Fusobacterium nucleatum의 테트라사이클린 내성여부를 검사하기 위한 세균배양법과 중합효소연쇄반응법의 비교

최재흥,성진효,국중기,김동기 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

The purposes of this study were to identify the detection and incidence of tetracycline resistance determinant tet(M) by PCR method and to evaluate the availability of PCR method guided for clinical use of antibiotics in dentistry. Subgingival plaque samples were collected from 172 sites of 29 patients. Both original sample and subculturd sample, PCR amplification was used to detect tet(M) in Fusobacterium nucleatum. The percentage of tet(M)-positive subjects and sites in original samples were 100%, 95.9%, respectively. And the percentage of tet(M)-positive subjects and sites in subcultured samples were 17.2%, 3.5%, respectively. In subcultured samples, probing pocket depth and clinical attachment level in tet(M)-positive sites were higher than in negative sites (p<0.05). The sensitivity and specificity of PCR method compared with broth dilution method as a gold standard were 0.91 and 0.86, respectively. The results suggested that tet(M) assay using PCR method was available to detect the tetracycline-resistant F. nucleatum.

춘천호내 인공습지 조성에 따른 흐름특성 분석

최한규,박재국,백효선 江原大學校 産業技術硏究所 2009 産業技術硏究 Vol.29 No.B

Based on the data interpretation on an artificial marsh built in Chun-cheon Lake, the study analyzed flow characteristics and found that flow was unstable due to sediment of natural river but the effect of artificial marsh was similar with that of river improvement works. Flow velocity in the section of artificial marsh was found to be 1m/sec. Therefore flow velocity was stable, which could contribute to improving water quality. A flow velocity as well as stream vector was improved.

N₂분위기에서 Solder 접합부의 젖음성 및 결함특성에 관한 연구

최명기,황선효,이창배,정재필,서창제 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

본 실험을 통하여 대기와 N_2분위기에서의 젖음력과 솔더 접합부의 결함특성에 대하여 연구 검토하였다. 모든 시편 조건에서 질소분위기에서의 젖음성이 대기 중에서 젖음성 보다 좋아졌다. 또한 N_2유량이 증가함으로서 젖음 시간은 짧아지고, 젖음력은 증가하였다. N_2분위기에서 브리지(Bridge)발생률이 25∼76%정도로 현저히 감소하였다. N_2분위기에서는 젖음력의 향상으로 솔더 접합부가 안정되었으며 결함 발생률도 현저하게 감소되는 것을 확인할 수 있었다. This study was prepared to find out wettability and properties of defects on solder joints in N_2 conditions. The wettability of solder joints in N_2 condition was better than that in atmosphere condition, and when the flow rate of N_2 was increased, it is found that the wetting time got a little bit short and the wetting force got stronger as time passed. Also the rate of bridge defects was specially decreased in N_2 conditions, showing the decreasing ratio of 25∼76%. The solder joints were stabilized and the rate of defects was decreased by cause to increasement of wetting force in N_2 conditions.

상악 유측절치 부위의 유치 과잉치에 관한 증례보고

최병재,한효정,이제호,김성오,손흥규 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.1

과잉치란 치배 형성기 이상으로 유치열기와 영구치열기에 정상보다 많이 발생하게 된 치아를 말한다. 유치 과잉치의 빈도는 0.03~1.9%로 상악 유측절치 부위에 호발하고 대부분은 정상 치아 형태로 맹출하며 정상 시기에 탈락하므로 보호자들이 인식하지 못하는 경우가 많다. 과잉치의 발생에 대해서는 현재 치판의 과활성으로 인해 제 3의 치배가 발생한다는 가설이 널리 받아들여지고 있고 유치과잉치가 발생할 경우 영구치열기에는 정상 또는 비정상적인 형태의 계승 과잉치가 존대한다고 보고된 바 있다. 유치 과잉치의 약 75%는 정상적으로 맹출하고 탈락하기 때문에 특별한 처치는 필요하지 않지만 계승 영구치 맹출에 영향을 주는지를 관찰하기 위하여 정기적인 구강 및 방선학적 검사가 필요하다. 본 두 증례의 경우 정상 치아 형태의 유치 과잉치가 유전치부 발육 공간을 이용하여 상악 유측절치 부위에 맹출하였고 방사선 사진 검사 결과 유치 과잉치 하방에 매복된 계승 과잉치가 관찰되었으므로 이에 보고하는 바이다. Most supernumerary primary teeth erupt in the primary lateral incisor region and are reported to occur in 0.03 to 1.9% in the primary dentition. Most parents fail to recognize them because of their normal shape, eruption and exfoliation. Several theories have been proposed for the etiology of hyperdontia and the dental lamina hyperactivity theory is most widely accepted. When a supernumerary primary tooth develops. it is reported that there also exists a supplemental or rudimentary form of a succedaneous supernumerary tooth. Supernumerary primary teeth do not need specific treatment as 75% of them erupt and exfoliate normally. Only periodic radiographic exams are necessary to find out whether there is any problem with the eruption of the succedaneous tooth. In the following two cases, a supplemental supernumerary primary tooth with a loss of the anterior developmental space was observed at the maxillary lateral incisor region. Radiographic examination revealed an impacted succedaneous supernumerary tooth at the palatal side of the supernumerary primary tooth.

성인의 경부 전면 중앙부위에서 발생한 기형종 1예

최월용,정효진,채종인,하태인,정상렬,이광재,채병도,최영식 고신대학교 의학부 2004 高神大學校 醫學部 論文集 Vol.19 No.1

Teratomas are embryonal neoplasms that show characteristics of three germ cell layers(ectoderm, mesoderm, and endoderm). They are distributed in the following regions: sacrococcygeal(57%), gonadal(29%), mediastinal(7%), cervical(3%), retroperitoneal(4%), and intracranial(3%) regions. Non-gonadal treatomas present in infancy whereas gonadal are seen in adolescence. Especially, teratomas that occurred in midline neck of adult are very rare and are confused with thyroglossal duct cysts, cystic hygromas, and thyroid tumors. We report, along with the review of appropriate literature, a case of histopathologically confirmed benign teratoma in the midline neck of a 33 years old woman.

그람양성구균에 대한 Teicoplanin과 Vancomycin의 시험관내 항균력

최태열,김경숙,전용관,서일혜,김정욱,이웅수,안정열,김홍석,정재용,최효선,김덕언,유진우 대한감염학회 1994 감염 Vol.26 No.1

An increasing frequency of methicillin resistant S. aureus(MRSA), methicillin resistant coagulase negative staphylococci(MRCNS) and Enterococcal infection have been observed in recent years. Teicoplanin is a new glycopeptide antibiotic obstained from the Actinoplanes teicomycetius. The molecular structure and spectrum of antimicrobial activity of teicoplanin is simillar to those of vancomycin, and has been reported to have an excellent in vitro and in vivo effect against various gram-positive infections. Therefore, we evaluated the in vitor susceptibility of gram positive cocci, such as, S. aureus, coagulase negative Staphylococci(CNS), and Enterococci to teicoplanin and vancomycin. The total 253 strains consisted of MSSA(40), MRSA(53), MSCNS(47), MRCNS(48), and Enterococci(65). They were assayed by disc diffusion and agar dilution. During the study, 57% of S. aureus and 49% of CNS showed resistance to methicillin. The inhibitory diameter of teicoplanin was 15-20mm in MSSA, 12-19mm in MRSA, 13-24mm in MSCNS, 11-23mm in MRCNS, and 15-22mm in Enterococci respectively, and showed sensitivity in all but 8 strains(3.2%). The range of the minimum inhibitory concentration (MIC) of teicoplanin to MSSA, MRSA, MSCNS, MRCNS and Enterococci were 9.12-2.0㎍/ml, 0.25-2.0㎍/ml, & 0.25-32㎍/ml, 0.12-1.0㎍/ml respectively. One case of S. haemolyticus was resistant to teicoplanin (32㎍/ml) by the agar dilution method. Eight minor (3.2%) and one major(0.4%) error was observed when the MIC and disk diffusion data were correlated with teicoplanin. As for vancomycin the inhibitory diameter was 17-21mm in MSSA, 15-21mm in MRSA, 18-26mm in MSCNS, 18-25mm in MRCNS, and 16-22mm in Enterococci respectively. The range of the MIC of vancomycin to MSSA, MRSA, MSCNS, MRCNS, and Enterococci were 0.25-1.0㎍/ml, 0.25-4.0㎍/ml, 0.5-2.0㎍/ml and 0.5-2.0㎍/ml respectively. One minor error (0.4%) was seen with the vancomycin disk. The MIC90 of MSSA and MRSA exhibited the same results in teicoplanin (1.0㎍/ml, 1.0㎍/ml), and vancomycin(2.0㎍/ml, 2.0㎍/ml). MSCNS and MRCNS exhibited greater MIC90 with teicoplanin(4.0㎍/ml, 8.0㎍/ml) than vancomycin(2.0㎍/ml, 2.0㎍/ml). Incontrase Enterococci were more susceptible to teicoplanin(0.5㎍/ml) than to vancomucin (2.0㎍/ml). Results from this analysis indicated that both teicoplanin and vancomycin were very excellent for gram positive infections, especially those resistant to methicillin.

GFRP 적층복합재료관의 신뢰성해석

조효남,이승재,최영민 한양대학교 공학기술연구소 1992 공학기술논문집 Vol.1 No.1

In general, the strength and stiffness of laminated composite cylindrical shells are very sensitive to the variation of slenderness parameters, some coupling-stiffness parameters, lamination angles, stacking sequence and number of lagers. In the paper, the effects of these factors on the strength and buckling reliabilities of GFRP laminated cyclindrical shells ale investigated based on the proposed strength and buckling limit state models. It may be concluded that the applicable ranges of the slenderness limits of the strength and buckling failure criteria for laminated composite cylindrical shells should be indentified and incorporated into the design formula with appropriate safety factors which provide uniform consistent reliability for balanced design in practice.

전두엽 상내측 신경교종의 수술 수 발생하는 운동보조영역 증후군

김재현,고영초,이채혁,권오기,최우진,박효일 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective : This retrospective study was aimed to correlate characteristic neurologic deficits of transient contralateral motor weakness with or without speech disturbance(Supplementary Motor Area, SMA syndrome) after the resection of the gliomas in the superior frontal gyrus, especially with the extent of resection of the tumors. Method : Ten patients with medial superior frontal glioma, who underwent gross total or subtotal resection of the tumor, as well as, partial or complete resection of the spolementary motor area were studied. The following parameters were evaluate 1) tumor location 2) extent of resection 3) degree and duration of postoperative deficits. Result : Postoperative neurologic deficits were transient contralateral motor weakness with or without motor dysphasia. As a whole, postsurgical SMA syndrome occurred in 3 patients out of 10 patients with medial superior frontal gliomas(30%), who underwent gross total or subtotal resection of the tumors. Motor deficits were present in 3 out of 10 patients and speech disturbances in 2 out of 3 left frontal gliomas. Recovery of neurological dysfunction was rapid occurring between the 5th 14th POD and their neurological function returned almost normal in two patients. In the remaining one patient, who had preoperative mild motor weakness showed incomplete recovery of the worsened motor weakness and newly developed speech disturbance till 1yr postoperatively. Conclusion : The postsurgical SMA syndrome in patients with glioma in the medial superior frontal gyrus was not so uncommon phenomenon and well correlated with the extent of surgical resection of the supplementary motor area. Thus, preoperative awareness and warning about the possibility of the development of this charicteristic SMA syndrome is necessary.

적응 임계치를 이용한 동영상 차분 블록 부호화 알고리즘

김태효,최재윤 경남대학교 신소재연구소 1997 論文集 Vol.9 No.-

본 논문은 적응 임계치를 이용한 동영상의 차분블록 부호화 알고리즘을 기술한 것이다. 적응 임계치는 영상 프레임 중에서 이동블록의 히스토그램으로부터 구해진다. 연속되는 영상의 이전 프레임과 현재 프레임의 차분프레임을 8×8부블록으로 분할하고 각 블록마다 적응임계치(adaptive threshold value)를 이용하여 이동성분을 포함하는 블록들을 검출한다. 이러한 이동성분의 데이터를 압축하기 위해 DCT(discrete cosine transform)처리하고, Huffman code로 부호화한다. 실험 결과, 복원 영상에 대한 PSNR이 44dB 이상의 양호한 특성을 가졌으나, 양자화처리를 하지 않았으므로 큰 압축률은 얻을 수 없었다. This paper describes the differential block coding algorithm for moving image using adaptive threshold value which is obtained from the histogram of the moving blocks. We split the difference frame between the previous frame and the current frame into 8 × 8 sub-blocks. The moving blocks are detected from each of sub-block using threshold value which is selected from the histogram data of difference between frames. Then they are performed DCT and Huffman coding in order to reduce the data. In simulation the PSNR from the reconstruction image was obtained from the test images. As a result, we confirmed that the PSNR have above 44dB in both of the test images, but owing to less quantization the reconstruction images have less compression rate.

출생 시 발생한 특발성 치은섬유종증

이효설,최형준,최병재,손홍규,이제호 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

치은섬유종증(Gingival fibromaotsis)은 치은조직의 섬유성 증식을 나타내는 드문 구강질환이다. 원인은 명확히 규명되지 않았으나 상염색체 우성 또는 열성의 유전성이거나 특발성일수 있다. 주로 영구치 맹출 시기에 나타나기 시작하나, 드물게 유치열기나 출생시부터 이환되는 경우도 있다. 치은은 서서히 증식하여 치아의 해부학적 치관부위를 덮거나 구개 변이를 일으켜 혀 운동장애를 야기하거나 입술 폐쇄를 방해하기도 한다. 이 증례의 환아는 14개월 된 여아로 출생 시부터 계속딘 치은증식을 주소로 내원하였다. 특별한 가족력이나 의학적 병력은 없었고, 임상 유전검사 결과 알려진 어떤 증후군으로 진단되지 않았으나, 신체발달이 지연되어 있었다. 펀치 생검을 하였으며, 조직검사명은 치은섬유유종증이었다. 가족력이 없어 특발성 치은섬유종증으로 진단하였다. 환아의 연령 및 전신 상태를 고려해 치은 절제술 등의 외과적 치료는 연기하기로 하였다. Gingival fibromatosis is a rare condition characterized by varying degrees of gingival hyperplasia. Gingival fibromatosis usually occurs as an isolated disorder or can be associated with a variety of other syndromes. It usually appears at the time of eruption of permanent dentition but, can develop at the time of eruption of the primary dentition and rarely at birth. It may deform palatal contour and subsequently restrict the tongue movement, resulting in interference during speech and mastication. In addition, it incapacitates maintenance of normal lip closure. A 14-month-old girl visited the department of pediatric dentistry, Yonsei University Dental Hospital, for the congenital gingival overgrowth. There was no one in the family, who showed similar pattern of gingival growth. The intraoral clinical examination revealed generalized severe enlargement throughout the maxillary and the mandibular arches. Enlarged gingival tissue was pink and had firm consistency. She was referred for chromosomal analysis, which confirmed absence of any known syndrome. Under local anesthesia, "Punch-biopsy" was performed on the labial area, and the specimen was histologically diagnosed as gingival fibromatosis. For she did not have any medical problem nor familiar history, she was diagnosed as having idiopathic gingival fibromatosis. Regarding her age and behavior, close follow-up was decided.