논문은 우리나라의 가업승계 지원을 위한 조세감면 혜택이 그 효과에 대한 검증 없이 지나치게 확대되어 왔다는 비판과 관련하여, 126개 중소기업에 대한 조사 자료를 바탕으로 가업승계를 위한 조세부담과 담세능력을 실증적으로 분석해보는데 그 목적이 있다. 분석결과에 따르면, 가업(家業)재산, 금융재산, 개인 부동산, 기타재산 등 피상속인인 경영자의 평균 상속재산은 101.5억 원이었고, 그 중 가업재산의 세법상 가치는 59.1억 원이었다. 상속재산을 후계자가 전부 물려받는다는 가정하에 모든 기업들이 가업상속공제를 받지 않을 경우에는 평균 38.0억 원의 상속세가, 반대로 모든 기업들이 가업상속공제를 받을 경우에는 평균 18.4억 원의 상속세가 부과되는 것으로 추산되었다. 조사일 현재 실제로 사전요건을 모두 충족하여 가업상속공제를 받을 수 있는 기업은 전체 샘플의 48%였는데, 이처럼 각 기업의 사전요건 충족여부를 판별하여 실제로 추산한 평균 상속세는 28.7억 원이었다. 상속받은 금융재산 및 기타 유동재산으로 부과된 상속세를 납부한다고 가정할 때, 모든 샘플 기업이 가업상속공제를 받지 않을 경우에는 평균 23.8억 원의 납부재원이 부족했으며, 모두가 가업상속공제를 받는다 하더라고 평균 4.2억 원 정도가 부족했다. 가업승계를 위한 상속세 납부재원이 부족한 이유는 상속재산 중 개인부동산의 비중이 지나치게 높기 때문인데, 이 같은 상속재산의 부동산 편중은 상속세 과세표준은 높이고 납부재원 확보를 위한 유동성은 떨어뜨림으로써 가업승계를 위한 조세부담을 가중시키는 요인으로 작용했다. 따라서 현행 제도하에서 가업승계를 위한 상속세 부담을 최소화하고 납부여력을 높이기 위해서는 상속재산 중 개인부동산 비중을 줄이는 등의 노력이 필요한 것으로 판단된다. 또한 회귀분석을 통해 경영자 개인의 재산 중 가업재산의 비중이 높을수록 해당기업의 이익률도 높다는 흥미로운 사실도 확인할 수 있었다. 가업승계를 위한 세제지원의 효과나 적정성에 대한 검증이 부족한 현실을 감안할 때 향후 관련 정책은 공제한도나 대상기업의 추가적인 확대 보다는 가업상속공제의 본래 취지를 살릴 수 있도록 사후관리 요건 등의 합리성을 제고하는데 초점을 맞출 필요가 있다. This paper addresses the succession tax burdens and taxpaying abilities of Korean SMEs using unique dataset of 126 companies using simulations. According to the results, the average money value of each ancestor`s total wealth is KRW 10.15 billion including stocks of family businesses, real estates, financial assets and other properties such as memberships and retirement pays. The average money value of family business is KRW 5.91 billion estimated on the relevant tax laws. The average amount of succession tax is KRW 3.80 billion for each successor to succeed all the inherited properties from his or her ancestor if he or she will not get tax deduction for family business succession. Under the assumption that all the successors can satisfy the preconditions for the full deduction, then the tax amount goes down to KRW 1.84 billion. But only 48.0% of the successors of sample companies actually satisfied the preconditions for the deduct and in this case the succession tax amount is KRW 2.87 billion. Under the assumption that all the successors cannot get the tax deduction and the imposed succession tax should be pay by the inherited liquid properties such as cash, financial asset and other liquid properties, then most of the successors confront with the lack of fund to pay, an amount up to KRW 23.8 billion on average. Under the assumption that all the successors can get the deduction fully, the fund shortage goes to KRW 420 million. The reason why the successors have not enough funds to pay succession taxes might be explained by the skewness in the portfolios of inherited properties. Simply, the ancestors have too much real estates and too little liquid assets. The propensity results in not only huge tax amount incurred for business succession but also the lack of fund liquidity to pay the tax. Interestingly, it is found that some of sample companies that are run by CEOs who have more business related assets and less personal real estates in their property portfolios show higher profitability than the others. In order to avoid troubles embedded in succession of family business in terms of tax issue, CEOs need to restructure their property portfolios before the event of succession. Also it is recommended for the policy makers to focus on improving the effectiveness and efficiency of the current succession tax system by reviewing the details of the relevant laws rather than to expand the limit amount of the deduction and the scope of beneficiaries of the deduction dramatically.

Preoperative Contrast-Enhanced CT Versus 18F-FDG PET/CT Evaluation and the Prognostic Value of Extranodal Extension for Surgical Patients with Head and Neck Squamous Cell Carcinoma

Lee, Jae Ryung,Choi, Young Jun,Roh, Jong-Lyel,Kim, Jae Seung,Lee, Jeong Hyun,Cho, Kyung-Ja,Choi, Seung-Ho,Nam, Soon Yuhl,Kim, Sang Yoon Springer - Society of Surgical Oncology 2015 Annals of Surgical Oncology Vol.22 No.suppl3

Intravitreal versus Posterior Subtenon Injection of Triamcinolone Acetonide for Diabetic Macular Edema

( Young Jae Choi ),( In Kyung Oh ),( Jae Ryung Oh ),( Kuhl Huh ) 대한안과학회 2006 Korean Journal of Ophthalmology Vol.20 No.4

Purpose: To compare the short-term effects of intravitreal versus posterior subtenon injection of triamcinolone acetonide for diabetic macular edema. Methods: This is a prospective and interventional study. Sixty eyes of 60 patients who had diffuse diabetic macular edema were assigned to receive a single intravitreal injection (4 mg) or a single posterior subtenon injection (40 mg) of triamcinolone acetonide. The central retinal thickness was measured using optical coherent tomography before injection and at 1 and 3 months after injection. Visual acuity and intraocular pressure (IOP) were also measured. Results: Both intravitreal and posterior subtenon injections of triamcinolone acetonide resulted in significant improvements in visual acuity at 1 month and 3 months after injection. Both groups resulted in a significant decrease in central macular thickness (CMT) at 1 month and 3 months post-injection. IOP in the intravitreal injection group was significantly higher than in the posterior subtenon injection group at 3 months after injection. Conclusions: The posterior subtenon injection of triamcinolone acetonide had a comparable effect to the intravitreal triamcinolone injection and showed a lower risk of elevated IOP. Posterior subtenon injection of triamcinolone acetonide may be a good alternative for the treatment of diffuse diabetic macular edema.

FeCo 자성 금속 중공형 섬유 고분자 복합재의 전자파 차폐 특성 연구

최재령 ( Jae Ryung Choi ),정병문 ( Byung Mun Jung ),최우혁 ( U Hyeok Choi ),조승찬 ( Seung Chan Cho ),박가현 ( Ka Hyun Park ),김원정 ( Won Jung Kim ),이상관 ( Sang Kwan Lee ),이상복 ( Sang Bok Lee ) 한국복합재료학회 2015 Composites research Vol.28 No.6

무전해 도금을 통해 제조한 FeCo 자성 금속 중공형 섬유와 EPDM 고분자를 이용하여 전자파 차폐 복합재를 제작하였다. 열처리 공정을 통하여 섬유의 종횡비를 제어하였으며 중공형 구조로 섬유를 제조한 후, 이를 EPDM수지에 첨가하여 복합재를 제조하였다. 자성 금속 중공형 섬유의 종횡비가 클수록 낮은 표면 저항 특성과 우수한 전자파 차폐 성능을 나타내었다. 약 100 μm 길이의 자성 금속 중공형 섬유를 이용한 두께 150 μm 전자파 차폐 복합재의 경우 밀도 1.18 g/cm3, 약 30 ohm/sq의 표면 저항, 그리고 30 dB의 전자파 차폐 성능을 나타내었다. 이는 종횡비가 큰 섬유에 의한 퍼콜레이션 임계치 이상의 전도성 네트워크 형성과 더불어, 낮은 표면 저항에 기인한 임피던스 차이에 의한 반사 손실 증가, 흡수 손실, 그리고 다중 내부 반사 손실에 의하여 우수한 전자파 차폐 성능을 나타내는 것으로 판단된다. Electromagnetic interference shielding composite with low density (1.18 g/cm3) was fabricated using electroless plated FeCo magnetic metal hollow fibers and ethylene propylene diene monomer (EPDM) polymer. Aspect ratio of the fibers were controlled and their hollow structure was obtained by heat treatment process. The FeCo hollow fibers were then mixed with EPDM to manufacture the composite. The higher aspect ratio of the magnetic metal hollow fibers resulted in high electromagnetic interference shielding effectiveness (30 dB) of the composite due to its low sheet resistance (30 ohm/sq). The enhanced electromagnetic interference shielding effectiveness was mainly attributed to the formation of conducting network over the percolation threshold by high aspect ratio of fibers as well as an increase of the reflection loss by impedance mismatch owing to low sheet resistance, absorption loss, and multiple internal reflections loss.

Poster Session : PS 0651 ; Respiratory Medicine ; Clinical Characteristics and Prognostic Factors of the Patients Who Admitted in Intensive Care Units with Nursing and Healthcare-Associated Pneumonia

( Ji Sun Choi ),( Myoung Kyu Lee ),( Sang Ha Kim ),( Won Yeon Lee ),( Suk Joong Yong ),( Kye Chul Shin ),( Jiwon Choi ),( Yeun Seoung Choi ),( Jae Ho Seong ),( Ye Ryung Jung ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Limited studies have been identifi ed about nursing and healthcare-associated pneumonia (NHCAP) requiring intensive care unit (ICU) admission. We evaluated the clinical and microbiological characteristics of NHCAP patients admitted to the ICU. Methods: NHCAP was categorized as four groups. Reviewed database included age, gender, comorbid diseases, laboratory data and microbiological Results: The severity of pneumonia was assessed by using the pneumonia severity index (PSI) and CURB-65. The 30-day mortality and duration of ICU stay were evaluated as endpoints Results: Total 428 patients (men, 67.1%) were reviewed. The mean age was 71.2 ± 11.9 year-old. Thirty-day mortality was 25.5%, and duration of ICU stay was 13.8 ± 13.3 days. Mortality (P = 0.349) had no signifi cant difference among four groups although duration of ICU stay (P = 0.008) was signifi cantly longer in group C and D. When we performed multivariate logistic analysis using signifi cant variables, PSI score (OR 1.015 95% CI 1.004-1.026, P = 0.009), serum HCO3- level (OR 0.954 95% CI 0.918-0.993, P = 0.020), duration of ICU stay (OR 0.971 95% CI 0.950-0.993, P = 0.010), multidrug-resistant (MDR) pathogens including ESBL-producing K. pneumoniae (OR 2.688 95% CI 1.237-5.840, P = 0.013) and MDR A. baumannii (OR 3.081 95% CI 1.504-6.311, P = 0.002) were signifi cantly associated with 30-day mortality. Conclusions: ESBL-producing K. pneumoniae and MDR A. baumannii were more often isolated and associated with mortality in NHCAP in ICU patients, therefore these MDR pathogens as well as PSI score should be considered as prognostic factors in NHCAP.