Development of a bivalent live vaccine against duck hepatitis A virus types 1 & 3 and vaccine program for breeder ducks in Korea

Jae?Hee Roh(노재희),Min Kang,Bai Wei,Se-Yeoun Cha,Jeong-Gon Cho,Hyung-Kwan Jang 한국가금학회 2017 한국가금학회 정기총회 및 학술발표회 Vol.2017 No.11

어린 오리에 치명적인 질병을 일으키는 오리바이러스성간염의 예방을 위해 혼합생백신 개발, 백신의 방어기전 연구 및 종오리백신 프로그램의 개발로 질병방어 및 제어를 목표로 연구를 진행하였다. 첫 번째, 국내에는 1형과 3형이 동시 유행하고 있으며, 최근에는 3형의 발생보고가 증가하는 추세이다. 특히 1형과 3형의 복합감염사례도 빈번히 발생하고 있다. 이런 상황에서 효율적인 질병관리를 위해 국내에 발생하는 오리간염 1형과 3형을 동시에 방어하는 혼합백신을 개발하고 그 효능을 확인하였으며, 운반 및 보관 용이성 향상을 위한 연구를 진행하였다. 두 번째, 오리감염 생백신의 3-5일 만에 조기면역을 획득하는 특성분석을 위해 세포성 및 체액성 면역반응을 평가하였다. Cytokine이 백신접종 그룹에서 증가하는 것을 확인하였고, 특히 IFN-α에서 강한 증가를 보였다. 또한 항체가 평가에서는 기존에 알려진 바와는 다르게 백신 후 3일째에 항체를 획득하였고, 10일째에는 최고수준의 항체가 수준을 나타냈다. 세 번째, 1주령이하의 어린 일령에 치명적인 질병의 특성상 모체이행항체에 의한 예방이 가장 효과적이라는 점에 착안하여 종오리백신 프로그램을 개발하고 농장에 적용하여 평가하였다. 종오리 농장 4개동 4천수의 종오리를 대상으로 백신을 실시하였으며, 모체의중화항체가(VN titer) 8 log2이상에서 후대병아리 14일령까지 100% 방어효능을 확인하였다. 모체이행항체의 전달률은 11%수준으로 나타났으며, 후대병아리의 항체가를 개체별 추적하여 계산한 결과 모체이행항체 반감기는 3-5일령임을 확인하였다. 본 연구에서는 오리에 치명적인 질병을 일으키는 오리바이러스성간염 예방을 위한 혼합생백신 개발에 관한 연구로 기존의 국내 상용화백신의 한계점을 극복하고, 국내에 유행하는 혈청형들을 단회백신으로 효과적으로 방어할 수 있는 혼합생백신을 개발하였으며, 백신의 특성상 조기면역에 대한 세포성 및 체액성 면역기전을 평가하였다. 또한 종오리백신 프로그램을 국내에 적용하여 모체이행항체에 의한 후대 병아리의 우수한 방어 효능을 확인하였다.

側腦室內 d-Tubocurarine이 家兎 腎臟機能에 미치는 影響

盧熙壯,許康敏,李載欣,昔廷鎬 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1

Effect of d-tubocurarine administered intracerebroventricularly on the renal function of rabb-its was investigated. 1) Intraventricular d-tubocurarine induced decrease of urine flow, renal plasma flow, glomerular filtration, and urinary sodium and potassium excretion, but increase of reabsorption of urinary sodium and potassium. 2) Correlation coefficient between changes of two parameters among urine volume, renal plasma flow, glomerular filtration and urinary sodium excretion was statistically significant. 3) Changes of various parameters of renal function induced by intraventricular d-tubocurarine were inhibited by phenol treatment on the renal artery except change of sodium. From the above results, it is suggested that the effect of intraventricular d-tubocurarine on the renal function of rabbit is due to renal hemodynamic changes by central sympathetic activation.

Carotid Siphon 질환의 경안와 초음파와 자기공명 혈관조영술의 진단적 가치

배희준,윤병우,노재규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

보건관리자의 자격에 따른 사업장 보건관리 업무수행 행태

이재희,노재훈,김규상,안연순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

This study was conducted to find out the characteristics, type of the duty and job satisfaction of health care managers at the worksite. The subjects of this study were 306 health care managers serving at worksite situated in Kyungin presently in 1994, concerning their job. Major dependent variables were health management, environmental management, and health planning related with health care managers job; these variables were measured by nominal scale consisted of 9 items respectively. The collected data were analysed and some major results are as follows: 1. It appeared that according to the qualification of health care managers, nurses showed high performing rate in duty of health management and health planning, industrial hygienist showed high performing rate relating to working environment managemant, and regarding their holding an additional post, the number of environmental managers held more an additionnal post than other qualified managers, thereby showing significant relatively, and however, no relation with qualification was there in decision-making. 2. The performing rate relating to health management was significantly correlate with female, youth, unmarried, higher education, general affairs in post of duty, general employee in position, only duty of health, low monthly income and nurse. But, the performing rate relating to environmental management was significantly correlate with manufacturing industries, industrial health and safety committee, male, old age, married, long work duration, additional post, high monthly income, and hygienist and environmental managers. The performing rate relating to health and environmental management, but the performing rate relating to health management was not significantly correlate with the performing rate relating to environmental management. 3. In multiple regression analysis, common major determinants of the performing duty relating to health management, environmental management and health planning were industrial health and safety committee, type of industry, education, and qualification of industry's health care managers. Additionally, age was selected as highly correlated with the performing duty relating to environmental management, and work duration and post of duty of health care managers in industry were selected as highly correlated with the performing duty relating to health planning. Based on the results indicated above, it could be understood that characteristics of the worksite - industrial health and safety committee, scale and types of industry, and characteristics of health care managers - age, education, post of duty, work duration and qualification had relations with their type of the duty. Therefore, it is required that the reference to the above-showing results such as guiding for them to precisely grasp their performing duty according to their qualification, heightening their participation in decision-making, extending the industrial health service, etc., operation and management of health care managers at the worksite should be made into being more efficient.

다환계 방향족 유기오염물을 함유한 폐수의 전기화학 처리

윤영재,강태구,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This work has concerned the possibility to apply both direct and indirect electrolysis process for the treatment of waste containing poliaromatic compounds. Two different kinds of electrode materials have been used: DSA-type anodes to carry out direct electrolysis and carbon felt cathodes to ferform indirect electrolysis. On the contrary, in the case of the tested wastewater especially containing naphthalen- and anthraquinon sulphonic compounds they do not seem to be very suitable materials. Better results have been achieved using the carbon felt cathodes. In this case the COD of the tested wastewater can be remarkably decreased using H_2O_2 as oxidation agent.

회분식 생물반응기를 이용한 BDOC_(rapid)와 BDOC_(slow) 결정

손희종,노재순,강임석 한국물환경학회 2004 한국물환경학회지 Vol.20 No.4

In this study, biodegradable organic matter was divided into a rapidly biodegradable fraction(BDOC_(rapid)) and a slowly biodegradable fraction(BDOC_(slow)) for various waters with different types of DOC. These fractions(BDOC_(rapid) and BDOC_(siow)) were defined by using a shaking incubation method modified from Carlson's method. Also, in this study, optimum incubation time and accuracy were investigated to determine BDOC_(rapid) and BDOC_(slow). When suspended bacteria obtained from raw water and BAC effluent, or attached bacteria from BAC was respectively used as an inoculum, the difference in total BDOC(BDOC_(total)) was minimal. Therefore, total BDOC was determined in 7~8 days by the shaking method, which is comparable with Servais's method by which BDOC was determined in 28 days. In addition, the difference of BDOC between these two methods was within 7%. Although BDOC_(rapid) and BDOC_(slow) were effectively determined by a method defined by Klevens, the difference in optimal incubation time was significant for different water samples. However, when using the shaking method, optimal incubation time for BDOC_(rapid) was found to be 3 days, therefore, the BDOC_(rapid) was defined as the difference between DOC_0 and DOC_(3days), and BDOC_(slow) was defined as the difference between BDOC_(total) and BDOC_(rapid). As a conclusion, for determining the fraction of BDOC using the shaking method, the concentrations of an inoculums and optimal incubation times used in this study were very effective.

전해질로 나피온을 사용한 Ti/IrO_2 전극상에서 유기물의 양극산화 반응

강태구,윤영재,김희정,노성희,김선일 한국공업화학회 2003 응용화학 Vol.7 No.1

This paper describes the anodic oxidation od various alphathic alcohols in pure water using Nafion cation exchange membrane as solid polymer electrolyte. The oxidation has been carried out on an IrO_2 anode under conditions of simultaneous oxygen evolution. The experimental results for the anodic oxidation of four different alcohols are in good agreement with the theoretical model presented in a previous paper. Finally a simple experimental method is described for the determination of the relative reactivity of organics oxidation on IrO_2 anodes.

담관 낭선암 1례

박건욱,홍기봉,정재열,노명환,한상영,최석렬,신우원,나서희 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1

장기간 보관한 멸균물품의 오염 상태에 관한 연구

주홍순,조순덕,정재심,신동분,임바올라,노은지,이선희,송영미,최정화,백병윤,김미나 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

Role of Carotid Artery Stenting in Prevention of Stroke for Asymptomatic Carotid Stenosis: Bayesian Cross-Design and Network Meta-Analyses

Jae-Hyung Roh,Hyun Jun Cho,Jae-Hwan Lee,Yongku Kim,Yeongwoo Park,Jae-Hyeong Park,Hee-Soon Park,Minsu Kim,Hyang Gon Jin,Yeji Cheon,In-Whan Seong 대한심장학회 2020 Korean Circulation Journal Vol.50 No.4

Background and Objectives: There is insufficient evidence regarding the optimal treatment for asymptomatic carotid stenosis. Methods: Bayesian cross-design and network meta-analyses were performed to compare the safety and efficacy among carotid artery stenting (CAS), carotid endarterectomy (CEA), and medical treatment (MT). We identified 18 studies (4 randomized controlled trials [RCTs] and 14 nonrandomized, comparative studies [NRCSs]) comparing CAS with CEA, and 4 RCTs comparing CEA with MT from MEDLINE, Cochrane Library, and Embase databases. Results: The risk for periprocedural stroke tended to increase in CAS, compared to CEA (odds ratio [OR], 1.86; 95% credible interval [CrI], 0.62–4.54). However, estimates for periprocedural myocardial infarction (MI) were quite heterogeneous in RCTs and NRCSs. Despite a trend of decreased risk with CAS in RCTs (OR, 0.70; 95% CrI, 0.27–1.24), the risk was similar in NRCSs (OR, 1.02; 95% CrI, 0.87–1.18). In indirect comparisons of MT and CAS, MT showed a tendency to have a higher risk for the composite of periprocedural death, stroke, MI, or nonperiprocedural ipsilateral stroke (OR, 1.30; 95% CrI, 0.74–2.73). Analyses of study characteristics showed that CEA-versus-MT studies took place about 10-year earlier than CEA-versus-CAS studies. Conclusions: A similar risk for periprocedural MI between CEA and CAS in NRCSs suggested that concerns about periprocedural MI accompanied by CEA might not matter in real-world practice when preoperative evaluation and management are working. Maybe the benefits of CAS over MT have been overestimated considering advances in medical therapy within10-year gap between CEA-versus-MT and CEA-versus-CAS studies.